ME03819B - Antitela za icos - Google Patents
Antitela za icosInfo
- Publication number
- ME03819B ME03819B MEP-2020-166A MEP2020166A ME03819B ME 03819 B ME03819 B ME 03819B ME P2020166 A MEP2020166 A ME P2020166A ME 03819 B ME03819 B ME 03819B
- Authority
- ME
- Montenegro
- Prior art keywords
- antibody
- amino acid
- acid sequence
- seq
- cancer
- Prior art date
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 14
- 210000004027 cell Anatomy 0.000 claims 9
- 241000124008 Mammalia Species 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 3
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 238000003364 immunohistochemistry Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 101100454807 Caenorhabditis elegans lgg-1 gene Proteins 0.000 claims 2
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 229940022399 cancer vaccine Drugs 0.000 claims 2
- 238000009566 cancer vaccine Methods 0.000 claims 2
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 101100217502 Caenorhabditis elegans lgg-3 gene Proteins 0.000 claims 1
- 108010041986 DNA Vaccines Proteins 0.000 claims 1
- 229940021995 DNA vaccine Drugs 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 150000003278 haem Chemical class 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 208000017572 squamous cell neoplasm Diseases 0.000 claims 1
- 238000010186 staining Methods 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 229940030325 tumor cell vaccine Drugs 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 229960004854 viral vaccine Drugs 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (18)
1. lzolovano monoklonsko antitelo koje se vezuje za ICOS, naznačeno time što antitelo sadrži (a) HCDR1 koji sadrži sekvencu amino-kiselina SEQ ID NO: 62; (b) HCDR2 koji sadrži sekvencu amino-kiselina SEQ ID NO: 63; (c) HCDR3 koji sadrži sekvencu amino kiselina SEQ ID NO: 64; (d) LCDR1 koji sadrži sekvencu amino-kiselina SEQ D NO: 65; (e) LCDR2 koji sadrži sekvencu amino-kiselina SEQ ID NO: 66; i (f) LCDR3 koji sadrži sekvencu amino-kiselina SEQ ID NO: 67, i što antitelo sadrži konstantni region teškog lanca humani lgG1 ili konstantni region teškog lanca humanog lgG3.
2. Antitelo prema zahtevu 1, koje sadrži varijabilni region teškog lanca (VH) ivarijabilni region lakog lanca (VL), naznačeno time što je VH najmanje 90% identičan sekvenc amino-kiselina SEQ ID NO:60,a VL je najmanje 90% identičan sekvenci amino-kiselina SEQ ID NO: 61.
3. Antitelo prema zahtevu 1, koje sadrži varijabilni region teškog lanca (VH) i varijabilni region lakog lanca (VL), naznačeno time sto VH sadrži sekvencu amino-kiselina SEQ ID NO: 60, a VL sadrži sekvencu amino-kiselina SEQ ID NO: 61.
4. Antitelo prema bilo kom od prethodnih zahteva, naznačeno time što antitelo sadrži konstantni region teškog lanca humanog lgG1.
5. Antitelo prema bilo kom od prethodnih zahteva, naznačeno time što je antitelo himemo antitelo ili humanizovano antitelo.
6. Antitelo prema zahtevu 1, naznačeno time sto teški lanac sadrži sekvencu amino-kiselina SEQ ID NO: 188, ili njegovu biološki aktivnu varijantu pri čemu je jedan ili više ostataka amino-kiselina dodat ili izbrisan na N- ili C-kraju polipeptida; i laki lanac sadrži sekvencu amino-kiselina SEQ ID NO: 189, ili njegovu biološki aktivnu varijantu pri čemu je jedan ili više ostataka amino-kiselina dodat ili izbrisan na N- ili C-kraju polipeptida.
7. Antitelo prema zahtevu 1, naznačeno time što teški lanac sadrži sekvencu amino-kiselina SEQ ID NO: 188, a laki lanac sadrži sekvencu amino-kiselina SEQ ID NO: 189.
8. Antitelo prema bilo kom od prethodnih zahteva, naznačeno time što davanje antitela sisaru ima za rezultat: (a) povećanje T efektorskih (Teff) ćelija kod sisara i/ili (b) aktivaciju Tefektorskih (Teff) ćelija sisara i/ili (c) smanjenje T regulatornih (Treg) ćelija kod sisara; pri čemu su Teff ćelije opciono CD4 + FoxP3-T ćelije, ili CD4 + FoxP3-T ćelije i CDS + T ćelije, ili CDS+ T ćelije; i pri čemu su Treg ćelije opciono CD4 + FoxP3 + T ćelije.
9. lzolovana nukleinska kiselina koja kodira antitelo prema bilo kom od zahteva 1 do 8, naznačena time što je nukleinska kiselina opciono sadržana u vektoru.
10.Ćelija domaćina koja sadrži vektor prema zahtevu 9, ili koja proizvodi antitelo prema bilo kom od zahteva 1 do 8.
11. Postupak za pravljenje anti-ICOS antitela, koji obuhvata kultivaciju ćelije domaćina prema zahtevu 10 pod uslovima pogodnim za ekspresiju antitela i prikupljanje antitela proizvedenog od ćelije domaćina.
12. Anti-ICOS antitelo koje se može proizvesti postupkom prema patentnom zahtevu 11.
13. Anti-ICOS antitelo prema bilo kom od zahteva 1 do 8 i 12 za upotrebu u postupku lečenja raka kod sisara.
14. Anti-ICOS antitelo za upotrebu prema zahtevu 13, pri čemu je rak izabran iz melanoma, nemikrocelulamog raka pluća (NSCLC), karcinoma bubrežnih ćelija (RCC), raka želuca, raka mokraćne bešike, difuznog velikog B-ćelijskog limfoma (DLBCL), Hodžkinovog limfoma, raka jajnika, skvamoznog ćelijskog raka glave i vrata (HNSCC) i trostruko negativnog raka dojke (TNBC).
15. Anti-ICOS antitelo za upotrebu prema zahtevu 13 ili zahtevu 14, koje je za upotrebu sa najmanje jednim dodatnim terapeutskim sredstvom, naznačeno time što je dodatno terapeutsko sredstvo izabrano iz anti-PD-1antitela i anti-PO-L1antitela ili opciono vakcine protiv raka, i pri čemu je vakcina protiv raka opciono izabrana između DNK vakcine, genetski napravljene virusne vakcine, genetski napravljene vakcine protiv tumorskih ćelija i vakcine protiv raka razvijene korišćenjem neoantigena.
16. Anti-ICOS antitelo za upotrebu prema bilo kom od zahteva 13 do 15, naznačeno time što je sisar čovek.
17. Anti-ICOS antitelo za upotrebu prema bilo kom od zahteva 13 do 16, naznačeno time što je određeni uzorak raka određen da eksprimuje ICOS, pri čemu uzorak opciono pokazuje 1+, 2+ ili 3+ obojenje ICOS imunohistohemijom (IHC).
18. Anti-ICOS antitelo za upotrebu prema bilo kom od zahteva 13 do 17, naznačeno time što je za uzorak određeno da ima nizak nivo PD-L1, ili da bude PD-L1-negativan, ili da ima povišen nivo PD-L1, pri čemu su nivoi PD-L1 opciono određeni korišćenjem IHC.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562137034P | 2015-03-23 | 2015-03-23 | |
| US201562147484P | 2015-04-14 | 2015-04-14 | |
| US201562156588P | 2015-05-04 | 2015-05-04 | |
| US201562242489P | 2015-10-16 | 2015-10-16 | |
| US201562255635P | 2015-11-16 | 2015-11-16 | |
| EP16769535.2A EP3273992B1 (en) | 2015-03-23 | 2016-03-22 | Antibodies to icos |
| PCT/US2016/023524 WO2016154177A2 (en) | 2015-03-23 | 2016-03-22 | Antibodies to icos |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME03819B true ME03819B (me) | 2021-04-20 |
Family
ID=56978549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2020-166A ME03819B (me) | 2015-03-23 | 2016-03-22 | Antitela za icos |
