MX2018001196A - Compuesto derivado de amida de 1,3,4-oxadiazol como inhibidor de histona desacetilasa 6 y composición farmacéutica que lo contiene. - Google Patents
Compuesto derivado de amida de 1,3,4-oxadiazol como inhibidor de histona desacetilasa 6 y composición farmacéutica que lo contiene.Info
- Publication number
- MX2018001196A MX2018001196A MX2018001196A MX2018001196A MX2018001196A MX 2018001196 A MX2018001196 A MX 2018001196A MX 2018001196 A MX2018001196 A MX 2018001196A MX 2018001196 A MX2018001196 A MX 2018001196A MX 2018001196 A MX2018001196 A MX 2018001196A
- Authority
- MX
- Mexico
- Prior art keywords
- diseases
- histone deacetylase
- hdac6
- new compounds
- inhibitor
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 1,3,4-oxadiazole amide Chemical class 0.000 title 1
- 229940122617 Histone deacetylase 6 inhibitor Drugs 0.000 title 1
- 102000011427 Histone Deacetylase 6 Human genes 0.000 abstract 5
- 108010023925 Histone Deacetylase 6 Proteins 0.000 abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 5
- 201000010099 disease Diseases 0.000 abstract 4
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010008805 Chromosomal abnormalities Diseases 0.000 abstract 1
- 208000031404 Chromosome Aberrations Diseases 0.000 abstract 1
- 206010010356 Congenital anomaly Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000019498 Skin and subcutaneous tissue disease Diseases 0.000 abstract 1
- 230000003542 behavioural effect Effects 0.000 abstract 1
- 210000002808 connective tissue Anatomy 0.000 abstract 1
- 208000010643 digestive system disease Diseases 0.000 abstract 1
- 208000016097 disease of metabolism Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000002124 endocrine Effects 0.000 abstract 1
- 208000030172 endocrine system disease Diseases 0.000 abstract 1
- 208000030533 eye disease Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 230000036244 malformation Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000003340 mental effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000002346 musculoskeletal system Anatomy 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 229940126585 therapeutic drug Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a nuevos compuestos que tienen actividad inhibidora de histona desacetilasa 6 (HDAC6), estereoisómeros de los mismos o sales farmacéuticamente aceptables de los mismos, el uso de los mismos para la preparación de medicamentos terapéuticos, composiciones farmacéuticas que contienen los mismos, un método para tratar enfermedades usando la composición y métodos para preparar los nuevos compuestos. Los nuevos compuestos, los estereoisómeros de los mismos o las sales farmacéuticamente aceptables de los mismos de acuerdo con la presente invención tienen actividad inhibidora de histona desacetilasa 6 (HDAC6) y son eficaces para la prevención o el tratamiento de enfermedades mediadas por HDAC6, incluyendo enfermedades infecciosas; neoplasias; enfermedades endocrinas, nutricionales y metabólicas; trastornos mentales y conductuales; enfermedades neurológicas; enfermedades del ojo y anexos; enfermedades cardiovasculares; enfermedades respiratorias; enfermedades digestivas; enfermedades de los tejidos cutáneo y subcutáneo; enfermedades del sistema musculoesquelético y del tejido conectivo; o malformaciones congénitas, deformaciones y anomalías cromosómicas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20150106007 | 2015-07-27 | ||
