MA52795B1 - Dérivés de carbamoylpyridone polycycliques pour le traitement du vih - Google Patents
Dérivés de carbamoylpyridone polycycliques pour le traitement du vihInfo
- Publication number
- MA52795B1 MA52795B1 MA52795A MA52795A MA52795B1 MA 52795 B1 MA52795 B1 MA 52795B1 MA 52795 A MA52795 A MA 52795A MA 52795 A MA52795 A MA 52795A MA 52795 B1 MA52795 B1 MA 52795B1
- Authority
- MA
- Morocco
- Prior art keywords
- sup
- hiv
- treatment
- img
- ring
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La présente invention concerne un composé représenté par la formule (I) : <img file="imga0001.tif" frnum="0001" he="29" id="ia01" img-content="chem" img-format="tif" inline="no" orientation="portrait" pgnum="0001" wi="72"/> dans laquelle le cycle A est un hétérocycle substitué ou non substitué ; le cycle C est un cycle benzénique ou similaire ; R<sup>1</sup> est un halogène ou similaire ; R<sup>2a</sup> et R<sup>2b</sup> sont chacun indépendamment un hydrogène ou similaire ; R<sup>3</sup> est un alkyle substitué ou non substitué ou similaire ; R<sup>4</sup> est un hydrogène ou similaire ; et n est un entier de 1 à 3.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018104156 | 2018-05-31 | ||
| PCT/JP2019/021446 WO2019230858A1 (fr) | 2018-05-31 | 2019-05-30 | Dérivé de carbamoylpyridone polycyclique |
| EP19810498.6A EP3805220B1 (fr) | 2018-05-31 | 2019-05-30 | Dérivés de carbamoylpyridone polycycliques pour le traitement du vih |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA52795A MA52795A (fr) | 2021-04-14 |
| MA52795B1 true MA52795B1 (fr) | 2024-09-30 |
Family
ID=68698918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA52795A MA52795B1 (fr) | 2018-05-31 | 2019-05-30 | Dérivés de carbamoylpyridone polycycliques pour le traitement du vih |
Country Status (36)
| Country | Link |
|---|---|
| US (3) | US11649236B2 (fr) |
| EP (2) | EP4257137A3 (fr) |
| JP (2) | JP7328962B2 (fr) |
| KR (2) | KR20250002769A (fr) |
| CN (2) | CN112513042B (fr) |
| AR (1) | AR115455A1 (fr) |
| AU (2) | AU2019277548B2 (fr) |
| BR (1) | BR112020024077A2 (fr) |
| CA (1) | CA3102063A1 (fr) |
| CL (1) | CL2020003002A1 (fr) |
| CO (1) | CO2020014294A2 (fr) |
| CR (2) | CR20200644A (fr) |
| DK (1) | DK3805220T3 (fr) |
| DO (1) | DOP2020000221A (fr) |
| EA (1) | EA202092921A1 (fr) |
| ES (1) | ES2984245T3 (fr) |
| FI (1) | FI3805220T3 (fr) |
| HR (1) | HRP20241221T1 (fr) |
| HU (1) | HUE068170T2 (fr) |
| IL (2) | IL313474A (fr) |
| LT (1) | LT3805220T (fr) |
| MA (1) | MA52795B1 (fr) |
| MD (1) | MD3805220T2 (fr) |
| MX (2) | MX2020012176A (fr) |
| MY (1) | MY198568A (fr) |
| PE (2) | PE20210477A1 (fr) |
| PH (1) | PH12020552000A1 (fr) |
| PL (1) | PL3805220T3 (fr) |
| PT (1) | PT3805220T (fr) |
| RS (1) | RS65891B1 (fr) |
| SG (1) | SG11202011382PA (fr) |
| SI (1) | SI3805220T1 (fr) |
| SM (1) | SMT202400330T1 (fr) |
| UA (1) | UA129229C2 (fr) |
| WO (1) | WO2019230858A1 (fr) |
| ZA (1) | ZA202007567B (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE059677T2 (hu) | 2019-03-22 | 2022-12-28 | Gilead Sciences Inc | Áthidalt triciklusos karbamoilpiridon-vegyületek és ezek gyógyszerészeti alkalmazása |
| JP7776335B2 (ja) * | 2019-11-28 | 2025-11-26 | 塩野義製薬株式会社 | 多環性ピリドピラジン誘導体 |
| US20230059640A1 (en) * | 2019-11-28 | 2023-02-23 | Shionogi & Co., Ltd. | Prophylactic and therapeutic pharmaceutical agent for hiv infectious diseases characterized by comprising combination of integrase inhibitor and anti-hiv agent |
| EP4110783A1 (fr) | 2020-02-24 | 2023-01-04 | Gilead Sciences, Inc. | Composés tétracycliques pour le traitement d'une infection par le vih |
| JP7407976B2 (ja) * | 2020-05-21 | 2024-01-04 | シーセン ファーマシューティカル カンパニー リミテッド | 縮合環誘導体及びその薬学的用途 |
| EP4188379A4 (fr) * | 2020-07-27 | 2024-08-28 | Merck Sharp & Dohme LLC | Inhibiteurs de l'endonucléase dépendante de la coiffe polycycliques pour le traitement ou la prévention de la grippe |
| CA3192145A1 (fr) * | 2020-09-30 | 2022-04-07 | Gilead Sciences, Inc. | Composes de carbamoylpyridone tricyclique pontes et leurs utilisations |
| PE20231297A1 (es) | 2021-01-19 | 2023-08-22 | Gilead Sciences Inc | Compuestos de piridotriazina sustituidos y usos de estos |
| CN117751118A (zh) * | 2021-07-30 | 2024-03-22 | 吉斯凯(苏州)制药有限公司 | 大环吡啶酮类化合物及其应用 |
| TW202446773A (zh) | 2022-04-06 | 2024-12-01 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
| WO2024061257A1 (fr) * | 2022-09-20 | 2024-03-28 | 吉斯凯(苏州)制药有限公司 | Composé cétone n-hétérocyclique polycyclique et son utilisation |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1549315A4 (fr) | 2002-09-11 | 2007-05-23 | Merck & Co Inc | Composes de dihydroxypyridopyrazine-1,6-diones utiles en tant qu'inhibiteurs de l'integrase du vih |
| MXPA05007010A (es) | 2002-12-27 | 2005-08-18 | Angeletti P Ist Richerche Bio | Tetrahidro-4h-pirido[1,2-a]pirimidinas y compuestos relacionados utiles como inhibidores de la integrasa del virus de inmunodeficiencia humana. |
| TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| EP1852434B1 (fr) | 2005-02-21 | 2011-07-13 | Shionogi Co., Ltd. | Dérivé de carbamoylpyridone bicyclique ayant une activité d'inhibition de la vih intégrase |
| LT3372281T (lt) | 2005-04-28 | 2021-12-10 | Viiv Healthcare Company | Policiklinis karbamoilpiridono darinys, turintis živ integrazės inhibitorinį aktyvumą |
| BRPI0617842A2 (pt) | 2005-10-27 | 2011-08-09 | Shionogi & Co | composto ou um sal farmaceuticamente aceitável ou um solvato do mesmo, e, composição farmacêutica |
| US10065950B2 (en) | 2010-02-26 | 2018-09-04 | Japan Tobacco Inc. | Substituted thiazoles as HIV integrase inhibitors |
| JP5766690B2 (ja) | 2010-04-12 | 2015-08-19 | 塩野義製薬株式会社 | インテグラーゼ阻害活性を有するピリドン誘導体 |
| KR20140090197A (ko) | 2011-10-12 | 2014-07-16 | 시오노기세야쿠 가부시키가이샤 | 인터그라아제 억제 활성을 갖는 폴리사이클릭 피리돈 유도체 |
| WO2014099586A1 (fr) | 2012-12-17 | 2014-06-26 | Merck Sharp & Dohme Corp. | Dérivés 4-pyridinonetriazines en tant qu'inhibiteurs de l'intégrase du vih |
| PH12019501848A1 (en) | 2012-12-21 | 2020-03-02 | Gilead Sciences Inc | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| EP2940019B1 (fr) | 2012-12-27 | 2018-03-28 | Japan Tobacco Inc. | DÉRIVÉ SUBSTITUÉ DE SPIROPYRIDO[1,2-a]PYRAZINE ET SON UTILISATION MÉDICALE EN TANT QU'INHIBITEUR D'INTÉGRASE DU VIH |
| EP2997033B1 (fr) | 2013-05-17 | 2017-11-15 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tricycliques fusionnés utiles en tant qu'inhibiteurs de l'intégrase du vih |
| WO2014200880A1 (fr) * | 2013-06-13 | 2014-12-18 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tricycliques fusionnés utiles en tant qu'inhibiteurs de l'intégrase du vih |
| NO2865735T3 (fr) | 2013-07-12 | 2018-07-21 | ||
| WO2015006731A1 (fr) | 2013-07-12 | 2015-01-15 | Gilead Sciences, Inc. | Composés de carbamoylpyridone polycyclique et leur utilisation pour le traitement des infections à vih |
| WO2015039348A1 (fr) | 2013-09-23 | 2015-03-26 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tétracycliques utiles comme inhibiteurs de l'intégrase du vih |
| TN2016000090A1 (en) | 2013-09-27 | 2017-07-05 | Merck Sharp & Dohme | Substituted quinolizine derivatives useful as hiv integrase inhibitors. |
| WO2015089847A1 (fr) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Composés à hétérocycles spirocycliques utiles en tant qu'inhibiteurs d'intégrase du vih |
| WO2015199167A1 (fr) | 2014-06-25 | 2015-12-30 | 日本たばこ産業株式会社 | PROCÉDÉ POUR PRÉPARER UN DÉRIVÉ SUBSTITUÉ DE SPIROPYRIDO[1,2-a]PYRAZINE ET INTERMÉDIAIRE |
| JPWO2016027879A1 (ja) | 2014-08-22 | 2017-06-01 | 塩野義製薬株式会社 | インテグラーゼ阻害活性を有する多環性ピリドン誘導体 |
| WO2016094198A1 (fr) | 2014-12-09 | 2016-06-16 | Merck Sharp & Dohme Corp. | Composés hétérocycliques spirocycliques utiles comme inhibiteurs du vih |
| WO2016090545A1 (fr) | 2014-12-09 | 2016-06-16 | Merck Sharp & Dohme Corp. | Composés hétérocycliques spirocycliques utiles en tant qu'inhibiteurs de l'intégrase du vih |
| TWI695003B (zh) * | 2014-12-23 | 2020-06-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| EP3285582B1 (fr) | 2015-03-26 | 2020-11-11 | Merck Sharp & Dohme Corp. | Dérivés de quinolizine substitués par un phosphate utiles en tant qu'inhibiteurs de l'intégrase du vih |
| BR112017020837A2 (pt) | 2015-04-02 | 2018-07-03 | Gilead Sciences, Inc. | compostos de carbamoilpiridona policíclicos e seu uso farmacêutico |
| WO2016187788A1 (fr) | 2015-05-25 | 2016-12-01 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tricycliques fusionnés utiles pour traiter l'infection au vih |
| EP3377065B1 (fr) | 2015-11-17 | 2022-05-18 | Merck Sharp & Dohme Corp. | Dérivés de pyridotriazine spirocyclique utiles en tant qu'inhibiteurs de l'intégrase du vih |
| US10548910B2 (en) | 2015-11-17 | 2020-02-04 | Merck Sharp & Dohme Corp. | Amido-substituted pyridotriazine derivatives useful as HIV integrase inhibitors |
| WO2017106071A1 (fr) | 2015-12-15 | 2017-06-22 | Merck Sharp & Dohme Corp. | Dérivés de quinolizine spirocycliques utiles en tant qu'inhibiteurs de l'intégrase du vih |
| WO2017113288A1 (fr) | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tricycliques condensés utiles en tant qu'inhibiteurs de l'intégrase du vih |
| EP3548031B1 (fr) | 2016-12-02 | 2023-07-19 | Merck Sharp & Dohme LLC | Composés hétérocycliques tricycliques utiles en tant qu'inhibiteurs de l'intégrase du vih |
| JOP20190130A1 (ar) | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv) |
| WO2019160783A1 (fr) | 2018-02-15 | 2019-08-22 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tricycliques utiles en tant qu'inhibiteurs de l'intégrase du vih |
| EP3784241A4 (fr) | 2018-04-27 | 2022-01-19 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tricycliques utiles en tant qu'inhibiteurs de l'intégrase du vih |
| CN110526930B (zh) | 2018-05-23 | 2022-06-03 | 莫云芬 | 抗hiv病毒的含硫多环-羟基吡啶酮甲酰胺类似物及其应用 |
| US11453669B2 (en) | 2018-05-31 | 2022-09-27 | Shionogi & Co., Ltd. | Polycyclic pyridone derivative |
| WO2019236396A1 (fr) | 2018-06-05 | 2019-12-12 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tricycliques utiles en tant qu'inhibiteurs de l'intégrase du vih |
| CN108957755B (zh) | 2018-07-27 | 2021-04-30 | 京东方科技集团股份有限公司 | 一种显示组件及其控制方法、平视显示器及汽车 |
| HUE059677T2 (hu) | 2019-03-22 | 2022-12-28 | Gilead Sciences Inc | Áthidalt triciklusos karbamoilpiridon-vegyületek és ezek gyógyszerészeti alkalmazása |
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2019
- 2019-05-30 WO PCT/JP2019/021446 patent/WO2019230858A1/fr not_active Ceased
- 2019-05-30 JP JP2020522577A patent/JP7328962B2/ja active Active
- 2019-05-30 IL IL313474A patent/IL313474A/en unknown
- 2019-05-30 ES ES19810498T patent/ES2984245T3/es active Active
- 2019-05-30 MA MA52795A patent/MA52795B1/fr unknown
- 2019-05-30 AU AU2019277548A patent/AU2019277548B2/en active Active
- 2019-05-30 CN CN201980050399.5A patent/CN112513042B/zh active Active
- 2019-05-30 AR ARP190101467A patent/AR115455A1/es unknown
- 2019-05-30 KR KR1020247040377A patent/KR20250002769A/ko active Pending
- 2019-05-30 HR HRP20241221TT patent/HRP20241221T1/hr unknown
- 2019-05-30 RS RS20240971A patent/RS65891B1/sr unknown
- 2019-05-30 MX MX2020012176A patent/MX2020012176A/es unknown
- 2019-05-30 CR CR20200644A patent/CR20200644A/es unknown
- 2019-05-30 SI SI201930798T patent/SI3805220T1/sl unknown
- 2019-05-30 LT LTEPPCT/JP2019/021446T patent/LT3805220T/lt unknown
- 2019-05-30 PE PE2020001863A patent/PE20210477A1/es unknown
- 2019-05-30 PT PT198104986T patent/PT3805220T/pt unknown
- 2019-05-30 EP EP23192706.2A patent/EP4257137A3/fr active Pending
- 2019-05-30 HU HUE19810498A patent/HUE068170T2/hu unknown
- 2019-05-30 BR BR112020024077-0A patent/BR112020024077A2/pt unknown
- 2019-05-30 IL IL279051A patent/IL279051B2/en unknown
- 2019-05-30 MD MDE20210334T patent/MD3805220T2/ro unknown
- 2019-05-30 CN CN202311258763.1A patent/CN117327072A/zh active Pending
- 2019-05-30 SG SG11202011382PA patent/SG11202011382PA/en unknown
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