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MX2009004293A - Una sal de 3-bencil-2-metil-2,3,3a,4,5,6,7,7a-octahidrobenzo[d]iso xasol-4-ona. - Google Patents

Una sal de 3-bencil-2-metil-2,3,3a,4,5,6,7,7a-octahidrobenzo[d]iso xasol-4-ona.

Info

Publication number
MX2009004293A
MX2009004293A MX2009004293A MX2009004293A MX2009004293A MX 2009004293 A MX2009004293 A MX 2009004293A MX 2009004293 A MX2009004293 A MX 2009004293A MX 2009004293 A MX2009004293 A MX 2009004293A MX 2009004293 A MX2009004293 A MX 2009004293A
Authority
MX
Mexico
Prior art keywords
octahydrobenzo
benzyl
methyl
salt
oxazol
Prior art date
Application number
MX2009004293A
Other languages
English (en)
Inventor
Fabio Neggiani
Laura Dini
Original Assignee
Abiogen Pharma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abiogen Pharma Spa filed Critical Abiogen Pharma Spa
Publication of MX2009004293A publication Critical patent/MX2009004293A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a la sal de fumarato del compuesto de la formula (I) en todas sus configuraciones estereoquímicas, un proceso para su preparación y su uso para tratar trastornos de humor, trastornos de ansiedad, depresión y condiciones convulsivas en la mejora de habilidad de aprendizaje en la revocación de amnesia, resolver el síndrome de abstinencia de fármacos y fármacos de abuso. Preferiblemente, la invención se refiere a sal de fumarato de rel-(3R,3aS,7aS)-3-bencil-2-metil-2,3 ,3a,4,5,6,7,7a-octahidrobenzo[d]isoxasol-4-ona.
MX2009004293A 2006-11-02 2007-10-31 Una sal de 3-bencil-2-metil-2,3,3a,4,5,6,7,7a-octahidrobenzo[d]iso xasol-4-ona. MX2009004293A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002102A ITMI20062102A1 (it) 2006-11-02 2006-11-02 Nuovui sali di 3-benzil-2-metil-2,3,3a,4,5,6,7,7a-ottaidrobenzo-d-isossazol-4-one
PCT/IB2007/003291 WO2008053325A1 (en) 2006-11-02 2007-10-31 A salt of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one

Publications (1)

Publication Number Publication Date
MX2009004293A true MX2009004293A (es) 2009-05-08

Family

ID=39145485

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2009004294A MX2009004294A (es) 2006-11-02 2007-10-31 Una sal de 3-bencil-2-metil-2,3,3a,4,5,6,7,7a-octahidrobenzo[d]iso xasol-4-ona.
MX2009004293A MX2009004293A (es) 2006-11-02 2007-10-31 Una sal de 3-bencil-2-metil-2,3,3a,4,5,6,7,7a-octahidrobenzo[d]iso xasol-4-ona.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2009004294A MX2009004294A (es) 2006-11-02 2007-10-31 Una sal de 3-bencil-2-metil-2,3,3a,4,5,6,7,7a-octahidrobenzo[d]iso xasol-4-ona.

Country Status (20)

Country Link
US (2) US20100069450A1 (es)
EP (2) EP2094674B1 (es)
JP (2) JP2010509309A (es)
KR (2) KR20090082452A (es)
CN (2) CN101535281A (es)
AT (2) ATE502021T1 (es)
AU (2) AU2007315832A1 (es)
BR (2) BRPI0718392A2 (es)
CA (2) CA2667515A1 (es)
DE (2) DE602007013278D1 (es)
HR (2) HRP20090477A2 (es)
IL (2) IL198443A0 (es)
IT (1) ITMI20062102A1 (es)
MX (2) MX2009004294A (es)
NO (2) NO20092115L (es)
NZ (2) NZ577978A (es)
RS (2) RS20090389A (es)
RU (2) RU2009120724A (es)
WO (2) WO2008053326A1 (es)
ZA (2) ZA200903618B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2112142A1 (en) * 2008-04-24 2009-10-28 Abiogen Pharma S.p.A. Process for preparing a crystalline form compound of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one
ITMI20080768A1 (it) * 2008-04-24 2009-10-25 Abiogen Pharma Spa Procedimento per la preparazione di un composto in forma cristallina di 3-benzil-2-metil-2,3,3a,4,5,6,7,7a-ottaidro-benzo[d]isossazol-4-one
EP2218721A1 (en) * 2009-02-11 2010-08-18 LEK Pharmaceuticals d.d. Novel salts of sitagliptin
WO2011010332A1 (en) * 2009-07-23 2011-01-27 Abiogen Pharma S.P.A. Process for preparing rel-(3r*,3as*,7as*)-3-benzyl-2-methyl-2,3, 3a,4,5,6,7,7a- octahydrobenzo[d]isoxazoi-4-one or a salt thereof
US10131642B1 (en) * 2015-01-30 2018-11-20 Boehringer Ingelheim International Gmbh Aldosterone synthase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4161595A (en) * 1978-10-02 1979-07-17 Bristol-Myers Company Levulinic acid salt
US4419358A (en) * 1981-11-12 1983-12-06 Mead Johnson & Company Isethionic acid salt of 9-cyclohexyl-2-propoxy-9H-purine-6-amine and compositions containing an effective bronchodilating concentration of it
GB2264299B (en) * 1992-02-19 1995-07-26 British Tech Group Iso-oxazolidine derivatives

Also Published As

Publication number Publication date
CN101535281A (zh) 2009-09-16
EP2094675A1 (en) 2009-09-02
RU2009120724A (ru) 2010-12-10
WO2008053325A1 (en) 2008-05-08
DE602007013801D1 (de) 2011-05-19
HRP20090477A2 (hr) 2009-11-30
CA2667513A1 (en) 2008-05-08
JP2010509309A (ja) 2010-03-25
ZA200903618B (en) 2010-07-28
DE602007013278D1 (de) 2011-04-28
EP2094675B1 (en) 2011-04-06
NZ577978A (en) 2010-10-29
CA2667515A1 (en) 2008-05-08
ATE504578T1 (de) 2011-04-15
AU2007315832A1 (en) 2008-05-08
BRPI0718391A2 (pt) 2013-11-26
AU2007315833A1 (en) 2008-05-08
US20100069450A1 (en) 2010-03-18
US20100069451A1 (en) 2010-03-18
MX2009004294A (es) 2009-05-08
RS20090388A (sr) 2010-12-31
ITMI20062102A1 (it) 2008-05-03
KR20090077014A (ko) 2009-07-13
HRP20090470A2 (hr) 2009-11-30
JP2010509310A (ja) 2010-03-25
RS20090389A (sr) 2010-12-31
IL198444A0 (en) 2010-02-17
WO2008053326A1 (en) 2008-05-08
EP2094674B1 (en) 2011-03-16
NO20092114L (no) 2009-05-29
NO20092115L (no) 2009-05-29
IL198443A0 (en) 2010-02-17
RU2009120667A (ru) 2010-12-10
EP2094674A1 (en) 2009-09-02
CN101535282A (zh) 2009-09-16
ATE502021T1 (de) 2011-04-15
BRPI0718392A2 (pt) 2013-11-26
ZA200903810B (en) 2010-07-28
NZ577311A (en) 2010-10-29
KR20090082452A (ko) 2009-07-30

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