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MA35062B1 - Dérivés d'amines hétérocycliques - Google Patents

Dérivés d'amines hétérocycliques

Info

Publication number
MA35062B1
MA35062B1 MA36362A MA36362A MA35062B1 MA 35062 B1 MA35062 B1 MA 35062B1 MA 36362 A MA36362 A MA 36362A MA 36362 A MA36362 A MA 36362A MA 35062 B1 MA35062 B1 MA 35062B1
Authority
MA
Morocco
Prior art keywords
group
disorders
atom
compounds
halogen
Prior art date
Application number
MA36362A
Other languages
English (en)
Inventor
Guido Galley
Roger Norcross
Philippe Pflieger
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45855803&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA35062(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA35062B1 publication Critical patent/MA35062B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE DES COMPOSÉS DE FORMULE (I), DANS LAQUELLE R1 REPRÉSENTE UN ATOME D'HYDROGÈNE, UN GROUPE ALKYLE INFÉRIEUR, UN ATOME D'HALOGÈNE, UN GROUPE ALKYLE INFÉRIEUR SUBSTITUÉ PAR UN ATOME D'HALOGÈNE, UN GROUPE ALCOXY INFÉRIEUR, UN GROUPE ALCOXY INFÉRIEUR SUBSTITUÉ PAR UN ATOME D'HALOGÈNE, UN GROUPE CYANO, NITRO, CYCLOALKYLE EN C3 À C6, -CH2-CYCLOALKYLE EN C3 À C6, -O-CH2-CYCLOALKYLE EN C3 À C6, -O-(CH2)2-O-ALKYLE INFÉRIEUR, S(O)2CH3, SF5, -C(O)NH-ALKYLE INFÉRIEUR, PHÉNYLE, -O-PYRIMIDINYLE, ÉVENTUELLEMENT SUBSTITUÉ PAR UN ALCOXY INFÉRIEUR SUBSTITUÉ PAR UN HALOGÈNE, OU UN GROUPE BENZYLE, OXÉTANYLE OU FURANYLE; M AR REPRÉSENTE UN GROUPE ARYLE OU HÉTÉROARYLE, CHOISI DANS LE GROUPE CONSTITUÉ DU PHÉNYLE, DU NAPHTYLE, DU PYRIMIDINYLE, DU PYRIDINYLE, DU BENZOTHIAZOLYLE, DU QUINOLINYLE, DU QUINAZOLINYLE, DU BENZO[D][1.3]DIOXOLYLE, DU 5,6,7,8- TÉTRAHYDRO-QUINAZOLINYLE, DU PYRAZOLYLE, DU PYRAZINYLE, DU PYRIDAZINYLE OU DU 1,3,4-OXADIAZOLYLE; Y REPRÉSENTE UNE LIAISON, -CH2-, -CH2CH2-, -CH(CF3)- OU -CH(CH3)-; R2 REPRÉSENTE UN ATOME D'HYDROGÈNE OU UN ALKYLE INFÉRIEUR; A REPRÉSENTE CR OU N; ET R REPRÉSENTE UN ATOME D'HYDROGÈNE, UN GROUPE CYANO, UN ATOME D'HALOGÈNE OU UN ALKYLE INFÉRIEUR; R' REPRÉSENTE UN ATOME D'HYDROGÈNE OU D'HALOGÈNE; SOUS RÉSERVE QUE LORSQUE R' REPRÉSENTE UN ATOME D'HALOGÈNE, ALORS A REPRÉSENTE CH; B REPRÉSENTE CH OU N; N EST ÉGAL À 0, 1 OU 2; X REPRÉSENTE UNE LIAISON, -CH2- OU -O-. L'INVENTION CONCERNE ÉGALEMENT DES SELS D'ADDITION ACIDES PHARMACEUTIQUEMENT ACTIFS DESDITS COMPOSÉS. ON S'EST APERÇU QUE LES COMPOSÉS DE FORMULE I PRÉSENTENT UNE BONNE AFFINITÉ POUR LES RÉCEPTEURS TAAR (RÉCEPTEURS ASSOCIÉS AUX AMINES À L'ÉTAT DE TRACE), ET NOTAMMENT POUR TAAR1. LESDITS COMPOSÉS PEUVENT ÊTRE UTILISÉS EN VUE DU TRAITEMENT DE LA DÉPRESSION, DES TROUBLES ANXIEUX, DU TROUBLE BIPOLAIRE, DU TROUBLE DE L'HYPERACTIVITÉ AVEC DÉFICIT DE L'ATTENTION (THADA), DES TROUBLES DUS AU STRESS, DES PSYCHOSES TELLES QUE LA SCHIZOPHRÉNIE, DES MALADIES NEUROLOGIQUES COMME LA MALADIE DE PARKINSON, DES AFFECTIONS NEURODÉGÉNÉRATIVES COMME LA MALADIE D'ALZHEIMER, DE L'ÉPILEPSIE, DE LA MIGRAINE, DE L'HYPERTENSION, DE L'ABUS DE SUBSTANCES PSYCHOACTIVES ET D'AFFECTIONS MÉTABOLIQUES COMME LES TROUBLES DE L'ALIMENTATION, LE DIABÈTE, LES COMPLICATIONS DU DIABÈTE, L'OBÉSITÉ, LA DYSLIPIDÉMIE, LES TROUBLES DE LA CONSOMMATION ET DE L'ASSIMILATION D'ÉNERGIE, LES TROUBLES ET LE DYSFONCTIONNEMENT DE L'HOMÉOSTASIE DE LA TEMPÉRATURE CORPORELLE, LES TROUBLES DU SOMMEIL ET DU RYTHME CIRCADIEN, AINSI QUE LES AFFECTIONS CARDIOVASCULAIRES.
MA36362A 2011-03-24 2012-03-21 Dérivés d'amines hétérocycliques MA35062B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11159566 2011-03-24
PCT/EP2012/054939 WO2012126922A1 (fr) 2011-03-24 2012-03-21 Dérivés d'amines hétérocycliques

