MA24078A1 - Procede pour l'utilisation de derives de tetrahydroisoquinoleine - Google Patents

Procede pour l'utilisation de derives de tetrahydroisoquinoleine

Info

Publication number: MA24078A1
Authority: MA; Morocco
Prior art keywords: tetrahydroisoquinolein; derivatives; tetrahydroisoquinolein derivatives
Prior art date: 1996-02-03

Application number

MA24483A

Other languages

English (en)

Inventor

Alanine Alexander

Butelmann Bernd

Mutel Vincent

Bourson Anne

Fischer Gunther

Paul Heltz Neidhart Marie

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-03

Filing date

1997-02-03

Publication date

1997-10-01

1997-02-03 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1997-10-01 Publication of MA24078A1 publication Critical patent/MA24078A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C07D221/12—Phenanthridines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Anesthesiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

MA24483A 1996-02-03 1997-02-03 Procede pour l'utilisation de derives de tetrahydroisoquinoleine MA24078A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP96101553		1996-02-03

Publications (1)

Publication Number	Publication Date
MA24078A1 true MA24078A1 (fr)	1997-10-01

Family

ID=8222462

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA24483A MA24078A1 (fr)	1996-02-03	1997-02-03	Procede pour l'utilisation de derives de tetrahydroisoquinoleine

Country Status (29)

Country	Link
US (2)	US5952344A (fr)
JP (1)	JP3217290B2 (fr)
KR (1)	KR100229298B1 (fr)
CN (1)	CN1167762A (fr)
AR (1)	AR005613A1 (fr)
AU (1)	AU723586B2 (fr)
BR (1)	BR9700816A (fr)
CA (1)	CA2196392A1 (fr)
CO (1)	CO4761069A1 (fr)
CZ (1)	CZ29497A3 (fr)
DE (1)	DE19703985A1 (fr)
ES (1)	ES2124672B1 (fr)
FR (1)	FR2744447B1 (fr)
GB (1)	GB2309642A (fr)
HR (1)	HRP970060A2 (fr)
HU (1)	HUP9700273A1 (fr)
ID (1)	ID15866A (fr)
IL (1)	IL120100A (fr)
IT (1)	IT1289621B1 (fr)
MA (1)	MA24078A1 (fr)
NO (1)	NO970431L (fr)
NZ (1)	NZ314130A (fr)
PE (1)	PE35698A1 (fr)
PL (1)	PL318256A1 (fr)
SG (1)	SG55273A1 (fr)
TR (1)	TR199700071A2 (fr)
TW (1)	TW427978B (fr)
YU (1)	YU3997A (fr)
ZA (1)	ZA97672B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2002250256B2 (en) *	2001-03-08	2008-04-03	Emory University	pH-dependent NMDA receptor antagonists
KR20100045983A (ko) *	2007-06-29	2010-05-04	에모리 유니버시티	신경보호를 위한 ｎｍｄａ 수용체 길항물질
JP2012158527A (ja) *	2011-01-31	2012-08-23	Mitsubishi Gas Chemical Co Inc	うつ予防
WO2025124571A1 (fr) *	2023-12-14	2025-06-19	斯莱普泰(上海)生物医药科技有限公司	Antagoniste du récepteur de nmda et son utilisation

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3217007A (en) *		1965-11-09		Halo- and nitro-substituted phenethyl-z- methyl tetrahydroisoquinolsnes
US3067203A (en) *		1962-12-04		Tetrahybroisqquinoline derivatives
NL286505A (fr) *	1961-12-15
CH418336A (de) *	1962-02-23	1966-08-15	Hoffmann La Roche	Verfahren zur Herstellung von Octahydrophenanthridinverbindungen
US3243438A (en) *	1962-02-23	1966-03-29	Hoffmann La Roche	Octahydro phenanthridine compounds
US3480714A (en) *	1966-02-07	1969-11-25	Ciba Geigy Corp	N-substituted isoquinolines as antiprotozoal agents
US3361767A (en) *	1966-04-04	1968-01-02	American Home Prod	10, 5(epoxymethano)-10, 11-dihydro-5h-dibenzo[a, d]cyclohepten-13-one and derivatives
GB1386076A (en) *	1971-06-03	1975-03-05	Wyeth John & Brother Ltd	Isoquinoline derivatives
US3803151A (en) *	1972-08-23	1974-04-09	Bristol Myers Co	Synthesis for the preparation of 3-hydroxy-n-alkylisomorphinans
JPS5291868A (en) *	1976-01-26	1977-08-02	Takeda Chem Ind Ltd	Indenopyridine derivatives
US4689330A (en) *	1985-04-15	1987-08-25	Janssen Pharmaceutica N.V.	Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines
ES2010668B3 (es) *	1985-12-13	1989-12-01	Laboratoire L Lafon Soc Anonyme Dite:	Procedimiento de preparacion de derivados de 5-fenil-1,4,5,6-tetrahidropirimidina.
DE68910999T2 (de) *	1988-02-19	1994-03-24	Smithkline Beecham Farma	1,2,3,4-Tetrahydroisoquinoline, Verfharen zu ihrer Herstellung und ihre Verwendung als Kappa-Rezeptor Agonisten.
US5011834A (en) *	1989-04-14	1991-04-30	State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon	PCP receptor ligands and the use thereof
AU642994B2 (en) *	1990-05-10	1993-11-04	Pfizer Inc.	Neuroprotective indolone and related derivatives
US5192751A (en) *	1992-07-24	1993-03-09	Eli Lilly And Company	Use of competitive NMDA receptor antagonists in the treatment of urinary incontinence
JPH0741481A (ja) *	1993-05-21	1995-02-10	Hokuriku Seiyaku Co Ltd	両性型三環系化合物
US5389638A (en) *	1993-09-10	1995-02-14	Abbott Laboratories	Tetrahydroisoquinolines as alpha-2 antagonists and biogenic amine uptake inhibitors
US5439915A (en) *	1994-10-20	1995-08-08	American Home Products Corporation	Pyrido[3,4-B]indole carboxamide derivatives as serotonergic agents
US5605906A (en) *	1995-03-24	1997-02-25	Merck Frosst Canada, Inc.	Cannabinoid receptor agonists
ZA9610738B (en) *	1995-12-22	1997-06-24	Warner Lambert Co	Subtype selective nmda receptor ligands and the use thereof

