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MX2009002377A - Derivados de indazol como moduladores de cinasa asociados con el receptor de interleucina-1. - Google Patents

Derivados de indazol como moduladores de cinasa asociados con el receptor de interleucina-1.

Info

Publication number
MX2009002377A
MX2009002377A MX2009002377A MX2009002377A MX2009002377A MX 2009002377 A MX2009002377 A MX 2009002377A MX 2009002377 A MX2009002377 A MX 2009002377A MX 2009002377 A MX2009002377 A MX 2009002377A MX 2009002377 A MX2009002377 A MX 2009002377A
Authority
MX
Mexico
Prior art keywords
modulators
interleukin
receptor
associated kinase
indazole derivatives
Prior art date
Application number
MX2009002377A
Other languages
English (en)
Inventor
Kevin Guckian
Charles Jewell
Patrick Conlan
Edward Yin-Shiang Lin
Timothy Chan
Original Assignee
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Publication of MX2009002377A publication Critical patent/MX2009002377A/es

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Immunology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
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  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
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  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
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  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a moduladores de cinasas IRAK y proporciona composiciones que comprenden tales moduladores, así como métodos para tratar afecciones o enfermedades mediadas por IRAK o asociadas a IRAK.
MX2009002377A 2006-09-07 2007-09-07 Derivados de indazol como moduladores de cinasa asociados con el receptor de interleucina-1. MX2009002377A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84280106P 2006-09-07 2006-09-07
PCT/US2007/019588 WO2008030584A2 (en) 2006-09-07 2007-09-07 Indazole derivatives as modulators of interleukin- 1 receptor-associated kinase

Publications (1)

Publication Number Publication Date
MX2009002377A true MX2009002377A (es) 2009-03-13

Family

ID=39157878

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009002377A MX2009002377A (es) 2006-09-07 2007-09-07 Derivados de indazol como moduladores de cinasa asociados con el receptor de interleucina-1.

Country Status (15)

Country Link
US (1) US8293923B2 (es)
EP (1) EP2061786A2 (es)
JP (1) JP2010502717A (es)
KR (1) KR20090049076A (es)
CN (1) CN101616910A (es)
AU (1) AU2007292929A1 (es)
BR (1) BRPI0716549A2 (es)
CA (1) CA2663100A1 (es)
IL (1) IL197274A0 (es)
MX (1) MX2009002377A (es)
NO (1) NO20091326L (es)
NZ (1) NZ575410A (es)
RU (1) RU2459821C2 (es)
WO (1) WO2008030584A2 (es)
ZA (1) ZA200901529B (es)

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MX366318B (es) 2010-11-19 2019-07-05 Ligand Pharm Inc Derivados de aminas heterocíclicas que inhiben la transducción de señal mediana por cinasa asociada con el receptor de interleucina-1.
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US9586948B2 (en) 2012-10-08 2017-03-07 Merck Sharp & Dohme Corp. Inhibitors of IRAK4 activity
EP2746259A1 (en) 2012-12-21 2014-06-25 Basf Se Substituted [1,2,4]triazole and imidazole compounds
EP2746260A1 (en) 2012-12-21 2014-06-25 Basf Se Substituted [1,2,4]triazole and imidazole compounds
RS56269B1 (sr) * 2013-02-07 2017-11-30 Merck Patent Gmbh Makrociklični piridazinon derivati
US9567320B2 (en) * 2013-02-07 2017-02-14 Merck Patent Gmbh Pyridazinone-amides derivatives
US20160166576A1 (en) 2013-07-11 2016-06-16 Merck Sharp & Dohme Corp. Substituted amidopyrazole inhibitors of interleukin receptor-associated kinases (irak-4)
TWI667233B (zh) * 2013-12-19 2019-08-01 德商拜耳製藥公司 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途
KR20160115933A (ko) 2014-01-10 2016-10-06 오리진 디스커버리 테크놀로지스 리미티드 Irak4 억제제로서의 인다졸 화합물
HRP20181795T1 (hr) * 2014-01-13 2019-01-25 Aurigene Discovery Technologies Limited Biciklički heterociklilni derivati kao inhibitori irak4
EP3157521A4 (en) * 2014-06-20 2018-02-14 Aurigene Discovery Technologies Limited Substituted indazole compounds as irak4 inhibitors
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EP3195865A1 (de) 2016-01-25 2017-07-26 Bayer Pharma Aktiengesellschaft Kombinationen von irak4 inhibitoren und btk inhibitoren
US10435396B2 (en) 2016-03-03 2019-10-08 Bayer Pharma Aktiegesellschaft 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs
EP3219329A1 (en) 2016-03-17 2017-09-20 Bayer Pharma Aktiengesellschaft Combinations of copanlisib
PL3448848T3 (pl) 2016-04-29 2024-03-11 Bayer Pharma Aktiengesellschaft Postać polimorficzna N-{6-(2-hydroksypropan-2-ylo)-2-[2-(metylosulfonylo)etylo]-2H-indazol-5-ilo}-6-(trifluorometylo)pirydyno-2-karboksyamidu
PT3448849T (pt) 2016-04-29 2020-06-30 Bayer Pharma AG Síntese de indazóis
AU2017272505B9 (en) 2016-06-01 2021-10-28 Bayer Pharma Aktiengesellschaft Substituted indazoles useful for treatment and prevention of allergic and/or inflammatory diseases in animals
CN106222183B (zh) * 2016-07-25 2019-11-08 南通大学 靶向人irak1基因的小干扰rna及其应用
JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
US11419875B2 (en) 2017-03-31 2022-08-23 Aurigene Discovery Technologies Limited Compounds and compositions for treating hematological disorders
MX2020004155A (es) 2017-10-19 2020-08-03 Bayer Animal Health Gmbh Uso de pirrolidonas heteroaromaticas fusionadas para el tratamiento y prevencion de enfermedades en animales.
EP3704108B1 (en) 2017-10-31 2024-04-24 Curis, Inc. Irak4 inhibitor in combination with a bcl-2 inhibitor for use in treating cancer
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
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WO2022140527A1 (en) 2020-12-23 2022-06-30 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
KR20240004476A (ko) 2021-04-08 2024-01-11 쿠리스 인코퍼레이션 암 치료를 위한 병용 요법
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Also Published As

Publication number Publication date
CA2663100A1 (en) 2008-03-13
EP2061786A2 (en) 2009-05-27
BRPI0716549A2 (pt) 2013-09-24
RU2459821C2 (ru) 2012-08-27
CN101616910A (zh) 2009-12-30
US8293923B2 (en) 2012-10-23
ZA200901529B (en) 2009-11-25
NO20091326L (no) 2009-04-01
JP2010502717A (ja) 2010-01-28
WO2008030584A2 (en) 2008-03-13
IL197274A0 (en) 2009-12-24
AU2007292929A1 (en) 2008-03-13
RU2009112598A (ru) 2010-10-20
NZ575410A (en) 2012-03-30
KR20090049076A (ko) 2009-05-15
US20110152260A1 (en) 2011-06-23
WO2008030584A3 (en) 2008-07-17

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