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MX2012004055A - Metodo para la preparacion de ester (r) -1-aril-2-tetrazolil-etili co de acido carbamico. - Google Patents

Metodo para la preparacion de ester (r) -1-aril-2-tetrazolil-etili co de acido carbamico.

Info

Publication number
MX2012004055A
MX2012004055A MX2012004055A MX2012004055A MX2012004055A MX 2012004055 A MX2012004055 A MX 2012004055A MX 2012004055 A MX2012004055 A MX 2012004055A MX 2012004055 A MX2012004055 A MX 2012004055A MX 2012004055 A MX2012004055 A MX 2012004055A
Authority
MX
Mexico
Prior art keywords
tetrazolyl
aryl
preparation
carbamic acid
thyl ester
Prior art date
Application number
MX2012004055A
Other languages
English (en)
Inventor
Sang Chul Lim
Moo Yong Uhm
Dae Won Lee
Hui Ho Kim
Dong Ho Lee
Hyun Seok Lee
Original Assignee
Sk Biopharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sk Biopharmaceuticals Co Ltd filed Critical Sk Biopharmaceuticals Co Ltd
Publication of MX2012004055A publication Critical patent/MX2012004055A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se divulga un método para la preparación de éster (R)-1-aril-2-tetrazolil-etílico de ácido carbámico, que comprende la reducción de enzima enantioselectiva de la arilcetona correspondiente y la carbamatación del alcohol resultante.
MX2012004055A 2009-10-15 2010-10-15 Metodo para la preparacion de ester (r) -1-aril-2-tetrazolil-etili co de acido carbamico. MX2012004055A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25186709P 2009-10-15 2009-10-15
PCT/KR2010/007069 WO2011046380A2 (en) 2009-10-15 2010-10-15 Method for preparation of carbamic acid (r)-1-aryl-2-tetrazolyl-ethyl ester

Publications (1)

Publication Number Publication Date
MX2012004055A true MX2012004055A (es) 2012-08-31

Family

ID=43876717

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012004055A MX2012004055A (es) 2009-10-15 2010-10-15 Metodo para la preparacion de ester (r) -1-aril-2-tetrazolil-etili co de acido carbamico.

Country Status (18)

Country Link
US (3) US8404461B2 (es)
EP (1) EP2488505B1 (es)
JP (1) JP5797656B2 (es)
KR (1) KR101708437B1 (es)
CN (1) CN102574821B (es)
AU (1) AU2010307466B2 (es)
BR (1) BR112012008858B1 (es)
CA (1) CA2776743C (es)
CL (1) CL2012000959A1 (es)
ES (1) ES2536488T3 (es)
HU (1) HUE025816T2 (es)
IL (1) IL218787A0 (es)
MX (1) MX2012004055A (es)
MY (1) MY162997A (es)
PL (1) PL2488505T3 (es)
RU (1) RU2539983C2 (es)
WO (1) WO2011046380A2 (es)
ZA (1) ZA201202629B (es)

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CN103694187A (zh) * 2014-01-06 2014-04-02 四川大学 5-氨基-1-苯甲酰氨基四唑及其金属配合物
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KR102421006B1 (ko) * 2016-05-19 2022-07-14 에스케이바이오팜 주식회사 두통의 예방학적 치료를 위한 카바메이트 화합물의 용도
KR102489052B1 (ko) 2016-05-19 2023-01-16 에스케이바이오팜 주식회사 섬유근육통 또는 섬유근육통의 연관된 기능적 증후군을 예방 또는 치료하기 위한 카바메이트 화합물의 용도
EP3556363B1 (en) 2016-12-14 2024-03-06 SK Biopharmaceuticals Co., Ltd. Use of carbamate compound for prevention, alleviation or treatment of pruritus
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EP3556366B1 (en) 2016-12-14 2025-10-22 SK Biopharmaceuticals Co., Ltd. Use of carbamate compounds for prevention, alleviation or treatment of bipolar disorder
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EP3556365B1 (en) 2016-12-14 2025-07-02 SK Biopharmaceuticals Co., Ltd. Use of carbamate compound for prevention, alleviation, or treatment of demyelinating disease
RU2761041C2 (ru) 2016-12-14 2021-12-02 ЭсКей БАЙОФАРМАСЬЮТИКАЛЗ КО., ЛТД. Парентеральный жидкий препарат, включающий карбаматное соединение
ES2982316T3 (es) * 2017-11-14 2024-10-15 Sk Biopharmaceuticals Co Ltd Uso de un compuesto de carbamato para prevenir, aliviar o tratar las crisis de ausencia o la epilepsia que muestra crisis de ausencia
KR102739580B1 (ko) 2017-11-14 2024-12-06 에스케이바이오팜 주식회사 후기 나트륨 전류의 증가와 관련된 질환을 예방 또는 치료하기 위한 카바메이트 화합물의 용도
EP3711756A4 (en) 2017-11-14 2021-11-24 SK Biopharmaceuticals Co., Ltd. USE OF A CARBAMATE COMPOUND TO PREVENT, RELAX, OR TREAT MYOTONIA
EP3711761A4 (en) 2017-11-14 2021-11-24 SK Biopharmaceuticals Co., Ltd. USE OF A CARBAMATE COMPOUND TO REDUCE OR TREAT DEVELOPMENTAL DISORDERS, INCLUDING FRAGILE X SYNDROME, ANGELMAN'S SYNDROME, OR RETT'S SYNDROME
JP7355747B2 (ja) 2017-11-14 2023-10-03 エスケー バイオファーマスティカルズ カンパニー リミテッド カルバメート化合物を含む統合失調症の予防、軽減又は治療用配合物
EP3711757B1 (en) 2017-11-14 2025-05-07 SK Biopharmaceuticals Co., Ltd. Use of a carbamate compound to prevent, alleviate or treat visceralgia or pain arising from visceral disease
WO2020060252A1 (ko) 2018-09-21 2020-03-26 에스케이바이오팜 주식회사 중첩발작의 예방, 경감 또는 치료에 대한 카바메이트 화합물의 용도
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KR20210062029A (ko) 2018-10-19 2021-05-28 에스케이바이오팜 주식회사 카바메이트 화합물의 당뇨병성 말초 신경병증 또는 화학요법 유발 말초 신경병증의 예방, 완화 또는 치료를 위한 용도
KR20220087475A (ko) 2019-10-24 2022-06-24 에스케이바이오팜 주식회사 선택성이 향상된 아릴 2-테트라졸-2-일 케톤을 제조하는 방법
US10611737B1 (en) 2019-10-24 2020-04-07 Sk Biopharmaceuticals Co., Ltd. Method for preparing aryl 2-tetrazol-2-yl ketone with improved selectivity
AU2020389425A1 (en) 2019-11-22 2022-06-02 Sk Biopharmaceuticals Co., Ltd. Oral pharmaceutical composition comprising carbamate compound and preparation method therefor
CN111705096A (zh) * 2020-06-29 2020-09-25 上海舒泽生物科技研究所 一种酶转化法生产β-烟酰胺单核苷酸的方法
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