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MX2017001980A - Derivado de quinolina muy puro y metodo para su produccion. - Google Patents

Derivado de quinolina muy puro y metodo para su produccion.

Info

Publication number
MX2017001980A
MX2017001980A MX2017001980A MX2017001980A MX2017001980A MX 2017001980 A MX2017001980 A MX 2017001980A MX 2017001980 A MX2017001980 A MX 2017001980A MX 2017001980 A MX2017001980 A MX 2017001980A MX 2017001980 A MX2017001980 A MX 2017001980A
Authority
MX
Mexico
Prior art keywords
production
quinoline derivative
pure quinoline
pure
formula
Prior art date
Application number
MX2017001980A
Other languages
English (en)
Other versions
MX394386B (es
Inventor
Nakamura Taiju
Abe Taichi
Miyashita Yusuke
Kuroda Hirofumi
Ayata Yusuke
Akao Atsushi
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55399727&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2017001980(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of MX2017001980A publication Critical patent/MX2017001980A/es
Publication of MX394386B publication Critical patent/MX394386B/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se proporciona un compuesto representado por la fórmula (IV) o una de sus sales, donde el contenido del compuesto representado por la fórmula (I) es menor o igual a 350 ppm en masa. (ver Fórmulas).
MX2017001980A 2014-08-28 2015-08-26 Derivado de quinolina muy puro y metodo para su produccion. MX394386B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2014174062 2014-08-28
JP2015034729 2015-02-25
PCT/JP2015/073946 WO2016031841A1 (ja) 2014-08-28 2015-08-26 高純度キノリン誘導体およびその製造方法

Publications (2)

Publication Number Publication Date
MX2017001980A true MX2017001980A (es) 2017-05-04
MX394386B MX394386B (es) 2025-03-24

Family

ID=55399727

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2017001980A MX394386B (es) 2014-08-28 2015-08-26 Derivado de quinolina muy puro y metodo para su produccion.
MX2022009299A MX2022009299A (es) 2014-08-28 2017-02-13 Derivado de quinolina muy puro y metodo para su produccion.
MX2022009300A MX2022009300A (es) 2014-08-28 2017-02-13 Derivado de quinolina muy puro y metodo para su produccion.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2022009299A MX2022009299A (es) 2014-08-28 2017-02-13 Derivado de quinolina muy puro y metodo para su produccion.
MX2022009300A MX2022009300A (es) 2014-08-28 2017-02-13 Derivado de quinolina muy puro y metodo para su produccion.

Country Status (24)

Country Link
US (5) US10259791B2 (es)
EP (4) EP3524595B1 (es)
JP (1) JP6659554B2 (es)
KR (3) KR102329681B1 (es)
CN (2) CN113683564A (es)
AU (1) AU2015309862C1 (es)
BR (1) BR112017002827B1 (es)
CA (1) CA2957005C (es)
DK (1) DK3524595T3 (es)
ES (1) ES2926687T3 (es)
HR (1) HRP20221047T1 (es)
HU (1) HUE059606T2 (es)
IL (2) IL302218B2 (es)
JO (2) JO3783B1 (es)
LT (1) LT3524595T (es)
MX (3) MX394386B (es)
PL (1) PL3524595T3 (es)
PT (1) PT3524595T (es)
RS (1) RS63559B1 (es)
SG (2) SG11201700855XA (es)
SI (1) SI3524595T1 (es)
SM (1) SMT202200367T1 (es)
TW (1) TWI721954B (es)
WO (1) WO2016031841A1 (es)

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CN113683564A (zh) * 2014-08-28 2021-11-23 卫材R&D管理有限公司 高纯度喹啉衍生物及其生产方法
LT3263106T (lt) 2015-02-25 2024-01-10 Eisai R&D Management Co., Ltd. Chinolino darinių kartumo sumažinimo būdas
CA2978226C (en) 2015-03-04 2025-02-18 Eisai R&D Management Co., Ltd. COMBINATION OF A PD-1 ANTAGONIST AND A VEGFR/FGFR/RET TYROSINE KINASE INHIBITOR TO TREAT CANCER
CN107801379B (zh) 2015-06-16 2021-05-25 卫材R&D管理有限公司 抗癌剂
RU2718048C2 (ru) 2015-08-20 2020-03-30 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Противоопухолевое терапевтическое средство
CN105801481A (zh) * 2016-05-20 2016-07-27 湖南欧亚生物有限公司 一种乐伐替尼的合成方法
CN108299294A (zh) * 2017-01-11 2018-07-20 江苏恒瑞医药股份有限公司 一种乐伐替尼杂质的制备方法
WO2018147275A1 (ja) 2017-02-08 2018-08-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 腫瘍治療用医薬組成物
RU2019134940A (ru) 2017-05-16 2021-06-16 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Лечение гепатоцеллюлярной карциномы
US11634388B2 (en) * 2018-06-01 2023-04-25 Chengdu Easton Biopharmaceuticals Co., Ltd. Crystal form of lenvatinib mesylate and preparation method therefor
CN111320580B (zh) * 2018-12-14 2022-12-20 江苏先声药业有限公司 一种仑伐替尼中间体的制备方法
CN111377864B (zh) * 2018-12-27 2022-03-18 江苏先声药业有限公司 一种仑伐替尼杂质及其制备方法和应用
CN109824590B (zh) * 2019-02-21 2022-03-22 扬子江药业集团有限公司 仑伐替尼及其盐的制备方法
CN109851556A (zh) * 2019-03-18 2019-06-07 扬子江药业集团有限公司 仑伐替尼或其甲磺酸盐药物杂质的制备方法
CN110283122B (zh) * 2019-06-26 2021-05-25 石药集团中奇制药技术(石家庄)有限公司 一种高纯度仑伐替尼及其盐的制备方法
CN110229103A (zh) * 2019-06-27 2019-09-13 尚科生物医药(上海)有限公司 一种乐伐替尼甲磺酸盐晶型b的制备方法
CN110563644A (zh) * 2019-10-30 2019-12-13 北京赛思源生物医药技术有限公司 一种仑伐替尼甲磺酸盐的新晶型
CN113045491B (zh) * 2019-12-26 2024-09-06 罗欣药业(上海)有限公司 一种仑伐替尼及中间体的制备方法
WO2021217537A1 (zh) * 2020-04-30 2021-11-04 天津睿创康泰生物技术有限公司 一种乐伐替尼游离碱晶型及其制备方法
CN115397416B (zh) * 2020-05-09 2023-12-05 北京睿创康泰医药研究院有限公司 包含仑伐替尼的分子水平的药物组合物及其制备方法和应用
CN113999173A (zh) * 2020-07-28 2022-02-01 药源药物化学(上海)有限公司 一种高纯度结晶的制备方法
CN112142662B (zh) * 2020-10-27 2022-03-08 南京法恩化学有限公司 一种甲磺酸乐伐替尼的制备方法
KR102576608B1 (ko) 2020-12-16 2023-09-12 쌍용씨앤이 주식회사 칼슘설포알루미네이트를 함유한 수경성 조성물 및 이를 포함하는 페이스트, 모르타르 및 콘크리트의 유동성 유지방법
JP6953054B1 (ja) * 2021-03-31 2021-10-27 Delta−Fly Pharma株式会社 湿度に敏感な医薬用途物質を安定化する方法及び安定製剤
CN115322149A (zh) * 2022-08-22 2022-11-11 思科(深圳)药物研发有限公司 一种甲磺酸仑伐替尼杂质及其制备方法

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