MX2013005187A - Composicion farmaceutica y forma galenica y forma galenica a base de drodedarona y su procedimiento de preparacion. - Google Patents
Composicion farmaceutica y forma galenica y forma galenica a base de drodedarona y su procedimiento de preparacion.Info
- Publication number
- MX2013005187A MX2013005187A MX2013005187A MX2013005187A MX2013005187A MX 2013005187 A MX2013005187 A MX 2013005187A MX 2013005187 A MX2013005187 A MX 2013005187A MX 2013005187 A MX2013005187 A MX 2013005187A MX 2013005187 A MX2013005187 A MX 2013005187A
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutical composition
- dosage form
- dronedarone
- oral administration
- preparation
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 239000002552 dosage form Substances 0.000 title abstract 3
- ZQTNQVWKHCQYLQ-UHFFFAOYSA-N dronedarone Chemical compound C1=CC(OCCCN(CCCC)CCCC)=CC=C1C(=O)C1=C(CCCC)OC2=CC=C(NS(C)(=O)=O)C=C12 ZQTNQVWKHCQYLQ-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002084 dronedarone Drugs 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 3
- 150000002632 lipids Chemical class 0.000 abstract 2
- 235000012054 meals Nutrition 0.000 abstract 2
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 150000001907 coumarones Chemical class 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere, de una manera general, a una composición farmacéutica para administración oral que contiene como principio activo un derivado de benzofurano con actividad antiarrítmica, en particular dronedarona y sus sales farmacéuticamente aceptables y al menos un excipiente lipídico, estando destinada tal composición farmacéutica en una forma galénica de tipo cápsula, en particular de envoltura dura. Esta composición farmacéutica y tal forma galénica que comprende tal composición tienen por objeto limitar el efecto comida después de la administración oral en el humano. El excipiente lipídico permite por una parte solubilizar el principio activo conforme a la invención y por otra parte evitar los efectos negativos del pH a nivel del tracto intestinal, permitiendo así exonerar el efecto comida de forma significativa.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1059306A FR2967067A1 (fr) | 2010-11-10 | 2010-11-10 | Composition pharmaceutique et forme galenique a base de dronedarone et son procede de preparation |
| PCT/FR2011/052622 WO2012063005A2 (fr) | 2010-11-10 | 2011-11-10 | Composition pharmaceutique et forme galenique a base de dronedarone et son procede de preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2013005187A true MX2013005187A (es) | 2013-07-03 |
Family
ID=44072520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013005187A MX2013005187A (es) | 2010-11-10 | 2011-11-10 | Composicion farmaceutica y forma galenica y forma galenica a base de drodedarona y su procedimiento de preparacion. |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US9018250B2 (es) |
| EP (1) | EP2637645B1 (es) |
| JP (1) | JP2013542244A (es) |
| KR (1) | KR20140091646A (es) |
| CN (1) | CN103347502B (es) |
| AU (1) | AU2011327910A1 (es) |
| BR (1) | BR112013011763A2 (es) |
| CA (1) | CA2817310A1 (es) |
| CY (1) | CY1120418T1 (es) |
| DK (1) | DK2637645T3 (es) |
| ES (1) | ES2670445T3 (es) |
| FR (1) | FR2967067A1 (es) |
| HR (1) | HRP20180793T1 (es) |
| HU (1) | HUE037446T2 (es) |
| IL (1) | IL226183A0 (es) |
| LT (1) | LT2637645T (es) |
| MX (1) | MX2013005187A (es) |
| PL (1) | PL2637645T3 (es) |
| PT (1) | PT2637645T (es) |
| RU (1) | RU2013126431A (es) |
| SG (1) | SG190240A1 (es) |
| SI (1) | SI2637645T1 (es) |
| TR (1) | TR201807058T4 (es) |
| WO (1) | WO2012063005A2 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2967067A1 (fr) * | 2010-11-10 | 2012-05-11 | Sanofi Aventis | Composition pharmaceutique et forme galenique a base de dronedarone et son procede de preparation |
| CN103126994B (zh) * | 2011-12-05 | 2017-03-29 | 北京虹湾医药技术有限公司 | 含决奈达隆的固体药物组合物 |
| JP6049409B2 (ja) * | 2012-11-08 | 2016-12-21 | 中日本カプセル 株式会社 | ハードカプセルの製造方法 |
| CN105412027B (zh) * | 2015-11-13 | 2018-10-26 | 青岛市海慈医疗集团 | 一种盐酸决奈达隆片剂的制备方法 |
| CN112137999A (zh) * | 2020-09-30 | 2020-12-29 | 郑州大学 | 盐酸决奈达隆在制备抗消化道肿瘤药物中的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3248401A (en) | 1966-04-26 | Diethylaminoe hoxybenzoyl benzofurans | ||
| US4806663A (en) | 1987-04-06 | 1989-02-21 | The University Of Tennessee Research Corporation | Certain 3-substituted 2-alkyl benzofuran derivatives |
| US4851554A (en) | 1987-04-06 | 1989-07-25 | University Of Tennessee Research Corporation | Certain 3-substituted 2-alkyl benzofuran derivatives |
