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Jens Luebeck
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Circular ecDNA promotes accessible chromatin and high oncogene expression
S Wu, KM Turner, N Nguyen, R Raviram, M Erb, J Santini, J Luebeck, ...
Nature 575 (7784), 699-703, 2019
6342019
Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers
H Kim, NP Nguyen, K Turner, S Wu, AD Gujar, J Luebeck, J Liu, ...
Nature Genetics 52 (9), 891-897, 2020
5552020
Combinatorial CRISPR–Cas9 screens for de novo mapping of genetic interactions
JP Shen, D Zhao, R Sasik, J Luebeck, A Birmingham, ...
Nature methods 14 (6), 573-576, 2017
4392017
Exploring the landscape of focal amplifications in cancer using AmpliconArchitect
V Deshpande, J Luebeck, NPD Nguyen, M Bakhtiari, KM Turner, ...
Nature communications 10 (1), 392, 2019
3512019
EcDNA hubs drive cooperative intermolecular oncogene expression
KL Hung, KE Yost, L Xie, Q Shi, K Helmsauer, J Luebeck, R Schöpflin, ...
Nature 600 (7890), 731-736, 2021
3252021
Quantitative missense variant effect prediction using large-scale mutagenesis data
VE Gray, RJ Hause, J Luebeck, J Shendure, DM Fowler
Cell systems 6 (1), 116-124. e3, 2018
2472018
Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA
EN Bergstrom, J Luebeck, M Petljak, A Khandekar, M Barnes, T Zhang, ...
Nature 602 (7897), 510-517, 2022
1662022
Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus
J Luebeck, AWT Ng, PC Galipeau, X Li, CA Sanchez, ...
Nature, 1-8, 2023
1622023
Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH
KL Hung, J Luebeck, SR Dehkordi, CI Colón, R Li, ITL Wong, C Coruh, ...
Nature Genetics, 1-9, 2022
1212022
Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis
D Zhao, MG Badur, J Luebeck, JH Magaña, A Birmingham, R Sasik, ...
Molecular cell 69 (4), 699-708. e7, 2018
1152018
Origins and impact of extrachromosomal DNA
C Bailey, O Pich, K Thol, TBK Watkins, J Luebeck, A Rowan, G Stavrou, ...
Nature 635 (8037), 193-200, 2024
1132024
Epigenetic dysregulation from chromosomal transit in micronuclei
AS Agustinus, D Al-Rawi, B Dameracharla, R Raviram, BSCL Jones, ...
Nature 619 (7968), 176-183, 2023
1102023
AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications
J Luebeck, C Coruh, SR Dehkordi, JT Lange, KM Turner, V Deshpande, ...
Nature Communications 11 (1), 1-14, 2020
962020
Plasticity of Extrachromosomal and Intrachromosomal BRAF Amplifications in Overcoming Targeted Therapy Dosage Challenges
K Song, JK Minami, A Huang, SR Dehkordi, SH Lomeli, J Luebeck, ...
Cancer discovery 12 (4), 1046-1069, 2022
822022
Enhancing transcription–replication conflict targets ecDNA-positive cancers
J Tang, NE Weiser, G Wang, S Chowdhry, EJ Curtis, Y Zhao, ITL Wong, ...
Nature 635 (8037), 210-218, 2024
732024
Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma
OS Chapman, J Luebeck, S Sridhar, ITL Wong, D Dixit, S Wang, G Prasad, ...
Nature Genetics, 1-11, 2023
70*2023
Coordinated inheritance of extrachromosomal DNAs in cancer cells
KL Hung, MG Jones, ITL Wong, EJ Curtis, JT Lange, BJ He, J Luebeck, ...
Nature 635 (8037), 201-209, 2024
682024
ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer
ND Nguyen, V Deshpande, J Luebeck, PS Mischel, V Bafna
Nucleic acids research 46 (7), 3309-3325, 2018
672018
EcSeg: Semantic Segmentation of Metaphase Images Containing Extrachromosomal DNA
U Rajkumar, K Turner, J Luebeck, V Deshpande, M Chandraker, ...
iScience 21, 428-435, 2019
602019
Extrachromosomal DNA in HPV-Mediated Oropharyngeal Cancer Drives Diverse Oncogene Transcription
J Pang, N Nguyen, J Luebeck, L Ball, A Finegersh, S Ren, T Nakagawa, ...
Clinical Cancer Research 27 (24), 6772-6786, 2021
492021
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Articles 1–20