DK3328843T3 - 1,3,4-oxadiazolsulfonamidderivat-forbindelser som histon- deacetylase-6-inhibitor, og den farmaceutske sammensætning - Google Patents
1,3,4-oxadiazolsulfonamidderivat-forbindelser som histon- deacetylase-6-inhibitor, og den farmaceutske sammensætning Download PDFInfo
- Publication number
- DK3328843T3 DK3328843T3 DK16830836.9T DK16830836T DK3328843T3 DK 3328843 T3 DK3328843 T3 DK 3328843T3 DK 16830836 T DK16830836 T DK 16830836T DK 3328843 T3 DK3328843 T3 DK 3328843T3
- Authority
- DK
- Denmark
- Prior art keywords
- oxadiazolesulfonamide
- inhibitors
- pharmaceutical composition
- histone deacetylase
- derivative compounds
- Prior art date
Links
- -1 1,3,4-OXADIAZOLESULFONAMIDE DERIVATIVE COMPOUNDS Chemical class 0.000 title 1
- 102000011427 Histone Deacetylase 6 Human genes 0.000 title 1
- 108010023925 Histone Deacetylase 6 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20150105976 | 2015-07-27 | ||
| PCT/KR2016/008214 WO2017018803A1 (en) | 2015-07-27 | 2016-07-27 | 1,3,4-oxadiazole sulfonamide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3328843T3 true DK3328843T3 (da) | 2023-01-09 |
Family
ID=57886873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16830836.9T DK3328843T3 (da) | 2015-07-27 | 2016-07-27 | 1,3,4-oxadiazolsulfonamidderivat-forbindelser som histon- deacetylase-6-inhibitor, og den farmaceutske sammensætning |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US10538498B2 (da) |
| EP (1) | EP3328843B1 (da) |
| JP (1) | JP6560436B2 (da) |
| KR (1) | KR101799007B1 (da) |
| CN (1) | CN107922362B (da) |
| AU (1) | AU2016299484B2 (da) |
| CA (1) | CA2993929C (da) |
| DK (1) | DK3328843T3 (da) |
| ES (1) | ES2935932T3 (da) |
| FI (1) | FI3328843T3 (da) |
| HR (1) | HRP20230052T1 (da) |
| HU (1) | HUE061174T2 (da) |
| MX (1) | MX376584B (da) |
| MY (1) | MY197262A (da) |
| NZ (1) | NZ739026A (da) |
| PH (1) | PH12018500212A1 (da) |
| PL (1) | PL3328843T3 (da) |
| PT (1) | PT3328843T (da) |
| RU (1) | RU2697665C1 (da) |
| TW (1) | TWI639587B (da) |
| WO (1) | WO2017018803A1 (da) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016258188B2 (en) | 2015-05-07 | 2021-08-26 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
| EP3291809B1 (en) | 2015-05-07 | 2021-08-25 | CHDI Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
| EP3330259B1 (en) | 2015-07-27 | 2020-06-10 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same |
| EP3328844B1 (en) | 2015-07-27 | 2019-11-27 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-oxadiazole sulfamide derivatives as histone deacetylase 6 inhibitor and pharmaceutical composition comprising the same |
| RU2697665C1 (ru) | 2015-07-27 | 2019-08-16 | Чонг Кун Данг Фармасьютикал Корп. | Производные 1,3,4-оксадиазолсульфонамида в качестве ингибиторов деацетилазы гистонов 6 и фармацевтическая композиция, содержащая их |
| PL3331864T3 (pl) * | 2015-08-04 | 2022-02-21 | Chong Kun Dang Pharmaceutical Corp. | Związki pochodne 1,3,4-oksadiazolu jako inhibitor deacetylazy histonowej 6 oraz zawierająca je kompozycja farmaceutyczna |
| ES2940413T3 (es) | 2015-10-12 | 2023-05-08 | Chong Kun Dang Pharmaceutical Corp | Compuestos derivados de oxadiazolamina como inhibidores de histona desacetilasa 6, y la composición farmacéutica que los comprende |
| WO2018153730A1 (en) * | 2017-02-21 | 2018-08-30 | Basf Se | Substituted oxadiazoles for combating phytopathogenic fungi |
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| EP3606913B1 (en) * | 2017-04-03 | 2022-04-27 | Syngenta Participations AG | Microbiocidal oxadiazole derivatives |
| CN111032651A (zh) | 2017-07-31 | 2020-04-17 | 武田药品工业株式会社 | 杂环化合物 |
| WO2019140254A1 (en) * | 2018-01-12 | 2019-07-18 | President And Fellows Of Harvard College | Multicyclic compounds and use of same for treating tuberculosis |
| WO2019140265A1 (en) | 2018-01-12 | 2019-07-18 | President And Fellows Of Harvard College | Trna synthetase inhibitors |
| KR102316234B1 (ko) | 2018-07-26 | 2021-10-22 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| US20220008414A1 (en) * | 2018-11-23 | 2022-01-13 | Chong Kun Dang Pharmaceutical Corp. | Pharmaceutical composition comprising histone deacetylase 6 inhibitors |
| WO2020158762A1 (ja) | 2019-01-30 | 2020-08-06 | 武田薬品工業株式会社 | 複素環化合物 |
| US12202823B2 (en) | 2019-04-17 | 2025-01-21 | Quimatryx, S.L. | 1,3,4-oxadiazole derivatives as histone deacetylase inhibitors |
| AU2020284606B2 (en) | 2019-05-31 | 2023-01-19 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-oxadiazole homophthalimide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
| BR112022005595A2 (pt) | 2019-09-27 | 2022-07-19 | Takeda Pharmaceuticals Co | Composto, medicamento, métodos para inibir histona deacetilase 6 e para profilaxia ou tratamento de doença de alzheimer ou paralisia supranuclear progressiva em um mamífero, e, uso de composto |
| AU2020407664A1 (en) | 2019-12-20 | 2022-08-18 | Tenaya Therapeutics, Inc. | Fluoroalkyl-oxadiazoles and uses thereof |
| KR102537616B1 (ko) | 2020-02-25 | 2023-05-26 | 주식회사 종근당 | 히스톤 탈아세틸화 효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| KR102576148B1 (ko) * | 2020-04-13 | 2023-09-07 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이를 포함하는 약제학적 조성물 |
| CN116157398B (zh) | 2020-08-07 | 2025-03-11 | 意大发马克股份公司 | 噁二唑系选择性组蛋白去乙酰化酶6抑制剂 |
| WO2022173727A1 (en) * | 2021-02-09 | 2022-08-18 | Celgene Corporation | Sulfonamides and their use for treatment of helminthic infections and diseases |
| KR20220139752A (ko) * | 2021-04-08 | 2022-10-17 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 싸이오카보닐 화합물 및 이를 포함하는 약제학적 조성물 |
| EP4326263A1 (en) | 2021-04-23 | 2024-02-28 | Tenaya Therapeutics, Inc. | Hdac6 inhibitors for use in the treatment of dilated cardiomyopathy |
| US20240252502A1 (en) | 2021-05-04 | 2024-08-01 | Tenaya Therapeutics, Inc. | Hdac6 inhibitors for treatment of metabolic disease and hfpef |
| CN114181187A (zh) * | 2021-11-24 | 2022-03-15 | 上海应用技术大学 | 一种4-甲磺酰胺基丁酰胺化合物的制备方法 |
| TW202337446A (zh) * | 2022-01-28 | 2023-10-01 | 韓商鐘根堂股份有限公司 | 用於預防或治療肺動脈高血壓之組合物 |
| KR20230144686A (ko) * | 2022-04-07 | 2023-10-17 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이의 용도 |
| KR20240035172A (ko) * | 2022-09-08 | 2024-03-15 | 주식회사 종근당 | 히스톤 탈아세틸화효소 6 억제제로서의 1,3,4-옥사다이아졸 유도체 화합물 및 이의 용도 |