1997
- 1997-01-20 TW TW086100559A patent/TW427978B/zh active
- 1997-01-22 PE PE1997000036A patent/PE35698A1/es not_active Application Discontinuation
- 1997-01-24 AU AU12335/97A patent/AU723586B2/en not_active Ceased
- 1997-01-27 ZA ZA9700672A patent/ZA97672B/xx unknown
- 1997-01-28 NZ NZ314130A patent/NZ314130A/en unknown
- 1997-01-28 IT IT97MI000153A patent/IT1289621B1/it active IP Right Grant
- 1997-01-29 HU HU9700273A patent/HUP9700273A1/hu unknown
- 1997-01-29 IL IL12010097A patent/IL120100A/xx active IP Right Grant
- 1997-01-29 SG SG1997000194A patent/SG55273A1/en unknown
- 1997-01-30 AR ARP970100377A patent/AR005613A1/es unknown
- 1997-01-30 BR BR9700816A patent/BR9700816A/pt active Search and Examination
- 1997-01-30 CA CA002196392A patent/CA2196392A1/fr not_active Abandoned
- 1997-01-31 GB GB9702049A patent/GB2309642A/en not_active Withdrawn
- 1997-01-31 ES ES009700190A patent/ES2124672B1/es not_active Expired - Fee Related
- 1997-01-31 CN CN97102918A patent/CN1167762A/zh active Pending
- 1997-01-31 NO NO970431A patent/NO970431L/no not_active Application Discontinuation
- 1997-01-31 TR TR97/00071A patent/TR199700071A2/xx unknown
- 1997-01-31 HR HR96101553.4A patent/HRP970060A2/hr not_active Application Discontinuation
- 1997-01-31 CZ CZ97294A patent/CZ29497A3/cs unknown
- 1997-01-31 CO CO97004754A patent/CO4761069A1/es unknown
- 1997-01-31 FR FR9701081A patent/FR2744447B1/fr not_active Expired - Fee Related
- 1997-01-31 KR KR1019970003011A patent/KR100229298B1/ko not_active Expired - Fee Related
- 1997-02-03 YU YU3997A patent/YU3997A/sh unknown
- 1997-02-03 ID IDP970316A patent/ID15866A/id unknown
- 1997-02-03 PL PL97318256A patent/PL318256A1/xx unknown
- 1997-02-03 MA MA24483A patent/MA24078A1/fr unknown
- 1997-02-03 DE DE19703985A patent/DE19703985A1/de not_active Withdrawn
- 1997-02-03 JP JP02013297A patent/JP3217290B2/ja not_active Expired - Fee Related
1998
- 1998-01-19 US US09/008,724 patent/US5952344A/en not_active Expired - Fee Related
1999
- 1999-05-26 US US09/320,307 patent/US6071929A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HU9700273D0 (en)	1997-03-28
NZ314130A (en)	1998-04-27
AU723586B2 (en)	2000-08-31
DE19703985A1 (de)	1997-10-30
FR2744447B1 (fr)	2000-09-29
US5952344A (en)	1999-09-14
JP3217290B2 (ja)	2001-10-09
HUP9700273A1 (hu)	1999-08-30
US6071929A (en)	2000-06-06
TR199700071A2 (tr)	1997-08-21
IL120100A (en)	2001-01-28
KR970061871A (ko)	1997-09-12
NO970431D0 (no)	1997-01-31
AU1233597A (en)	1997-08-07
FR2744447A1 (fr)	1997-08-08
CN1167762A (zh)	1997-12-17
CZ29497A3 (en)	1997-08-13
ES2124672B1 (es)	1999-11-16
AR005613A1 (es)	1999-06-23
KR100229298B1 (ko)	1999-11-01
JPH09221474A (ja)	1997-08-26
IL120100A0 (en)	1997-04-15
TW427978B (en)	2001-04-01
CO4761069A1 (es)	1999-04-27
YU3997A (sh)	1999-09-27
SG55273A1 (en)	1998-12-21
PE35698A1 (es)	1998-07-16
GB2309642A (en)	1997-08-06
GB9702049D0 (en)	1997-03-19
BR9700816A (pt)	1998-07-07
NO970431L (no)	1997-08-04
CA2196392A1 (fr)	1997-08-04
ES2124672A1 (es)	1999-02-01
HRP970060A2 (en)	1998-04-30
IT1289621B1 (it)	1998-10-15
ITMI970153A1 (it)	1998-07-28
ZA97672B (en)	1997-08-04
PL318256A1 (en)	1997-08-04
ID15866A (id)	1997-08-14

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