[go: up one dir, main page]

MX2017000182A - Compuestos de pirazol como moduladores de fshr y usos de los mismos. - Google Patents

Compuestos de pirazol como moduladores de fshr y usos de los mismos.

Info

Publication number
MX2017000182A
MX2017000182A MX2017000182A MX2017000182A MX2017000182A MX 2017000182 A MX2017000182 A MX 2017000182A MX 2017000182 A MX2017000182 A MX 2017000182A MX 2017000182 A MX2017000182 A MX 2017000182A MX 2017000182 A MX2017000182 A MX 2017000182A
Authority
MX
Mexico
Prior art keywords
fshr
modulators
same
compounds
pirazol
Prior art date
Application number
MX2017000182A
Other languages
English (en)
Other versions
MX389867B (es
Inventor
Yu Henry
Qi Changhe
Tempest Paul
G Nataraja Selvaraj
S Palmer Stephen
Original Assignee
Tocopherx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tocopherx Inc filed Critical Tocopherx Inc
Publication of MX2017000182A publication Critical patent/MX2017000182A/es
Publication of MX389867B publication Critical patent/MX389867B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a compuestos de pirazol, y composiciones farmacéuticamente aceptables de los mismos. Los compuestos y las composiciones se pueden utilizar como moduladores aloestéricos positivos del receptor de hormona estimulante folículoestimulante (FSHR).
MX2017000182A 2014-06-23 2014-12-22 Compuestos de pirazol como moduladores de fshr y usos de los mismos. MX389867B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2014/080519 WO2015196335A1 (en) 2014-06-23 2014-06-23 Pyrazole compounds as modulators of fshr and uses thereof
PCT/CN2014/094459 WO2015196759A1 (en) 2014-06-23 2014-12-22 Pyrazole compounds as modulators of fshr and uses thereof

Publications (2)

Publication Number Publication Date
MX2017000182A true MX2017000182A (es) 2017-06-30
MX389867B MX389867B (es) 2025-03-20

Family

ID=54936412

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017000182A MX389867B (es) 2014-06-23 2014-12-22 Compuestos de pirazol como moduladores de fshr y usos de los mismos.

Country Status (12)

Country Link
US (3) US10208055B2 (es)
EP (1) EP3157929B1 (es)
JP (3) JP6557331B2 (es)
KR (1) KR102416279B1 (es)
CN (1) CN106573937B (es)
AU (3) AU2014398875B2 (es)
CA (1) CA2955415A1 (es)
DK (1) DK3157929T3 (es)
ES (1) ES2972131T3 (es)
MX (1) MX389867B (es)
RU (1) RU2752173C2 (es)
WO (2) WO2015196335A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015196335A1 (en) 2014-06-23 2015-12-30 Tocopherx, Inc. Pyrazole compounds as modulators of fshr and uses thereof
CN106977523A (zh) * 2017-03-30 2017-07-25 河南师范大学 具有苯基并四氢吡咯结构的fshr拮抗剂及其制备方法
CN106967076A (zh) * 2017-03-30 2017-07-21 河南师范大学 一种具有6h‑二苯并吡喃结构化合物及其制备方法
CN106866692A (zh) * 2017-03-30 2017-06-20 毛阿龙 具有苯并1,4‑二氧杂环己二烯酮结构的fshr拮抗剂的制备方法
WO2019126730A1 (en) 2017-12-22 2019-06-27 Petra Pharma Corporation Chromenopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors
AU2019262169B2 (en) 2018-05-03 2024-05-02 Jiangsu Hengrui Medicine Co., Ltd. Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (RORy) and pharmaceutical uses thereof
TW202112784A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之𠳭唏并嘧啶衍生物
CN113754678B (zh) * 2020-06-02 2023-03-10 江苏恒瑞医药股份有限公司 二氢硫代色烯并吡唑类衍生物、其制备方法及其在医药上的应用
CN115835863B (zh) * 2020-07-09 2025-08-12 江苏恒瑞医药股份有限公司 氧杂氮杂双环类衍生物、其制备方法及其在医药上的应用
US20230234962A1 (en) 2020-07-29 2023-07-27 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Oxa-azaspiro derivative, and preparation method therefor and pharmaceutical use thereof
MX2024004444A (es) 2021-10-14 2024-05-08 Incyte Corp Compuestos de quinolina como inhibidores de la proteina del virus de sarcoma de rata kirsten (kras).
AU2023329447A1 (en) * 2022-08-26 2025-04-10 Celmatix Inc. Novel modulators of fshr and uses thereof
EP4598928A1 (en) * 2022-10-05 2025-08-13 Radionetics Oncology, Inc. Follicle-stimulating hormone receptor (fshr) targeted therapeutics and uses thereof
KR20250157379A (ko) 2023-03-08 2025-11-04 훼링 비.브이. 소분자 fsh 수용체 조절제
WO2024263803A2 (en) * 2023-06-21 2024-12-26 Celmatix Inc. Novel modulators of fshr and uses thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8814586D0 (en) * 1988-06-20 1988-07-27 Erba Carlo Spa Tricyclic 3-oxo-propanenitrile derivatives & process for their preparation
JP2004505051A (ja) 2000-07-27 2004-02-19 スミスクライン　ビーチャム　コーポレーション 卵胞刺激ホルモン活性のアゴニスト
ES2286275T3 (es) * 2001-09-19 2007-12-01 Pharmacia Corporation Compuestos de pirazolo sustituidos para el tratamiento de la inflamacion.
WO2004069824A1 (ja) 2003-02-07 2004-08-19 Daiichi Pharmaceutical Co., Ltd. ピラゾール誘導体
MX2007014085A (es) * 2005-05-12 2008-02-07 Wyeth Corp Pirrolobenzodiazepinas y derivados de carboxamida heterociclica como antagonistas de receptor de hormona estimulante del foliculo.
WO2008035356A2 (en) * 2006-09-20 2008-03-27 Glenmark Pharmaceuticals Limited Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
IT1393930B1 (it) * 2009-02-25 2012-05-17 Neuroscienze Pharmaness S C A R L Composti farmaceutici
IT1394400B1 (it) 2009-02-25 2012-06-15 Neuroscienze Pharmaness S C Ar L Composizioni farmaceutiche
TWI461426B (zh) * 2009-05-27 2014-11-21 Merck Sharp & Dohme （二氫）咪唑並異〔５，１－ａ〕喹啉類
JP5735526B2 (ja) * 2009-11-13 2015-06-17 メルク セローノ ソシエテ アノニム 三環式ピラゾールアミン誘導体
ES2796774T3 (es) 2011-07-01 2020-11-30 Merck Patent Gmbh Dihidropirazoles, composiciones farmacéuticas de los mismos y su uso para el tratamiento de trastornos de fertilidad
CA2834199C (en) 2011-07-18 2020-01-07 Merck Patent Gmbh Benzamides as allosteric modulators of the fsh receptor
CN104080784B (zh) 2012-01-10 2017-07-18 默克专利有限公司 用作卵泡刺激素调节剂的苯甲酰胺衍生物
BR112014019351A8 (pt) 2012-02-08 2017-07-11 Merck Patent Gmbh Análogos de tiazolidinona deuterados como agonistas para o receptor do hormônio folículo estimulante
CA2912921C (en) * 2013-06-24 2021-05-18 Merck Patent Gmbh Pyrazole compounds as modulators of fshr and uses thereof
EP3013823B1 (en) 2013-06-24 2017-11-01 Merck Patent GmbH Imidazole compounds as modulators of fshr and uses thereof
WO2015196335A1 (en) * 2014-06-23 2015-12-30 Tocopherx, Inc. Pyrazole compounds as modulators of fshr and uses thereof

