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MX2016015467A - Derivados de carbonitrilo como moduladores selectivos del receptor de androgenos. - Google Patents

Derivados de carbonitrilo como moduladores selectivos del receptor de androgenos.

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Publication number
MX2016015467A
MX2016015467A MX2016015467A MX2016015467A MX2016015467A MX 2016015467 A MX2016015467 A MX 2016015467A MX 2016015467 A MX2016015467 A MX 2016015467A MX 2016015467 A MX2016015467 A MX 2016015467A MX 2016015467 A MX2016015467 A MX 2016015467A
Authority
MX
Mexico
Prior art keywords
linear
branched chain
chain alkyl
hydrogen
androgen receptor
Prior art date
Application number
MX2016015467A
Other languages
English (en)
Inventor
Robert Verhoest Patrick
Lvovich Piatnitski Chekler Eugene
Matthew Gilbert Adam
Jal Unwalla Rayomand
Thomas Anderson James
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX2016015467A publication Critical patent/MX2016015467A/es

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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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Abstract

La presente invención se refiere a un compuesto de la Fórmula 1, 2 o 3: (ver Fórmula) en donde A es N o -CR0--, en donde R0 es hidrógeno, C1-C6 alquilo de cadena lineal o ramificada, etc., Z es -CRe --, o, -N--, en donde Re es hidrógeno, C1-C6 alquilo de cadena lineal o ramificada, etc.; R1 es hidrógeno, C1-C6 alquilo de cadena lineal o ramificada, etc.; R2 son independientemente hidrógeno o C1-C6 alquilo de cadena lineal o ramificada; R3 y R4 son independientemente hidrógeno, C1-C6 alquilo de cadena lineal o ramificada, etc.;. R5y R6 son independientemente hidrógeno o C1-C6 alquilo de cadena lineal o ramificada, etc.; R8 es hidrógeno, C1-C6 alquilo de cadena lineal o ramificada, etc.; R9 y R10 son independientemente hidrógeno o C1-C6 alquilo de cadena lineal o ramificada, etc.; Q es --CO--, --(CH2)q--, --(CHRs)q--, o -(CRsRt)q--, en donde Rs y Rt son independientemente C1-C6 alquilo de cadena lineal o ramificada, arilo, alquilarilo, heteroarilo o alquilheteroarilo, en donde q es 0, 1, 2, o 3; and, en donde n es 0, 1, 2, 3, 4 o 5; o, su sal farmacéuticamente aceptable, para el tratamiento de ciertas enfermedades, particularmente aquellas afectadas o mediadas por el receptor de andrógenos, a combinaciones que comrpenden dichos compuestos con un segundo ingrediente farmacéuticamente activo, a composiciones que contienen dichas combinaciones, y a dichas combinaciones para el tratamiento de varias enfermedades, incluyendo aquellas afectadas o mediadas por el receptor de andrógenos.
MX2016015467A 2014-05-30 2015-05-18 Derivados de carbonitrilo como moduladores selectivos del receptor de androgenos. MX2016015467A (es)

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US201462004979P 2014-05-30 2014-05-30
US201562149881P 2015-04-20 2015-04-20
PCT/IB2015/053658 WO2015181676A1 (en) 2014-05-30 2015-05-18 Carbonitrile derivatives as selective androgen receptor modulators

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US (1) US10328082B2 (es)
EP (1) EP3148587B1 (es)
JP (2) JP6649902B2 (es)
KR (1) KR20160147007A (es)
CN (1) CN106572997A (es)
AU (2) AU2015265571A1 (es)
BR (1) BR112016027778A2 (es)
CA (1) CA2950390C (es)
ES (1) ES2864079T3 (es)
IL (1) IL249267A0 (es)
MX (1) MX2016015467A (es)
RU (1) RU2016146826A (es)
SG (1) SG11201609050UA (es)
WO (1) WO2015181676A1 (es)

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