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MX2009008039A - Gamma lactamas substituidas como agentes terapeuticos. - Google Patents

Gamma lactamas substituidas como agentes terapeuticos.

Info

Publication number
MX2009008039A
MX2009008039A MX2009008039A MX2009008039A MX2009008039A MX 2009008039 A MX2009008039 A MX 2009008039A MX 2009008039 A MX2009008039 A MX 2009008039A MX 2009008039 A MX2009008039 A MX 2009008039A MX 2009008039 A MX2009008039 A MX 2009008039A
Authority
MX
Mexico
Prior art keywords
therapeutic agents
substituted gamma
gamma lactams
lactams
substituted
Prior art date
Application number
MX2009008039A
Other languages
English (en)
Inventor
David W Old
Wha Bin Im
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of MX2009008039A publication Critical patent/MX2009008039A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invención se refiere a un compuesto de la fórmula (I) o a una sal, profármaco, o un metabolito del mismo, farmacéuticamente aceptable. Y, A, y B son como se describen aquí. También se describen métodos, composiciones, y medicamentos relacionados con estos compuestos. (ver fórmula (I)).
MX2009008039A 2007-01-31 2008-01-29 Gamma lactamas substituidas como agentes terapeuticos. MX2009008039A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88741507P 2007-01-31 2007-01-31
PCT/US2008/052318 WO2008094912A2 (en) 2007-01-31 2008-01-29 Substituted gamma lactams as therapeutic agents

Publications (1)

Publication Number Publication Date
MX2009008039A true MX2009008039A (es) 2009-08-18

Family

ID=39639429

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009008039A MX2009008039A (es) 2007-01-31 2008-01-29 Gamma lactamas substituidas como agentes terapeuticos.

Country Status (11)

Country Link
US (1) US7960381B2 (es)
EP (1) EP2121672B1 (es)
JP (1) JP5566692B2 (es)
KR (1) KR101561706B1 (es)
CN (1) CN101595106B (es)
AU (1) AU2008210559B2 (es)
BR (1) BRPI0808377B8 (es)
CA (1) CA2676291C (es)
MX (1) MX2009008039A (es)
NZ (1) NZ578698A (es)
WO (1) WO2008094912A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8377984B2 (en) * 2008-01-29 2013-02-19 Allergan, Inc. Substituted gamma lactams as therapeutic agents
EP2288600A1 (en) * 2008-04-24 2011-03-02 Allergan, Inc. Substituted arylcyclopentenes as prostaglandin ep2 agonists
WO2009132088A1 (en) * 2008-04-24 2009-10-29 Allergan, Inc. Substituted gamma lactams as therapeutic agents
JP2011518834A (ja) * 2008-04-24 2011-06-30 アラーガン インコーポレイテッド 治療剤としての置換ガンマラクタム
BRPI0912342A2 (pt) * 2008-05-09 2015-10-06 Allergan Inc tiazolidinonas, oxazolidinonas substituídas terapêuticas, e compostos relacionados
EP2285775B1 (en) * 2008-05-20 2017-03-22 Allergan, Inc. Lactams and their use in the treatment of inter alia ocular hypertension or baldness

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004521954A (ja) * 2001-07-16 2004-07-22 エフ．ホフマン−ラ　ロシュ　アーゲー Ｅｐ４受容体作用薬としてのプロスタグランジン類似体
MXPA04004164A (es) * 2001-11-05 2004-09-06 Allergan Inc Analogos de omega-cicloalquil 17-heteroaril prostaglandina e2 como agonistas del receptor ep2.
CN1653046A (zh) * 2002-03-05 2005-08-10 小野药品工业株式会社 8－氮杂前列腺素衍生化合物以及包含该化合物作为活性成分的药物
US6573294B1 (en) * 2002-05-14 2003-06-03 Allergan, Inc. 8-azaprostaglandin analogs as agents for lowering intraocular pressure
US7419999B2 (en) 2002-06-10 2008-09-02 Applied Research Systems Ars Holding N.V. Gamma lactams as prostaglandin agonists and use thereof
US7091231B2 (en) * 2004-12-10 2006-08-15 Allergan, Inc. 12-Aryl prostaglandin analogs
CN105520941B (zh) * 2005-03-10 2020-05-01 阿勒根公司 作为治疗剂的取代的γ内酰胺
CA2645867A1 (en) 2006-03-20 2007-09-27 Allergan, Inc. Substituted gamma lactams as prostaglandin ep2 agonists

Also Published As

Publication number Publication date
WO2008094912A2 (en) 2008-08-07
BRPI0808377A2 (pt) 2014-07-08
KR20090104905A (ko) 2009-10-06
US7960381B2 (en) 2011-06-14
EP2121672B1 (en) 2014-12-10
AU2008210559A1 (en) 2008-08-07
NZ578698A (en) 2012-04-27
CA2676291C (en) 2017-11-28
CN101595106A (zh) 2009-12-02
EP2121672A2 (en) 2009-11-25
CN101595106B (zh) 2014-05-07
CA2676291A1 (en) 2008-08-07
AU2008210559B2 (en) 2014-03-06
JP5566692B2 (ja) 2014-08-06
BRPI0808377B8 (pt) 2021-05-25
KR101561706B1 (ko) 2015-10-19
US20100093729A1 (en) 2010-04-15
JP2010516817A (ja) 2010-05-20
BRPI0808377B1 (pt) 2020-01-21
WO2008094912B1 (en) 2008-11-20
WO2008094912A3 (en) 2008-10-09

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Legal Events

Date Code Title Description
FG Grant or registration