Publications (1)

Publication Number Publication Date
MA35062B1 true MA35062B1 (fr) 2014-04-03

Family

ID=45855803

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36362A MA35062B1 (fr) 2011-03-24 2012-03-21 Dérivés d'amines hétérocycliques

Country Status (23)

Country Link
US (1) US8802673B2 (fr)
EP (1) EP2688870B1 (fr)
JP (1) JP5716128B2 (fr)
KR (1) KR101518660B1 (fr)
CN (1) CN103443074B (fr)
AR (1) AR085478A1 (fr)
AU (1) AU2012230378B2 (fr)
BR (1) BR112013024312A2 (fr)
CA (1) CA2828283A1 (fr)
CL (1) CL2013002664A1 (fr)
CO (1) CO6801736A2 (fr)
CR (1) CR20130419A (fr)
EA (1) EA023237B1 (fr)
EC (1) ECSP13012896A (fr)
IL (1) IL228246A (fr)
MA (1) MA35062B1 (fr)
MX (1) MX351918B (fr)
PE (1) PE20140425A1 (fr)
PH (1) PH12013501905A1 (fr)
SG (1) SG193556A1 (fr)
UA (1) UA113167C2 (fr)
WO (1) WO2012126922A1 (fr)
ZA (1) ZA201306757B (fr)

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WO2022053541A1 (fr) * 2020-09-10 2022-03-17 Eracal Therapeutics Ltd. Composés à utiliser comme anorexigène
AR129909A1 (es) 2022-07-15 2024-10-09 Hoffmann La Roche Cetorreductasa mutante con mayor actividad de cetorreductasa así como métodos y usos de esta

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Also Published As

Publication number Publication date
AR085478A1 (es) 2013-10-02
KR101518660B1 (ko) 2015-05-07
IL228246A (en) 2017-10-31
CR20130419A (es) 2013-10-09
PH12013501905A1 (en) 2019-10-11
US8802673B2 (en) 2014-08-12
US20120245172A1 (en) 2012-09-27
KR20130132656A (ko) 2013-12-04
BR112013024312A2 (pt) 2016-07-19
EP2688870A1 (fr) 2014-01-29
UA113167C2 (xx) 2016-12-26
CL2013002664A1 (es) 2014-05-09
ZA201306757B (en) 2015-04-29
CN103443074A (zh) 2013-12-11
ECSP13012896A (es) 2013-11-29
EA201391341A1 (ru) 2014-06-30
JP2014508790A (ja) 2014-04-10
EP2688870B1 (fr) 2017-02-01
CA2828283A1 (fr) 2012-09-27
MX2013010954A (es) 2013-10-07
NZ616150A (en) 2014-09-26
CN103443074B (zh) 2016-04-13
MX351918B (es) 2017-11-03
CO6801736A2 (es) 2013-11-29
JP5716128B2 (ja) 2015-05-13
AU2012230378A1 (en) 2013-09-12
HK1190703A1 (zh) 2014-07-11
SG193556A1 (en) 2013-11-29
AU2012230378B2 (en) 2016-09-15
EA023237B1 (ru) 2016-05-31
PE20140425A1 (es) 2014-03-28
WO2012126922A1 (fr) 2012-09-27

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