MA35451B1 - Dérivés de pyrrolopyrimidine et de purine - Google Patents
Dérivés de pyrrolopyrimidine et de purineInfo
- Publication number
- MA35451B1 MA35451B1 MA36848A MA36848A MA35451B1 MA 35451 B1 MA35451 B1 MA 35451B1 MA 36848 A MA36848 A MA 36848A MA 36848 A MA36848 A MA 36848A MA 35451 B1 MA35451 B1 MA 35451B1
- Authority
- MA
- Morocco
- Prior art keywords
- pyrrolopyrimidine
- purine derivatives
- formula
- purine
- derivatives
- Prior art date
Links
- KDOPAZIWBAHVJB-UHFFFAOYSA-N 5h-pyrrolo[3,2-d]pyrimidine Chemical compound C1=NC=C2NC=CC2=N1 KDOPAZIWBAHVJB-UHFFFAOYSA-N 0.000 title 1
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
L'invention concerne des composés représentés par la formule (i) ou des sels pharmaceutiquement acceptables de ces composés. Dans la formule, q, t, v, w, x, y, z, le cycle a, r
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161538103P | 2011-09-22 | 2011-09-22 | |
| US201261639639P | 2012-04-27 | 2012-04-27 | |
| PCT/IB2012/054702 WO2013042006A1 (fr) | 2011-09-22 | 2012-09-10 | Dérivés de pyrrolopyrimidine et de purine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA35451B1 true MA35451B1 (fr) | 2014-09-01 |
Family
ID=47116127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA36848A MA35451B1 (fr) | 2011-09-22 | 2014-03-21 | Dérivés de pyrrolopyrimidine et de purine |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US9040547B2 (fr) |
| EP (1) | EP2758402B9 (fr) |
| JP (1) | JP5914667B2 (fr) |
| KR (1) | KR20140059246A (fr) |
| CN (1) | CN103814030A (fr) |
| AP (1) | AP2014007475A0 (fr) |
| AR (1) | AR088760A1 (fr) |
| AU (1) | AU2012311184A1 (fr) |
| BR (1) | BR112014006840A2 (fr) |
| CA (1) | CA2847540C (fr) |
| CL (2) | CL2014002726A1 (fr) |
| CO (1) | CO6910196A2 (fr) |
| CR (1) | CR20140132A (fr) |
| DO (1) | DOP2014000055A (fr) |
| EA (1) | EA201490673A1 (fr) |
| ES (1) | ES2575710T3 (fr) |
| IL (1) | IL231592A0 (fr) |
| MA (1) | MA35451B1 (fr) |
| MD (1) | MD20140023A2 (fr) |
| MX (1) | MX2014003501A (fr) |
| NI (1) | NI201400023A (fr) |
| PE (1) | PE20141228A1 (fr) |
| PH (1) | PH12014500638A1 (fr) |
| SG (1) | SG2014014450A (fr) |
| TN (1) | TN2014000115A1 (fr) |
| TW (1) | TWI492946B (fr) |
| UA (1) | UA110259C2 (fr) |
| UY (1) | UY34342A (fr) |
| WO (1) | WO2013042006A1 (fr) |
Families Citing this family (55)
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| PL2300013T5 (pl) | 2008-05-21 | 2025-04-28 | Takeda Pharmaceutical Company Limited | Pochodne fosforu jako inhibitor kinazy |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| EP2571361A4 (fr) | 2010-05-19 | 2013-11-13 | Univ North Carolina | Composés de pyrazolopyrimidine pour le traitement du cancer |
| LT2585470T (lt) * | 2010-06-23 | 2017-04-10 | Hanmi Science Co., Ltd. | Nauji kondensuoti pirimidino dariniai tirozino kinazės aktyvumo slopinimui |
| EP2704572B1 (fr) | 2011-05-04 | 2015-12-30 | Ariad Pharmaceuticals, Inc. | Composés permettant d'inhiber la prolifération cellulaire dans les cancers induits par l'egfr |
