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MX2011011246A - Derivados de 1-h-pirazolo [4,3-c] isoquinoleinas, su preparacion y su uso en terapeutica. - Google Patents

Derivados de 1-h-pirazolo [4,3-c] isoquinoleinas, su preparacion y su uso en terapeutica.

Info

Publication number
MX2011011246A
MX2011011246A MX2011011246A MX2011011246A MX2011011246A MX 2011011246 A MX2011011246 A MX 2011011246A MX 2011011246 A MX2011011246 A MX 2011011246A MX 2011011246 A MX2011011246 A MX 2011011246A MX 2011011246 A MX2011011246 A MX 2011011246A
Authority
MX
Mexico
Prior art keywords
sub
group
pyrazolo
preparation
therapeutic use
Prior art date
Application number
MX2011011246A
Other languages
English (en)
Inventor
Fabienne Thompson
Stephanie Deprets
Frank Halley
Laurent Schio
Georges Delettre
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX2011011246A publication Critical patent/MX2011011246A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención se refiere a un compuesto de fórmula (I), en la que: R1 representa un grupo fenilo sustituido opcionalmente con uno o varios átomo(s) de halógeno; R2 representa : un átomo de hidrógeno o de halógeno o un grupo ciano ; un grupo - C(=O)Y en el que Y representa un átomo de hidrógeno, un grupo -NH2 o -OR3 un grupo -C(=S)NH2 un grupo -C(=NH)NH-OH ; un grupo -CH2OH o -CH2F; un grupo -CH=N-OH; un grupo -CH=CH2 o -CC-R3 un grupo 1-1 o H Ra, representando un átomo de hidrógeno o un grupo alquilo(C1-C4) ; R4 representa un grupo -NH2, alquilo(C1-C4), fluoroalquilo(C1-C4) o cicloalquilo(C3-C7).
MX2011011246A 2009-04-24 2010-04-22 Derivados de 1-h-pirazolo [4,3-c] isoquinoleinas, su preparacion y su uso en terapeutica. MX2011011246A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0901995A FR2944792B1 (fr) 2009-04-24 2009-04-24 Derives de 1h-pyrazolo[4,3-c]isoquinoleines, leur preparation et leur application en therapeutique
PCT/FR2010/050773 WO2010122272A1 (fr) 2009-04-24 2010-04-22 DERIVES DE 1-PYRAZOLO[4,3-c]ISOQUINOLEINES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publications (1)

Publication Number Publication Date
MX2011011246A true MX2011011246A (es) 2012-02-13

Family

ID=41259738

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011011246A MX2011011246A (es) 2009-04-24 2010-04-22 Derivados de 1-h-pirazolo [4,3-c] isoquinoleinas, su preparacion y su uso en terapeutica.

Country Status (25)

Country Link
US (1) US8461175B2 (es)
EP (1) EP2421864B1 (es)
JP (1) JP5722880B2 (es)
KR (1) KR101675609B1 (es)
CN (1) CN102459260B (es)
AR (1) AR076393A1 (es)
AU (1) AU2010240742B2 (es)
BR (1) BRPI1013724A2 (es)
CA (1) CA2791947A1 (es)
CY (1) CY1115678T1 (es)
DK (1) DK2421864T3 (es)
ES (1) ES2515240T3 (es)
FR (1) FR2944792B1 (es)
HR (1) HRP20141058T1 (es)
IL (1) IL215733A (es)
MX (1) MX2011011246A (es)
MY (1) MY156362A (es)
PL (1) PL2421864T3 (es)
PT (1) PT2421864E (es)
RU (1) RU2530775C2 (es)
SG (1) SG175338A1 (es)
SI (1) SI2421864T1 (es)
TW (1) TWI468405B (es)
UY (1) UY32575A (es)
WO (1) WO2010122272A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109020972B (zh) * 2018-10-08 2021-03-09 广东石油化工学院 一种三唑并[1，5-a]喹啉衍生物的制备方法
WO2023039510A1 (en) * 2021-09-10 2023-03-16 The Trustees Of Columbia University In The City Of New York Gpx4 inhibitors and uses thereof
CN116535356A (zh) * 2023-03-06 2023-08-04 中国药科大学 3-氨基-5-苯基-吡唑类衍生物微管蛋白抑制剂及其制备和医药用途
EP4506003A1 (en) 2023-08-07 2025-02-12 S.Yu Yunusov Institute of Chemistry of Plant Substances of the Academy of Sciences of the Republic of Uzbekistan Halogen derivatives of (4´,5´- methylenedioxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline for use in the treatment of leukemia

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600752D0 (en) * 1986-01-14 1986-02-19 Roussel Lab Ltd Chemical compounds
DE10229762A1 (de) * 2002-07-03 2004-01-22 Aventis Pharma Deutschland Gmbh Pyrazoloisoquinolinenderivaten zur Inhibierung von NFkappaB-induzierende Kinase
MXPA05013485A (es) * 2003-07-03 2006-04-05 Aventis Pharma Inc Derivados de pirazoloisoquinolina como inhibidores de cinasa.
US7132428B2 (en) * 2003-07-03 2006-11-07 Aventis Pharmaceuticals Inc. Pyrazoloisoquinoline derivative as kinase inhibitors for the treatment of various disorders
US7872014B2 (en) * 2003-07-23 2011-01-18 Exelixis, Inc. Anaplastic lymphoma kinase modulators and methods of use
AR058223A1 (es) * 2005-11-25 2008-01-23 Palau Pharma Sa Un comuesto de derivados de pirazoloisoquinolina, un procedimiento para l a preparacion de dicho compuesto y una composicion farmaceutica que comprende dicho compuesto

Also Published As

Publication number Publication date
WO2010122272A1 (fr) 2010-10-28
EP2421864A1 (fr) 2012-02-29
FR2944792A1 (fr) 2010-10-29
HK1167387A1 (en) 2012-11-30
US8461175B2 (en) 2013-06-11
US20120115898A1 (en) 2012-05-10
DK2421864T3 (da) 2014-11-10
CN102459260B (zh) 2015-06-10
EP2421864B1 (fr) 2014-08-06
CY1115678T1 (el) 2017-01-25
TWI468405B (zh) 2015-01-11
CA2791947A1 (fr) 2010-10-28
AU2010240742A1 (en) 2011-11-17
MY156362A (en) 2016-02-15
RU2011147658A (ru) 2013-05-27
SG175338A1 (en) 2011-11-28
HRP20141058T1 (hr) 2014-12-19
BRPI1013724A2 (pt) 2016-04-05
IL215733A0 (en) 2012-01-31
KR101675609B1 (ko) 2016-11-11
UY32575A (es) 2010-11-30
SI2421864T1 (sl) 2014-11-28
FR2944792B1 (fr) 2011-05-20
PT2421864E (pt) 2014-10-07
CN102459260A (zh) 2012-05-16
AU2010240742B2 (en) 2015-11-19
PL2421864T3 (pl) 2014-12-31
TW201041887A (en) 2010-12-01
JP2012524766A (ja) 2012-10-18
AR076393A1 (es) 2011-06-08
KR20120007060A (ko) 2012-01-19
ES2515240T3 (es) 2014-10-29
IL215733A (en) 2014-02-27
JP5722880B2 (ja) 2015-05-27
HK1170736A1 (en) 2013-03-08
RU2530775C2 (ru) 2014-10-10

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