| EP4602038A1 (en) * | 2022-10-14 | 2025-08-20 | Chong Kun Dang Pharmaceutical Corp. | Sulfoximine compounds as histone deacetylase 6 inhibitor, and pharmaceutical composition comprising the same |
| WO2025215092A1 (en) | 2024-04-10 | 2025-10-16 | Institut National de la Santé et de la Recherche Médicale | Selective hdac6 inhibitors for use in the treatment of myotonic dystrophy type 1 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0276432A3 (de) | 1986-12-12 | 1988-10-26 | Ciba-Geigy Ag | Schädlingsbekämpfungsmittel |
| KR100265385B1 (ko) | 1998-02-27 | 2000-11-01 | 윤여표 | 순환기 질환의 예방 및 치료 효능을 갖는 홍경천 추출물 |
| US6897220B2 (en) | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| US7868204B2 (en) | 2001-09-14 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
| EP1482940A2 (en) | 2001-10-03 | 2004-12-08 | Pharmacia Corporation | Prodrugs of substituted polycyclic compounds useful for selective inhibition of the coagulation cascade |
| SI1465861T1 (sl) * | 2001-12-20 | 2009-12-31 | Bristol Myers Squibb Co | Alfa-(n-sulfonamido)acetamidni derivati kot beta-amiloid inhibitorji |
| KR20080032188A (ko) | 2005-07-14 | 2008-04-14 | 다케다 샌디에고, 인코포레이티드 | 히스톤 탈아세틸화 효소 억제제 |
| EP2468752A1 (en) * | 2005-08-04 | 2012-06-27 | Sirtris Pharmaceuticals, Inc. | Thiazolopyridine derivatives as sirtuin-modulators |
| WO2007032445A1 (ja) | 2005-09-16 | 2007-03-22 | Kyowa Hakko Kogyo Co., Ltd. | タンパク質キナーゼ阻害剤 |
| GB0603041D0 (en) * | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| CA2648785A1 (en) | 2006-03-23 | 2007-09-27 | Prolysis Ltd. | Antibacterial agents |
| TW200808707A (en) | 2006-06-14 | 2008-02-16 | Methylgene Inc | Sulfamide and sulfamate derivatives as histone deacetylase inhibitors |
| EP1878730A1 (en) | 2006-07-12 | 2008-01-16 | Bayer Schering Pharma Aktiengesellschaft | Substituted isoxazolines, pharmaceutical compositions containing the same, methods of preparing the same, and uses of the same |
| DK2099489T3 (da) | 2006-12-11 | 2014-08-18 | Genentech Inc | Sammensætninger og fremgangsmåder til behandling af en neoplasme |
| WO2009010479A2 (en) | 2007-07-13 | 2009-01-22 | Euroscreen S.A. | Heterocyclic methylene piperidine derivatives and their use |
| KR100903743B1 (ko) | 2007-08-28 | 2009-06-19 | 전병태 | 소화기계 질환개선 및 예방용 식품 조성물 |
| CA2703848C (en) | 2007-11-02 | 2016-10-11 | Momenta Pharmaceuticals, Inc. | Non-anticoagulant polysaccharide compositions |
| CN101918389A (zh) | 2007-11-02 | 2010-12-15 | 梅特希尔基因公司 | 组蛋白脱乙酰酶抑制剂 |
| CA2731730C (en) | 2008-07-23 | 2017-06-13 | President And Fellows Of Harvard College | Deacetylase inhibitors and uses thereof |
| EP2421528A4 (en) * | 2009-04-20 | 2012-10-17 | Inst Oneworld Health | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING 1,3,4-OXADIAZOLE DERIVATIVES |
| WO2010126002A1 (ja) | 2009-04-28 | 2010-11-04 | 塩野義製薬株式会社 | ヘテロ環スルホンアミド化合物を含有する医薬 |
| JP2011008205A (ja) | 2009-05-27 | 2011-01-13 | Fujifilm Corp | 二軸性光学異方性膜を作製するための組成物 |
| US8431538B2 (en) | 2009-07-22 | 2013-04-30 | The Board Of Trustees Of The University Of Illinois | HDAC inhibitors and therapeutic methods of using same |
| WO2011088192A1 (en) | 2010-01-13 | 2011-07-21 | Tempero Pharmaceuticals, Inc. | Compounds and methods |
