| Origins and mechanisms of miRNAs and siRNAs RW Carthew, EJ Sontheimer Cell 136 (4), 642-655, 2009 | 6670 | 2009 |
| CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA LA Marraffini, EJ Sontheimer science 322 (5909), 1843-1845, 2008 | 2397 | 2008 |
| Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways YS Lee, K Nakahara, JW Pham, K Kim, Z He, EJ Sontheimer, RW Carthew Cell 117 (1), 69-81, 2004 | 1814 | 2004 |
| CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea LA Marraffini, EJ Sontheimer Nature Reviews Genetics 11 (3), 181-190, 2010 | 1426 | 2010 |
| Self versus non-self discrimination during CRISPR RNA-directed immunity LA Marraffini, EJ Sontheimer Nature 463 (7280), 568-571, 2010 | 1043 | 2010 |
| Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis Z Hou, Y Zhang, NE Propson, SE Howden, LF Chu, EJ Sontheimer, ... Proceedings of the National Academy of Sciences 110 (39), 15644-15649, 2013 | 1028 | 2013 |
| Target DNA interference with crRNA EJ Sontheimer, LA Marraffini US Patent App. 12/565,589, 2010 | 688 | 2010 |
| Assembly and function of RNA silencing complexes EJ Sontheimer Nature Reviews Molecular Cell Biology 6 (2), 127-138, 2005 | 656 | 2005 |
| A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila JW Pham, JL Pellino, YS Lee, RW Carthew, EJ Sontheimer Cell 117 (1), 83-94, 2004 | 611 | 2004 |
| The U5 and U6 small nuclear RNAs as active site components of the spliceosome EJ Sontheimer, JA Steitz Science 262 (5142), 1989-1996, 1993 | 548 | 1993 |
| Naturally occurring off-switches for CRISPR-Cas9 A Pawluk, N Amrani, Y Zhang, B Garcia, Y Hidalgo-Reyes, J Lee, A Edraki, ... Cell 167 (7), 1829-1838. e9, 2016 | 458 | 2016 |
| Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses D Wang, H Mou, S Li, Y Li, S Hough, K Tran, J Li, H Yin, DG Anderson, ... Human gene therapy 26 (7), 432-442, 2015 | 445 | 2015 |
| Site-specific cross-linking of mammalian U5 snRNP to the 5'splice site before the first step of pre-mRNA splicing. JR Wyatt, EJ Sontheimer, JA Steitz Genes & Development 6 (12b), 2542-2553, 1992 | 417 | 1992 |
| Processing-independent CRISPR RNAs limit natural transformation in Neisseria meningitidis Y Zhang, N Heidrich, BJ Ampattu, CW Gunderson, HS Seifert, C Schoen, ... Molecular cell 50 (4), 488-503, 2013 | 410 | 2013 |
| Silencing by small RNAs is linked to endosomal trafficking YS Lee, S Pressman, AP Andress, K Kim, JL White, JJ Cassidy, X Li, ... Nature cell biology 11 (9), 1150-1156, 2009 | 410 | 2009 |
| Silence from within: endogenous siRNAs and miRNAs EJ Sontheimer, RW Carthew Cell 122 (1), 9-12, 2005 | 396 | 2005 |
| A broad-spectrum inhibitor of CRISPR-Cas9 LB Harrington, KW Doxzen, E Ma, JJ Liu, GJ Knott, A Edraki, B Garcia, ... Cell 170 (6), 1224-1233. e15, 2017 | 326 | 2017 |
| A compact, high-accuracy Cas9 with a dinucleotide PAM for in vivo genome editing A Edraki, A Mir, R Ibraheim, I Gainetdinov, Y Yoon, CQ Song, Y Cao, ... Molecular cell 73 (4), 714-726. e4, 2019 | 316 | 2019 |
| Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice P Liu, SQ Liang, C Zheng, E Mintzer, YG Zhao, K Ponnienselvan, A Mir, ... Nature communications 12 (1), 2121, 2021 | 291 | 2021 |
| Metal ion catalysis during splicing of premessenger RNA EJ Sontheimer, S Sun, JA Piccirilli Nature 388 (6644), 801-805, 1997 | 253 | 1997 |
Aamir MirDirector at CRISPR TherapeuticsVerified email at crisprtx.com
