MX2008004268A - Metoclopramida de liberacion prolongada de 24 horas. - Google Patents
Metoclopramida de liberacion prolongada de 24 horas.Info
- Publication number
- MX2008004268A MX2008004268A MX2008004268A MX2008004268A MX2008004268A MX 2008004268 A MX2008004268 A MX 2008004268A MX 2008004268 A MX2008004268 A MX 2008004268A MX 2008004268 A MX2008004268 A MX 2008004268A MX 2008004268 A MX2008004268 A MX 2008004268A
- Authority
- MX
- Mexico
- Prior art keywords
- active principle
- metoclopramide
- release
- chlorhydrate
- gel
- Prior art date
Links
- TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 title abstract 4
- 229960004503 metoclopramide Drugs 0.000 title abstract 4
- 238000013268 sustained release Methods 0.000 title abstract 2
- 239000012730 sustained-release form Substances 0.000 title abstract 2
- 229920001477 hydrophilic polymer Polymers 0.000 abstract 2
- 229920001600 hydrophobic polymer Polymers 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 238000007906 compression Methods 0.000 abstract 1
- 230000006835 compression Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000036571 hydration Effects 0.000 abstract 1
- 238000006703 hydration reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000011148 porous material Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención consiste en una composición farmacéutica de clorhidrato de metoclopramida de liberación prolongada, en comprimidos con 30 mg del principio activo, para su uso en trastornos gastrointestinales. La formulación está compuesta principalmente por un polímero hidrofílico, un polímero hidrofóbico, un componente hidrofílico y clorhidrato de metoclopramida. El polímero hidrofílico se hincha por hidratación al ponerse en contacto con el agua formando una capa de gel que controla la liberación del principio activo. El agua al interior de la matriz disuelve el principio activo y éste se difunde hacia el exterior a través de la capa de gel. El polímero hidrofóbico exhibe propiedades de deformación bajo compresión, tendiendo a rodear las partículas del principio activo reduciendo la cantidad y las dimensiones de los poros en la estructura matricial, retardando como consecuencia, la liberación del principio activo. El componente hidrofílico forma parte de la estructura de la capa de gel dando soporte a la misma. El principio activo es el clorhidrato de metoclopramida o una sal farmacéuticamente aceptable de la misma.
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2008004268A MX2008004268A (es) | 2008-03-28 | 2008-03-28 | Metoclopramida de liberacion prolongada de 24 horas. |
| CA2757023A CA2757023C (en) | 2008-03-28 | 2009-03-27 | 24-hour extended-release metoclopramide |
| ARP090101110A AR071571A1 (es) | 2008-03-28 | 2009-03-27 | Metoclopramida de liberacion prolongada 24 horas. composicion farmaceutica. |
| PE2009000459A PE20091824A1 (es) | 2008-03-28 | 2009-03-27 | Metoclopramida de liberacion prolongada de 24 horas |
| PCT/MX2009/000026 WO2009120054A1 (es) | 2008-03-28 | 2009-03-27 | Metoclopramida de liberación prolongada de 24 horas |
| PE2014000265A PE20141001A1 (es) | 2008-03-28 | 2009-03-27 | Metoclopramida de liberacion prolongada de 24 horas |
| BRPI0906346A BRPI0906346A2 (pt) | 2008-03-28 | 2009-03-27 | "composição farmacêutica de liberação prolongada" |
| PE2009000458A PE20091737A1 (es) | 2008-03-28 | 2009-03-27 | Metoclopramida de liberacion prolongada 12 horas |
| US12/935,187 US20110033536A1 (en) | 2008-03-28 | 2009-03-27 | 24-hour sustained-release metoclopramide |
| CL2009000775A CL2009000775A1 (es) | 2008-03-28 | 2009-03-27 | Composicion farmaceutica de liberacion prolongada en forma de comprimido que comprende 21-35 mg de clorhidrato de metoclopramida, polimeros hidrofilicos e hidrofobicos y componentes hidrofilicos que promueven la penetracion de agua al comprimido; y su uso para tratar o prevenir vomitos, reflujo gastrico esofagico y nauseas. |
