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MX2012002368A - Novedosos fosfonatos de nucleosido y analogos. - Google Patents

Novedosos fosfonatos de nucleosido y analogos.

Info

Publication number
MX2012002368A
MX2012002368A MX2012002368A MX2012002368A MX2012002368A MX 2012002368 A MX2012002368 A MX 2012002368A MX 2012002368 A MX2012002368 A MX 2012002368A MX 2012002368 A MX2012002368 A MX 2012002368A MX 2012002368 A MX2012002368 A MX 2012002368A
Authority
MX
Mexico
Prior art keywords
analogs
nucleoside phosphonates
novel nucleoside
compounds
phosphonates
Prior art date
Application number
MX2012002368A
Other languages
English (en)
Inventor
Steven Dong
Peter G M Wuts
Original Assignee
Epiphany Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epiphany Biosciences Inc filed Critical Epiphany Biosciences Inc
Publication of MX2012002368A publication Critical patent/MX2012002368A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015—Esters of acyclic unsaturated acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se proporcionan compuestos y composiciones para el tratamiento, prevención o mejora de una variedad de trastornos médicos asociados con infecciones virales y/o proliferación celular; los compuestos proporcionados aquí son fosfonatos de nucleósido y ésteres de los mismos.
MX2012002368A 2009-08-27 2010-08-27 Novedosos fosfonatos de nucleosido y analogos. MX2012002368A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23767909P 2009-08-27 2009-08-27
PCT/US2010/047054 WO2011031567A1 (en) 2009-08-27 2010-08-27 Novel nucleoside phosphonates and analogs

Publications (1)

Publication Number Publication Date
MX2012002368A true MX2012002368A (es) 2012-07-25

Family

ID=43732752

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012002368A MX2012002368A (es) 2009-08-27 2010-08-27 Novedosos fosfonatos de nucleosido y analogos.

Country Status (13)

Country Link
US (1) US20130018018A1 (es)
EP (1) EP2470194A4 (es)
JP (1) JP2013503197A (es)
KR (1) KR20120124383A (es)
CN (1) CN102781462A (es)
AU (1) AU2010292500A1 (es)
BR (1) BR112012008050A2 (es)
CA (1) CA2772261A1 (es)
IL (1) IL218276A0 (es)
MX (1) MX2012002368A (es)
RU (1) RU2012106469A (es)
WO (1) WO2011031567A1 (es)
ZA (1) ZA201202032B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10814006B2 (en) 2015-07-14 2020-10-27 University Of Iowa Research Foundation Fluorescent prodrugs
US11793308B2 (en) 2019-04-08 2023-10-24 EQX Global LLC Height adjusted seismic base isolation system

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182759A (en) * 1978-06-05 1980-01-08 Sterling Drug Inc. Arylalkyl and aryloxyalkyl phosphonates and use as antiviral agents
CA1288098C (en) * 1984-08-24 1991-08-27 Richard L. Tolman 4-(guanin-9-yl)butanals and their 3-oxa, 3-thia and 2-ene derivatives having antiviral and antitumor activity
US5247085A (en) * 1987-11-30 1993-09-21 Beecham Group P.L.C. Antiviral purine compounds
EP0338168A1 (en) * 1988-04-19 1989-10-25 Merrell Dow Pharmaceuticals Inc. Phosphonoalkylpurine derivatives
US5302585A (en) * 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
DE69218968T2 (de) * 1991-10-11 1997-10-09 Inst Of Organic Chemistry And Antivirale acyclische phosphonomethoxyalkyl substituierte, alkenyl und alkynyl purin und pyrimidin-derivate
JP2007523180A (ja) * 2004-02-17 2007-08-16 エルジー・ライフ・サイエンシーズ・リミテッド Ｈｉｖ感染治療に有用なヌクレオシドホスホネート誘導体
EP1866319B1 (en) * 2005-04-01 2011-11-23 The Regents of The University of California Phosphono-pent-2-en-1-yl nucleosides and analogs
WO2007130783A2 (en) * 2006-05-03 2007-11-15 Chimerix, Inc. Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates

Also Published As

Publication number Publication date
IL218276A0 (en) 2012-04-30
KR20120124383A (ko) 2012-11-13
WO2011031567A1 (en) 2011-03-17
US20130018018A1 (en) 2013-01-17
EP2470194A4 (en) 2013-03-06
CN102781462A (zh) 2012-11-14
BR112012008050A2 (pt) 2017-07-04
RU2012106469A (ru) 2013-11-10
JP2013503197A (ja) 2013-01-31
EP2470194A1 (en) 2012-07-04
AU2010292500A1 (en) 2012-03-15
CA2772261A1 (en) 2011-03-17
ZA201202032B (en) 2012-12-27

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal