| A molecularly annotated platform of patient-derived xenografts (“xenopatients”) identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer A Bertotti, G Migliardi, F Galimi, F Sassi, D Torti, C Isella, D Corà, ... Cancer discovery 1 (6), 508-523, 2011 | 1107 | 2011 |
| Stromal contribution to the colorectal cancer transcriptome C Isella, A Terrasi, SE Bellomo, C Petti, G Galatola, A Muratore, A Mellano, ... Nature genetics 47 (4), 312-319, 2015 | 713 | 2015 |
| The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets E Medico, M Russo, G Picco, C Cancelliere, E Valtorta, G Corti, ... Nature communications 6 (1), 7002, 2015 | 354 | 2015 |
| Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer C Isella, F Brundu, SE Bellomo, F Galimi, E Zanella, R Porporato, C Petti, ... Nature communications 8 (1), 15107, 2017 | 329 | 2017 |
| Increased lactate secretion by cancer cells sustains non-cell-autonomous adaptive resistance to MET and EGFR targeted therapies M Apicella, E Giannoni, S Fiore, KJ Ferrari, D Fernández-Pérez, C Isella, ... Cell metabolism 28 (6), 848-865. e6, 2018 | 297 | 2018 |
| Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts XY Woo, J Giordano, A Srivastava, ZM Zhao, MW Lloyd, R de Bruijn, ... Nature genetics 53 (1), 86-99, 2021 | 205 | 2021 |
| The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis H Ling, K Pickard, C Ivan, C Isella, M Ikuo, R Mitter, R Spizzo, MD Bullock, ... Gut 65 (6), 977-989, 2016 | 159 | 2016 |
| MiR-1 Downregulation Cooperates with MACC1 in Promoting MET Overexpression in Human Colon Cancer C Migliore, V Martin, VP Leoni, A Restivo, L Atzori, A Petrelli, C Isella, ... Clinical Cancer Research 18 (3), 737-747, 2012 | 159 | 2012 |
| The thioxotriazole copper (II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells S Tardito, C Isella, E Medico, L Marchio, E Bevilacqua, M Hatzoglou, ... Journal of Biological Chemistry 284 (36), 24306-24319, 2009 | 147 | 2009 |
| Genetic and expression analysis of MET, MACC1, and HGF in metastatic colorectal cancer: response to met inhibition in patient xenografts and pathologic correlations F Galimi, D Torti, F Sassi, C Isella, D Corà, S Gastaldi, D Ribero, ... Clinical cancer research 17 (10), 3146-3156, 2011 | 142 | 2011 |
| IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies ER Zanella, F Galimi, F Sassi, G Migliardi, F Cottino, SM Leto, B Lupo, ... Science translational medicine 7 (272), 272ra12-272ra12, 2015 | 128 | 2015 |
| The miR-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85β R Sessa, G Seano, L di Blasio, PA Gagliardi, C Isella, E Medico, F Cotelli, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1823 (10), 1925-1935, 2012 | 115 | 2012 |
| A subset of colorectal cancers with cross-sensitivity to olaparib and oxaliplatin S Arena, G Corti, E Durinikova, M Montone, NM Reilly, M Russo, ... Clinical Cancer Research 26 (6), 1372-1384, 2020 | 110 | 2020 |
| MicroRNA–mRNA interactions underlying colorectal cancer molecular subtypes L Cantini, C Isella, C Petti, G Picco, S Chiola, E Ficarra, M Caselle, ... Nature communications 6 (1), 8878, 2015 | 92 | 2015 |
| A comprehensive PDX gastric cancer collection captures cancer cell–intrinsic transcriptional MSI traits S Corso, C Isella, SE Bellomo, M Apicella, S Durando, C Migliore, ... Cancer research 79 (22), 5884-5896, 2019 | 91 | 2019 |
| Neuropilin-1 upregulation elicits adaptive resistance to oncogene-targeted therapies S Rizzolio, G Cagnoni, C Battistini, S Bonelli, C Isella, ... The Journal of clinical investigation 128 (9), 3976-3990, 2018 | 90 | 2018 |
| Patient-derived xenografts (PDXs) as model systems for human cancer F Invrea, R Rovito, E Torchiaro, C Petti, C Isella, E Medico Current opinion in biotechnology 63, 151-156, 2020 | 86 | 2020 |
| High USP6NL levels in breast cancer sustain chronic AKT phosphorylation and GLUT1 stability fueling aerobic glycolysis D Avanzato, E Pupo, N Ducano, C Isella, G Bertalot, C Luise, S Pece, ... Cancer research 78 (13), 3432-3444, 2018 | 82 | 2018 |
| A molecular signature for Epithelial to Mesenchymal transition in a human colon cancer cell system is revealed by large-scale microarray analysis T Joyce, D Cantarella, C Isella, E Medico, A Pintzas Clinical & experimental metastasis 26 (6), 569-587, 2009 | 80 | 2009 |
| Prospective patient stratification into robust cancer‐cell intrinsic subtypes from colorectal cancer biopsies M Alderdice, SD Richman, S Gollins, JP Stewart, C Hurt, R Adams, ... The Journal of pathology 245 (1), 19-28, 2018 | 78 | 2018 |
Enzo MedicoProfessor of Histology, University of Torino and Head of the Laboratory of Oncogenomics, CandioloVerified email at ircc.it