| CO10130863A CO6311074A2 (es) | 2008-03-28 | 2010-10-22 | Metoclopramida de liberacion prolongada 12 horas |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MX2008004268A MX2008004268A (es) | 2008-03-28 | 2008-03-28 | Metoclopramida de liberacion prolongada de 24 horas. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2008004268A true MX2008004268A (es) | 2009-09-28 |
Family
ID=41114143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2008004268A MX2008004268A (es) | 2008-03-28 | 2008-03-28 | Metoclopramida de liberacion prolongada de 24 horas. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20110033536A1 (es) |
| AR (1) | AR071571A1 (es) |
| BR (1) | BRPI0906346A2 (es) |
| CA (1) | CA2757023C (es) |
| CL (1) | CL2009000775A1 (es) |
| CO (1) | CO6311074A2 (es) |
| MX (1) | MX2008004268A (es) |
| PE (3) | PE20141001A1 (es) |
| WO (1) | WO2009120054A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2008004267A (es) * | 2008-03-28 | 2009-09-28 | Posi Visionary Solutions Llp | Metoclopramida de liberacion prolongada de 12 horas. |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2492661A1 (fr) * | 1980-10-28 | 1982-04-30 | Laruelle Claude | Nouvelle forme galenique d'administration du metoclopramide, son procede de preparation et medicament comprenant cette nouvelle forme |
| FR2576213B1 (fr) * | 1985-01-21 | 1989-02-24 | Cortial | Nouveau procede d'obtention de formes pharmaceutiques a liberation prolongee |
| JPS6261916A (ja) * | 1985-09-12 | 1987-03-18 | Fujisawa Pharmaceut Co Ltd | 持続性製剤 |
| GB8613688D0 (en) * | 1986-06-05 | 1986-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| US6372254B1 (en) * | 1998-04-02 | 2002-04-16 | Impax Pharmaceuticals Inc. | Press coated, pulsatile drug delivery system suitable for oral administration |
| US6770262B2 (en) * | 2000-03-30 | 2004-08-03 | Questcor Pharmaceuticals, Inc. | Nasal administration of agents for the treatment of gastroparesis |
| RU2358730C2 (ru) * | 2002-05-01 | 2009-06-20 | Новартис Аг | Производное эпотилона для лечения гепатомы и других раковых заболеваний |
| AR040680A1 (es) * | 2002-07-25 | 2005-04-13 | Pharmacia Corp | Composicion de tabletas de liberacion sostenida |
| GB0317904D0 (en) * | 2003-07-31 | 2003-09-03 | Jagotec Ag | Improvements in or relating to organic compounds |
-
2008
- 2008-03-28 MX MX2008004268A patent/MX2008004268A/es active IP Right Grant
-
2009
- 2009-03-27 BR BRPI0906346A patent/BRPI0906346A2/pt not_active Application Discontinuation
- 2009-03-27 US US12/935,187 patent/US20110033536A1/en not_active Abandoned
- 2009-03-27 AR ARP090101110A patent/AR071571A1/es not_active Application Discontinuation
- 2009-03-27 CL CL2009000775A patent/CL2009000775A1/es unknown
- 2009-03-27 PE PE2014000265A patent/PE20141001A1/es not_active Application Discontinuation
- 2009-03-27 PE PE2009000458A patent/PE20091737A1/es not_active Application Discontinuation
- 2009-03-27 CA CA2757023A patent/CA2757023C/en active Active
- 2009-03-27 PE PE2009000459A patent/PE20091824A1/es active IP Right Grant
- 2009-03-27 WO PCT/MX2009/000026 patent/WO2009120054A1/es not_active Ceased
-
2010
- 2010-10-22 CO CO10130863A patent/CO6311074A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PE20141001A1 (es) | 2014-08-25 |
| AR071571A1 (es) | 2010-06-30 |
| BRPI0906346A2 (pt) | 2016-07-26 |
| CA2757023C (en) | 2017-09-05 |
| WO2009120054A1 (es) | 2009-10-01 |
| CO6311074A2 (es) | 2011-08-22 |
| US20110033536A1 (en) | 2011-02-10 |
| CA2757023A1 (en) | 2009-10-01 |
| PE20091737A1 (es) | 2009-11-25 |
| PE20091824A1 (es) | 2009-11-25 |
| CL2009000775A1 (es) | 2009-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |