MX2007002633A - Mejoras con relacion a vesiculas meningococales de membrana exterior. - Google Patents
Mejoras con relacion a vesiculas meningococales de membrana exterior.Info
- Publication number
- MX2007002633A MX2007002633A MX2007002633A MX2007002633A MX2007002633A MX 2007002633 A MX2007002633 A MX 2007002633A MX 2007002633 A MX2007002633 A MX 2007002633A MX 2007002633 A MX2007002633 A MX 2007002633A MX 2007002633 A MX2007002633 A MX 2007002633A
- Authority
- MX
- Mexico
- Prior art keywords
- vaccine
- meningococcal
- outbreak
- omvs
- outer membrane
- Prior art date
Links
- 239000012528 membrane Substances 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 5
- 241000040340 Oat mosaic virus Species 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 206010027249 Meningitis meningococcal Diseases 0.000 abstract 1
- 201000010924 Meningococcal meningitis Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Las OMV dirigidas contra capas epidermicas especificas pueden ser altamente efectivas en el control de epidemias localizadas de enfermedad. En combinacion con tecnicas de elaboracion reproducibles y a gran escala, se pueden producir rapidamente una vacuna despues de una epidemia. La invencion proporciona un metodo para preparar una vacuna de vesicula de membrana exterior (OMV) meningococal, que comprende los pasos de: (i) identificar el serosubtipo de una cepa meningococal asociada con una epidemia de meningitis meningococal, (ii) preparar las OMV de una cepa meningococal que tiene el serosubtipo identificado en el paso (i) para el uso en la elaboracion de vacuna. El metodo puede comprender uno o ambos de los pasos adicionales de (iii) formular las OMV como una vacuna; y (iv) distribuir la vacuna en un area geografica afectada por, o que probablemente se va a afectar por, la epidemia. La cepa meningococal estara tipicamente en el serogrupo B, pero puede estar en cabmio en el serogrupo A, C, W135, Y, etc.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0419627.5A GB0419627D0 (en) | 2004-09-03 | 2004-09-03 | Immunogenic bacterial vesicles with outer membrane proteins |
| PCT/IB2005/002801 WO2006024946A2 (en) | 2004-09-03 | 2005-09-05 | Improvements relating to meningococcal outer membrane vesicles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007002633A true MX2007002633A (es) | 2007-05-15 |
Family
ID=33156002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007002633A MX2007002633A (es) | 2004-09-03 | 2005-09-05 | Mejoras con relacion a vesiculas meningococales de membrana exterior. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8808711B2 (es) |
| EP (1) | EP1784213B1 (es) |
| JP (2) | JP2008511608A (es) |
| CN (2) | CN101115501A (es) |
| AU (1) | AU2005278896B2 (es) |
| BR (1) | BRPI0514883A (es) |
| CA (1) | CA2578588A1 (es) |
| ES (1) | ES2527859T3 (es) |
| GB (1) | GB0419627D0 (es) |
| MX (1) | MX2007002633A (es) |
| NZ (1) | NZ553521A (es) |
| RU (1) | RU2420312C2 (es) |
| WO (1) | WO2006024946A2 (es) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9513371D0 (en) * | 1995-06-30 | 1995-09-06 | Biocine Spa | Immunogenic detoxified mutant toxins |
| EP2270174A1 (en) | 1999-05-19 | 2011-01-05 | Novartis Vaccines and Diagnostics S.r.l. | Combination neisserial compositions |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
| GB0408977D0 (en) * | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
| DK2004225T3 (da) * | 2006-03-22 | 2012-08-06 | Novartis Ag | Programmer for vaccination med meningocockonjugater |
| US10828361B2 (en) * | 2006-03-22 | 2020-11-10 | Glaxosmithkline Biologicals Sa | Regimens for immunisation with meningococcal conjugates |
| CA2702871A1 (en) | 2007-10-19 | 2009-04-23 | Novartis Ag | Meningococcal vaccine formulations |
| DK2268618T3 (en) | 2008-03-03 | 2015-08-17 | Novartis Ag | Compounds and compositions as TLR aktivitetsmodulatorer |
| EP2296699A4 (en) | 2008-05-30 | 2013-11-13 | U S A As Represented By The Secretary Of The Army On Behalf Of Walter Reed Army | POLYVALENT MENINGOCOCCULAR FUEL WITH NATIVE OUTER MEMBRANE VESICLES, METHOD OF MANUFACTURE AND USE |
