MX2011007373A - Metodos para identificar pacientes que responderan bien a tratamiento para el cancer. - Google Patents
Metodos para identificar pacientes que responderan bien a tratamiento para el cancer.Info
- Publication number
- MX2011007373A MX2011007373A MX2011007373A MX2011007373A MX2011007373A MX 2011007373 A MX2011007373 A MX 2011007373A MX 2011007373 A MX2011007373 A MX 2011007373A MX 2011007373 A MX2011007373 A MX 2011007373A MX 2011007373 A MX2011007373 A MX 2011007373A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- cancer treatment
- respond well
- identifying patients
- patients
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 229940121372 histone deacetylase inhibitor Drugs 0.000 abstract 4
- 239000003276 histone deacetylase inhibitor Substances 0.000 abstract 4
- 239000002246 antineoplastic agent Substances 0.000 abstract 2
- 229940127089 cytotoxic agent Drugs 0.000 abstract 2
- 238000011285 therapeutic regimen Methods 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a métodos para identificar pacientes que responderán bien a tratamiento para el cáncer con un régimen terapéutico que comprende el uso de un inhibidor de histona desacetilasa (HDACi) y uno o más agentes quimioterapéuticos adicionales. La invención se refiere también a métodos para tratar a estos pacientes con un régimen terapéutico que comprende el uso de un inhibidor de histona desacetilasa (HDACi) y uno o más agentes 10 quimioterapéuticos adicionales.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20512409P | 2009-01-14 | 2009-01-14 | |
| GBGB0900555.4A GB0900555D0 (en) | 2009-01-14 | 2009-01-14 | New methods |
| PCT/EP2010/000077 WO2010081662A2 (en) | 2009-01-14 | 2010-01-11 | Methods for identifying patients who will respond well to cancer treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011007373A true MX2011007373A (es) | 2011-08-08 |
Family
ID=40379541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011007373A MX2011007373A (es) | 2009-01-14 | 2010-01-11 | Metodos para identificar pacientes que responderan bien a tratamiento para el cancer. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100190694A1 (es) |
| EP (1) | EP2387397A2 (es) |
| JP (1) | JP2012515143A (es) |
| CA (1) | CA2749051A1 (es) |
| GB (1) | GB0900555D0 (es) |
| MX (1) | MX2011007373A (es) |
| WO (1) | WO2010081662A2 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013024730A2 (pt) * | 2011-04-01 | 2016-12-20 | Threshold Pharmaceuticals Inc | métodos para tratamento do câncer |
| US9511046B2 (en) * | 2013-01-11 | 2016-12-06 | Abraxis Bioscience, Llc | Methods of treating pancreatic cancer |
| WO2015069489A1 (en) | 2013-11-06 | 2015-05-14 | Merck Patent Gmbh | Predictive biomarker for hypoxia-activated prodrug therapy |
| WO2017070441A1 (en) * | 2015-10-23 | 2017-04-27 | Icahn School Of Medicine At Mount Sinai | Identifying and treating cancer patients who are suitable for a targeted therapy using an hdac6 inhibitor |
| CN108685947A (zh) * | 2017-04-11 | 2018-10-23 | 上海尚泰生物技术有限公司 | 结直肠癌肝转移原发灶和转移灶配对模型 |
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| US6071923A (en) * | 1994-09-16 | 2000-06-06 | Bar-Ilan University | Retinoyloxy aryl-substituted alkylene butyrates useful for the treatment of cancer and other proliferative diseases |
| IL142531A0 (en) * | 1998-10-13 | 2002-03-10 | Fujisawa Pharmaceutical Co | Cyclic peptide compound, processes for the preparation thereof and pharmaceutical compositions containing the same |
| US20070148228A1 (en) * | 1999-02-22 | 2007-06-28 | Merrion Research I Limited | Solid oral dosage form containing an enhancer |
| WO2000064946A2 (en) * | 1999-04-28 | 2000-11-02 | Board Of Regents, The University Of Texas System | Compositions and methods for cancer treatment by selectively inhibiting vegf |
| DK1233958T3 (da) * | 1999-11-23 | 2011-10-17 | Methylgene Inc | Hæmmere af histondeacetylase |
| EP2083005A1 (en) * | 2000-09-29 | 2009-07-29 | TopoTarget UK Limited | Carbamic acid compounds comprising an amide linkage as HDAC inhibitors |
| EP2292593A3 (en) * | 2000-09-29 | 2011-05-25 | TopoTarget UK Limited | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors |
| GB0023983D0 (en) * | 2000-09-29 | 2000-11-15 | Prolifix Ltd | Therapeutic compounds |
| EP1364206A2 (en) * | 2001-01-09 | 2003-11-26 | Novartis AG | Rapid method for screening compounds for in vivo activity |
| WO2002074298A1 (en) * | 2001-03-21 | 2002-09-26 | Ono Pharmaceutical Co., Ltd. | Il-6 production inhibitors |
| EP1431267A4 (en) * | 2001-08-09 | 2004-12-22 | Ono Pharmaceutical Co | COMPOUNDS DERIVED FROM CARBOXYLIC ACID AND MEDICAMENTS COMPRISING SUCH COMPOUNDS AS ACTIVE INGREDIENT |
| US6897220B2 (en) * | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| CA2467629A1 (en) * | 2001-11-20 | 2003-05-30 | Oncomedx, Inc. | Methods for evaluating drug-resistance gene expression in the cancer patient |
| DE60318387T2 (de) * | 2002-01-11 | 2008-12-18 | Rath, Matthias, Dr. | Polyphenole enthaltende pharmazeutische nahrungsmittelergänzungsformel und ihre anwendung in der krebsbehandlung |
| US20050288227A1 (en) * | 2002-02-15 | 2005-12-29 | Marks Paul A | Use of thioredoxin measurements for diagnostics and treatments |
| WO2003070188A2 (en) * | 2002-02-15 | 2003-08-28 | Sloan-Kettering Institute For Cancer Research | Method of treating trx mediated diseases |
| US20070060614A1 (en) * | 2002-03-04 | 2007-03-15 | Bacopoulos Nicholas G | Methods of treating cancer with hdac inhibitors |
| US20040132825A1 (en) * | 2002-03-04 | 2004-07-08 | Bacopoulos Nicholas G. | Methods of treating cancer with HDAC inhibitors |
| US7148257B2 (en) * | 2002-03-04 | 2006-12-12 | Merck Hdac Research, Llc | Methods of treating mesothelioma with suberoylanilide hydroxamic acid |
| MXPA04008577A (es) * | 2002-03-04 | 2005-07-13 | Aton Pharma Inc | Metodos para inducir diferenciacion terminal. |
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| US8883148B2 (en) * | 2002-04-26 | 2014-11-11 | Asan Laboratories Company (Cayman), Limited | Prevention of joint destruction |
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| US7606215B2 (en) * | 2003-04-07 | 2009-10-20 | Paul Poniatowski | Audio/visual information dissemination system |
| US20040220242A1 (en) * | 2003-05-02 | 2004-11-04 | Leland Shapiro | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions |
| EP1491188A1 (en) * | 2003-06-25 | 2004-12-29 | G2M Cancer Drugs AG | Topical use of valproic acid for the prevention or treatment of skin disorders |
| PL379887A1 (pl) * | 2003-08-26 | 2006-11-27 | Merck Hdac Research, Llc | Sposób leczenia raka inhibitorami HDAC |
| ATE353107T1 (de) * | 2003-08-28 | 2007-02-15 | Hoffmann La Roche | Abhängigkeit des symptomfreien überlebens 5-fu behandelter darmkrebspatienten vom verhältnis der mrna-expressionshöhe aus thymidinphosphorylase und dihydropyrimidindehydrogenase |
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| US20090246198A1 (en) * | 2008-03-31 | 2009-10-01 | Takeda Pharmaceutical Company Limited | Mapk/erk kinase inhibitors and methods of use thereof |
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| US8637554B2 (en) * | 2008-05-07 | 2014-01-28 | The Trustees Of The University Of Pennsylvania | Methods for treating thyroid cancer |
-
2009
- 2009-01-14 GB GBGB0900555.4A patent/GB0900555D0/en not_active Ceased
-
2010
- 2010-01-11 JP JP2011544847A patent/JP2012515143A/ja active Pending
- 2010-01-11 CA CA2749051A patent/CA2749051A1/en not_active Abandoned
- 2010-01-11 WO PCT/EP2010/000077 patent/WO2010081662A2/en not_active Ceased
- 2010-01-11 MX MX2011007373A patent/MX2011007373A/es not_active Application Discontinuation
- 2010-01-11 EP EP10701451A patent/EP2387397A2/en not_active Withdrawn
- 2010-01-14 US US12/657,160 patent/US20100190694A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012515143A (ja) | 2012-07-05 |
| GB0900555D0 (en) | 2009-02-11 |
| CA2749051A1 (en) | 2010-07-22 |
| WO2010081662A3 (en) | 2010-09-23 |
| EP2387397A2 (en) | 2011-11-23 |
| WO2010081662A2 (en) | 2010-07-22 |
| US20100190694A1 (en) | 2010-07-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |