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MX2013010793A - Metodo y composiciones para inmunoterapia celular. - Google Patents

Metodo y composiciones para inmunoterapia celular.

Info

Publication number
MX2013010793A
MX2013010793A MX2013010793A MX2013010793A MX2013010793A MX 2013010793 A MX2013010793 A MX 2013010793A MX 2013010793 A MX2013010793 A MX 2013010793A MX 2013010793 A MX2013010793 A MX 2013010793A MX 2013010793 A MX2013010793 A MX 2013010793A
Authority
MX
Mexico
Prior art keywords
tumor
cells
specific
compositions
cellular immunotherapy
Prior art date
Application number
MX2013010793A
Other languages
English (en)
Other versions
MX359513B (es
Inventor
Stanley R Riddell
Michael Hudecek
Original Assignee
Hutchinson Fred Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46208746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2013010793(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hutchinson Fred Cancer Res filed Critical Hutchinson Fred Cancer Res
Publication of MX2013010793A publication Critical patent/MX2013010793A/es
Publication of MX359513B publication Critical patent/MX359513B/es

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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
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    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
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    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex
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    • C12N2510/00—Genetically modified cells

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  • Organic Chemistry (AREA)
  • Immunology (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Wood Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
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  • Developmental Biology & Embryology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
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Abstract

La presente invención proporciona métodos y composiciones para conferir y/o aumentar respuestas inmunitarias mediadas por la inmunoterapia celular, tal como a través de la transferencia adoptiva de células T CD8+ específicas de tumor genéticamente modificadas en la presencia de células de tumor CD4+ genéticamente modificadas específicas de tumor, en donde la células T CD4+ confieren y/o aumentan una habilidad de las células T CD8+ para sostener la reactividad anti-tumoral y aumentar y/o maximizar la proliferación específica de tumor de la células T CD8+ específicas del tumor de interés. Las formulaciones farmacéuticas producidas por el método, y métodos que los utilizan, también se describen.
MX2013010793A 2011-03-23 2012-03-23 Metodo y composiciones para inmunoterapia celular. MX359513B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161466552P 2011-03-23 2011-03-23
PCT/US2012/030388 WO2012129514A1 (en) 2011-03-23 2012-03-23 Method and compositions for cellular immunotherapy

Publications (2)

Publication Number Publication Date
MX2013010793A true MX2013010793A (es) 2014-03-21
MX359513B MX359513B (es) 2018-10-01

Family

ID=46208746

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2013010793A MX359513B (es) 2011-03-23 2012-03-23 Metodo y composiciones para inmunoterapia celular.
MX2018011917A MX2018011917A (es) 2011-03-23 2013-09-20 Metodo y composiciones para inmunoterapia celular.

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Application Number Title Priority Date Filing Date
MX2018011917A MX2018011917A (es) 2011-03-23 2013-09-20 Metodo y composiciones para inmunoterapia celular.

Country Status (16)

Country Link
US (2) US9987308B2 (es)
EP (1) EP2689010B2 (es)
JP (5) JP6203705B2 (es)
KR (1) KR101976882B1 (es)
CN (3) CN106074601A (es)
AU (3) AU2012230780B2 (es)
BR (1) BR112013024395B1 (es)
CA (1) CA2830953C (es)
ES (1) ES2841983T3 (es)
IL (1) IL228603B (es)
MX (2) MX359513B (es)
NZ (1) NZ743310A (es)
RU (1) RU2688185C2 (es)
SG (2) SG193591A1 (es)
WO (1) WO2012129514A1 (es)
ZA (1) ZA201901167B (es)

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