MC1983A1 - Composes heterocycliques,leur preparation et medicaments qui contiennent de tels composes - Google Patents
Composes heterocycliques,leur preparation et medicaments qui contiennent de tels composesInfo
- Publication number
- MC1983A1 MC1983A1 MC882012A MC2012A MC1983A1 MC 1983 A1 MC1983 A1 MC 1983A1 MC 882012 A MC882012 A MC 882012A MC 2012 A MC2012 A MC 2012A MC 1983 A1 MC1983 A1 MC 1983A1
- Authority
- MC
- Monaco
- Prior art keywords
- formula
- radical
- compound
- given
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878724912A GB8724912D0 (en) | 1987-10-23 | 1987-10-23 | Indole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MC1983A1 true MC1983A1 (fr) | 1989-11-23 |
Family
ID=10625806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MC882012A MC1983A1 (fr) | 1987-10-23 | 1988-10-21 | Composes heterocycliques,leur preparation et medicaments qui contiennent de tels composes |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0313397B1 (pt) |
| JP (1) | JP2501631B2 (pt) |
| CN (1) | CN1035113A (pt) |
| AT (1) | ATE90089T1 (pt) |
| AU (1) | AU604165B2 (pt) |
| DD (1) | DD283140A5 (pt) |
| DE (1) | DE3881472T2 (pt) |
| DK (1) | DK586588A (pt) |
| ES (1) | ES2054825T3 (pt) |
| FI (1) | FI884879A7 (pt) |
| GB (1) | GB8724912D0 (pt) |
| HU (1) | HU202230B (pt) |
| IL (1) | IL88122A0 (pt) |
| MC (1) | MC1983A1 (pt) |
| NZ (1) | NZ226671A (pt) |
| PL (1) | PL158305B1 (pt) |
| PT (1) | PT88829B (pt) |
| ZA (1) | ZA887900B (pt) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT95899A (pt) * | 1989-11-17 | 1991-09-13 | Glaxo Group Ltd | Processo para a preparacao de derivados indole |
| IL96891A0 (en) * | 1990-01-17 | 1992-03-29 | Merck Sharp & Dohme | Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them |
| DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
| DK0486666T3 (da) * | 1990-06-07 | 1998-03-30 | Zeneca Ltd | Terapeutisk heterocykliske forbindelser |
| EP0494774A1 (en) * | 1991-01-11 | 1992-07-15 | MERCK SHARP & DOHME LTD. | Indazole-substituted fivemembered heteroaromatic compounds |
| US5317103A (en) * | 1991-01-15 | 1994-05-31 | Merck Sharp & Dohme Limited | Indole-substituted five-membered heteroaromatic compounds as 5-HT1 agonists |
| CZ283018B6 (cs) * | 1991-02-01 | 1997-12-17 | Merck Sharp And Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi |
| TW263508B (pt) * | 1991-02-12 | 1995-11-21 | Pfizer | |
| GB9104136D0 (en) * | 1991-02-27 | 1991-04-17 | Merck Sharp & Dohme | Therapeutic agents |
| BR9206810A (pt) * | 1991-11-25 | 1995-10-31 | Pfizer | Derivados de indol |
| EP0545478A1 (en) * | 1991-12-03 | 1993-06-09 | MERCK SHARP & DOHME LTD. | Heterocyclic compounds as tachykinin antagonists |
| US5409941A (en) * | 1992-02-03 | 1995-04-25 | Pfizer Inc. | 5-heteroyl indole derivatives |
| TW288010B (pt) * | 1992-03-05 | 1996-10-11 | Pfizer | |
