ME00055B - Primjena docetaksel/doksorubicin/ciklofosfamida u adjuvantnoj terapiji raka dojke i jajnika - Google Patents
Primjena docetaksel/doksorubicin/ciklofosfamida u adjuvantnoj terapiji raka dojke i jajnikaInfo
- Publication number
- ME00055B ME00055B MEP-2008-163A MEP2008163A ME00055B ME 00055 B ME00055 B ME 00055B ME P2008163 A MEP2008163 A ME P2008163A ME 00055 B ME00055 B ME 00055B
- Authority
- ME
- Montenegro
- Prior art keywords
- docetaxel
- cyclophosphamide
- doxorubicin
- ovarian cancer
- application according
- Prior art date
Links
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 title claims abstract 12
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 title claims abstract 6
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 title claims abstract 6
- 229960004397 cyclophosphamide Drugs 0.000 title claims abstract 6
- 229960003668 docetaxel Drugs 0.000 title claims abstract 6
- 229960004679 doxorubicin Drugs 0.000 title claims abstract 6
- 206010033128 Ovarian cancer Diseases 0.000 title claims abstract 3
- 206010061535 Ovarian neoplasm Diseases 0.000 title claims abstract 3
- 238000009098 adjuvant therapy Methods 0.000 title claims abstract 3
- 206010006187 Breast cancer Diseases 0.000 title claims 2
- 208000026310 Breast neoplasm Diseases 0.000 title claims 2
- 210000000481 breast Anatomy 0.000 title 1
- 206010055113 Breast cancer metastatic Diseases 0.000 claims abstract 3
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Ovaj pronalazak se odnosi na novi metod adjuvantne terapije u lečenju metastaznog raka dojke ili raka jajnika, koji obuhvata administriranje šest ciklusa docetaksela, doksorubicina i ciklofosfamida obolelom pacijentu, pri čemu doze imaju naznačen terapeutski efekat u poređenju sa drugim tadjuvantnim terapijama.
Claims (8)
1. Primena docetaksela za proizvodnju Jeka za lečenje metastaznog raka dojke ili jajnika, adjuvantnom terapijom u kombinaciji sa doksorubicinom i ciklofosfamidom i koji omogućava povećan stepen preživaljv;mja.
2.Pri mena prema zahtevu l, naznačena time, što su docetaskel , doksorubicin i ciklofosfamid administrirani odvojeno.
3.Primena prema zaptevu 1, naznačena time, što je za lečenje metastaznog raka dojke.
4.Primena prema zahtevu 3, naznačena time, što s u kod raka dojke prekomerno eksprimovani ER, PR i / ili HER2.
5.Primena prema zahtevu 2, naznačena time, što su docetaksel , doksorubicin i ciklofosfamid administrirani jednom na svake 3 nedelje.
6.Primena prema zahtevu 2, naznačena time, što je docetaksel administriran u dozi od oko 75mg/m2 po ciklusu.
7.Primena prema zahtevu 2, naznačena time, štoje doksorubicin administriran u dozi od oko 50 mg/m 2 po ciklusu.
8.Prirnena prema zahtevu 2, naznačena time, što je ciklofosfamid administriran u dozi od oko 500 mg/m2 po ciklusu.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38085002P | 2002-05-17 | 2002-05-17 | |
| PCT/EP2003/007443 WO2003097164A1 (en) | 2002-05-17 | 2003-05-15 | Use of docetaxel/doxorubicin/cyclophosphamide in adjuvant therapy of breast and ovarian cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME00055B true ME00055B (me) | 2010-10-10 |
Family
ID=29550025
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2008-163A ME00055B (me) | 2002-05-17 | 2003-05-15 | Primjena docetaksel/doksorubicin/ciklofosfamida u adjuvantnoj terapiji raka dojke i jajnika |
| MEP-163/08A MEP16308A (en) | 2002-05-17 | 2003-05-15 | Use of docetaxel/doxorubicin/cyclophosphamide in adjuvant therapy of breast and ovarian cancer |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-163/08A MEP16308A (en) | 2002-05-17 | 2003-05-15 | Use of docetaxel/doxorubicin/cyclophosphamide in adjuvant therapy of breast and ovarian cancer |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US20040014694A1 (me) |
| EP (1) | EP1507573A1 (me) |
| JP (1) | JP4773719B2 (me) |
| KR (1) | KR20050000544A (me) |
| CN (1) | CN1652845A (me) |
| AU (1) | AU2003244646B2 (me) |
| BR (1) | BR0310026A (me) |
| CA (1) | CA2486124A1 (me) |
| CR (1) | CR7575A (me) |
| EC (1) | ECSP045433A (me) |
| HR (1) | HRPK20041072B3 (me) |
| IL (1) | IL165214A0 (me) |
| MA (1) | MA27417A1 (me) |
| ME (2) | ME00055B (me) |
| MX (1) | MXPA04010640A (me) |
| MY (1) | MY146533A (me) |
| NO (1) | NO20045370L (me) |
| NZ (1) | NZ535992A (me) |
| OA (1) | OA12819A (me) |
| PA (1) | PA8574001A1 (me) |
| RS (1) | RS96304A (me) |
| RU (1) | RU2321396C2 (me) |
| TN (1) | TNSN04217A1 (me) |
| TW (1) | TWI374741B (me) |
| UA (1) | UA81628C2 (me) |
| UY (1) | UY27812A1 (me) |
| WO (1) | WO2003097164A1 (me) |
| ZA (1) | ZA200408549B (me) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2344899T3 (es) * | 2003-09-25 | 2010-09-09 | Astellas Pharma Inc. | Agente antitumoral que comprende un inhibidor de histona desacetilasa y un inhibidor de topoisomerasa ii. |
| GB0326486D0 (en) * | 2003-11-14 | 2003-12-17 | Pharma Mar Sau | Combination treatment |
| RU2265440C2 (ru) * | 2004-01-13 | 2005-12-10 | Ростовский научно-исследовательский онкологический институт МЗ РФ | Способ предоперационного лечения рака молочной железы |
| JP2006316040A (ja) | 2005-05-13 | 2006-11-24 | Genentech Inc | Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法 |
| US7776832B2 (en) * | 2006-04-21 | 2010-08-17 | Gem Pharmaceuticals, Llc | Anticancer treatment with a combination of taxanes and 13-deoxyanthracyclines |
| US20080085879A1 (en) * | 2006-08-31 | 2008-04-10 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods of treating estrogen-responsive conditions by orphan nuclear receptor activation |
| MY169449A (en) * | 2011-04-01 | 2019-04-11 | Astrazeneca Ab | Therapeutic treatment |
| US20140329786A1 (en) | 2011-11-30 | 2014-11-06 | Astrazeneca Ab | Combination treatment of cancer |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| WO2014169067A1 (en) * | 2013-04-09 | 2014-10-16 | Merrimack Pharmaceuticals, Inc. | Compositions for improving outcomes of liposomal chemotherapy |
| RU2020120593A (ru) | 2014-04-25 | 2020-09-01 | Дженентек, Инк. | Способы лечения раннего рака молочной железы трастузумабом-mcc-dm1 и пертузумабом |
| WO2016005962A2 (en) | 2014-07-11 | 2016-01-14 | Dr. Reddy’S Laboratories Limited | Stable liquid formulations of cyclophosphamide and processes |
| US10849916B2 (en) | 2014-07-11 | 2020-12-01 | Dr. Reddys Laboratories Limited | Stable liquid formulations of cyclophosphamide and its impurities |
| JP6769982B2 (ja) | 2015-03-06 | 2020-10-14 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | Ｒａｓ変異と関連するがんの治療方法 |
| ES2910035T3 (es) | 2015-07-13 | 2022-05-11 | Beyondspring Pharmaceuticals Inc | Composiciones de plinabulina |
| EP3366296B1 (en) * | 2015-10-22 | 2020-01-15 | Universidade De Santiago De Compostela | Methods for using regulators for increasing the expression or activation of p53 and/or regulators for reducing or inhibiting the expression of p63-alpha, for the treatment of non-alcoholic fatty liver disease (nafld) and/or non-alcoholic steatohepatitis (nash) |
| CA3013467A1 (en) | 2016-02-08 | 2017-08-17 | Beyondspring Pharmaceuticals, Inc. | Compositions containing tucaresol or its analogs |
| EP3463337A4 (en) | 2016-06-06 | 2020-02-12 | Beyondspring Pharmaceuticals, Inc. | COMPOSITION AND METHOD FOR REDUCING NEUTROPENIA |
| WO2018039452A1 (en) * | 2016-08-24 | 2018-03-01 | The Wistar Institute Of Anatomy And Biology | Methods of treating cancers with chemotherapy with reduced toxicity |
| WO2018067575A1 (en) * | 2016-10-03 | 2018-04-12 | Indiana University Research And Technology Corporation | Combination drug therapy reduces parp-1 related dna repair and increases the efficacy of genotoxic agents |
| CN110431135A (zh) | 2017-01-06 | 2019-11-08 | 大连万春布林医药有限公司 | 微管蛋白结合化合物及其治疗用途 |
| KR20190109479A (ko) | 2017-02-01 | 2019-09-25 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 호중구감소증의 감소 방법 |
| KR20190096384A (ko) | 2017-03-02 | 2019-08-19 | 제넨테크, 인크. | Her2-양성 유방암 어쥬번트 치료 |
| SG11202006985TA (en) | 2018-01-24 | 2020-08-28 | Beyondspring Pharmaceuticals Inc | Composition and method for reducing thrombocytopenia via the administration of plinabulin |
| WO2019246603A1 (en) | 2018-06-22 | 2019-12-26 | Ohio State Innovation Foundation | Methods and compositions for inhibition of dihydroorotate dehydrogenase |
| WO2022216908A1 (en) | 2021-04-09 | 2022-10-13 | Beyondspring Pharmaceuticals, Inc. | Therapeutic compositions and methods for treating tumors |
| CN115969792A (zh) * | 2023-01-29 | 2023-04-18 | 常州金远药业制造有限公司 | 一种紫杉烷类药物与环磷酰胺共载载药脂质体制备方法 |
| CN116870019A (zh) * | 2023-02-03 | 2023-10-13 | 大连理工大学 | 一种具有协同增效作用的药物组合物及其在癌症化疗中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| MX9102128A (es) | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
| FR2697752B1 (fr) * | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
| US6441026B1 (en) * | 1993-11-08 | 2002-08-27 | Aventis Pharma S.A. | Antitumor compositions containing taxane derivatives |
| US5565478A (en) * | 1994-03-14 | 1996-10-15 | The United States Of America As Represented By The Department Of Health & Human Services | Combination therapy using signal transduction inhibitors with paclitaxel and other taxane analogs |
| US6262054B1 (en) * | 1996-02-01 | 2001-07-17 | Sloan-Kettering Institute Of Cancer Research | Combination therapy method for treating breast cancer using edatrexate |
| US6323205B1 (en) * | 1996-07-17 | 2001-11-27 | Sloan-Kettering Institute For Cancer Research | Combinations of 10-propargyl-10-deazaaminopterin and taxols and methods of using same in the treatment of tumors |
| US6541508B2 (en) * | 1999-09-13 | 2003-04-01 | Nobex Corporation | Taxane prodrugs |
| TWI310684B (en) * | 2000-03-27 | 2009-06-11 | Bristol Myers Squibb Co | Synergistic pharmaceutical kits for treating cancer |
