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MC1985A1 - Derives d'acides amines - Google Patents

Derives d'acides amines

Info

Publication number
MC1985A1
MC1985A1 MC882008A MC2008A MC1985A1 MC 1985 A1 MC1985 A1 MC 1985A1 MC 882008 A MC882008 A MC 882008A MC 2008 A MC2008 A MC 2008A MC 1985 A1 MC1985 A1 MC 1985A1
Authority
MC
Monaco
Prior art keywords
hydroxy
isopropyl
cyclohexylmethyl
acid
carbamoyl
Prior art date
Application number
MC882008A
Other languages
English (en)
French (fr)
Inventor
Branca Quirico
Edenhofer Albrecht
Gutknecht Eva-Maria
Neidhart Werner
Ramuz Henri
Wostl Wolfgang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MC1985A1 publication Critical patent/MC1985A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/08Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0821Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1024Tetrapeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MC882008A 1987-10-06 1988-10-03 Derives d'acides amines MC1985A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH390387 1987-10-06

Publications (1)

Publication Number Publication Date
MC1985A1 true MC1985A1 (fr) 1989-11-23

Family

ID=4265984

Family Applications (1)

Application Number Title Priority Date Filing Date
MC882008A MC1985A1 (fr) 1987-10-06 1988-10-03 Derives d'acides amines

Country Status (14)

Country Link
EP (1) EP0310918A3 (pt)
JP (1) JPH02256658A (pt)
KR (1) KR890006572A (pt)
AU (1) AU627156B2 (pt)
DK (1) DK523288A (pt)
FI (1) FI884598A7 (pt)
HU (1) HUT49322A (pt)
IL (1) IL87871A0 (pt)
MC (1) MC1985A1 (pt)
NO (1) NO884434L (pt)
NZ (1) NZ226395A (pt)
PT (1) PT88679A (pt)
YU (1) YU185188A (pt)
ZA (1) ZA887322B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU595309B2 (en) * 1986-05-09 1990-03-29 Dainippon Pharmaceutical Co. Ltd. Tripeptide derivatives
US4895834A (en) * 1986-12-15 1990-01-23 Warner-Lambert Company Renin inhibitors III
US5023236A (en) * 1988-04-07 1991-06-11 Corvas, Inc. Factor VII/VIIA active site inhibitors
EP0391180A3 (de) * 1989-04-04 1991-04-03 F. Hoffmann-La Roche Ag Peptidartige Aminosäurederivate mit reninhemmender Wirkung
CA2012901A1 (en) * 1989-04-05 1990-10-05 Quirico Branca Amino acid derivatives
US5374731A (en) * 1989-09-12 1994-12-20 Hoechst Aktiengesellschaft Amino acid derivatives with renin-inhibiting properties, a process for the preparation thereof, agents containing these, and the use thereof
DE4008403A1 (de) * 1990-03-16 1991-09-19 Merck Patent Gmbh Glykolsaeurederivate
US5516784A (en) * 1991-08-13 1996-05-14 Schering Corporation Anti-HIV (AIDS) agents
US5422349A (en) * 1992-08-14 1995-06-06 G. D. Seale & Co. Morpholino-oxazinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5693815A (en) * 1993-01-17 1997-12-02 Schering Corporation Peptides
US5563127A (en) * 1993-03-24 1996-10-08 The Dupont Merck Pharmaceutical Company Boronic acid and ester inhibitors of thrombin
FR2741066B1 (fr) * 1995-11-14 1997-12-12 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
FR2752422B1 (fr) * 1996-08-16 1998-11-06 Lipha Composition pharmaceutique contenant des acides 4-oxo-butanoiques
YU68900A (sh) * 1998-05-12 2002-12-10 Warner-Lambert Company Kombinacije inhibitora protein farnesiltransferaze i hmg coa reduktaze i njihova upotreba u tretmanu raka
AU2008247488B2 (en) * 2007-05-04 2014-02-27 Marina Biotech, Inc. Amino acid lipids and uses thereof
GB0919194D0 (en) 2009-11-02 2009-12-16 Lytix Biopharma As Compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652551A (en) * 1984-06-22 1987-03-24 Abbott Laboratories Renin inhibiting compounds
DK34086A (da) * 1985-01-23 1986-07-24 Abbott Lab Peptidylaminodioler
IL81234A (en) * 1986-01-16 1992-09-06 Abbott Lab Peptidylaminodiols,process for their preparation and pharmaceutical compositions comprising them
US4792555A (en) * 1987-03-20 1988-12-20 American Home Products Corporation Phospholipase A2 inhibitors

Also Published As

Publication number Publication date
ZA887322B (en) 1989-06-28
FI884598A0 (fi) 1988-10-06
EP0310918A2 (de) 1989-04-12
NZ226395A (en) 1991-12-23
PT88679A (pt) 1989-07-31
YU185188A (en) 1990-12-31
AU2330788A (en) 1989-06-08
IL87871A0 (en) 1989-03-31
AU627156B2 (en) 1992-08-20
DK523288A (da) 1989-04-07
FI884598A7 (fi) 1989-04-07
EP0310918A3 (de) 1990-12-12
DK523288D0 (da) 1988-09-20
NO884434L (no) 1989-04-07
KR890006572A (ko) 1989-06-14
HUT49322A (en) 1989-09-28
NO884434D0 (no) 1988-10-05
JPH02256658A (ja) 1990-10-17

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