MX2014000116A - Metodos y acidos nucleicos para determinar el pronostico de un sujeto con cancer. - Google Patents
Metodos y acidos nucleicos para determinar el pronostico de un sujeto con cancer.Info
- Publication number
- MX2014000116A MX2014000116A MX2014000116A MX2014000116A MX2014000116A MX 2014000116 A MX2014000116 A MX 2014000116A MX 2014000116 A MX2014000116 A MX 2014000116A MX 2014000116 A MX2014000116 A MX 2014000116A MX 2014000116 A MX2014000116 A MX 2014000116A
- Authority
- MX
- Mexico
- Prior art keywords
- prognosis
- determining
- nucleic acids
- methods
- cancer subject
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 238000004393 prognosis Methods 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000011987 methylation Effects 0.000 abstract 1
- 238000007069 methylation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La invención proporciona métodos, ácidos nucleicos y kits para determinar el pronóstico de un sujeto que tiene cáncer. La invención describe las secuencias genómicas, los patrones de metilación que tienen utilidad para la detección mejorada del trastorno, permitiendo con esto el diagnóstico y tratamiento mejorado de pacientes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161505919P | 2011-07-08 | 2011-07-08 | |
| PCT/EP2012/063436 WO2013007702A1 (en) | 2011-07-08 | 2012-07-09 | Methods and nucleic acids for determining the prognosis of a cancer subject |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014000116A true MX2014000116A (es) | 2014-03-27 |
| MX358117B MX358117B (es) | 2018-08-06 |
Family
ID=46458553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014000116A MX358117B (es) | 2011-07-08 | 2012-07-09 | Métodos y ácidos nucleicos para determinar el pronóstico de un sujeto con cáncer. |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US10626462B2 (es) |
| EP (1) | EP2729579B1 (es) |
| JP (1) | JP6397762B2 (es) |
| KR (1) | KR102046668B1 (es) |
| CN (2) | CN108048573A (es) |
| AU (1) | AU2012282528B2 (es) |
| BR (1) | BR112014000443B1 (es) |
| CA (1) | CA2840149C (es) |
| DK (1) | DK2729579T3 (es) |
| EA (1) | EA034232B1 (es) |
| ES (1) | ES2654561T3 (es) |
| HR (1) | HRP20180001T1 (es) |
| HU (1) | HUE036036T2 (es) |
| IL (1) | IL230303B (es) |
| LT (1) | LT2729579T (es) |
| MX (1) | MX358117B (es) |
| NO (1) | NO2729579T3 (es) |
| PH (1) | PH12014500063A1 (es) |
| SI (1) | SI2729579T1 (es) |
| WO (1) | WO2013007702A1 (es) |
| ZA (1) | ZA201400089B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| US10706957B2 (en) | 2012-09-20 | 2020-07-07 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of tumor from plasma |
| CN106574303A (zh) * | 2014-06-04 | 2017-04-19 | 奎斯特诊断投资股份有限公司 | 用于结肠直肠癌的甲基化的标志物 |
| CN104745575B (zh) | 2014-08-08 | 2019-03-12 | 博诚研究中心 | 用于检测细胞增殖性异常或疾病程度分级的基因组合物及其用途 |
| GB2552267B (en) | 2014-12-31 | 2020-06-10 | Guardant Health Inc | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results |
| CN106148501A (zh) * | 2015-04-23 | 2016-11-23 | 博诚研究中心 | 一种检测Septin9基因甲基化的试剂盒及其应用 |
| EP3118329B1 (en) * | 2015-07-15 | 2019-05-15 | Universiteit Gent | Probes and a methylation in situ hybridization assay |
| WO2017043497A1 (ja) * | 2015-09-08 | 2017-03-16 | 国立大学法人山口大学 | 大腸腫瘍の有無を検査する方法 |
| CN116445593A (zh) | 2016-08-10 | 2023-07-18 | 格里尔公司 | 测定一生物样品的一甲基化图谱的方法 |
| CN110770354B (zh) | 2017-04-19 | 2024-03-19 | 鹍远基因公司 | 用于文库构建和序列分析的组合物和方法 |
| CN107385056A (zh) * | 2017-08-10 | 2017-11-24 | 上海时代基因医学科技有限公司 | 一种检测SEPT9基因不同Cpg岛甲基化的试剂盒及应用 |
| WO2019076949A1 (en) * | 2017-10-18 | 2019-04-25 | Deutsches Krebsforschungszentrum | MEANS AND METHODS FOR CLASSIFYING COLORECTAL CANCERS |
| EP3717502B1 (en) * | 2017-11-29 | 2025-04-23 | The Regents of The University of Michigan | Compositions and methods for characterizing cancer |
| CN108796080B (zh) * | 2018-06-06 | 2022-06-07 | 苏州唯善生物科技有限公司 | 用于结直肠癌诊断、检测或筛查的引物和探针组 |
| CN109055552A (zh) * | 2018-08-23 | 2018-12-21 | 北京迈基诺基因科技股份有限公司 | 检测Septin9基因启动子是否甲基化的方法及其专用成套试剂 |
| CN112195243A (zh) * | 2020-09-22 | 2021-01-08 | 北京华大吉比爱生物技术有限公司 | 一种检测多基因甲基化的试剂盒及其应用 |
| KR102404750B1 (ko) * | 2021-10-14 | 2022-06-07 | 주식회사 엔도믹스 | 세포 유리 dna를 이용한 대장암 진단을 위한 메틸화 마커 유전자 및 이의 용도 |
| CN114561452A (zh) * | 2022-03-10 | 2022-05-31 | 天津市人民医院 | mSEPT9作为预测结直肠癌患者术后复发风险标志物及用于评价化疗方案有效性的应用 |
| KR102559496B1 (ko) * | 2022-04-26 | 2023-07-25 | 연세대학교 산학협력단 | 핵산의 메틸화 여부 확인용 조성물 및 핵산의 메틸화 여부를 확인하는 방법 |
| CN115248313A (zh) * | 2022-08-03 | 2022-10-28 | 中山市人民医院 | 肠癌外周血免疫细胞m5C标志物的应用 |
| CN115029462B (zh) * | 2022-08-10 | 2022-11-08 | 中国农业科学院农业质量标准与检测技术研究所 | 一种动植物疫病的核酸标准物质、形貌模拟方法及其应用 |
| WO2024064369A1 (en) * | 2022-09-23 | 2024-03-28 | Flagship Pioneering Innovations Vi, Llc | Methods for amplifying nucleic acids |
| WO2024107441A1 (en) * | 2022-11-14 | 2024-05-23 | Trustees Of Dartmouth College | Systemic biomarkers for the dynamic assessment of tumor burden and treatment efficacy in high grade gliomas |
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| US412900A (en) | 1889-10-15 | roaers | ||
| US150000A (en) | 1874-04-21 | Improvement in cigar mouth - pieces | ||
| US5585481A (en) | 1987-09-21 | 1996-12-17 | Gen-Probe Incorporated | Linking reagents for nucleotide probes |
| US5457183A (en) | 1989-03-06 | 1995-10-10 | Board Of Regents, The University Of Texas System | Hydroxylated texaphyrins |
| US5245022A (en) | 1990-08-03 | 1993-09-14 | Sterling Drug, Inc. | Exonuclease resistant terminally substituted oligonucleotides |
| US5565552A (en) | 1992-01-21 | 1996-10-15 | Pharmacyclics, Inc. | Method of expanded porphyrin-oligonucleotide conjugate synthesis |
| US5574142A (en) | 1992-12-15 | 1996-11-12 | Microprobe Corporation | Peptide linkers for improved oligonucleotide delivery |
| SE501439C2 (sv) | 1993-06-22 | 1995-02-13 | Pharmacia Lkb Biotech | Sätt och anordning för analys av polynukleotidsekvenser |
| WO1995015373A2 (en) | 1993-11-30 | 1995-06-08 | Mcgill University | Inhibition of dna methyltransferase |
| US5597696A (en) | 1994-07-18 | 1997-01-28 | Becton Dickinson And Company | Covalent cyanine dye oligonucleotide conjugates |
| US5514758A (en) | 1994-09-30 | 1996-05-07 | The Goodyear Tire & Rubber Company | Process for making latex for high performance masking tape |
| US5786146A (en) | 1996-06-03 | 1998-07-28 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US6017704A (en) | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US6251594B1 (en) | 1997-06-09 | 2001-06-26 | Usc/Norris Comprehensive Cancer Ctr. | Cancer diagnostic method based upon DNA methylation differences |
| DE19754482A1 (de) | 1997-11-27 | 1999-07-01 | Epigenomics Gmbh | Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke |
| US7700324B1 (en) | 1998-11-03 | 2010-04-20 | The Johns Hopkins University School Of Medicine | Methylated CpG island amplification (MCA) |
| US5958773A (en) | 1998-12-17 | 1999-09-28 | Isis Pharmaceuticals Inc. | Antisense modulation of AKT-1 expression |
| US6331393B1 (en) | 1999-05-14 | 2001-12-18 | University Of Southern California | Process for high-throughput DNA methylation analysis |
| CN1150317C (zh) * | 1999-08-10 | 2004-05-19 | 中国医学科学院肿瘤医院肿瘤研究所 | 一种食管癌相关新基因 |
| AU2002224328A1 (en) * | 2000-09-20 | 2002-04-02 | Case Western Reserve University | Methods and compositions for detecting cancers associated with methylation of hmlh1promoter dna |
| DE10112515B4 (de) | 2001-03-09 | 2004-02-12 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität |
| US7473767B2 (en) | 2001-07-03 | 2009-01-06 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
| CN1187456C (zh) * | 2001-11-27 | 2005-02-02 | 暨南大学 | CpG岛甲基化检测试剂盒及其应用 |
| DE10348407A1 (de) * | 2003-10-17 | 2005-05-19 | Widschwendter, Martin, Prof. | Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben |
| DE602004031405D1 (de) | 2003-12-11 | 2011-03-31 | Epigenomics Ag | Marker zur Prognose der Reaktion auf Therapie bzw. der Überlebensrate von Brustkrebspatienten |
| JP4765058B2 (ja) | 2004-12-13 | 2011-09-07 | 国立大学法人 岡山大学 | 核酸修飾前の検体の前処理方法 |
| CN114921544A (zh) | 2005-04-15 | 2022-08-19 | Epi基因组股份公司 | 分析细胞增殖性病症的方法和核酸 |
| WO2007085497A2 (en) | 2006-01-30 | 2007-08-02 | Epigenomics Ag | Markers for the prediction of outcome of anthracycline treatment |
| ES2587068T3 (es) * | 2006-04-17 | 2016-10-20 | Epigenomics Ag | Métodos y ácidos nucleicos para la detección de desórdenes celulares proliferativos colorrectales |
| WO2008009479A1 (en) * | 2006-07-21 | 2008-01-24 | Epigenomics Ag | Methods and nucleic acids for analyses for cellular proliferative disorders |
| JP2010517582A (ja) * | 2007-02-12 | 2010-05-27 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 結腸癌の早期検出および予後診断の方法 |
| JP5378687B2 (ja) | 2007-03-02 | 2013-12-25 | エフ．ホフマン−ラ ロシュ アーゲー | Ｂａｓｐ１遺伝子および／またはｓｒｄ５ａ２遺伝子中のメチル化シトシンを利用する、肝臓癌、肝臓癌発症リスク、肝臓癌再発リスク、肝臓癌悪性度および肝臓癌の経時的進展の検出方法 |
| WO2010032797A1 (ja) | 2008-09-19 | 2010-03-25 | シスメックス株式会社 | 乳癌の転移の判定方法及び血清の評価方法 |
| WO2010065916A1 (en) * | 2008-12-04 | 2010-06-10 | Rush University Medical Center | Dna methylation based test for monitoring efficacy of treatment |
| EP2309005B1 (en) | 2009-08-03 | 2015-03-04 | Epigenomics AG | Methods for preservation of genomic DNA sequence complexity |
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2012
- 2012-07-09 JP JP2014517844A patent/JP6397762B2/ja not_active Expired - Fee Related
- 2012-07-09 CA CA2840149A patent/CA2840149C/en active Active
- 2012-07-09 BR BR112014000443-9A patent/BR112014000443B1/pt not_active IP Right Cessation
- 2012-07-09 EP EP12732686.6A patent/EP2729579B1/en active Active
- 2012-07-09 DK DK12732686.6T patent/DK2729579T3/en active
- 2012-07-09 PH PH1/2014/500063A patent/PH12014500063A1/en unknown
- 2012-07-09 AU AU2012282528A patent/AU2012282528B2/en active Active
- 2012-07-09 US US14/131,445 patent/US10626462B2/en active Active - Reinstated
- 2012-07-09 MX MX2014000116A patent/MX358117B/es active IP Right Grant
- 2012-07-09 EA EA201400117A patent/EA034232B1/ru not_active IP Right Cessation
- 2012-07-09 LT LTEP12732686.6T patent/LT2729579T/lt unknown
- 2012-07-09 HU HUE12732686A patent/HUE036036T2/hu unknown
- 2012-07-09 NO NO12732686A patent/NO2729579T3/no unknown
- 2012-07-09 HR HRP20180001TT patent/HRP20180001T1/hr unknown
- 2012-07-09 ES ES12732686.6T patent/ES2654561T3/es active Active
- 2012-07-09 WO PCT/EP2012/063436 patent/WO2013007702A1/en not_active Ceased
- 2012-07-09 CN CN201810020458.1A patent/CN108048573A/zh active Pending
- 2012-07-09 SI SI201231155T patent/SI2729579T1/en unknown
- 2012-07-09 CN CN201280033813.XA patent/CN103732759A/zh active Pending
- 2012-07-09 KR KR1020147003119A patent/KR102046668B1/ko active Active
-
2014
- 2014-01-02 IL IL230303A patent/IL230303B/en active IP Right Grant
- 2014-01-06 ZA ZA2014/00089A patent/ZA201400089B/en unknown
-
2020
- 2020-03-10 US US16/814,321 patent/US11261499B2/en active Active
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2022
- 2022-01-18 US US17/577,836 patent/US12110558B2/en active Active
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2024
- 2024-08-30 US US18/821,050 patent/US20250101527A1/en active Pending
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| Date | Code | Title | Description |
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| FG | Grant or registration |