| KR102063098B1 (ko) | 2011-10-03 | 2020-01-08 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 암 치료를 위한 피롤로피리미딘 화합물 |
| JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Egfr発動性がんの細胞増殖阻害用化合物 |
| CN104302627A (zh) | 2012-05-22 | 2015-01-21 | 北卡罗来纳大学教堂山分校 | 用于治疗癌症的嘧啶化合物 |
| WO2014062774A1 (fr) | 2012-10-17 | 2014-04-24 | The University Of North Carolina At Chapel Hill | Composés pyrazolopyrimidines pour le traitement du cancer |
| EP2925752A4 (fr) | 2012-11-27 | 2016-06-01 | Univ North Carolina | Composés à base de pyrimidine utilisables à des fins de traitement du cancer |
| US9346812B2 (en) | 2013-01-16 | 2016-05-24 | Signal Pharmaceuticals, Llc | Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith |
| BR112015023020A2 (pt) * | 2013-03-14 | 2017-07-18 | Pfizer | combinação de inibidor de egfr t790m e inibidor de egfr para o tratamento de câncer pulmonar de células não-pequenas |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| KR101657616B1 (ko) * | 2013-05-24 | 2016-09-19 | 주식회사유한양행 | 피리미딘 고리를 포함하는 바이사이클릭 유도체 및 그의 제조방법 |
| CA2924362C (fr) * | 2013-09-18 | 2018-12-18 | Beijing Hanmi Pharmaceutical Co., Ltd. | Compose inhibiteur d'activites de kinase de btk et/ou de jak3 |
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| UA115388C2 (uk) * | 2013-11-21 | 2017-10-25 | Пфайзер Інк. | 2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань |
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| US9815841B2 (en) | 2014-01-29 | 2017-11-14 | Glaxosmithkline Intellectual Property Development Limited | Compounds |
| CN106458914B (zh) * | 2014-03-28 | 2020-01-14 | 常州捷凯医药科技有限公司 | 作为axl抑制剂的杂环化合物 |
| WO2015157123A1 (fr) | 2014-04-11 | 2015-10-15 | The University Of North Carolina At Chapel Hill | Composés de pyrrolopyrimidine spécifiques de mertk |
| JP6427599B2 (ja) * | 2014-05-19 | 2018-11-21 | チャンスー ヘンルイ メディシン カンパニー,リミテッド | チロシンキナーゼ阻害剤としての置換エチニルヘテロ二環式化合物 |
| NZ629796A (en) * | 2014-07-14 | 2015-12-24 | Signal Pharm Llc | Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use |
| WO2016010886A1 (fr) | 2014-07-14 | 2016-01-21 | Signal Pharmaceuticals, Llc | Méthodes de traitement d'un cancer à l'aide de composés de pyrrolopyrimidine substitués, compositions de ceux-ci |
| CN105524068B (zh) | 2014-09-30 | 2017-11-24 | 上海海雁医药科技有限公司 | 氮杂双环衍生物、其制法与医药上的用途 |
| CN105085489B (zh) | 2014-11-05 | 2019-03-01 | 益方生物科技(上海)有限公司 | 嘧啶或吡啶类化合物、其制备方法和医药用途 |
| US10870651B2 (en) | 2014-12-23 | 2020-12-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
| HK1244278B (zh) | 2015-03-20 | 2020-04-17 | 正大天晴药业集团股份有限公司 | 喹唑啉衍生物的盐及其制备方法 |
| AU2016243529B2 (en) * | 2015-03-27 | 2021-03-25 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
| CN106236060B (zh) | 2015-06-04 | 2021-04-09 | 松下知识产权经营株式会社 | 生物体信息检测装置 |
| WO2017087905A1 (fr) * | 2015-11-20 | 2017-05-26 | Denali Therapeutics Inc. | Composés, compositions, et procédés |
| CN108495563B (zh) * | 2015-11-25 | 2022-04-26 | R.J.雷诺兹烟草公司 | 烟碱盐、共晶体和盐共晶体配合物 |