Country Status (34)
| Country | Link |
|---|---|
| US (3) | US10023635B2 (me) |
| EP (2) | EP3735986A1 (me) |
| JP (2) | JP6944924B2 (me) |
| KR (2) | KR20230164243A (me) |
| CN (2) | CN107530428B (me) |
| AU (2) | AU2016235362B2 (me) |
| BR (1) | BR112017020054A2 (me) |
| CA (1) | CA2978185A1 (me) |
| CL (1) | CL2017002401A1 (me) |
| CO (1) | CO2017010618A2 (me) |
| CY (1) | CY1123409T1 (me) |
| DK (1) | DK3273992T3 (me) |
| EA (1) | EA037621B1 (me) |
| EC (1) | ECSP17070399A (me) |
| ES (1) | ES2811345T3 (me) |
| HR (1) | HRP20201090T1 (me) |
| HU (1) | HUE049938T2 (me) |
| IL (2) | IL254338B (me) |
| LT (1) | LT3273992T (me) |
| MA (1) | MA53297A (me) |
| MD (1) | MD3273992T2 (me) |
| ME (1) | ME03819B (me) |
| MX (2) | MX386500B (me) |
| PH (2) | PH12017501748B1 (me) |
| PL (1) | PL3273992T3 (me) |
| PT (1) | PT3273992T (me) |
| RS (1) | RS60614B1 (me) |
| RU (1) | RU2742241C2 (me) |
| SG (2) | SG11201707769VA (me) |
| SI (1) | SI3273992T1 (me) |
| SM (1) | SMT202000444T1 (me) |
| TW (1) | TWI719970B (me) |
| WO (1) | WO2016154177A2 (me) |
| ZA (1) | ZA201705920B (me) |
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|---|---|---|---|---|
| CN104826106B (zh) | 2009-09-30 | 2019-01-11 | 斯隆凯特林防癌纪念中心 | 用于治疗癌症的组合免疫疗法 |
| SG193428A1 (en) | 2011-03-31 | 2013-10-30 | Inst Nat Sante Rech Med | Antibodies directed against icos and uses thereof |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| JP6647315B2 (ja) | 2015-01-09 | 2020-02-14 | イーチュービクス コーポレイション | 組み合わせ免疫療法のための方法および組成物 |
| AU2016235362B2 (en) * | 2015-03-23 | 2021-12-16 | Jounce Therapeutics, Inc. | Antibodies to ICOS |
| EP3286213B1 (en) * | 2015-04-20 | 2021-08-04 | Etubics Corporation | Methods and compositions for combination immunotherapy |
| GB201516047D0 (en) | 2015-09-10 | 2015-10-28 | Cancer Rec Tech Ltd | Method |
| KR20180066236A (ko) | 2015-10-22 | 2018-06-18 | 조운스 테라퓨틱스, 인크. | Icos 발현을 계측하기 위한 유전자 특질 |
| WO2017175156A1 (en) | 2016-04-07 | 2017-10-12 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides useful as protein modulators |
| JOP20170083B1 (ar) | 2016-04-07 | 2022-03-14 | Glaxosmithkline Ip Dev Ltd | أميدات هتيروسيكلية مفيدة كمعدلات بروتين |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| WO2017220989A1 (en) | 2016-06-20 | 2017-12-28 | Kymab Limited | Anti-pd-l1 and il-2 cytokines |
| WO2018029474A2 (en) | 2016-08-09 | 2018-02-15 | Kymab Limited | Anti-icos antibodies |
| KR20230044038A (ko) * | 2016-08-09 | 2023-03-31 | 키맵 리미티드 | 항-icos 항체 |
| EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| WO2018115859A1 (en) * | 2016-12-20 | 2018-06-28 | Kymab Limited | Multispecific antibody with combination therapy for immuno-oncology |
| US20200190191A1 (en) * | 2016-12-20 | 2020-06-18 | Kymab Limited | Multispecific antibody with combination therapy for immuno-oncology |
| JP2020509009A (ja) | 2017-02-27 | 2020-03-26 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | キナーゼ阻害剤としての複素環式アミド |
| US20200024351A1 (en) * | 2017-04-03 | 2020-01-23 | Jounce Therapeutics, Inc. | Compositions and Methods for the Treatment of Cancer |
| TWI788340B (zh) * | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
| WO2018225033A1 (en) | 2017-06-09 | 2018-12-13 | Glaxosmithkline Intellectual Property Development Limited | Combination therapy |