| GB0822634D0 (en) * | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
| NZ593674A (en) | 2008-12-17 | 2013-03-28 | Novartis Ag | Meningococcal vaccines including hemoglobin receptor |
| EP2440245B1 (en) | 2009-06-10 | 2017-12-06 | GlaxoSmithKline Biologicals SA | Benzonaphthyridine-containing vaccines |
| AU2010288239B2 (en) | 2009-08-27 | 2014-01-16 | Novartis Ag | Adjuvant comprising aluminium, oligonucleotide and polycation |
| SG178954A1 (en) | 2009-09-02 | 2012-04-27 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
| TWI445708B (zh) | 2009-09-02 | 2014-07-21 | Irm Llc | 作為ｔｌｒ活性調節劑之化合物及組合物 |
| WO2011057148A1 (en) | 2009-11-05 | 2011-05-12 | Irm Llc | Compounds and compositions as tlr-7 activity modulators |
| MX339146B (es) | 2009-12-15 | 2016-05-13 | Novartis Ag | Suspension homogenea de compuestos inmunopotenciadores y usos de los mismos. |
| EP2547357A1 (en) | 2010-03-18 | 2013-01-23 | Novartis AG | Adjuvanted vaccines for serogroup b meningococcus |
| EP2549990A1 (en) | 2010-03-23 | 2013-01-30 | Irm Llc | Compounds (cystein based lipopeptides) and compositions as tlr2 agonists used for treating infections, inflammations, respiratory diseases etc. |
| US9259462B2 (en) | 2010-09-10 | 2016-02-16 | Glaxosmithkline Biologicals Sa | Developments in meningococcal outer membrane vesicles |
| EP2707009A1 (en) | 2011-05-12 | 2014-03-19 | Novartis AG | Antipyretics to enhance tolerability of vesicle-based vaccines |
| ES2654613T3 (es) | 2012-02-02 | 2018-02-14 | Glaxosmithkline Biologicals Sa | Promotores para una expresión aumentada de proteínas en meningococos |
| JP2015517089A (ja) | 2012-03-08 | 2015-06-18 | ノバルティス アーゲー | タンパク質ベースの髄膜炎菌ワクチンのためのインビトロ有効性アッセイ |
| WO2013151706A2 (en) | 2012-04-06 | 2013-10-10 | Cornell University | Subunit vaccine delivery platform for robust humoral and cellular immune responses |
| US10376573B2 (en) | 2012-06-14 | 2019-08-13 | Glaxosmithkline Biologicals Sa | Vaccines for serogroup X meningococcus |
| AU2013311702A1 (en) | 2012-09-06 | 2015-02-19 | Novartis Ag | Combination vaccines with serogroup B meningococcus and D/T/P |
| EP2897635A1 (en) | 2012-09-18 | 2015-07-29 | Novartis AG | Outer membrane vesicles |
| EP2953620A1 (en) | 2013-02-07 | 2015-12-16 | GlaxoSmithKline Biologicals SA | Pharmaceutical compositions comprising vesicles |
| EA034954B1 (ru) | 2014-02-28 | 2020-04-10 | Глаксосмитклайн Байолоджикалс Са | МОДИФИЦИРОВАННЫЕ МЕНИНГОКОККОВЫЕ ПОЛИПЕПТИДЫ fHbp |
| CN113827712A (zh) * | 2014-07-17 | 2021-12-24 | 葛兰素史密丝克莱恩生物有限公司 | 脑膜炎球菌疫苗 |
| AU2015289192A1 (en) | 2014-07-17 | 2017-02-02 | Glaxosmithkline Biologicals S.A. | Modified meningococcal fHbp polypeptides |
| KR101742236B1 (ko) * | 2014-10-29 | 2017-05-31 | 인하대학교 산학협력단 | 쯔쯔가무시병에 대한 면역 조성물 및 이의 제조방법 |
| CN105669964B (zh) * | 2016-03-04 | 2017-11-21 | 博瑞生物医药（苏州）股份有限公司 | 卵巢癌特异靶向的生物可降解双亲性聚合物、由其制备的聚合物囊泡及应用 |
| CA3035320A1 (en) * | 2016-09-02 | 2018-03-08 | Glaxosmithkline Biologicals Sa | Vaccines for neisseria gonorrhoeae |
| JP7369690B2 (ja) | 2017-09-08 | 2023-10-26 | エヴェロ バイオサイエンシズ，インコーポレーテッド | 細菌の細胞外小胞 |
| GB202115077D0 (en) | 2021-10-21 | 2021-12-08 | Glaxosmithkline Biologicals Sa | Assay |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2848965A1 (de) | 1978-11-11 | 1980-05-22 | Behringwerke Ag | Verfahren zur herstellung von membranproteinen aus neisseria meningitidis und diese enthaltende vaccine |
| EP0624376B1 (en) * | 1993-05-13 | 2000-03-15 | American Cyanamid Company | Preparation and uses of LOS-depleted outer membrane proteins of gram-negative cocci |
| ES2128055T3 (es) * | 1994-04-20 | 1999-05-01 | Us Army | Vacuna contra infecciones de bacterias gram-negativas. |
| US6180111B1 (en) * | 1995-05-18 | 2001-01-30 | University Of Maryland | Vaccine delivery system |
| PL338146A1 (en) * | 1997-07-17 | 2000-09-25 | North American Vaccine | Immunogenic complex combinations consisting of meningococcal porine of b group and h. influenzae polysaccharide |
