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MX2009013955A - Dominios de union de proteina morfogenica osea (bmp) de proteinas de la familia de proteina de molecula repulsiva de la direccion (rgm) y sus fragmentos funcionales, y su uso. - Google Patents

Dominios de union de proteina morfogenica osea (bmp) de proteinas de la familia de proteina de molecula repulsiva de la direccion (rgm) y sus fragmentos funcionales, y su uso.

Info

Publication number
MX2009013955A
MX2009013955A MX2009013955A MX2009013955A MX2009013955A MX 2009013955 A MX2009013955 A MX 2009013955A MX 2009013955 A MX2009013955 A MX 2009013955A MX 2009013955 A MX2009013955 A MX 2009013955A MX 2009013955 A MX2009013955 A MX 2009013955A
Authority
MX
Mexico
Prior art keywords
bmp
rgm
binding domains
protein
bone morphogenetic
Prior art date
Application number
MX2009013955A
Other languages
English (en)
Inventor
Martin Schmidt
Axel Meyer
Bernhard Mueller
Gregor Schaffar
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of MX2009013955A publication Critical patent/MX2009013955A/es

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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators

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Abstract

La presente invención se refiere a la identificación y uso de dominios de unión de proteína morfogenética ósea (BMP) de miembros de la familia de molécula de guía repulsiva (RGM), y fragmentos de polipéptido y proteínas de fusión derivadas de los mismos. Los dominios, es decir, los fragmentos de péptido y proteínas de fusión, de acuerdo con la invención son adecuados como agentes para la inmunización activa o pasiva de individuos, o como agentes de diagnóstico y terapéuticos para usarse para enfermedades o condiciones médicas en donde está involucrado un origen o progresión de un miembro de la familia RGM y un receptor celular asociado con esta molécula, tal como neogenina y/oBMP en particular. La invención además se refiere a anticuerpos monoclonales y policlonales dirigidos contra los dominios de unión de acuerdo con la invención, y contra los polipéptidos derivados de los mismos, y a métodos para producir los polipéptidos, proteínas de fusión, y anticuerpos de acuerdo con la invención.
MX2009013955A 2007-09-06 2008-09-08 Dominios de union de proteina morfogenica osea (bmp) de proteinas de la familia de proteina de molecula repulsiva de la direccion (rgm) y sus fragmentos funcionales, y su uso. MX2009013955A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07115856A EP2033971A1 (de) 2007-09-06 2007-09-06 Bone Morphogenetic Protein (BMP)-bindende Domänen von Proteinen der Repulsive Guidance Molecule (RGM) Proteinfamilie und funktionale Fragmente davon sowie deren Verwendung
PCT/EP2008/007339 WO2009030500A1 (en) 2007-09-06 2008-09-08 Bone morphogenetic protein (bmp)-binding domains of proteins of the repulsive guidance molecule (rgm) protein family and functional fragments thereof, and use of same

Publications (1)

Publication Number Publication Date
MX2009013955A true MX2009013955A (es) 2010-10-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009013955A MX2009013955A (es) 2007-09-06 2008-09-08 Dominios de union de proteina morfogenica osea (bmp) de proteinas de la familia de proteina de molecula repulsiva de la direccion (rgm) y sus fragmentos funcionales, y su uso.

Country Status (8)