| US4831054A (en) | 1988-04-18 | 1989-05-16 | Taro Pharmaceuticals, Ltd. | 2-Alkyl-3-benzoylbenzofurans useful for treating cardiac arrhythmia |
| AT391316B (de) | 1988-09-15 | 1990-09-25 | Ebewe Arzneimittel | Neue thienyloxy-alkylamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| FR2665444B1 (fr) | 1990-08-06 | 1992-11-27 | Sanofi Sa | Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant. |
| US5364880A (en) | 1993-06-16 | 1994-11-15 | Advanced Therapies, Inc. | Compound for treatment of cardiac arrhythmia, synthesis, and methods of use |
| FR2764800B1 (fr) * | 1997-06-23 | 1999-09-10 | Sanofi Sa | Composition pharmaceutique solide contenant des derives de benzofuranne |
| FR2813306B1 (fr) | 2000-08-23 | 2005-10-21 | Sanofi Synthelabo | Aminoalkybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant |
| UA80393C2 (uk) * | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
| ITRM20030074A1 (it) * | 2003-02-21 | 2004-08-22 | Pharmacia Italia Spa | Formulazioni semisolide a rilascio immediato intese |
| WO2005048979A2 (en) * | 2003-10-06 | 2005-06-02 | Torrent Pharmaceuticals Limited | Pharmaceutical composition having casing with multiple micro tablets |
| KR100921947B1 (ko) * | 2003-11-19 | 2009-10-15 | (주)아모레퍼시픽 | 피부 미백 화장료 조성물 |
| WO2008063323A2 (en) | 2006-10-13 | 2008-05-29 | Reliant Pharmaceuticals, Inc. | Treatment with antiarrhythmics and omega-3 fatty acids and a combination product thereof |
| CN102188417A (zh) * | 2010-03-19 | 2011-09-21 | 江苏恒瑞医药股份有限公司 | 决奈达隆药物组合物 |
| FR2967067A1 (fr) * | 2010-11-10 | 2012-05-11 | Sanofi Aventis | Composition pharmaceutique et forme galenique a base de dronedarone et son procede de preparation |
-
2010
- 2010-11-10 FR FR1059306A patent/FR2967067A1/fr active Pending
-
2011
- 2011-11-10 EP EP11796739.8A patent/EP2637645B1/fr active Active
- 2011-11-10 SI SI201131482T patent/SI2637645T1/en unknown
- 2011-11-10 AU AU2011327910A patent/AU2011327910A1/en not_active Abandoned
- 2011-11-10 BR BR112013011763A patent/BR112013011763A2/pt not_active IP Right Cessation
- 2011-11-10 CA CA 2817310 patent/CA2817310A1/fr not_active Abandoned
- 2011-11-10 WO PCT/FR2011/052622 patent/WO2012063005A2/fr not_active Ceased
- 2011-11-10 JP JP2013538255A patent/JP2013542244A/ja active Pending
- 2011-11-10 KR KR20137014632A patent/KR20140091646A/ko not_active Ceased
- 2011-11-10 CN CN201180064600.9A patent/CN103347502B/zh active Active
- 2011-11-10 DK DK11796739.8T patent/DK2637645T3/en active
- 2011-11-10 PL PL11796739T patent/PL2637645T3/pl unknown
- 2011-11-10 LT LTEP11796739.8T patent/LT2637645T/lt unknown
- 2011-11-10 MX MX2013005187A patent/MX2013005187A/es not_active Application Discontinuation
- 2011-11-10 PT PT117967398T patent/PT2637645T/pt unknown
- 2011-11-10 HU HUE11796739A patent/HUE037446T2/hu unknown
- 2011-11-10 ES ES11796739.8T patent/ES2670445T3/es active Active
- 2011-11-10 TR TR2018/07058T patent/TR201807058T4/tr unknown
- 2011-11-10 SG SG2013036199A patent/SG190240A1/en unknown
- 2011-11-10 HR HRP20180793TT patent/HRP20180793T1/hr unknown
- 2011-11-10 RU RU2013126431/15A patent/RU2013126431A/ru not_active Application Discontinuation
-
2013
- 2013-05-06 IL IL226183A patent/IL226183A0/en unknown
- 2013-05-06 US US13/887,562 patent/US9018250B2/en not_active Expired - Fee Related
-
2015
- 2015-03-26 US US14/669,668 patent/US20150196528A1/en not_active Abandoned
-
2018
- 2018-05-18 CY CY20181100511T patent/CY1120418T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG190240A1 (en) | 2013-06-28 |
| CN103347502B (zh) | 2017-04-26 |
| IL226183A0 (en) | 2013-07-31 |
| US9018250B2 (en) | 2015-04-28 |
| TR201807058T4 (tr) | 2018-06-21 |
| FR2967067A1 (fr) | 2012-05-11 |
| BR112013011763A2 (pt) | 2016-09-13 |
| EP2637645B1 (fr) | 2018-02-21 |
| WO2012063005A3 (fr) | 2012-09-13 |
| ES2670445T3 (es) | 2018-05-30 |
| CA2817310A1 (fr) | 2012-05-18 |
| EP2637645A2 (fr) | 2013-09-18 |
| HUE037446T2 (hu) | 2018-09-28 |
| US20150196528A1 (en) | 2015-07-16 |
| US20130245115A1 (en) | 2013-09-19 |
| DK2637645T3 (en) | 2018-06-06 |
| WO2012063005A2 (fr) | 2012-05-18 |
| KR20140091646A (ko) | 2014-07-22 |
| CY1120418T1 (el) | 2019-07-10 |
| JP2013542244A (ja) | 2013-11-21 |
| CN103347502A (zh) | 2013-10-09 |
| SI2637645T1 (en) | 2018-06-29 |
| HRP20180793T1 (hr) | 2018-06-29 |
| PL2637645T3 (pl) | 2018-08-31 |
| LT2637645T (lt) | 2018-06-11 |
| RU2013126431A (ru) | 2014-12-20 |
| AU2011327910A1 (en) | 2013-05-30 |
| PT2637645T (pt) | 2018-05-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |