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MX2012001974A - Compuestos de biarilo y metodos de uso de los mismos. - Google Patents

Compuestos de biarilo y metodos de uso de los mismos.

Info

Publication number
MX2012001974A
MX2012001974A MX2012001974A MX2012001974A MX2012001974A MX 2012001974 A MX2012001974 A MX 2012001974A MX 2012001974 A MX2012001974 A MX 2012001974A MX 2012001974 A MX2012001974 A MX 2012001974A MX 2012001974 A MX2012001974 A MX 2012001974A
Authority
MX
Mexico
Prior art keywords
methods
compounds
biaryl compounds
compositions
biaryl
Prior art date
Application number
MX2012001974A
Other languages
English (en)
Inventor
Mark W Holladay
Gang Liu
Shimin Xu
Sunny Abraham
Original Assignee
Ambit Biosciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambit Biosciences Corp filed Critical Ambit Biosciences Corp
Publication of MX2012001974A publication Critical patent/MX2012001974A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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Abstract

En la presente se proveen compuestos para el tratamiento de enfermedades mediadas con quinasa KIT, CSF-1R y/o FLT3. También se proveen composiciones farmacéuticas que comprenden los compuestos y métodos de usar los compuestos y composiciones.
MX2012001974A 2009-08-19 2010-08-18 Compuestos de biarilo y metodos de uso de los mismos. MX2012001974A (es)

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CA2770454A1 (en) 2011-02-24
JP2013502429A (ja) 2013-01-24
BR112012003661A2 (pt) 2017-04-25
EP2467137A1 (en) 2012-06-27
CN102470127A (zh) 2012-05-23
KR20120059558A (ko) 2012-06-08
WO2011022473A1 (en) 2011-02-24
US20130035326A1 (en) 2013-02-07

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