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MX2017007429A - Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr). - Google Patents

Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr).

Info

Publication number
MX2017007429A
MX2017007429A MX2017007429A MX2017007429A MX2017007429A MX 2017007429 A MX2017007429 A MX 2017007429A MX 2017007429 A MX2017007429 A MX 2017007429A MX 2017007429 A MX2017007429 A MX 2017007429A MX 2017007429 A MX2017007429 A MX 2017007429A
Authority
MX
Mexico
Prior art keywords
respiratory syncytial
syncytial virus
rsv
replication
inhibitory activity
Prior art date
Application number
MX2017007429A
Other languages
English (en)
Other versions
MX368162B (es
Inventor
Abdellah Tahri
Ludwig Paul Cooymans
Pierre Jean-Marie Bernard Raboisson
Sandrine Marie Helene Vendeville
Lili Hu
Tim Hugo Maria Jonckers
Samuël Dominique Demin
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of MX2017007429A publication Critical patent/MX2017007429A/es
Publication of MX368162B publication Critical patent/MX368162B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención se refiere a compuestos de pirazolopirimidina bicíclicos sustituidos de fórmula (I) novedosos que tienen actividad antiviral, en particular, que tienen una actividad inhibidora sobre la replicación del virus sincicial respiratorio (VSR); la invención se refiere además a la preparación de tales compuestos novedosos, a composiciones que comprenden estos compuestos y a los compuestos para usarse en el tratamiento de la infección por el virus sincicial respiratorio. (ver Fórmula).
MX2017007429A 2014-12-08 2015-12-07 Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr). MX368162B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14196782 2014-12-08
PCT/EP2015/078762 WO2016091774A1 (en) 2014-12-08 2015-12-07 Piperidine substituted pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (rsv)

Publications (2)

Publication Number Publication Date
MX2017007429A true MX2017007429A (es) 2017-09-28
MX368162B MX368162B (es) 2019-09-20

Family

ID=52006929

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017007429A MX368162B (es) 2014-12-08 2015-12-07 Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr).

Country Status (13)

Country Link
US (1) US9981976B2 (es)
EP (1) EP3230287B1 (es)
JP (2) JP2017537118A (es)
KR (1) KR102522832B1 (es)
CN (1) CN107001377B (es)
AU (1) AU2015359624B2 (es)
CA (1) CA2963051C (es)
EA (1) EA032081B1 (es)
ES (1) ES2704740T3 (es)
MX (1) MX368162B (es)
SG (1) SG11201704397VA (es)
WO (1) WO2016091774A1 (es)
ZA (1) ZA201703899B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107207512B (zh) 2014-12-08 2019-09-10 爱尔兰詹森科学公司 对呼吸道合胞病毒(rsv)的复制具有抑制活性的哌啶取代的三环吡唑并[1，5-a]嘧啶衍生物
JO3637B1 (ar) 2015-04-28 2020-08-27 Janssen Sciences Ireland Uc مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv
TW201932470A (zh) 2017-11-29 2019-08-16 愛爾蘭商健生科學愛爾蘭無限公司 具有抗ｒｓｖ活性之吡唑并嘧啶
EA202091835A1 (ru) 2018-01-31 2020-10-20 Янссен Сайенсиз Айрлэнд Анлимитед Компани Замещенные циклоалкилом пиразолопиримидины, обладающие активностью против rsv
MX2020011200A (es) 2018-04-23 2020-11-13 Janssen Sciences Ireland Unlimited Co Compuestos heteroaromaticos que tienen actividad contra vrs.
AU2019359166B2 (en) * 2018-10-10 2024-07-11 Curovir Ab 2,6-dimethyl-N-((pyridin-4-yl)methyl)imidazo(1,2-b)pyridazin-8-amine and 2,5-dimethyl-N-((pyridin-4-yl)methyl)pyrazolo(1,5-a)pyrimidin-7-amine derivatives for treating viral infections
WO2020109224A1 (en) * 2018-11-26 2020-06-04 Janssen Sciences Ireland Unlimited Company Further heteroaromatic compounds having activity against rsv
EP3903788A4 (en) 2018-12-27 2022-09-07 Taisho Pharmaceutical Co., Ltd. PYRAZOLO[1,5-A] PYRIMIDINE MACROCYCLIC COMPOUND
JP7248255B2 (ja) * 2019-01-29 2023-03-29 シャンドン スアンズ ファーマ カンパニー，リミテッド ヘキソングルコキナーゼ阻害剤およびその使用
JP7403661B2 (ja) * 2019-12-24 2023-12-22 杭州中美華東製薬有限公司 Ｋｈｋ阻害効果を有する化合物
CN115209952B (zh) 2020-01-13 2025-05-30 维基分析有限公司 经取代的吡唑并嘧啶及其用途
JP7618338B2 (ja) * 2020-04-20 2025-01-21 エルジー・ケム・リミテッド ３－アザビシクロアルキル誘導体およびこれを含む薬剤学的組成物
CN113754640B (zh) * 2020-06-03 2023-02-14 山东轩竹医药科技有限公司 氘代的己酮糖激酶抑制剂及其用途
CN112724157B (zh) * 2021-01-23 2022-04-19 中国科学院新疆理化技术研究所 二氢噁唑并[5,4-d]吡咯并[1,2-a]嘧啶-9(5H)-酮类衍生物及用途
CA3223875A1 (en) * 2021-06-25 2022-12-29 Shigeru Matsuoka Heterocycloalkyl-substituted polyheteroazole derivatives as medicaments for treating and/or preventing rs virus infections
MX2024002008A (es) 2021-08-19 2024-03-05 Syngenta Crop Protection Ag Metodo para controlar plagas resistentes a diamidas y compuestos para el mismo.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU727572B2 (en) * 1997-02-14 2000-12-14 Pola Chemical Industries Inc. Remedies/preventives for respiratory diseases
EP1504004B1 (en) * 2002-05-10 2007-06-27 SmithKline Beecham Corporation Substituted pyrazolopyrimidines
JPWO2005030773A1 (ja) * 2003-09-26 2006-12-07 大日本住友製薬株式会社 新規ピラゾロピリミジン誘導体
GB0327319D0 (en) * 2003-11-24 2003-12-24 Pfizer Ltd Novel pharmaceuticals
HUE029174T2 (hu) * 2010-06-24 2017-02-28 Gilead Sciences Inc Pirazolo[1,5-A]pirimidinek és -triazinok mint antivirális szerek
EP2794611B1 (en) 2011-12-22 2017-10-11 Gilead Sciences, Inc. Pyrazolo[1,5-a]pyrimidines as antiviral agents
EP2838900B1 (en) * 2012-04-17 2019-08-21 Gilead Sciences, Inc. Compounds and methods for antiviral treatment
CN107207512B (zh) 2014-12-08 2019-09-10 爱尔兰詹森科学公司 对呼吸道合胞病毒(rsv)的复制具有抑制活性的哌啶取代的三环吡唑并[1，5-a]嘧啶衍生物

Also Published As

Publication number Publication date
AU2015359624B2 (en) 2020-01-02
MX368162B (es) 2019-09-20
EA032081B1 (ru) 2019-04-30
JP2020011991A (ja) 2020-01-23
WO2016091774A1 (en) 2016-06-16
SG11201704397VA (en) 2017-06-29
EA201791274A1 (ru) 2017-10-31
EP3230287A1 (en) 2017-10-18
ZA201703899B (en) 2019-01-30
EP3230287B1 (en) 2018-10-10
KR102522832B1 (ko) 2023-04-17
CN107001377A (zh) 2017-08-01
AU2015359624A1 (en) 2017-04-13
CA2963051C (en) 2023-10-17
US20170349591A1 (en) 2017-12-07
KR20170090424A (ko) 2017-08-07
CA2963051A1 (en) 2016-06-16
CN107001377B (zh) 2019-09-10
US9981976B2 (en) 2018-05-29
JP6628930B1 (ja) 2020-01-15
ES2704740T3 (es) 2019-03-19
JP2017537118A (ja) 2017-12-14

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