| AU761495B2 (en) | 1998-05-29 | 2003-06-05 | Chiron Corporation | Combination meningitidis B/C vaccines |
| EP1741443B1 (en) | 1998-05-29 | 2014-05-21 | Novartis Vaccines and Diagnostics, Inc. | Combination meningitidis B/C vaccines |
| GB9918319D0 (en) * | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
| WO2001034642A2 (en) | 1999-11-12 | 2001-05-17 | University Of Iowa Research Foundation | Control of neisserial membrane synthesis |
| NO20002828D0 (no) | 2000-06-02 | 2000-06-02 | Statens Inst For Folkehelse | Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav |
| KR20030024811A (ko) * | 2000-07-27 | 2003-03-26 | 칠드런즈 하스피틀 앤드 리써치 센터 앳 오클랜드 | 나이세리아 메닌지티디스에 의하여 유발되는 질병에 대한광범위하게 유효한 보호를 위한 백신 |
| EP1409013B1 (en) * | 2001-07-26 | 2009-11-18 | Novartis Vaccines and Diagnostics S.r.l. | Vaccines comprising aluminium adjuvants and histidine |
| GB0130123D0 (en) * | 2001-12-17 | 2002-02-06 | Microbiological Res Agency | Outer membrane vesicle vaccine and its preparation |
| GB0213622D0 (en) * | 2002-06-13 | 2002-07-24 | Glaxosmithkline Biolog Sa | Vaccine Corporation |
| WO2004014417A2 (en) | 2002-08-02 | 2004-02-19 | Glaxosmithkline Biologicals Sa | Vaccine compositions comprising l2 and/or l3 immunotype lipooligosaccharides from lgtb- neisseria minigitidis |
| GB0220194D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
| GB0227346D0 (en) * | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| WO2004054611A1 (en) | 2002-12-16 | 2004-07-01 | Nasjonalt Folkehelseinstitutt | Meningococcal vaccine based on outer membrane proteins porb2 and pora |
| US7031284B2 (en) * | 2003-03-03 | 2006-04-18 | Interdigital Technology Corporation | Wireless communication method and apparatus for optimizing multi-user detection |
| GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
| WO2005064021A2 (en) | 2003-12-23 | 2005-07-14 | Glaxosmithkline Biologicals S.A. | Vaccine |
| EP2032160B2 (en) * | 2006-06-12 | 2013-04-03 | GlaxoSmithKline Biologicals S.A. | Vaccine |
-
2004
- 2004-09-03 GB GBGB0419627.5A patent/GB0419627D0/en not_active Ceased
-
2005
- 2005-09-05 US US11/661,996 patent/US8808711B2/en not_active Expired - Fee Related
- 2005-09-05 CA CA002578588A patent/CA2578588A1/en not_active Abandoned
- 2005-09-05 BR BRPI0514883-9A patent/BRPI0514883A/pt not_active IP Right Cessation
- 2005-09-05 NZ NZ553521A patent/NZ553521A/en not_active IP Right Cessation
- 2005-09-05 CN CNA2005800294697A patent/CN101115501A/zh active Pending
- 2005-09-05 EP EP05782411.2A patent/EP1784213B1/en not_active Expired - Lifetime
- 2005-09-05 RU RU2007111838/15A patent/RU2420312C2/ru not_active IP Right Cessation
- 2005-09-05 ES ES05782411.2T patent/ES2527859T3/es not_active Expired - Lifetime
- 2005-09-05 WO PCT/IB2005/002801 patent/WO2006024946A2/en not_active Ceased
- 2005-09-05 CN CN201010169356A patent/CN101862451A/zh active Pending
- 2005-09-05 MX MX2007002633A patent/MX2007002633A/es active IP Right Grant
- 2005-09-05 AU AU2005278896A patent/AU2005278896B2/en not_active Ceased
- 2005-09-05 JP JP2007529033A patent/JP2008511608A/ja active Pending
-
2011
- 2011-08-26 JP JP2011185225A patent/JP2011236254A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GB0419627D0 (en) | 2004-10-06 |
| AU2005278896B2 (en) | 2011-12-22 |
| WO2006024946A3 (en) | 2006-11-30 |
| AU2005278896A1 (en) | 2006-03-09 |
| CN101115501A (zh) | 2008-01-30 |
| JP2008511608A (ja) | 2008-04-17 |
| RU2007111838A (ru) | 2008-10-10 |
| BRPI0514883A (pt) | 2008-06-24 |
| NZ553521A (en) | 2010-01-29 |
| RU2420312C2 (ru) | 2011-06-10 |
| US20080063665A1 (en) | 2008-03-13 |
| ES2527859T3 (es) | 2015-01-30 |
| CN101862451A (zh) | 2010-10-20 |
| CA2578588A1 (en) | 2006-03-09 |
| JP2011236254A (ja) | 2011-11-24 |
| WO2006024946A2 (en) | 2006-03-09 |
| US8808711B2 (en) | 2014-08-19 |
| EP1784213B1 (en) | 2014-10-29 |
| EP1784213A2 (en) | 2007-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC | Change of company name or juridical status | ||
| FG | Grant or registration |