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MA50912A - Inhibiteurs d'acss2 et leurs procédés d'utilisation - Google Patents

Inhibiteurs d'acss2 et leurs procédés d'utilisation

Info

Publication number
MA50912A
MA50912A MA050912A MA50912A MA50912A MA 50912 A MA50912 A MA 50912A MA 050912 A MA050912 A MA 050912A MA 50912 A MA50912 A MA 50912A MA 50912 A MA50912 A MA 50912A
Authority
MA
Morocco
Prior art keywords
procedures
acss2
inhibitors
acss2 inhibitors
Prior art date
Application number
MA050912A
Other languages
English (en)
Inventor
Simone Botti
Omri Erez
Andreas Goutopoulos
Marc Labelle
Philippe Nakache
Original Assignee
Metabomed Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabomed Ltd filed Critical Metabomed Ltd
Publication of MA50912A publication Critical patent/MA50912A/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • C07D231/26—1-Phenyl-3-methyl-5- pyrazolones, unsubstituted or substituted on the phenyl ring
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
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    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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US12133852B2 (en) 2017-11-15 2024-11-05 Epivario, Inc. ACSS2 inhibitors and methods of use thereof
WO2020069093A1 (fr) * 2018-09-26 2020-04-02 The Trustees Of The University Of Pennsylvania Compositions et méthodes pour inhiber acss2
US11795160B2 (en) 2019-02-22 2023-10-24 Insilico Medicine Ip Limited Kinase inhibitors
CA3136083A1 (fr) * 2019-05-14 2020-11-19 Metabomed Ltd Inhibiteurs d'acss2 et leurs procedes d'utilisation
EP3983391A4 (fr) * 2019-06-12 2023-06-28 The Wistar Institute Inhibiteurs de l'acétyl-coa synthétase 2 (acss2) et leurs procédés d'utilisation
EP3995573A4 (fr) * 2019-07-05 2023-08-16 Si, Longlong Virus ciblé protéolytique, vaccin vivant de celui-ci, procédé de préparation correspondant et son utilisation
EP3766879A1 (fr) * 2019-07-19 2021-01-20 Basf Se Dérivés de pytazole pesticides
PH12022551379A1 (en) 2019-12-06 2023-05-03 Vertex Pharma Substituted tetrahydrofurans as modulators of sodium channels
DK4347031T3 (da) 2021-06-04 2025-12-01 Vertex Pharma N-(hydroxyalkyl-(hetero)aryl)-tetrahydrofuran-carboxamider som modulatorer af natriumkanaler
CN113912596B (zh) * 2021-11-25 2022-12-02 江苏科技大学 一种基于苯并噻唑母体的钯离子检测荧光探针及其制备方法与应用
TW202515873A (zh) * 2023-06-29 2025-04-16 大陸商上海翰森生物醫藥科技有限公司 一種三并環類衍生物抑制劑的晶型及其製備方法
WO2025019604A2 (fr) * 2023-07-18 2025-01-23 The General Hospital Corporation Chimères ciblant la protéolyse pour le traitement de la neurodégénérescence
CN116808042A (zh) * 2023-08-08 2023-09-29 江苏省人民医院（南京医科大学第一附属医院） 乙酰辅酶a合成酶2抑制剂在治疗胰腺神经内分泌肿瘤中的应用

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US3905997A (en) * 1974-06-21 1975-09-16 Warner Lambert Co 3-Aryl-5-oxo-2-pyrazoline-4-carboxanilides and process therefor
US4134987A (en) * 1976-01-14 1979-01-16 Huppatz John L Compounds and compositions
US4207317A (en) * 1978-03-13 1980-06-10 Ciba-Geigy Corporation 1-Aryl-4-carbamoyl-pyrazolin-5-ones
JPH11291635A (ja) * 1998-04-06 1999-10-26 Mitsubishi Paper Mills Ltd 感熱記録材料
AR034897A1 (es) 2001-08-07 2004-03-24 Hoffmann La Roche Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos
CA2465978C (fr) 2001-09-14 2015-04-07 Soon Hyung Woo Inhibiteurs de l'histone-deacetylase
WO2007026215A1 (fr) 2005-08-29 2007-03-08 Glenmark Pharmaceuticals S.A. Dérivés de pyrazole tels que les ligands du récepteur de cannabinoïde, compositions pharmaceutiques les contenant et procédés pour leur préparation
WO2008121861A2 (fr) * 2007-03-28 2008-10-09 Xenon Pharmaceuticals Inc. Composés à base de pyrazole et de pyrrole utiles dans le traitement de troubles du métabolisme du fer
JP2013526540A (ja) 2010-05-12 2013-06-24 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｒキナーゼ阻害剤として有用な化合物
WO2013159224A1 (fr) * 2012-04-25 2013-10-31 University Of Manitoba Dérivés 2-carbamo(thio)yl-1,3-dioxopropylés en thérapie du cancer
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BR112020009729A2 (pt) 2020-11-03
EP3710430A1 (fr) 2020-09-23
EP3710430A4 (fr) 2021-06-23
US20190263758A1 (en) 2019-08-29
US10851064B2 (en) 2020-12-01
WO2019097515A1 (fr) 2019-05-23
JP2021503013A (ja) 2021-02-04
CN111566092A (zh) 2020-08-21
EP3710430B9 (fr) 2024-10-30
SG11202004318PA (en) 2020-06-29
JP7217752B2 (ja) 2023-02-03
IL274504B2 (en) 2024-12-01
EP3710430B1 (fr) 2024-07-03
IL274504B1 (en) 2024-08-01
KR20200089291A (ko) 2020-07-24
AU2018370096A1 (en) 2020-06-11
IL274504A (en) 2020-06-30
CA3080675A1 (fr) 2019-05-23
CN111566092B (zh) 2025-02-25
MX2020004994A (es) 2020-10-12

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