Country Link
US (1) US20100322948A1 (es)
EP (2) EP2033971A1 (es)
JP (1) JP2010537655A (es)
CN (1) CN101778864A (es)
CA (1) CA2690974A1 (es)
MX (1) MX2009013955A (es)
TW (1) TW200916482A (es)
WO (1) WO2009030500A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7981420B2 (en) 2000-12-22 2011-07-19 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. Therapeutic use of antibodies directed against repulsive guidance molecule (RGM)
WO2007039256A2 (de) 2005-09-30 2007-04-12 Abbott Gmbh & Co. Kg Bindungsdomänen von proteinen der repulsive guidance molecule (rgm) proteinfamilie und funktionale fragmente davon sowie deren verwendung
US8962803B2 (en) * 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
BR112012013734A2 (pt) 2009-12-08 2017-01-10 Abbott Gmbh & Co Kg anticorpos monoclonais contra a proteína rgm a para uso no tratamento da degeneração da camada de fibras nervosas da retina.
US9334323B2 (en) * 2009-12-09 2016-05-10 Mitsubishi Tanabe Pharma Corporation Method of reducing recurrence of multiple sclerosis symptoms in a mammal by administering an anti-repulsive guidance molecule neutralizing antibody
AU2012251919B2 (en) 2011-01-19 2016-12-15 Ferrumax Pharmaceuticals, Inc. Compositions for regulating iron homeostasis and methods of using same
CA3204283A1 (en) 2011-12-14 2013-06-20 AbbVie Deutschland GmbH & Co. KG Composition and method for the diagnosis and treatment of iron-related disorders
SG11201404263TA (en) 2012-01-27 2014-08-28 Abbvie Deutschland Composition and method for diagnosis and treatment of diseases associated with neurite degeneration
EP3613765B1 (en) * 2012-08-03 2024-10-02 Dana-Farber Cancer Institute, Inc. Antibody against repulsive guidance molecule b (rgmb)
WO2014052393A2 (en) 2012-09-25 2014-04-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for the diagnosis and treatment of sjögren's syndrome
US20160000794A1 (en) * 2012-09-25 2016-01-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Methods for the diagnosis and treatment of sjogren's syndrome
WO2015120138A2 (en) * 2014-02-05 2015-08-13 Dana-Farber Cancer Institute, Inc. AGENTS THAT MODULATE RGMb-NEOGENIN-BMP SIGNALING AND METHODS OF USE THEREOF
US10265437B2 (en) 2014-03-14 2019-04-23 The Research Foundation For The State University Of New York Neurogenic regulation of bone growth and bone degradation
KR102613528B1 (ko) * 2015-04-28 2023-12-12 미쓰비시 타나베 파마 코퍼레이션 RGMa 결합 단백질 및 그 사용
WO2017044862A1 (en) * 2015-09-11 2017-03-16 Abbvie Inc. Methods for treating relapsing forms of multiple sclerosis
RU2018120173A (ru) * 2015-11-03 2019-12-04 Те Борд Оф Трастиз Оф Те Лилэнд Стэнфорд Джуниор Юниверсити БЛОКАДА RGMb ДЛЯ ОСЛАБЛЕНИЯ ИММУННЫХ РЕАКЦИЙ, АССОЦИИРОВАННЫХ С ТРАНСПЛАНТАЦИЕЙ
CN108034712A (zh) * 2017-12-28 2018-05-15 上海市儿童医院 川崎病冠状动脉病变风险诊断与检测试剂盒
US20210196823A1 (en) * 2018-06-08 2021-07-01 Pfizer Inc. Methods of Treating Metabolic Disease
WO2019246013A1 (en) * 2018-06-22 2019-12-26 The Children's Hospital Of Philadelphia Peptides to enhance bone growth, repair and cell function
CN113508301A (zh) * 2018-10-05 2021-10-15 梅塔福拉生物系统公司 衍生自b型猪内源性病毒受体结合结构域的配体在诊断与smvt相关的疾病中的用途
KR20230012539A (ko) 2020-05-13 2023-01-26 디스크 메디슨, 인크. 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체
CN116874598B (zh) * 2023-07-11 2024-10-01 广西大学 一种大片吸虫bmp单克隆抗体及其制备方法与应用

