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MA43821A - Pyrimidines et variantes de celles-ci, et leurs utilisations - Google Patents

Pyrimidines et variantes de celles-ci, et leurs utilisations

Info

Publication number
MA43821A
MA43821A MA043821A MA43821A MA43821A MA 43821 A MA43821 A MA 43821A MA 043821 A MA043821 A MA 043821A MA 43821 A MA43821 A MA 43821A MA 43821 A MA43821 A MA 43821A
Authority
MA
Morocco
Prior art keywords
pyrimidins
variants
Prior art date
Application number
MA043821A
Other languages
English (en)
Inventor
Anthony P Ford
Joel R Gever
Ronald Charles Hawley
Prabha Ibrahim
Original Assignee
Afferent Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Afferent Pharmaceuticals Inc filed Critical Afferent Pharmaceuticals Inc
Publication of MA43821A publication Critical patent/MA43821A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Otolaryngology (AREA)
MA043821A 2016-03-14 2017-03-09 Pyrimidines et variantes de celles-ci, et leurs utilisations MA43821A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662308157P 2016-03-14 2016-03-14
US201662363630P 2016-07-18 2016-07-18

Publications (1)

Publication Number Publication Date
MA43821A true MA43821A (fr) 2018-11-28

Family

ID=59850807

Family Applications (1)

Application Number Title Priority Date Filing Date
MA043821A MA43821A (fr) 2016-03-14 2017-03-09 Pyrimidines et variantes de celles-ci, et leurs utilisations

Country Status (11)

Country Link
US (1) US10822311B2 (fr)
EP (1) EP3430000B1 (fr)
JP (1) JP6968810B2 (fr)
KR (2) KR20180122406A (fr)
CN (1) CN108834412B (fr)
AU (1) AU2017233841B9 (fr)
CA (1) CA3016773A1 (fr)
MA (1) MA43821A (fr)
MX (1) MX390482B (fr)
RU (1) RU2761439C2 (fr)
WO (1) WO2017160569A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017233841B9 (en) 2016-03-14 2021-09-09 Afferent Pharmaceuticals Inc. Pyrimidines and variants thereof, and uses therefor
KR102377805B1 (ko) 2016-03-25 2022-03-22 애퍼런트 파마슈티컬스 인크. 피리미딘 및 그의 변이체, 및 그의 용도
AU2017378785B2 (en) * 2016-12-20 2021-07-29 Afferent Pharmaceuticals, Inc. Crystalline salts and polymorphs of a P2X3 antagonist
AU2018246806B2 (en) 2017-03-29 2022-05-12 Ligachem Biosciences Inc. Pyrrolobenzodiazepine dimer precursor and ligand-linker conjugate compound thereof
CN107540699A (zh) * 2017-10-16 2018-01-05 康化（上海）新药研发有限公司 一种2‑氨基‑3‑氟吡啶‑4‑硼酸盐酸盐的合成方法
EP3846794A4 (fr) * 2018-09-06 2022-06-22 Monash University Méthode de traitement d'un trouble respiratoire du sommeil
AU2019358327B2 (en) * 2018-10-10 2025-04-24 Glaxosmithkline Intellectual Property (No. 3) Limited Treatment of pruritus with P2X3 antagonists
WO2020141923A2 (fr) 2019-01-03 2020-07-09 주식회사 레고켐 바이오사이언스 Composé dimère de pyrrolobenzodiazépine présentant une sécurité améliorée et son utilisation
KR20200084802A (ko) 2019-01-03 2020-07-13 주식회사 레고켐 바이오사이언스 안전성이 향상된 피롤로벤조디아제핀 이량체 화합물 및 이의 용도
WO2020174283A1 (fr) 2019-02-25 2020-09-03 Bellus Health Cough Inc. Traitement avec des modulateurs de p2x3
CN114007620B (zh) * 2019-04-30 2024-08-06 北京泰德制药股份有限公司 二氨基嘧啶类化合物治疗子宫内膜异位相关的疼痛的方法
WO2020221276A1 (fr) * 2019-04-30 2020-11-05 北京泰德制药股份有限公司 Sel d'un composé diaminopyrimidine, forme solide de celui-ci, procédé de préparation correspondant et utilisation associée
MX2021013300A (es) * 2019-04-30 2022-02-11 Beijing Tide Pharmaceutical Co Ltd Forma sólida de un compuesto de diaminopirimidina o un hidrato del mismo, método de preparación del mismo, y aplicación del mismo.
CN114007619B (zh) * 2019-04-30 2024-08-06 北京泰德制药股份有限公司 二氨基嘧啶类化合物治疗咳嗽的方法
WO2020244607A1 (fr) * 2019-06-06 2020-12-10 北京泰德制药股份有限公司 Antagoniste du récepteur p2x3 et/ou p2x2/3, composition pharmaceutique le contenant et son utilisation
GB202006382D0 (en) 2020-04-30 2020-06-17 Spermatech As Use

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2953567A (en) * 1956-11-23 1960-09-20 Burroughs Wellcome Co 5-phenylmercaptopyrimidines and method
CA2369945A1 (fr) * 1999-04-06 2000-10-12 James L. Kelley Thiopyrimidines neurotrophiques substitues
ATE354573T1 (de) 2000-12-21 2007-03-15 Vertex Pharma ßPYRAZOLVERBINDUNGEN, DIE SICH ALS PROTEINKINASEINHIBITOREN EIGNENß
BR122018003623B8 (pt) 2004-03-05 2021-07-27 Hoffmann La Roche diaminopirimidinas, seus usos, e composição farmacêutica
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BR112018068399A2 (pt) 2019-01-15
WO2017160569A1 (fr) 2017-09-21
KR102489454B1 (ko) 2023-01-17
KR20210144941A (ko) 2021-11-30
US10822311B2 (en) 2020-11-03
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EP3430000B1 (fr) 2022-12-28
CN108834412B (zh) 2022-11-25
MX390482B (es) 2025-03-11
CA3016773A1 (fr) 2017-09-21
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RU2018134945A3 (fr) 2020-05-19
MX2018011136A (es) 2019-01-14
RU2761439C2 (ru) 2021-12-08
US20190389811A1 (en) 2019-12-26
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JP6968810B2 (ja) 2021-11-17
EP3430000A1 (fr) 2019-01-23
AU2017233841B9 (en) 2021-09-09
AU2017233841A1 (en) 2018-09-06

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