[go: up one dir, main page]

MX2009011254A - Derivados de purinas sustituidas que contienen 2,6-dinitrogeno, preparacion y usos de los mismos. - Google Patents

Derivados de purinas sustituidas que contienen 2,6-dinitrogeno, preparacion y usos de los mismos.

Info

Publication number
MX2009011254A
MX2009011254A MX2009011254A MX2009011254A MX2009011254A MX 2009011254 A MX2009011254 A MX 2009011254A MX 2009011254 A MX2009011254 A MX 2009011254A MX 2009011254 A MX2009011254 A MX 2009011254A MX 2009011254 A MX2009011254 A MX 2009011254A
Authority
MX
Mexico
Prior art keywords
compounds
dinitrogen
substituted purine
preparation
containing substituted
Prior art date
Application number
MX2009011254A
Other languages
English (en)
Inventor
Zhanggui Wu
Jianyong Yuan
Gang Chen
Original Assignee
Zhe Jiang Medicine Co Ltd Xinc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhe Jiang Medicine Co Ltd Xinc filed Critical Zhe Jiang Medicine Co Ltd Xinc
Publication of MX2009011254A publication Critical patent/MX2009011254A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención proporciona compuestos de purinas sustituidas que contienen 2,6-dinitrógeno de la fórmula (A), o sales o solvatos de ello, o los solvatos de las sales de ello, así como composiciones farmacéuticas que contienen tales compuestos. Los compuestos de la presente invención tienen características de toxicidad inferior, amplio espectro anticáncer, actividad anticáncer superior, buena estabilidad y similares. Los compuestos son útiles para la elaboración de un medicamento antitumoral. La presente invención también proporciona un proceso para preparar estos compuestos. (ver fórmula A).
MX2009011254A 2007-04-20 2008-04-17 Derivados de purinas sustituidas que contienen 2,6-dinitrogeno, preparacion y usos de los mismos. MX2009011254A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNA2007100397251A CN101289449A (zh) 2007-04-20 2007-04-20 2,6-二含氮取代的嘌呤衍生物及其制备方法和应用
PCT/CN2008/000782 WO2008128428A1 (en) 2007-04-20 2008-04-17 2, 6-dinitrogen-containing substituted purine derivatives, the preparation and uses thereof

Publications (1)

Publication Number Publication Date
MX2009011254A true MX2009011254A (es) 2010-03-09

Family

ID=39875073

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009011254A MX2009011254A (es) 2007-04-20 2008-04-17 Derivados de purinas sustituidas que contienen 2,6-dinitrogeno, preparacion y usos de los mismos.

Country Status (11)

Country Link
US (1) US8580763B2 (es)
EP (1) EP2149574B1 (es)
JP (1) JP2010524862A (es)
KR (1) KR101563371B1 (es)
CN (1) CN101289449A (es)
AU (1) AU2008241256B2 (es)
BR (1) BRPI0810006A2 (es)
CA (1) CA2684638C (es)
MX (1) MX2009011254A (es)
RU (1) RU2498987C2 (es)
WO (1) WO2008128428A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011156889A1 (en) 2010-06-14 2011-12-22 Trt Pharma Inc. Novel modulators of nrf2 and uses thereof
CN103936742B (zh) * 2013-01-17 2017-05-03 程鹏 含嘌呤基的新型pi3k抑制剂及其制备方法和应用
CN104418858B (zh) * 2013-08-30 2018-12-11 浙江医药股份有限公司新昌制药厂 2,6-二含氮取代的嘌呤衍生物及其制备方法和其药物组合物与应用
WO2018004992A1 (en) 2016-07-01 2018-01-04 Res Usa, Llc Conversion of methane to dimethyl ether
WO2018004994A1 (en) 2016-07-01 2018-01-04 Res Usa, Llc Fluidized bed membrane reactor
WO2018004993A1 (en) 2016-07-01 2018-01-04 Res Usa, Llc Reduction of greenhouse gas emission
CN114980900A (zh) * 2020-01-13 2022-08-30 上海华禹生物科技有限公司 N2-喹啉或异喹啉取代的嘌呤衍生物在癌症治疗中的用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5461195A (en) * 1977-10-21 1979-05-17 Takeda Chem Ind Ltd N2-substituted phenyl-2,6-diaminonebularin
JPS56152437U (es) * 1980-04-14 1981-11-14
DE3529497A1 (de) 1985-08-17 1987-02-26 Boehringer Mannheim Gmbh N(pfeil hoch)6(pfeil hoch)-disubstituierte purinderivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
EP0353955A3 (en) 1988-08-02 1991-08-14 Beecham Group Plc Novel compounds
KR910000441B1 (ko) 1988-10-18 1991-01-25 한국과학기술원 비고리 퓨린유도체의 제조방법
WO1992001968A1 (en) 1990-07-23 1992-02-06 Alexander Leon Multi-mode remote control system
JPH0848631A (ja) * 1994-06-02 1996-02-20 Takeda Chem Ind Ltd 血管透過性亢進抑制剤
JPH10120682A (ja) 1996-10-24 1998-05-12 Ajinomoto Co Inc プリン誘導体の製造方法
GB9918035D0 (en) * 1999-07-30 1999-09-29 Novartis Ag Organic compounds
JP2003055377A (ja) 2001-08-16 2003-02-26 Mitsui Chemicals Inc ２−アミノ−６−シクロプロピルアミノ−９ｈ−プリンの製造法
JP2003119197A (ja) 2001-10-15 2003-04-23 Mitsui Chemicals Inc ２−アミノ−６−シクロプロピルアミノ−９ｈ−プリンの製造法
US6897307B2 (en) 2002-03-28 2005-05-24 Novartis Ag Process for preparing 2,6-diaminopurine derivatives
AU2004264419B2 (en) * 2003-08-15 2009-01-15 Irm Llc 6-substituted anilino purines as RTK inhibitors
GB0405009D0 (en) * 2004-03-05 2004-04-07 Cambridge Biotechnology Ltd Analgesics
GB0407723D0 (en) * 2004-04-05 2004-05-12 Novartis Ag Organic compounds
CN100526315C (zh) * 2005-06-16 2009-08-12 浙江医药股份有限公司新昌制药厂 N2-喹啉或异喹啉取代的嘌呤衍生物及其制备方法和其用途
CN101148448B (zh) * 2006-09-20 2010-08-04 浙江医药股份有限公司新昌制药厂 N2-喹啉取代的嘌呤衍生物的制备方法
CN101148449B (zh) * 2006-09-20 2010-08-11 浙江医药股份有限公司新昌制药厂 2-(6-喹啉氨基)-6-环丙氨基-9h-嘌呤成盐的方法

Also Published As

Publication number Publication date
KR20100017150A (ko) 2010-02-16
CN101289449A (zh) 2008-10-22
KR101563371B1 (ko) 2015-10-26
RU2498987C2 (ru) 2013-11-20
EP2149574A1 (en) 2010-02-03
AU2008241256A1 (en) 2008-10-30
CA2684638C (en) 2016-07-05
AU2008241256B2 (en) 2014-04-24
EP2149574B1 (en) 2015-12-02
CA2684638A1 (en) 2008-10-30
RU2009138453A (ru) 2011-05-27
WO2008128428A1 (en) 2008-10-30
BRPI0810006A2 (pt) 2014-10-14
JP2010524862A (ja) 2010-07-22
EP2149574A4 (en) 2011-06-15
US8580763B2 (en) 2013-11-12
US20100144663A1 (en) 2010-06-10

Similar Documents

Publication Publication Date Title
TW200610527A (en) Novel fluoroglycoside derivatives of pyrazoles, medicaments containing these compounds, and the use thereof
IL184872A0 (en) Pyrazole derivatives, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments for treatment and prevention of cancers
IL185063A0 (en) Pyrazole derivatives, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments for treatment and prevention of cancers
TW200833675A (en) Nicotinamide derivatives
MX2011011661A (es) Compuestos 1-cianoetilheterociclilcarboxamida sustituidos 750.
MX2009011254A (es) Derivados de purinas sustituidas que contienen 2,6-dinitrogeno, preparacion y usos de los mismos.
MY139302A (en) Novel heterocyclic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof
MY139303A (en) Novel aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof
TN2010000167A1 (en) Organic compounds
TW200519106A (en) Organic compounds
TW200801003A (en) Novel compounds
TW200613243A (en) Novel compounds
UA86595C2 (ru) Гамма-кристаллическая форма гидрохлорида ивабрадина, способ ее получения и фармацевтическая композиция, которая ее содержит
IL180136A0 (en) 2,4,6-trisubstituted pyrimidines as phosphotidylinositol (pi) 3-kinase inhibitors and their use in the treatment of cancer
TW200745084A (en) Novel compounds
MX2010013682A (es) Derivados de 2,4-diamino-l,3,5-triazina triciclicos utiles para el tratamiento del cancer y trastornos mieloproliferativos.
MY149512A (en) Pyrazolylaminopyridine derivatives useful as kinase inhibitors
MX2010009022A (es) Derivados 16 alfa, 17 alfa-acetal glucocorticoesteroideos y su uso.
GEP20125547B (en) (aza) indole derivative substituted in position 5, pharmaceutical composition comprising it, intermediate compounds and preparation process therefor
MY152018A (en) Indole derivatives as anticancer agents
MY135850A (en) Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use
MX2009006010A (es) Derivados de amina y su uso en enfermedades mediadas por el adrenoreceptor beta 2.
ZA200604410B (en) Imidazole derivatives, processes for preparing them and their uses
TW200626553A (en) Novel compounds
WO2004060264A3 (en) Metastin derivatives and their use

Legal Events

Date Code Title Description
FG Grant or registration