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634665A (en) * 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5179017A (en) * 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4510245A (en) * 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
AU4434585A (en) * 1985-03-30 1986-10-23 Marc Ballivet Method for obtaining dna, rna, peptides, polypeptides or proteins by means of a dna recombinant technique
US5618920A (en) * 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
EP0279582A3 (en) * 1987-02-17 1989-10-18 Pharming B.V. Dna sequences to target proteins to the mammary gland for efficient secretion
DE3883899T3 (de) * 1987-03-18 1999-04-22 Sb2, Inc., Danville, Calif. Geänderte antikörper.
US5006309A (en) * 1988-04-22 1991-04-09 Abbott Laboratories Immunoassay device with liquid transfer between wells by washing
US5089424A (en) * 1988-06-14 1992-02-18 Abbott Laboratories Method and apparatus for heterogeneous chemiluminescence assay
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
CA2090126C (en) * 1990-08-02 2002-10-22 John W. Schrader Methods for the production of proteins with a desired function
US5877397A (en) * 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) * 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) * 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
JPH05504841A (ja) * 1990-09-14 1993-07-22 バイオサイト・ダイアグノスティックス・インコーポレイテッド リガンドレセプター及びリガンドのコンプレックスに対する抗体及びリガンド―レセプターアッセーでのそれらの用途
ATE221379T1 (de) * 1991-05-01 2002-08-15 Jackson H M Found Military Med Verfahren zur behandlung infektiöser respiratorischer erkrankungen
CA2069530A1 (en) * 1991-06-03 1992-12-04 Cass J. Grandone Reagent pack for immunoassays
ES2341666T3 (es) * 1991-12-02 2010-06-24 Medimmune Limited Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
US5714350A (en) * 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
US5733743A (en) * 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US5352803A (en) * 1992-03-30 1994-10-04 Abbott Laboratories 5(6)-methyl substituted fluorescein derivatives
ES2148225T3 (es) * 1992-03-30 2000-10-16 Abbott Lab Reactivos y procedimientos que permiten la deteccion y la cuantificacion de la tiroxina en muestras de fluido.
US6019944A (en) * 1992-05-21 2000-02-01 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US5516637A (en) * 1994-06-10 1996-05-14 Dade International Inc. Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
US6019968A (en) * 1995-04-14 2000-02-01 Inhale Therapeutic Systems, Inc. Dispersible antibody compositions and methods for their preparation and use
US5747262A (en) * 1995-10-16 1998-05-05 The Regents Of The University Of California Neurological drug screens
JP2978435B2 (ja) * 1996-01-24 1999-11-15 チッソ株式会社 アクリロキシプロピルシランの製造方法
US5714352A (en) * 1996-03-20 1998-02-03 Xenotech Incorporated Directed switch-mediated DNA recombination
US5855913A (en) * 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US6699658B1 (en) * 1996-05-31 2004-03-02 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
US6017517A (en) * 1996-12-18 2000-01-25 The Dial Corporation Method for treating human nails
CA2311574A1 (en) * 1997-12-02 1999-06-10 Medarex, Inc. Cells expressing anti-fc receptor binding components
US6464686B1 (en) * 1998-01-21 2002-10-15 Abbott Laboratories Polyurethane feeding tube and associated adaptors
US6231768B1 (en) * 1999-01-19 2001-05-15 Nalco Chemical Company Rheology modification of settled solids in mineral processing
EP1396543A3 (en) * 1999-07-08 2004-03-31 Research Association for Biotechnology Primers for synthesizing full length cDNA clones and their use
CN1371416B (zh) * 1999-08-24 2012-10-10 梅达里克斯公司 人ctla-4抗体及其应用
MXPA02010011A (es) * 2000-04-11 2003-04-25 Genentech Inc Anticuerpos multivalentes y usos para los mismos.
AU2001274888A1 (en) * 2000-05-19 2001-12-03 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
US7449308B2 (en) * 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
DK1790728T3 (da) * 2000-11-06 2010-12-06 Cancer Rec Tech Ltd Billeddannelse, diagnose og behandling af sygdom
US7981420B2 (en) * 2000-12-22 2011-07-19 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. Therapeutic use of antibodies directed against repulsive guidance molecule (RGM)
US6890763B2 (en) * 2001-04-30 2005-05-10 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1350 daltons
US20100036502A1 (en) * 2008-08-07 2010-02-11 Exogenesis Corporation Medical device for bone implant and method for producing such device
CA2388761A1 (en) * 2001-06-18 2002-12-18 Pfizer Inc. Wound healing biomarkers
WO2003020894A2 (en) * 2001-08-31 2003-03-13 Joslin Diabetes Center, Inc. Insulin related transcription factor and uses thereof
US8435529B2 (en) * 2002-06-14 2013-05-07 Immunomedics, Inc. Combining radioimmunotherapy and antibody-drug conjugates for improved cancer therapy
US6864239B2 (en) * 2002-03-27 2005-03-08 Theratechnologies Inc. Methods and compounds for prevention and treatment of elevated intraocular pressure and related conditions