| US5510362A (en) * | 1992-03-13 | 1996-04-23 | Merck, Sharp And Dohme Limited | Imidazole, triazole and tetrazole derivatives |
| GB9207396D0 (en) * | 1992-04-03 | 1992-05-13 | Merck Sharp & Dohme | Therapeutic agents |
| US5747501A (en) | 1992-04-07 | 1998-05-05 | Pfizer, Inc. | Indole derivatives |
| US6380233B1 (en) | 1992-04-07 | 2002-04-30 | Pfizer Inc | Indole derivatives as 5-HT1 agonists |
| ATE148465T1 (de) * | 1992-04-10 | 1997-02-15 | Pfizer | Acylaminoindolderivate als 5-ht1 agonisten |
| GB9207930D0 (en) * | 1992-04-10 | 1992-05-27 | Pfizer Ltd | Indoles |
| GB9208463D0 (en) * | 1992-04-16 | 1992-06-03 | Merck Sharp & Dohme | Therapeutic agents |
| GB9210400D0 (en) * | 1992-05-15 | 1992-07-01 | Merck Sharp & Dohme | Therapeutic agents |
| GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
| KR100286411B1 (ko) * | 1992-06-05 | 2001-04-16 | 더블유. 지. 콜 | 치환된 트리아졸의 설페이트 염, 이의 제조방법 및 이를 포함하는 약제학적 조성물 |
| GB9215526D0 (en) * | 1992-07-22 | 1992-09-02 | Merck Sharp & Dohme | Chemical process |
| JPH07509452A (ja) * | 1992-07-24 | 1995-10-19 | メルク シヤープ エンド ドーム リミテツド | イミダゾール，トリアゾール及びテトラゾール誘導体 |
| IL106445A (en) * | 1992-07-30 | 1998-01-04 | Merck Sharp & Dohme | History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them |
| TW251284B (pt) * | 1992-11-02 | 1995-07-11 | Pfizer | |
| GB9226537D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| LT3594B (en) | 1993-07-29 | 1995-12-27 | Merck Sharp & Dohme | Imidazole,triazole and tetrazole derivatives |
| ES2070087B1 (es) * | 1993-08-13 | 1996-02-16 | Pfizer | Derivados de indol |
| US6423731B2 (en) | 1994-01-06 | 2002-07-23 | Zeneca Limited | Indole derivatives as prodrugs of 5-HT1-like receptor agonists |
| GB9401436D0 (en) * | 1994-01-26 | 1994-03-23 | Wellcome Found | Therapeutic heterocyclic compounds |
| GB9407447D0 (en) * | 1994-04-14 | 1994-06-08 | Glaxo Group Ltd | Chemical compounds |
| EP0765322B1 (en) * | 1994-06-01 | 2001-07-25 | AstraZeneca AB | Indole derivatives as prodrugs of 5-ht1-like receptor agonists |
| MX9700693A (es) * | 1994-07-26 | 1997-04-30 | Pfizer | Derivados del 4-indol. |
| AU699281B2 (en) * | 1994-12-06 | 1998-11-26 | Merck Sharp & Dohme Limited | Azetidine, pyrrolidine and piperidine derivatives as 5HT1 receptor agonists |
| US6909005B1 (en) | 1995-08-07 | 2005-06-21 | Astrazeneca Uk Limited | One post synthesis of 2-oxazolidinone derivatives |
| GB9516145D0 (en) * | 1995-08-07 | 1995-10-04 | Wellcome Found | Improved chemical synthesis |
| GB9516143D0 (en) | 1995-08-07 | 1995-10-04 | Wellcome Found | Improved chemical synthesis |
| US5998438A (en) * | 1996-11-26 | 1999-12-07 | Allelix Biopharmaceuticals, Inc. | 5-cyclo indole compounds |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| WO2000000490A2 (en) * | 1998-06-26 | 2000-01-06 | Eli Lilly And Company | 5-ht1f agonists |
| JP4455992B2 (ja) | 2002-06-21 | 2010-04-21 | スベン ライフ サイエンシズ リミティド | 治療薬剤として有用なセロトニン受容体親和性を有するアリールアルキル・インドール、その製造方法、並びにそれらを含む医薬組成物 |
| NZ537770A (en) | 2002-06-21 | 2007-03-30 | Suven Life Sciences Ltd | Tetracyclic arylsulfonyl indoles having serotonin receptor affinity |
| DK1581492T3 (da) | 2002-11-28 | 2008-11-10 | Suven Life Sciences Ltd | N-arylsulfonyl-3-substituerede indoler med serotoninreceptoraffinitet, fremgangsmåde til fremstilling heraf og en farmaceutisk sammensætning indeholdende disse |
| EA009193B1 (ru) | 2002-11-28 | 2007-12-28 | Сувен Лайф Сайенсиз Лимитед | N-арилсульфонил-3-аминоалкоксииндолы |
| EA009367B1 (ru) | 2002-12-18 | 2007-12-28 | Сувен Лайф Сайенсиз Лимитед | ПРОИЗВОДНЫЕ 5-ТИА-5-ДИОКСО-4b-АЗАИНДЕНО[2,1-a]ИНДЕНА, ОБЛАДАЮЩИЕ АФФИННОСТЬЮ К РЕЦЕПТОРУ СЕРОТОНИНА |
| DE102005018191A1 (de) | 2005-04-19 | 2006-10-26 | Grünenthal GmbH | Substituierte zyklische Harnstoff-Derivate und deren Verwendung zur Herstellung von Arzneimitteln |
| BR112018015367A2 (pt) | 2016-01-27 | 2018-12-18 | Instar Tech A S | carreadores oromucosais de nanofibra para tratamento terapêutico |
| CN112759550A (zh) * | 2019-11-04 | 2021-05-07 | 上海科技大学 | 一种平滑受体拮抗剂 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4833153A (en) | 1985-11-08 | 1989-05-23 | Glaxo Group Limited | Indole derivatives |
| GB8600397D0 (en) | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
-
1987
- 1987-10-23 GB GB878724912A patent/GB8724912D0/en active Pending
-
1988
- 1988-10-21 EP EP88309943A patent/EP0313397B1/en not_active Expired - Lifetime
- 1988-10-21 DK DK586588A patent/DK586588A/da not_active Application Discontinuation
- 1988-10-21 NZ NZ226671A patent/NZ226671A/xx unknown
- 1988-10-21 ES ES88309943T patent/ES2054825T3/es not_active Expired - Lifetime
- 1988-10-21 CN CN88108816A patent/CN1035113A/zh active Pending
- 1988-10-21 ZA ZA887900A patent/ZA887900B/xx unknown
- 1988-10-21 FI FI884879A patent/FI884879A7/fi not_active Application Discontinuation
- 1988-10-21 IL IL88122A patent/IL88122A0/xx unknown
- 1988-10-21 HU HU885431A patent/HU202230B/hu unknown
- 1988-10-21 PL PL1988275423A patent/PL158305B1/pl unknown
- 1988-10-21 MC MC882012A patent/MC1983A1/fr unknown
- 1988-10-21 DE DE88309943T patent/DE3881472T2/de not_active Expired - Fee Related
- 1988-10-21 AT AT88309943T patent/ATE90089T1/de not_active IP Right Cessation
- 1988-10-21 JP JP63265917A patent/JP2501631B2/ja not_active Expired - Lifetime
- 1988-10-21 PT PT88829A patent/PT88829B/pt not_active IP Right Cessation
- 1988-10-21 DD DD88320940A patent/DD283140A5/de not_active IP Right Cessation
- 1988-10-24 AU AU24181/88A patent/AU604165B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| IL88122A0 (en) | 1989-06-30 |
| GB8724912D0 (en) | 1987-11-25 |
| PT88829B (pt) | 1993-01-29 |
| PL275423A1 (en) | 1989-08-07 |
| NZ226671A (en) | 1991-09-25 |
| ES2054825T3 (es) | 1994-08-16 |
| DD283140A5 (de) | 1990-10-03 |
| JP2501631B2 (ja) | 1996-05-29 |
| FI884879A0 (fi) | 1988-10-21 |
| HUT50163A (en) | 1989-12-28 |
| DK586588D0 (da) | 1988-10-21 |