| PCT/KR2016/008216 WO2017018804A1 (ko) | 2015-07-27 | 2016-07-27 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 아마이드 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018001196A true MX2018001196A (es) | 2018-05-22 |
| MX377262B MX377262B (es) | 2025-03-07 |
Family
ID=57886896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018001196A MX377262B (es) | 2015-07-27 | 2016-07-27 | Compuesto derivado de amida de 1,3,4-oxadiazol como inhibidor de histona desacetilasa 6 y composición farmacéutica que lo contiene. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10584117B2 (es) |
| EP (1) | EP3330259B1 (es) |
| JP (1) | JP6559325B2 (es) |
| KR (1) | KR101799009B1 (es) |
| CN (1) | CN108026056B (es) |
| AU (1) | AU2016299485B2 (es) |
| CA (1) | CA2993918C (es) |
| DK (1) | DK3330259T3 (es) |
| ES (1) | ES2814229T3 (es) |
| HR (1) | HRP20201304T1 (es) |
| HU (1) | HUE051537T2 (es) |
| MX (1) | MX377262B (es) |
| MY (1) | MY190301A (es) |
| NZ (1) | NZ739211A (es) |
| PH (1) | PH12018500162B1 (es) |
| PL (1) | PL3330259T3 (es) |
| PT (1) | PT3330259T (es) |
| RU (1) | RU2700696C2 (es) |
| WO (1) | WO2017018804A1 (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11325286B2 (en) * | 2009-09-24 | 2022-05-10 | Sealed Air Corporation (Us) | Mixing machine for producing foam within a bag |
| AU2016299486B2 (en) | 2015-07-27 | 2019-08-01 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-oxadiazole sulfamide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
| DK3330259T3 (da) | 2015-07-27 | 2020-08-10 | Chong Kun Dang Pharmaceutical Corp | 1,3,4-oxadiazolamidderivativ-forbindelse som histondeacetylase-6-inhibitor og farmaceutisk sammensætning indeholdende denne |
| DK3328843T3 (da) | 2015-07-27 | 2023-01-09 | Chong Kun Dang Pharmaceutical Corp | 1,3,4-oxadiazolsulfonamidderivat-forbindelser som histon- deacetylase-6-inhibitor, og den farmaceutske sammensætning |
| EP3331864B1 (en) | 2015-08-04 | 2021-11-03 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
| MX384527B (es) | 2015-10-12 | 2025-03-14 | Chong Kun Dang Pharmaceutical Corp | Compuestos derivados de oxadiazolamina como inhibidores de histona desacetilasa 6, y la composición farmacéutica que comprende los mismos |
| US10357493B2 (en) | 2017-03-10 | 2019-07-23 | Selenity Therapeutics (Bermuda), Ltd. | Metalloenzyme inhibitor compounds |
| EP3661931A1 (en) * | 2017-07-31 | 2020-06-10 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| WO2019040105A2 (en) * | 2017-08-21 | 2019-02-28 | Acadia Pharmaceuticals Inc. | COMPOUNDS, SALTS THEREOF AND METHODS FOR THE TREATMENT OF DISEASES |
| KR102316234B1 (ko) | 2018-07-26 | 2021-10-22 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| JP7470058B2 (ja) * | 2019-01-30 | 2024-04-17 | 武田薬品工業株式会社 | 複素環化合物 |
| DK3956324T3 (da) * | 2019-04-17 | 2024-05-13 | Quimatryx S L | 1,3,4-oxadiazol-derivater som histondeacetylase-inhibitorer |
| BR112021023770A2 (pt) * | 2019-05-31 | 2022-01-11 | Chong Kun Dang Pharmaceutical Corp | Compostos de derivado de 1,3,4-oxadiazol como inibidor de histona desacetilase 6 e a composição farmacêutica que compreende os mesmos |
| TWI748491B (zh) * | 2019-05-31 | 2021-12-01 | 韓商鐘根堂股份有限公司 | 作為組蛋白去乙醯酶6抑制劑之1,3,4-㗁二唑高鄰苯二甲醯亞胺衍生化合物及包含彼之醫藥組合物 |
| AR120040A1 (es) | 2019-09-27 | 2022-01-26 | Takeda Pharmaceuticals Co | Compuesto heterocíclico |