WO2003089608A2 (en) * 2002-04-18 2003-10-30 The General Hospital Corporation Drg11-responsive (dragon) gene family
WO2003095978A2 (en) * 2002-05-09 2003-11-20 Surromed, Inc. Methods for time-alignment of liquid chromatography-mass spectrometry data
EP1535065A4 (en) * 2002-06-11 2007-07-11 Burnham Inst NEUROPROTECTOR SYNERGY OF ERYTHROPOIETIN AND INSULIN-LIKE GROWTH FACTOR
WO2004003150A2 (en) * 2002-06-26 2004-01-08 Yale University Modulators and modulation of the interacton between rgm and neogenin
EP1380644A1 (en) * 2002-07-08 2004-01-14 Kylix B.V. The use of specified TCF target genes to identify drugs for the treatment of cancer, in particular colorectal cancer, in which TCF/beta-catenin/WNT signalling plays a central role
US20040018577A1 (en) * 2002-07-29 2004-01-29 Emerson Campbell John Lewis Multiple hybrid immunoassay
US7541440B2 (en) * 2002-09-30 2009-06-02 Immunomedics, Inc. Chimeric, human and humanized anti-granulocyte antibodies and methods of use
US20050013809A1 (en) * 2002-12-02 2005-01-20 Owens Samuel M. Antibodies against drugs of abuse
US20050058649A1 (en) * 2002-12-02 2005-03-17 Landes Gregory M. Antibodies directed to phospholipase A2 and uses thereof
EP1440981A3 (en) * 2003-01-21 2005-11-23 Research Association for Biotechnology Full-length human cdna
US20060104968A1 (en) * 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
US20070166711A1 (en) * 2003-04-15 2007-07-19 Samuels Mark E Juvenile hemochromatosis gene (hfe2a), expression products and uses thereof
US20060003391A1 (en) * 2003-08-11 2006-01-05 Ring Brian Z Reagents and methods for use in cancer diagnosis, classification and therapy
EP1660534A2 (en) * 2003-08-22 2006-05-31 MedImmune, Inc. Humanization of antibodies
US7682833B2 (en) * 2003-09-10 2010-03-23 Abbott Point Of Care Inc. Immunoassay device with improved sample closure
US20060063208A1 (en) * 2004-08-02 2006-03-23 Woolf Clifford J DRG11-responsive (DRAGON) gene and uses thereof
WO2006021955A2 (en) * 2004-08-23 2006-03-02 Mor Research Applications Ltd. Use of bat monoclonal antibody for immunotherapy
US7919093B2 (en) * 2004-11-16 2011-04-05 Trustees Of Boston University Roles for dual endothelin-1/angiotensin II receptor (Dear) in hypertension and angiogenesis
US7504225B2 (en) * 2005-05-12 2009-03-17 Applied Genomics, Inc. Reagents and methods for use in cancer diagnosis, classification and therapy
DK1904104T3 (da) * 2005-07-08 2013-11-11 Biogen Idec Inc SP35-antistoffer og anvendelser heraf
US7612181B2 (en) * 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
WO2007039256A2 (de) * 2005-09-30 2007-04-12 Abbott Gmbh & Co. Kg Bindungsdomänen von proteinen der repulsive guidance molecule (rgm) proteinfamilie und funktionale fragmente davon sowie deren verwendung
US8865763B2 (en) * 2005-10-14 2014-10-21 Alltech, Inc. Methods and compositions for altering cell function
US20080004255A1 (en) * 2005-10-14 2008-01-03 Alltech, Inc. Methods and compositions for altering cell function
US8871715B2 (en) * 2005-10-14 2014-10-28 Alltech, Inc. Use of selenium compounds, especially selenium yeasts for altering cognitive function
US7883855B2 (en) * 2006-07-21 2011-02-08 Abbott Laboratories Immunosuppressant drug extraction reagent for immunoassays
JPWO2008038599A1 (ja) * 2006-09-25 2010-01-28 国立大学法人 千葉大学 軸索再生促進剤
US7984828B2 (en) * 2006-10-18 2011-07-26 Schmidt Norman G Device to allow for cleaning access in semi-solid metering machines
WO2008061013A2 (en) * 2006-11-10 2008-05-22 Amgen Inc. Antibody-based diagnostics and therapeutics
EP2094731A2 (en) * 2006-11-10 2009-09-02 UCB Pharma S.A. Anti human sclerostin antibodies
US8070827B2 (en) * 2007-07-03 2011-12-06 Histogenics Corporation Method for use of a double-structured tissue implant for treatment of tissue defects
US20090054984A1 (en) * 2007-08-20 2009-02-26 Histogenics Corporation Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects
EP2182887B1 (en) * 2007-08-20 2016-12-14 Histogenics Corporation A method for improvement of differentiation of mesenchymal stem cells using a double-structured tissue implant
CN104548091A (zh) * 2008-02-11 2015-04-29 治疗科技公司 用于肿瘤治疗的单克隆抗体
US8962803B2 (en) * 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
US8314213B2 (en) * 2008-04-18 2012-11-20 Xencor, Inc. Human equivalent monoclonal antibodies engineered from nonhuman variable regions
CA2737035A1 (en) * 2008-09-30 2010-04-08 Abbott Laboratories Improved method of rna display
CN102227440A (zh) * 2008-09-30 2011-10-26 雅培制药有限公司 改良的抗体文库
US8268314B2 (en) * 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
US20110020221A1 (en) * 2009-04-09 2011-01-27 The Johns Hopkins University Cancer stem cell expression patterns and compounds to target cancer stem cells
NZ598791A (en) * 2009-10-23 2014-05-30 Millennium Pharm Inc Anti-gcc antibody molecules and related compositions and methods

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