| AU604165B2 (en) | 1990-12-06 |
| JPH01146882A (ja) | 1989-06-08 |
| PL158305B1 (en) | 1992-08-31 |
| EP0313397B1 (en) | 1993-06-02 |
| DE3881472D1 (de) | 1993-07-08 |
| CN1035113A (zh) | 1989-08-30 |
| AU2418188A (en) | 1989-04-27 |
| HU202230B (en) | 1991-02-28 |
| DE3881472T2 (de) | 1993-12-16 |
| ZA887900B (en) | 1990-06-27 |
| ATE90089T1 (de) | 1993-06-15 |
| DK586588A (da) | 1989-04-24 |
| FI884879A7 (fi) | 1989-04-24 |
| EP0313397A1 (en) | 1989-04-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MC1983A1 (fr) | Composes heterocycliques,leur preparation et medicaments qui contiennent de tels composes | |
| RU2160736C2 (ru) | Производные индола и их физиологически приемлемые соли и сольваты, способы их получения, лекарственное средство для лечения или профилактики клинических состояний, для которых показан прием агониста "5-нт1-подобного" рецептора, и способ его получения | |
| CH651550A5 (fr) | Derives de l'indole, leur preparation et compositions pharmaceutiques les contenant. | |
| FR2530625A1 (fr) | Derives d'indole, procedes pour leur preparation et compositions pharmaceutiques les contenant | |
| EP1255751A2 (fr) | Derives de 1,3-dihydro-2h-indol-2-one et leur utilisation en tant que ligands des recepteurs v1b ou v1b et v1a de l'arginine-vasopressine | |
| FR2555987A1 (fr) | Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation | |
| WO1995018105A1 (fr) | Derives de 1,3-dihydroindol-2-one substitues en 3 par un groupe azote comme agonistes et/ou antagonistes de la vasopressine et/ou de l'ocytocine | |
| WO1997000860A1 (fr) | Composes agonistes du recepteur cb¿2? | |
| FR2488607A1 (fr) | Derives de l'indole, leur preparation et leurs utilisations pharmaceutiques | |
| CH652394A5 (fr) | Derives indoliques, leur preparation et medicaments les renfermant. | |
| FR2722190A1 (fr) | Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant | |
| JPH09512248A (ja) | ５−ｈｔ▲下１▼作動薬としてのインドール誘導体 | |
| FR2574793A1 (fr) | Composes derives d'indole, compositions pharmaceutiques les contenant et procede pour leur preparation | |
| JP2669765B2 (ja) | （１ｈ−インドール−１−イル）−２−（アミノ）アセトアミドおよび関連した（１ｈ−インドール−１−イル）−（アミノアルキル）アミド、中間体およびそれらの製法ならびにそれらを含有する神経保護剤 | |
| JPH09510706A (ja) | ドパミン作動性活性を有するベンゾイミダゾール誘導体 | |
| CH671017A5 (pt) | ||
| CA2301750A1 (fr) | Derives d'indole comme agonistes de 5-ht1b et 5-ht1d | |
| JPH09506083A (ja) | フエニルインドール化合物 | |
| FR2600061A1 (fr) | Derives d'indole, composition pharmaceutique les contenant et procede pour leur preparation | |
| US5225431A (en) | Therapeutic substituted indole compounds and compositions thereof | |
| TW200526651A (en) | 3-substituted β-lactamyl vasopressin V1a antagonists | |
| FR2462436A1 (fr) | Nouvelles 2-(5-pyrazolylamino)-2-imidazolines, utiles notamment comme agents anti-inflammatoires, et compositions pharmaceutiques les contenant |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| YP | Annual fee paid |