| CR20220325A (es) | 2019-12-20 | 2022-08-19 | Tenaya Therapeutics Inc | Fluoroalquil-oxadiazoles y sus usos |
| KR102537616B1 (ko) | 2020-02-25 | 2023-05-26 | 주식회사 종근당 | 히스톤 탈아세틸화 효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| KR102576148B1 (ko) * | 2020-04-13 | 2023-09-07 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| JP7642859B2 (ja) * | 2021-04-08 | 2025-03-10 | チョン クン ダン ファーマシューティカル コーポレーション | ヒストン脱アセチル化酵素６阻害剤としての１，３，４－オキサジアゾールチオカルボニル化合物およびこれを含む薬剤学的組成物 |
| JP2024514356A (ja) | 2021-04-23 | 2024-04-01 | テナヤ セラピューティクス， インコーポレイテッド | 拡張型心筋症の治療に使用するためのｈｄａｃ６阻害剤 |
| KR20240016950A (ko) | 2021-05-04 | 2024-02-06 | 테나야 테라퓨틱스, 인코포레이티드 | 대사 질환 및 hfpef의 치료에 사용하기 위한 2-플루오로알킬-1,3,4-옥사디아졸-5-일-티아졸, hdac6 억제제 |
| CA3254864A1 (en) * | 2022-04-07 | 2023-10-12 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-OXADIAZOLE DERIVATIVES USED AS HISTONE DEACETYLASE 6 INHIBITORS, AND THEIR USES |
| KR20240035172A (ko) * | 2022-09-08 | 2024-03-15 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이의 용도 |
| TW202517274A (zh) * | 2023-06-30 | 2025-05-01 | 韓商鐘根堂股份有限公司 | 化合物之新穎製備方法及新結晶形式 |
| WO2025215092A1 (en) | 2024-04-10 | 2025-10-16 | Institut National de la Santé et de la Recherche Médicale | Selective hdac6 inhibitors for use in the treatment of myotonic dystrophy type 1 |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4871753A (en) | 1986-12-12 | 1989-10-03 | Ciba-Geigy Corporation | 3-Phenyl-5-trifluoromethyl-1,2,4-oxadiazole compounds which are useful pesticides |
| KR100265385B1 (ko) | 1998-02-27 | 2000-11-01 | 윤여표 | 순환기 질환의 예방 및 치료 효능을 갖는 홍경천 추출물 |
| US6897220B2 (en) | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| US7868204B2 (en) | 2001-09-14 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
| BR0213129A (pt) | 2001-10-03 | 2004-08-10 | Pharmacia Corp | Pró-drogas de compostos policìclicos substituìdos, úteis para inibição seletiva da cascata da coagulação |
| NZ533603A (en) | 2001-12-20 | 2007-02-23 | Bristol Myers Squibb Co | Alpha-(N-sulphonamido)acetamide derivatives as beta-amyloid inhibitors used for treating Alzheimer's Disease and Down's syndrome |
| WO2005040152A1 (en) * | 2003-10-20 | 2005-05-06 | E.I. Dupont De Nemours And Company | Heteroyclylphenyl-and heterocyclylpyridyl-substituted azolecarboxamides as herbicides |
| ZA200800901B (en) | 2005-07-14 | 2010-05-26 | Takeda San Diego Inc | Histone deacetylase inhibitors |
| ES2431050T3 (es) | 2005-08-04 | 2013-11-22 | Sirtris Pharmaceuticals, Inc. | Benzotiazoles y tiazolopiridinas como moduladores de la sirtuína |
| WO2007032445A1 (ja) | 2005-09-16 | 2007-03-22 | Kyowa Hakko Kogyo Co., Ltd. | タンパク質キナーゼ阻害剤 |
| JP2009514858A (ja) * | 2005-11-03 | 2009-04-09 | メルク エンド カムパニー インコーポレーテッド | アリール−ピラゾリルモチーフを有するヒストンデアセチラーゼ阻害剤 |
| ATE518564T1 (de) | 2006-03-23 | 2011-08-15 | Biota Europe Ltd | Benzamide- und pyridylamide-derivate als antibakterielle mittel |
| US20070293530A1 (en) * | 2006-06-14 | 2007-12-20 | Methylgene Inc. | Sulfamide and sulfamate derivatives as histone deacetylase inhibitors |
| EP1878730A1 (en) | 2006-07-12 | 2008-01-16 | Bayer Schering Pharma Aktiengesellschaft | Substituted isoxazolines, pharmaceutical compositions containing the same, methods of preparing the same, and uses of the same |
| MX2009006202A (es) | 2006-12-11 | 2009-06-22 | Genentech Inc | Composiciones y metodos para el tratamiento de neoplasma. |
| WO2009010479A2 (en) | 2007-07-13 | 2009-01-22 | Euroscreen S.A. | Heterocyclic methylene piperidine derivatives and their use |
