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ME00812B - Humana antitela prema humanom delti sličnom ligandu 4 - Google Patents

Humana antitela prema humanom delti sličnom ligandu 4

Info

Publication number
ME00812B
ME00812B MEP-2009-224A MEP22409A ME00812B ME 00812 B ME00812 B ME 00812B ME P22409 A MEP22409 A ME P22409A ME 00812 B ME00812 B ME 00812B
Authority
ME
Montenegro
Prior art keywords
antibody
fragment
human
antigen
production
Prior art date
Application number
MEP-2009-224A
Other languages
English (en)
French (fr)
Inventor
Nicholas J Papadopoulos
Joel H Martin
Eric Smith
Irene Noguera-Troise
Gavin Thurston
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of ME00812B publication Critical patent/ME00812B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Claims (10)

1.    Humano antitelo ili fragment antitela, koji specifično vezuju humani delti-sličan ligand 4 (hD114), navedeno antitelo ili fragment antitela sadrže teški lanac varijabilnog regiona/laki lanac varijabilnog regiona (HCVR/LCVR) koji su izabrani od sledećih parova amino kiselinskih sekvenci SEQ ID NO:429/437 i 901/903.
2.    Humano antitelo ili fragment antitela, prema zahtevu 1, dalje sadrži konstantni region izabran iz grupe, koja se sastoji od SEQ ID NO:950, 951 i 952.
3.    Izolovani molekul nukleinske kiseline kodira antitelo ili antigen-vezujući fragment, prema zahtevu 1 ili 2.
4.    Vektor sadrži molekul nukleinske kiseline, prema zahtevu 3.
5.    Ćelija domaćina sadrži vektor, prema zahtevu 4.
6.    Ćelije domaćina, prema zahtevu 5, koje su prokariotske ili eukariotske ćelije, biraju se od ćelija E. coli ili CHO ćelija.
7.    Postupak za proizvodnju anti-humanog D114 antitela ili njegovog antigen-vezujućeg fragmenta, koji obuhvata uzgajanje ćelija domaćina, prema zahtevu 5 ili 6, u uslovima koji omogućavaju proizvodnju antitela ili njegovog fragmenta i obnavljanje tako dobijenog antitela ili fragmenta.    •
8.    Upotreba antitela ili fragmenta antitela koje se vezuje za antigen, prema zahtevu 1 ili 2, za proizvodnju leka za lečenje kancera kod ljudi.
9.    Antitelo ili fragment antitela, prema zahtevu 1 ili 2, za upotrebu u postupku za lečenje kancera kod ljudi.
10.    Smeša koja sadrži antitelo ili fragment antitela, prema zahtevu 1 ili 2 i, prihvatljivi nosač.
MEP-2009-224A 2006-12-14 2007-12-14 Humana antitela prema humanom delti sličnom ligandu 4 ME00812B (me)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US87492206P 2006-12-14 2006-12-14
US91641507P 2007-05-07 2007-05-07
US98532307P 2007-11-05 2007-11-05
PCT/US2007/025653 WO2008076379A2 (en) 2006-12-14 2007-12-14 Human antibodies to human delta like ligand 4

Publications (1)

Publication Number Publication Date
ME00812B true ME00812B (me) 2013-02-28

Family

ID=39491524

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2009-224A ME00812B (me) 2006-12-14 2007-12-14 Humana antitela prema humanom delti sličnom ligandu 4

Country Status (33)

Country Link
US (9) US7919593B2 (me)
EP (2) EP2115003B1 (me)
JP (2) JP5677744B2 (me)
KR (1) KR101516569B1 (me)
CN (1) CN101611055B (me)
AU (1) AU2007334366B2 (me)
BR (1) BRPI0720021A2 (me)
CA (1) CA2672622C (me)
CR (1) CR10863A (me)
CY (1) CY1113087T1 (me)
DK (1) DK2115003T3 (me)
DO (1) DOP2009000140A (me)
EC (1) ECSP099404A (me)
ES (1) ES2386480T3 (me)
GT (1) GT200900167A (me)
HR (1) HRP20120536T1 (me)
IL (1) IL198612A (me)
MA (1) MA31092B1 (me)
ME (1) ME00812B (me)
MX (2) MX2009005963A (me)
MY (1) MY164461A (me)
NI (1) NI200900115A (me)
NO (1) NO347649B1 (me)
NZ (1) NZ577616A (me)
PL (1) PL2115003T3 (me)
PT (1) PT2115003E (me)
RS (1) RS52439B (me)
RU (1) RU2448979C2 (me)
SG (2) SG177193A1 (me)
SI (1) SI2115003T1 (me)
SV (1) SV2009003296A (me)
TN (1) TN2009000245A1 (me)
WO (1) WO2008076379A2 (me)

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