| WO2018225035A1 (en) | 2017-06-09 | 2018-12-13 | Glaxosmithkline Intellectual Property Development Limited | Combination therapy with icos agonist and ox40 agonist to treat cancer |
| US20200190195A1 (en) | 2017-06-09 | 2020-06-18 | Glaxosmithkline Intellectual Property Development Limited | Combination therapy with icos agonist and ox40 agonist to treat cancer |
| EP3641813A4 (en) | 2017-06-18 | 2021-04-21 | Kindred Biosciences, Inc. | IL17A ANTIBODIES AND ANTAGONISTS FOR USE IN VETERINARY MEDICINE |
| GB201709808D0 (en) | 2017-06-20 | 2017-08-02 | Kymab Ltd | Antibodies |
| WO2019005762A1 (en) * | 2017-06-26 | 2019-01-03 | Abbvie Inc. | TREATMENT OF NON-SMALL CELL LUNG CANCER |
| GB201712032D0 (en) | 2017-07-26 | 2017-09-06 | Bioinvent Int Ab | Antibodies and uses thereof |
| CN111295394B (zh) * | 2017-08-11 | 2024-06-11 | 豪夫迈·罗氏有限公司 | 抗cd8抗体及其用途 |
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| JP2020534015A (ja) | 2017-09-22 | 2020-11-26 | ユニヴァーシティ オブ ワシントン | 細胞分子のｉｎ ｓｉｔｕコンビナトリアル標識化 |
| TW201927771A (zh) | 2017-10-05 | 2019-07-16 | 英商葛蘭素史密斯克藍智慧財產發展有限公司 | 可作為蛋白質調節劑之雜環醯胺及其使用方法 |
| BR112020006780A2 (pt) | 2017-10-05 | 2020-10-06 | Glaxosmithkline Intellectual Property Development Limited | moduladores do estimulador de genes do interferon (sting) |
| WO2019122882A1 (en) * | 2017-12-19 | 2019-06-27 | Kymab Limited | Bispecific antibody for icos and pd-l1 |
| GB201721338D0 (en) | 2017-12-19 | 2018-01-31 | Kymab Ltd | Anti-icos Antibodies |
| CN111699196A (zh) | 2017-12-22 | 2020-09-22 | 震动疗法公司 | 针对lilrb2的抗体 |
| TW202000891A (zh) | 2018-03-07 | 2020-01-01 | 英商葛蘭素史克智慧財產發展有限公司 | 純化抗體之方法 |
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- 2016-03-22 MX MX2017012129A patent/MX386500B/es unknown
- 2016-03-22 EP EP20167918.0A patent/EP3735986A1/en not_active Withdrawn
- 2016-03-22 HR HRP20201090TT patent/HRP20201090T1/hr unknown
- 2016-03-22 EP EP16769535.2A patent/EP3273992B1/en active Active
- 2016-03-22 LT LTEP16769535.2T patent/LT3273992T/lt unknown
- 2016-03-22 CN CN202210469652.4A patent/CN114907481A/zh active Pending
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2017
- 2017-08-31 ZA ZA201705920A patent/ZA201705920B/en unknown
- 2017-09-05 IL IL254338A patent/IL254338B/en unknown
- 2017-09-22 CL CL2017002401A patent/CL2017002401A1/es unknown
- 2017-09-25 MX MX2021011667A patent/MX2021011667A/es unknown
- 2017-10-18 CO CONC2017/0010618A patent/CO2017010618A2/es unknown
- 2017-10-23 EC ECIEPI201770399A patent/ECSP17070399A/es unknown
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2018
- 2018-06-20 US US16/012,867 patent/US10570203B2/en active Active
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2020
- 2020-08-12 CY CY20201100755T patent/CY1123409T1/el unknown
- 2020-09-16 US US17/022,856 patent/US20210171635A1/en not_active Abandoned
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2021
- 2021-09-13 JP JP2021148509A patent/JP2022002520A/ja active Pending
- 2021-09-29 IL IL286807A patent/IL286807A/en unknown
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2022
- 2022-03-01 AU AU2022201408A patent/AU2022201408A1/en not_active Abandoned
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