| KR100903743B1 (ko) | 2007-08-28 | 2009-06-19 | 전병태 | 소화기계 질환개선 및 예방용 식품 조성물 |
| JP2011502133A (ja) | 2007-11-02 | 2011-01-20 | メシルジーン インコーポレイテッド | ヒストンデアセチラーゼの阻害剤 |
| EP2207811B1 (en) | 2007-11-02 | 2017-01-04 | Momenta Pharmaceuticals, Inc. | Non-anticoagulant polysaccharide compositions |
| RU2515611C2 (ru) | 2008-07-23 | 2014-05-20 | Президент Энд Феллоуз Оф Гарвард Колледж | Ингибиторы деацетилазы и их применение |
| EP2421528A4 (en) | 2009-04-20 | 2012-10-17 | Inst Oneworld Health | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING 1,3,4-OXADIAZOLE DERIVATIVES |
| WO2010126002A1 (ja) | 2009-04-28 | 2010-11-04 | 塩野義製薬株式会社 | ヘテロ環スルホンアミド化合物を含有する医薬 |
| JP2011008205A (ja) * | 2009-05-27 | 2011-01-13 | Fujifilm Corp | 二軸性光学異方性膜を作製するための組成物 |
| WO2011011186A2 (en) | 2009-07-22 | 2011-01-27 | The Board Of Trustees Of The University Of Illinois | Hdac inhibitors and therapeutic methods using the same |
| US8981084B2 (en) | 2010-01-13 | 2015-03-17 | Tempero Pharmaceuticals, Inc. | Oxadiazole HDAC inhibitors |
| CN103221047B (zh) | 2010-01-13 | 2014-12-17 | 坦颇罗制药股份有限公司 | 化合物和方法 |
| CN102933558B (zh) | 2010-01-22 | 2016-03-16 | 埃斯泰隆制药公司 | 作为蛋白质去乙酰化酶抑制剂的反向酰胺化合物及其使用方法 |
| KR20130010895A (ko) | 2010-02-25 | 2013-01-29 | 피라말 엔터프라이지즈 리미티드 | 옥사디아졸 화합물, 그의 제조방법 및 용도 |
| AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| KR20130066633A (ko) | 2010-05-12 | 2013-06-20 | 버텍스 파마슈티칼스 인코포레이티드 | Ａｔｒ 키나제의 억제제로서 유용한 화합물 |
| US8697739B2 (en) | 2010-07-29 | 2014-04-15 | Novartis Ag | Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof |
| KR101657751B1 (ko) | 2010-12-09 | 2016-09-19 | 욱크하르트 리미티드 | 케토라이드 화합물 |
| KR101262870B1 (ko) | 2011-01-28 | 2013-05-09 | 환인제약 주식회사 | 호장근 추출물을 함유하는 호흡기 질환의 예방 또는 치료용 조성물 |
| CA2841113A1 (en) | 2011-07-08 | 2013-01-17 | Novartis Ag | Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease |
| EP2734500A4 (en) | 2011-07-20 | 2015-04-08 | Gen Hospital Corp | SELECTIVE HISTONDEACETYLASE-6 INHIBITORS FOR THE TREATMENT OF BONE DISORDERS |
| WO2013041407A1 (en) | 2011-09-19 | 2013-03-28 | Cellzome Ag | Hydroxamic acids as hdac6 inhibitors |
| AU2012319188B2 (en) | 2011-10-03 | 2016-11-24 | Sloan-Kettering Institute For Cancer Research | Novel molecules that selectively inhibit histone deacetylase 6 relative to histone deacetylase 1 |
| WO2013066833A1 (en) | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods to inhibit histone deacetylase (hdac) enzymes |
| WO2013066839A2 (en) | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
| WO2013066835A2 (en) * | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
| WO2013066838A1 (en) | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
| US9670193B2 (en) | 2011-11-28 | 2017-06-06 | Novartis Ag | Trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease |
| JP6272773B2 (ja) | 2011-11-29 | 2018-01-31 | ナンジン アルゲン ファルマ カンパニー リミテッドＮａｎｊｉｎｇ Ａｌｌｇｅｎ Ｐｈａｒｍａ Ｃｏ． Ｌｔｄ． | Ｈｄａｃ６阻害剤・抗腫瘍剤用複素環アミド化合物 |
| JP6233812B2 (ja) | 2012-03-07 | 2017-11-22 | エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド | 選択的ヒストンデアセチラーゼ６阻害剤 |
| JP2016532711A (ja) | 2013-09-06 | 2016-10-20 | オーリジーン ディスカバリー テクノロジーズ リミテッドＡｕｒｉｇｅｎｅ Ｄｉｓｃｏｖｅｒｙ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｉｍｉｔｅｄ | 免疫調節剤としての１，３，４−オキサジアゾール及び１，３，４−チアジアゾールの誘導体 |
| HRP20181965T1 (hr) | 2013-12-12 | 2019-02-08 | Chong Kun Dang Pharmaceutical Corp. | Novi derivati azaindola kao selektivni inhibitori histonske deacetilaze (hdac) i farmaceutski pripravci koji ih sadrže |
| CN104744446B (zh) | 2013-12-30 | 2019-06-25 | 广东东阳光药业有限公司 | 杂芳化合物及其在药物中的应用 |
| KR101909092B1 (ko) | 2014-11-24 | 2018-10-17 | (주) 메디프론디비티 | 바닐로이드 수용체 리간드 ii로서의 치환된 옥사졸계 및 싸이아졸계 카복스아미드 및 우레아 유도체 |
| CN106349451B (zh) | 2015-07-14 | 2020-11-13 | 罗门哈斯公司 | 用于制备疏水改性环氧烷氨基甲酸酯聚合物的方法 |
| DK3328843T3 (da) | 2015-07-27 | 2023-01-09 | Chong Kun Dang Pharmaceutical Corp | 1,3,4-oxadiazolsulfonamidderivat-forbindelser som histon- deacetylase-6-inhibitor, og den farmaceutske sammensætning |
| DK3330259T3 (da) | 2015-07-27 | 2020-08-10 | Chong Kun Dang Pharmaceutical Corp | 1,3,4-oxadiazolamidderivativ-forbindelse som histondeacetylase-6-inhibitor og farmaceutisk sammensætning indeholdende denne |
| AU2016299486B2 (en) | 2015-07-27 | 2019-08-01 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-oxadiazole sulfamide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
| EP3331864B1 (en) | 2015-08-04 | 2021-11-03 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
| MX384527B (es) | 2015-10-12 | 2025-03-14 | Chong Kun Dang Pharmaceutical Corp | Compuestos derivados de oxadiazolamina como inhibidores de histona desacetilasa 6, y la composición farmacéutica que comprende los mismos |
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2016
- 2016-07-27 DK DK16830837.7T patent/DK3330259T3/da active
- 2016-07-27 CA CA2993918A patent/CA2993918C/en active Active
- 2016-07-27 PT PT168308377T patent/PT3330259T/pt unknown
- 2016-07-27 HR HRP20201304TT patent/HRP20201304T1/hr unknown
- 2016-07-27 KR KR1020160095334A patent/KR101799009B1/ko active Active
- 2016-07-27 WO PCT/KR2016/008216 patent/WO2017018804A1/ko not_active Ceased
- 2016-07-27 MX MX2018001196A patent/MX377262B/es active IP Right Grant
- 2016-07-27 ES ES16830837T patent/ES2814229T3/es active Active
- 2016-07-27 AU AU2016299485A patent/AU2016299485B2/en active Active
- 2016-07-27 US US15/748,081 patent/US10584117B2/en active Active
- 2016-07-27 PL PL16830837T patent/PL3330259T3/pl unknown
- 2016-07-27 CN CN201680053218.0A patent/CN108026056B/zh active Active
- 2016-07-27 MY MYPI2018700206A patent/MY190301A/en unknown
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|---|---|
| EP3330259A1 (en) | 2018-06-06 |
| AU2016299485A1 (en) | 2018-02-08 |
| NZ739211A (en) | 2019-05-31 |
| JP6559325B2 (ja) | 2019-08-14 |
| BR112018001716A2 (pt) | 2018-11-06 |
| CN108026056A (zh) | 2018-05-11 |
| RU2700696C2 (ru) | 2019-09-19 |
| CA2993918C (en) | 2020-09-29 |
| WO2017018804A1 (ko) | 2017-02-02 |
| EP3330259A4 (en) | 2019-01-16 |
| ES2814229T3 (es) | 2021-03-26 |
| DK3330259T3 (da) | 2020-08-10 |
| AU2016299485B2 (en) | 2019-02-07 |
| RU2018106914A (ru) | 2019-08-27 |
| PH12018500162B1 (en) | 2021-10-06 |
| HUE051537T2 (hu) | 2021-03-01 |
| PH12018500162A1 (en) | 2018-07-30 |
| HK1251939A1 (zh) | 2019-05-03 |
| KR101799009B1 (ko) | 2017-11-17 |
| PL3330259T3 (pl) | 2021-02-08 |
| MY190301A (en) | 2022-04-13 |
| JP2018521110A (ja) | 2018-08-02 |
| HRP20201304T1 (hr) | 2020-11-27 |
| CN108026056B (zh) | 2021-08-03 |
| RU2018106914A3 (es) | 2019-08-27 |
| US20180215743A1 (en) | 2018-08-02 |
| US10584117B2 (en) | 2020-03-10 |
| CA2993918A1 (en) | 2017-02-02 |
| EP3330259B1 (en) | 2020-06-10 |
| PT3330259T (pt) | 2020-09-03 |
| MX377262B (es) | 2025-03-07 |
| KR20170013187A (ko) | 2017-02-06 |
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