| US20020128228A1 (en) * | 2000-12-01 | 2002-09-12 | Wen-Jen Hwu | Compositions and methods for the treatment of cancer |
-
2003
- 2003-05-15 UA UA20041210381A patent/UA81628C2/uk unknown
- 2003-05-15 OA OA1200400307A patent/OA12819A/en unknown
- 2003-05-15 AU AU2003244646A patent/AU2003244646B2/en not_active Ceased
- 2003-05-15 EP EP03738122A patent/EP1507573A1/en not_active Withdrawn
- 2003-05-15 CA CA002486124A patent/CA2486124A1/en not_active Abandoned
- 2003-05-15 ME MEP-2008-163A patent/ME00055B/me unknown
- 2003-05-15 KR KR10-2004-7018431A patent/KR20050000544A/ko not_active Withdrawn
- 2003-05-15 JP JP2004505157A patent/JP4773719B2/ja not_active Expired - Fee Related
- 2003-05-15 MX MXPA04010640A patent/MXPA04010640A/es active IP Right Grant
- 2003-05-15 CN CNA038112388A patent/CN1652845A/zh active Pending
- 2003-05-15 RU RU2004136984/15A patent/RU2321396C2/ru not_active IP Right Cessation
- 2003-05-15 NZ NZ535992A patent/NZ535992A/en not_active IP Right Cessation
- 2003-05-15 BR BR0310026-0A patent/BR0310026A/pt not_active IP Right Cessation
- 2003-05-15 HR HR20041072A patent/HRPK20041072B3/xx not_active IP Right Cessation
- 2003-05-15 RS YU96304A patent/RS96304A/sr unknown
- 2003-05-15 WO PCT/EP2003/007443 patent/WO2003097164A1/en not_active Ceased
- 2003-05-15 ME MEP-163/08A patent/MEP16308A/xx unknown
- 2003-05-15 IL IL16521403A patent/IL165214A0/xx unknown
- 2003-05-16 MY MYPI20031829A patent/MY146533A/en unknown
- 2003-05-16 TW TW092113275A patent/TWI374741B/zh not_active IP Right Cessation
- 2003-05-16 US US10/439,827 patent/US20040014694A1/en not_active Abandoned
- 2003-05-16 PA PA20038574001A patent/PA8574001A1/es unknown
- 2003-05-16 UY UY27812A patent/UY27812A1/es not_active Application Discontinuation
-
2004
- 2004-10-21 ZA ZA2004/08549A patent/ZA200408549B/en unknown
- 2004-11-03 MA MA27924A patent/MA27417A1/fr unknown
- 2004-11-11 TN TNP2004000217A patent/TNSN04217A1/en unknown
- 2004-11-16 EC EC2004005433A patent/ECSP045433A/es unknown
- 2004-11-17 CR CR7575A patent/CR7575A/es unknown
- 2004-12-08 NO NO20045370A patent/NO20045370L/no not_active Application Discontinuation
-
2007
- 2007-06-28 US US11/769,859 patent/US20070265213A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| UY27812A1 (es) | 2003-11-28 |
| HRPK20041072B3 (hr) | 2007-07-31 |
| MA27417A1 (fr) | 2005-07-01 |
| CN1652845A (zh) | 2005-08-10 |
| RU2004136984A (ru) | 2005-06-27 |
| RS96304A (sr) | 2006-10-27 |
| NZ535992A (en) | 2008-11-28 |
| UA81628C2 (uk) | 2008-01-25 |
| TWI374741B (en) | 2012-10-21 |
| ZA200408549B (en) | 2006-01-25 |
| EP1507573A1 (en) | 2005-02-23 |
| HRP20041072A2 (en) | 2005-06-30 |
| CA2486124A1 (en) | 2003-11-27 |
| OA12819A (en) | 2006-07-10 |
| AU2003244646B2 (en) | 2008-08-07 |
| CR7575A (es) | 2006-05-10 |
| NO20045370L (no) | 2004-12-08 |
| TW200407152A (en) | 2004-05-16 |
| JP4773719B2 (ja) | 2011-09-14 |
| KR20050000544A (ko) | 2005-01-05 |
| AU2003244646A1 (en) | 2003-12-02 |
| MEP16308A (en) | 2010-06-10 |
| ECSP045433A (es) | 2005-01-03 |
| WO2003097164A1 (en) | 2003-11-27 |
| TNSN04217A1 (en) | 2007-03-12 |
| RU2321396C2 (ru) | 2008-04-10 |
| IL165214A0 (en) | 2005-12-18 |
| US20070265213A1 (en) | 2007-11-15 |
| MXPA04010640A (es) | 2005-08-16 |
| MY146533A (en) | 2012-08-15 |
| JP2005529925A (ja) | 2005-10-06 |
| US20040014694A1 (en) | 2004-01-22 |
| BR0310026A (pt) | 2005-02-15 |
| PA8574001A1 (es) | 2003-12-19 |
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