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MX2009005920A - Nuevos 2-imidazoles como ligandos para receptores asociados con trazas de amina. - Google Patents

Nuevos 2-imidazoles como ligandos para receptores asociados con trazas de amina.

Info

Publication number
MX2009005920A
MX2009005920A MX2009005920A MX2009005920A MX2009005920A MX 2009005920 A MX2009005920 A MX 2009005920A MX 2009005920 A MX2009005920 A MX 2009005920A MX 2009005920 A MX2009005920 A MX 2009005920A MX 2009005920 A MX2009005920 A MX 2009005920A
Authority
MX
Mexico
Prior art keywords
disorders
sup
lower alkyl
compounds
halogen
Prior art date
Application number
MX2009005920A
Other languages
English (en)
Inventor
Guido Galley
Henri Stalder
Katrin Groebke Zbinden
Roger Norcross
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38895831&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009005920(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009005920A publication Critical patent/MX2009005920A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/06—Antihyperlipidemics
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a compuestos de la fórmula (I) en donde X-R1 es -CH2- y 2Y-R es -CH(alcoxi inferior)-, -CH(alquilo inferior)-, -O-, -S-, -S(O)-, S(O)2- o -CH2-; o X-R1 es -NH- y Y-R2 es -CH(alquilo inferior)- o -CH2-; Ar es fenilo o naftilo, los anillos están opcionalmente sustituidos por uno o dos sustituyentes, seleccionados del grupo que consiste de halógeno, alcoxi inferior, alquilo inferior y por alquilo inferior sustituido por halógeno; y a sales de adición de ácido farmacéuticamente aceptables. Se ha encontrado que los compuestos de la fórmula I tienen buena afinidad con los receptores asociados a las trazas de aminas (TAAR), en especial el TAAR1. Los compuestos pueden utilizarse para el tratamiento de depresión, trastornos de ansiedad, trastorno bipolar, trastorno de hiperactividad con déficit de atención (ADHD), trastornos relacionados con el estrés, trastornos psicóticos como la esquizofrenia, enfermedades neurológicas como enfermedad de Parkinson, trastornos neurodegenerativos como enfermedad de Alzheimer, epilepsia, migraña, hipertensión, abuso de sustancias y trastornos metabólicos como trastornos alimenticios, diabetes, complicaciones diabéticas, obesidad, dislipidemia, trastornos de consumo y asimilación de energía, trastornos y malfuncionamiento de la temperatura corporal, homeostasis, trastornos del sueño y ritmo circadiano y trastornos cardiovasculares.
MX2009005920A 2006-12-13 2007-12-03 Nuevos 2-imidazoles como ligandos para receptores asociados con trazas de amina. MX2009005920A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06126005 2006-12-13
PCT/EP2007/063153 WO2008071574A1 (en) 2006-12-13 2007-12-03 Novel 2 -imidazoles as ligands for trace amine associated receptors (taar)

Publications (1)

Publication Number Publication Date
MX2009005920A true MX2009005920A (es) 2009-06-16

Family

ID=38895831

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005920A MX2009005920A (es) 2006-12-13 2007-12-03 Nuevos 2-imidazoles como ligandos para receptores asociados con trazas de amina.

Country Status (16)

Country Link
US (1) US7858653B2 (es)
EP (1) EP2101762B1 (es)
JP (1) JP2010513238A (es)
KR (1) KR101189348B1 (es)
CN (1) CN101557810B (es)
AR (1) AR064222A1 (es)
AT (1) ATE509628T1 (es)
AU (1) AU2007332641A1 (es)
BR (1) BRPI0720047A2 (es)
CA (1) CA2672617A1 (es)
CL (1) CL2007003566A1 (es)
ES (1) ES2364701T3 (es)
MX (1) MX2009005920A (es)
PE (1) PE20081479A1 (es)
TW (1) TW200831468A (es)
WO (1) WO2008071574A1 (es)

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CL2007003566A1 (es) 2008-07-04
EP2101762B1 (en) 2011-05-18
ES2364701T3 (es) 2011-09-12
TW200831468A (en) 2008-08-01
AR064222A1 (es) 2009-03-18
ATE509628T1 (de) 2011-06-15
KR101189348B1 (ko) 2012-10-09
JP2010513238A (ja) 2010-04-30
KR20090089464A (ko) 2009-08-21
AU2007332641A1 (en) 2008-06-19
US7858653B2 (en) 2010-12-28
CA2672617A1 (en) 2008-06-19
CN101557810A (zh) 2009-10-14
EP2101762A1 (en) 2009-09-23
US20080146634A1 (en) 2008-06-19
WO2008071574A1 (en) 2008-06-19
BRPI0720047A2 (pt) 2013-12-24
PE20081479A1 (es) 2008-10-18
CN101557810B (zh) 2012-11-21

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