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| US10709708B2 (en) | 2016-03-17 | 2020-07-14 | The University Of North Carolina At Chapel Hill | Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor |
| CN109311857B (zh) | 2016-06-16 | 2021-11-12 | 戴纳立制药公司 | 作为用于治疗神经退化性病症的lrrk2抑制剂的嘧啶-2-基氨基-1h-吡唑 |
| CN114795151A (zh) | 2016-06-30 | 2022-07-29 | 松下知识产权经营株式会社 | 方法及系统 |
| EP3587422A4 (fr) * | 2017-02-22 | 2020-05-06 | Daegu-Gyeongbuk Medical Innovation Foundation | Composé dérivé de pyrrolo-pyrimidine, son procédé de préparation, et composition pharmaceutique comprenant ledit composé en tant que principe actif pour la prévention ou le traitement d'une maladie liée à la protéine kinase |
| KR102398659B1 (ko) * | 2017-03-17 | 2022-05-16 | 주식회사 대웅제약 | 카이네이즈 저해제로서의 피롤로트리아진 유도체 |
| US10807951B2 (en) | 2017-10-13 | 2020-10-20 | The Regents Of The University Of California | mTORC1 modulators |
| CA3083583A1 (fr) * | 2017-12-05 | 2019-06-13 | Oscotec Inc. | Derive de pyrrolo(pyrazolo)pyrimidine utilise en tant qu'inhibiteur de lrrk2 |
| MX2020006799A (es) | 2017-12-28 | 2020-09-03 | Daewoong Pharmaceutical Co Ltd | Derivados de oxi-fluoropiperidina como inhibidor de cinasa. |
| KR102577241B1 (ko) * | 2017-12-28 | 2023-09-11 | 주식회사 대웅제약 | 카이네이즈 저해제로서의 아미노-플루오로피페리딘 유도체 |
| KR102577242B1 (ko) * | 2017-12-28 | 2023-09-11 | 주식회사 대웅제약 | 카이네이즈 저해제로서의 아미노-메틸피페리딘 유도체 |
| AU2019295632B2 (en) | 2018-06-25 | 2025-03-06 | Dana-Farber Cancer Institute, Inc. | Taire family kinase inhibitors and uses thereof |
| KR102377007B1 (ko) * | 2018-09-20 | 2022-03-22 | 한미약품 주식회사 | 상피세포 성장인자 수용체 돌연변이 저해 효과를 갖는 신규 융합 피리미딘 골격 설폰아마이드 유도체 |
| EP3842435A4 (fr) * | 2018-09-20 | 2022-05-11 | Hanmi Pharm. Co., Ltd. | Nouveau dérivé de sulfonamide présentant un squelette de pyrimidine fusionné, ayant un effet inhibiteur de mutation du récepteur du facteur de croissance épidermique |
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| TW202214643A (zh) * | 2020-09-22 | 2022-04-16 | 大陸商江蘇先聲藥業有限公司 | 嘧啶并吡咯類化合物 |
| CN114315838B (zh) * | 2020-09-30 | 2024-09-03 | 江苏先声药业有限公司 | 嘧啶并吡咯类化合物 |
| CN114907357A (zh) * | 2021-02-07 | 2022-08-16 | 江苏先声药业有限公司 | 嘧啶并吡咯类化合物 |
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- 2012-09-10 KR KR20147007254A patent/KR20140059246A/ko not_active Ceased
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- 2012-09-10 JP JP2014531341A patent/JP5914667B2/ja active Active
- 2012-09-10 SG SG2014014450A patent/SG2014014450A/en unknown
- 2012-09-10 EP EP12780286.6A patent/EP2758402B9/fr active Active
- 2012-09-10 CA CA2847540A patent/CA2847540C/fr not_active Expired - Fee Related
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- 2012-09-10 ES ES12780286.6T patent/ES2575710T3/es active Active
- 2012-09-10 WO PCT/IB2012/054702 patent/WO2013042006A1/fr not_active Ceased
- 2012-09-10 AU AU2012311184A patent/AU2012311184A1/en not_active Abandoned
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