| US8901156B2 (en) | 2010-01-13 | 2014-12-02 | Tempero Pharmaceuticals, Inc. | Compounds and methods |
| EP2526093B1 (en) | 2010-01-22 | 2016-08-17 | Acetylon Pharmaceuticals, Inc. | Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof |
| CA2791162A1 (en) | 2010-02-25 | 2011-09-01 | Piramal Enterprises Limited | Oxadiazole compounds, their preparation and use |
| AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| KR20130066633A (ko) | 2010-05-12 | 2013-06-20 | 버텍스 파마슈티칼스 인코포레이티드 | Ａｔｒ 키나제의 억제제로서 유용한 화합물 |
| US8697739B2 (en) * | 2010-07-29 | 2014-04-15 | Novartis Ag | Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof |
| AU2011340204B2 (en) | 2010-12-09 | 2016-04-14 | Wockhardt Limited | Ketolide compounds |
| KR101262870B1 (ko) | 2011-01-28 | 2013-05-09 | 환인제약 주식회사 | 호장근 추출물을 함유하는 호흡기 질환의 예방 또는 치료용 조성물 |
| EA201490228A1 (ru) | 2011-07-08 | 2014-08-29 | Новартис Аг | Новые производные трифторметилоксадиазола и их применение для лечения заболевания |
| WO2013013113A2 (en) | 2011-07-20 | 2013-01-24 | The General Hospital Corporation | Histone deacetylase 6 selective inhibitors for the treatment of bone disease |
| WO2013041407A1 (en) | 2011-09-19 | 2013-03-28 | Cellzome Ag | Hydroxamic acids as hdac6 inhibitors |
| EP2763531A4 (en) | 2011-10-03 | 2015-11-18 | Univ Columbia | NEW MOLECULES FOR THE SELECTIVE INHIBITION OF HISTONDEACETYLASE 6 IN RELATION TO HISTONDEACETYLASE 1 |
| WO2013066839A2 (en) | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
| WO2013066833A1 (en) | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods to inhibit histone deacetylase (hdac) enzymes |
| WO2013066835A2 (en) | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
| WO2013066838A1 (en) | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
| ES2606630T3 (es) | 2011-11-28 | 2017-03-24 | Novartis Ag | Derivados de trifluorometil-oxadiazol novedosos y su uso en el tratamiento de enfermedad |
| JP6272773B2 (ja) | 2011-11-29 | 2018-01-31 | ナンジン アルゲン ファルマ カンパニー リミテッドＮａｎｊｉｎｇ Ａｌｌｇｅｎ Ｐｈａｒｍａ Ｃｏ． Ｌｔｄ． | Ｈｄａｃ６阻害剤・抗腫瘍剤用複素環アミド化合物 |
| JP6233812B2 (ja) | 2012-03-07 | 2017-11-22 | エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド | 選択的ヒストンデアセチラーゼ６阻害剤 |
| MX2016002971A (es) | 2013-09-06 | 2016-10-07 | Aurigene Discovery Tech Ltd | Derivados de 1,3,4-oxadiazol y 1,3,4-tiadiazol como inmunomoduladores. |
| PL3080125T3 (pl) | 2013-12-12 | 2019-06-28 | Chong Kun Dang Pharmaceutical Corp. | Pochodne azaindolu jako selektywne inhibitory deacetylazy histonowej (HDAC) i zawierające je kompozycje farmaceutyczne |
| CN104744446B (zh) | 2013-12-30 | 2019-06-25 | 广东东阳光药业有限公司 | 杂芳化合物及其在药物中的应用 |
| CN107108593B (zh) | 2014-11-24 | 2020-03-24 | 美迪福伦Dbt有限公司 | 作为类香草素受体配体ii的基于取代的恶唑和噻唑的羧酰胺和脲衍生物 |
| CN106349451B (zh) | 2015-07-14 | 2020-11-13 | 罗门哈斯公司 | 用于制备疏水改性环氧烷氨基甲酸酯聚合物的方法 |
| RU2697665C1 (ru) | 2015-07-27 | 2019-08-16 | Чонг Кун Данг Фармасьютикал Корп. | Производные 1,3,4-оксадиазолсульфонамида в качестве ингибиторов деацетилазы гистонов 6 и фармацевтическая композиция, содержащая их |
| EP3328844B1 (en) | 2015-07-27 | 2019-11-27 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-oxadiazole sulfamide derivatives as histone deacetylase 6 inhibitor and pharmaceutical composition comprising the same |
| EP3330259B1 (en) | 2015-07-27 | 2020-06-10 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same |
| PL3331864T3 (pl) | 2015-08-04 | 2022-02-21 | Chong Kun Dang Pharmaceutical Corp. | Związki pochodne 1,3,4-oksadiazolu jako inhibitor deacetylazy histonowej 6 oraz zawierająca je kompozycja farmaceutyczna |
| ES2940413T3 (es) | 2015-10-12 | 2023-05-08 | Chong Kun Dang Pharmaceutical Corp | Compuestos derivados de oxadiazolamina como inhibidores de histona desacetilasa 6, y la composición farmacéutica que los comprende |
-
2016
- 2016-07-27 RU RU2018106877A patent/RU2697665C1/ru active
- 2016-07-27 DK DK16830836.9T patent/DK3328843T3/da active
- 2016-07-27 HU HUE16830836A patent/HUE061174T2/hu unknown
- 2016-07-27 NZ NZ739026A patent/NZ739026A/en unknown
- 2016-07-27 EP EP16830836.9A patent/EP3328843B1/en active Active
- 2016-07-27 MY MYPI2018700258A patent/MY197262A/en unknown
- 2016-07-27 WO PCT/KR2016/008214 patent/WO2017018803A1/en not_active Ceased
- 2016-07-27 KR KR1020160095332A patent/KR101799007B1/ko active Active
- 2016-07-27 FI FIEP16830836.9T patent/FI3328843T3/fi active
- 2016-07-27 AU AU2016299484A patent/AU2016299484B2/en active Active
- 2016-07-27 CN CN201680044430.0A patent/CN107922362B/zh active Active
- 2016-07-27 TW TW105123824A patent/TWI639587B/zh active
- 2016-07-27 US US15/747,952 patent/US10538498B2/en active Active
- 2016-07-27 MX MX2018001193A patent/MX376584B/es active IP Right Grant
- 2016-07-27 PT PT168308369T patent/PT3328843T/pt unknown
- 2016-07-27 JP JP2018503804A patent/JP6560436B2/ja active Active
- 2016-07-27 PL PL16830836.9T patent/PL3328843T3/pl unknown
- 2016-07-27 ES ES16830836T patent/ES2935932T3/es active Active
- 2016-07-27 HR HRP20230052TT patent/HRP20230052T1/hr unknown
- 2016-07-27 CA CA2993929A patent/CA2993929C/en active Active
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2018
- 2018-01-26 PH PH12018500212A patent/PH12018500212A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2993929C (en) | 2020-10-20 |
| HK1251571A1 (zh) | 2019-02-01 |
| PH12018500212A1 (en) | 2018-08-13 |
| US20180251437A1 (en) | 2018-09-06 |
| AU2016299484B2 (en) | 2019-08-01 |
| PL3328843T3 (pl) | 2023-02-27 |
| EP3328843B1 (en) | 2022-10-26 |
| WO2017018803A1 (en) | 2017-02-02 |
| MY197262A (en) | 2023-06-08 |
| EP3328843A4 (en) | 2019-01-16 |
| RU2697665C1 (ru) | 2019-08-16 |
| JP2018526343A (ja) | 2018-09-13 |
| MX376584B (es) | 2025-03-07 |
| CN107922362B (zh) | 2021-06-15 |
| FI3328843T3 (fi) | 2023-01-31 |
| HUE061174T2 (hu) | 2023-05-28 |
| JP6560436B2 (ja) | 2019-08-14 |
| BR112018001720A2 (pt) | 2018-11-06 |
| HRP20230052T1 (hr) | 2023-03-03 |
| ES2935932T3 (es) | 2023-03-13 |
| KR20170013836A (ko) | 2017-02-07 |
| EP3328843A1 (en) | 2018-06-06 |
| CN107922362A (zh) | 2018-04-17 |
| US10538498B2 (en) | 2020-01-21 |
| MX2018001193A (es) | 2018-05-22 |
| TW201712001A (zh) | 2017-04-01 |
| TWI639587B (zh) | 2018-11-01 |
| AU2016299484A1 (en) | 2018-02-01 |
| KR101799007B1 (ko) | 2017-11-17 |
| CA2993929A1 (en) | 2017-02-02 |
| NZ739026A (en) | 2019-03-29 |
| PT3328843T (pt) | 2023-01-24 |
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