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ME00417B - Jedinjenja i kompozicije koja moduliraju hedgehog signalni put - Google Patents

Jedinjenja i kompozicije koja moduliraju hedgehog signalni put

Info

Publication number
ME00417B
ME00417B MEP-2008-556A MEP55608A ME00417B ME 00417 B ME00417 B ME 00417B ME P55608 A MEP55608 A ME P55608A ME 00417 B ME00417 B ME 00417B
Authority
ME
Montenegro
Prior art keywords
function
stimulation
provides
hedgehog
compositions
Prior art date
Application number
MEP-2008-556A
Other languages
English (en)
French (fr)
Inventor
Wenqi Gao
Jiqing Jiang
Yongqin Wan
Dai Cheng
Dong Han
Xu Wu
Shifeng Pan
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38668605&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME00417(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ME00417B publication Critical patent/ME00417B/me

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
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    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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  • Chemical & Material Sciences (AREA)
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  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Pronalazak obezbedjuje  postupak za modulaciju aktivnosti hedgehog signalnog  puta. Preciznije,  pronalazak  obezbedjuje postupak za inhibiciju  poremećenih stanja rasta koja nastaju iz fenotipa kao što je gubitak funkcije Ptc, stimulacija funkcije hedgehod, stimulacija funkcije smoothened ili Gli, uključujući kontakt ćelije sa dovoljnom količinom jedinjenja  formule I. Pronalazak obezbedjuje  postupak za modulaciju aktivnosti hedgehog signalnog  puta. Preciznije,  pronalazak  obezbedjuje postupak za inhibiciju  poremećenih stanja rasta koja nastaju iz fenotipa kao što je gubitak funkcije Ptc, stimulacija funkcije  hedgehod, stimulacija funkcije smoothened ili Gli, uključujući kontakt ćelije sa dovoljnom količinom jedinjenja  formule I.

Claims (1)

1.Jedinjenje, N-(6-((2R,6S)-2,6-dimetilmorfolino)piridin-3-il)-2-metil-4'-(trifluorometoksi)-[1,1’-bifenil]-3-karboksamid, formule: ili njene farmaceutski prihvatljive soli.
MEP-2008-556A 2006-05-05 2007-05-04 Jedinjenja i kompozicije koja moduliraju hedgehog signalni put ME00417B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79794906P 2006-05-05 2006-05-05
PCT/US2007/068292 WO2007131201A2 (en) 2006-05-05 2007-05-04 Compounds and compositions as hedgehog pathway modulators

Publications (1)

Publication Number Publication Date
ME00417B true ME00417B (me) 2011-10-10

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ID=38668605

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MEP-2008-556A ME00417B (me) 2006-05-05 2007-05-04 Jedinjenja i kompozicije koja moduliraju hedgehog signalni put

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US (2) US8178563B2 (me)
EP (2) EP2021328B1 (me)
JP (2) JP4891396B2 (me)
KR (1) KR101076943B1 (me)
CN (2) CN102746285B (me)
AR (2) AR060858A1 (me)
AU (1) AU2007247860C1 (me)
BR (1) BRPI0711333B8 (me)
CA (1) CA2650248C (me)
CL (1) CL2007001269A1 (me)
CR (1) CR10399A (me)
CU (1) CU23760B7 (me)
CY (1) CY2015054I1 (me)
DK (1) DK2021328T3 (me)
EA (1) EA018302B1 (me)
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ES (2) ES2422557T3 (me)
GE (1) GEP20105103B (me)
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JO (1) JO2883B1 (me)
LT (1) LTC2021328I2 (me)
LU (1) LU92883I2 (me)
MA (1) MA30426B1 (me)
ME (1) ME00417B (me)
MX (1) MX2008014190A (me)
MY (1) MY153574A (me)
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NO (3) NO341215B1 (me)
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SI (1) SI2021328T1 (me)
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UA (1) UA93548C2 (me)
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