| (2022) T Zhang, EH Krekels, C Knibbe Drug pharmacokinetics in the obese population: challenging common …, 2013 | 477 | 2013 |
| The role of population PK–PD modelling in paediatric clinical research RFW De Cock, C Piana, EHJ Krekels, M Danhof, K Allegaert, CAJ Knibbe European journal of clinical pharmacology 67 (Suppl 1), 5-16, 2011 | 290 | 2011 |
| Pharmacokinetics and pharmacodynamics of posaconazole L Chen, EHJ Krekels, PE Verweij, JB Buil, CAJ Knibbe, RJM Brüggemann Drugs 80 (7), 671-695, 2020 | 203 | 2020 |
| Morphine glucuronidation in preterm neonates, infants and children younger than 3 years CAJ Knibbe, EHJ Krekels, JN van den Anker, J DeJongh, GWE Santen, ... Clinical pharmacokinetics 48 (6), 371-385, 2009 | 184 | 2009 |
| Allometric scaling of clearance in paediatric patients: when does the magic of 0.75 fade? EAM Calvier, EHJ Krekels, PAJ Välitalo, A Rostami-Hodjegan, D Tibboel, ... Clinical pharmacokinetics 56 (3), 273-285, 2017 | 131 | 2017 |
| Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy V Kantae, EHJ Krekels, MJV Esdonk, P Lindenburg, AC Harms, ... Metabolomics 13 (1), 9, 2017 | 108 | 2017 |
| Evidence-based morphine dosing for postoperative neonates and infants EHJ Krekels, D Tibboel, SN De Wildt, I Ceelie, A Dahan, M Van Dijk, ... Clinical pharmacokinetics 53 (6), 553-563, 2014 | 83 | 2014 |
| Morphine clearance in children: does race or genetics matter? S Sadhasivam, EH Krekels, V Chidambaran, HR Esslinger, ... Journal of opioid management 8 (4), 217-226, 2012 | 81 | 2012 |
| Systematic evaluation of the descriptive and predictive performance of paediatric morphine population models EHJ Krekels, JGC van Hasselt, D Tibboel, M Danhof, CAJ Knibbe Pharmaceutical research 28 (4), 797-811, 2011 | 80 | 2011 |
| Developmental changes in morphine clearance across the entire paediatric age range are best described by a bodyweight-dependent exponent model C Wang, S Sadhavisvam, EHJ Krekels, A Dahan, D Tibboel, M Danhof, ... Clinical drug investigation 33 (7), 523-534, 2013 | 78 | 2013 |
| Pharmacokinetic modeling of paracetamol uptake and clearance in zebrafish larvae: expanding the allometric scale in vertebrates with five orders of magnitude V Kantae, EHJ Krekels, A Ordas, O González, RC van Wijk, AC Harms, ... Zebrafish 13 (6), 504-510, 2016 | 77 | 2016 |
| Predictive performance of a recently developed population pharmacokinetic model for morphine and its metabolites in new datasets of (preterm) neonates, infants and children EHJ Krekels, J DeJongh, RA van Lingen, CD van der Marel, I Choonara, ... Clinical pharmacokinetics 50 (1), 51-63, 2011 | 72 | 2011 |
| Systems pharmacology of hepatic metabolism in zebrafish larvae RC van Wijk, EHJ Krekels, T Hankemeier, HP Spaink, PH van der Graaf Drug Discovery Today: Disease Models 22, 27-34, 2016 | 63 | 2016 |
| From pediatric covariate model to semiphysiological function for maturation: part I–extrapolation of a covariate model from morphine to Zidovudine EHJ Krekels, M Neely, E Panoilia, D Tibboel, E Capparelli, M Danhof, ... CPT: pharmacometrics & systems pharmacology 1 (10), 1-9, 2012 | 56 | 2012 |
| Advances in paediatric pharmacokinetics CAJ Knibbe, EHJ Krekels, M Danhof Expert opinion on drug metabolism & toxicology 7 (1), 1-8, 2011 | 55 | 2011 |
| From pediatric covariate model to semiphysiological function for maturation: part II—sensitivity to physiological and physicochemical properties EHJ Krekels, TN Johnson, SM Den Hoedt, A Rostami‐Hodjegan, ... CPT: pharmacometrics & systems pharmacology 1 (10), 1-8, 2012 | 54 | 2012 |
| Pain and distress caused by endotracheal suctioning in neonates is better quantified by behavioural than physiological items: a comparison based on item response theory modelling PAJ Välitalo, M van Dijk, EHJ Krekels, S Gibbins, SHP Simons, D Tibboel, ... Pain 157 (8), 1611-1617, 2016 | 50 | 2016 |
| Amikacin pharmacokinetics to optimize dosing in neonates with perinatal asphyxia treated with hypothermia S Cristea, A Smits, A Kulo, CAJ Knibbe, M Van Weissenbruch, ... Antimicrobial agents and chemotherapy 61 (12), 10.1128/aac. 01282-17, 2017 | 49 | 2017 |
| Non-maturational covariates for dynamic systems pharmacology models in neonates, infants, and children: Filling the gaps beyond developmental pharmacology K Allegaert, SHP Simons, D Tibboel, EH Krekels, CA Knibbe, ... European Journal of Pharmaceutical Sciences 109, S27-S31, 2017 | 49 | 2017 |
| Evidence-based drug treatment for special patient populations through model-based approaches EHJ Krekels, JGC van Hasselt, JN van den Anker, K Allegaert, D Tibboel, ... European Journal of Pharmaceutical Sciences 109, S22-S26, 2017 | 49 | 2017 |
Catherijne A.J. KnibbeProfessor of Individualized Drug Treatment, Leiden UniversityVerified email at antoniusziekenhuis.nl