Also Published As

Publication number Publication date
US20170253605A1 (en) 2017-09-07
EP3157929A1 (en) 2017-04-26
JP2021038245A (ja) 2021-03-11
DK3157929T3 (da) 2024-02-05
WO2015196335A1 (en) 2015-12-30
WO2015196759A1 (en) 2015-12-30
ES2972131T3 (es) 2024-06-11
AU2021204814A1 (en) 2021-08-05
JP6557331B2 (ja) 2019-08-07
US10208055B2 (en) 2019-02-19
RU2017101829A3 (es) 2018-08-30
CN106573937B (zh) 2022-02-11
US20220402929A1 (en) 2022-12-22
AU2014398875B2 (en) 2019-11-21
JP2019196375A (ja) 2019-11-14
RU2017101829A (ru) 2018-07-27
CN106573937A (zh) 2017-04-19
RU2752173C2 (ru) 2021-07-23
CA2955415A1 (en) 2015-12-30
AU2014398875A1 (en) 2017-02-02
KR102416279B1 (ko) 2022-07-01
US10941152B2 (en) 2021-03-09
AU2020201240A1 (en) 2020-03-12
EP3157929A4 (en) 2018-03-07
JP2017524733A (ja) 2017-08-31
US20190135823A1 (en) 2019-05-09
MX389867B (es) 2025-03-20
AU2021204814B2 (en) 2023-07-20
KR20170033314A (ko) 2017-03-24
EP3157929B1 (en) 2023-12-13

Similar Documents

Publication Publication Date Title
MX2017000182A (es) Compuestos de pirazol como moduladores de fshr y usos de los mismos.
CY1124595T1 (el) Ρυθμιση δραστικοτητας συμπληρωματος
CL2017001289A1 (es) Compuestos bicíclicos fusionados, sus composiciones y su uso para el tratamiento de enfermedades relacionadas con la modulación del receptor x farnesoide (fxr).
MX387228B (es) Compuestos de pirazol como moduladores del receptor de hormona estimuladora de foliculo y sus usos.
ECSP17016797A (es) Indazoles sustituidos con benzilo como inhibidores de bub1
BR112016021687A2 (pt) Comunicação através de nós de rede dedicados
CL2018001478A1 (es) Agonistas del receptor de apelina y métodos de uso
UY35485A (es) Compuestos heterocíclicos y usos de los mismos
NI201700129A (es) Azabenzimidazoles y su uso como moduladores del receptor ampa.
CL2015002125A1 (es) Moduladores de receptores nmda de espiro-lactama y sus usos.
ECSP15043696A (es) Compuestos de heteroarilo y sus usos
MX374558B (es) Compuestos de heteroarilo y sus usos.
CR20150524A (es) Compuestos de heteroarilo y sus usos
MX2016015565A (es) Ciertos inhibidores de la proteina quinasa.
AR101905A1 (es) Compuestos bicíclicos
NI201400079A (es) Nuevos derivados de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
DK3191450T3 (da) Pyridonderivater som kinasehæmmere omarrangeret under transfektion (ret)
MY186048A (en) Heterocyclic compounds and their uses
DK3727453T3 (da) Flydende sammensætning til administration
MX2017013874A (es) Imidazopirazinas y pirazolopirimidinas y su uso como moduladores del receptor de ampa.
DK3325487T3 (da) Formulering til bløde, anticholinerge analoger
DK3325080T3 (da) Fremgangsmåder til bedre indgivelse af aktive midler til tumorer
NZ766530A (en) Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases
PH12017500239A1 (en) Abiraterone acetate formulation and methods of use
DK3265459T3 (da) Amidforbindelser som 5-ht4-receptoragonister