| Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding TN Starr, AJ Greaney, SK Hilton, D Ellis, KHD Crawford, AS Dingens, ... cell 182 (5), 1295-1310. e20, 2020 | 2286 | 2020 |
| Protein stability promotes evolvability JD Bloom, ST Labthavikul, CR Otey, FH Arnold Proceedings of the National Academy of Sciences 103 (15), 5869-5874, 2006 | 1456 | 2006 |
| Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies AJ Greaney, AN Loes, KHD Crawford, TN Starr, KD Malone, HY Chu, ... Cell host & microbe 29 (3), 463-476. e6, 2021 | 1402 | 2021 |
| Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition AJ Greaney, TN Starr, P Gilchuk, SJ Zost, E Binshtein, AN Loes, SK Hilton, ... Cell host & microbe 29 (1), 44-57. e9, 2021 | 1233 | 2021 |
| Why highly expressed proteins evolve slowly DA Drummond, JD Bloom, C Adami, CO Wilke, FH Arnold Proceedings of the National Academy of Sciences 102 (40), 14338-14343, 2005 | 946 | 2005 |
| Protocol and reagents for pseudotyping lentiviral particles with SARS-CoV-2 spike protein for neutralization assays KHD Crawford, R Eguia, AS Dingens, AN Loes, KD Malone, CR Wolf, ... Viruses 12 (5), 513, 2020 | 898 | 2020 |
| Prospective mapping of viral mutations that escape antibodies used to treat COVID-19 TN Starr, AJ Greaney, A Addetia, WW Hannon, MC Choudhary, ... Science 371 (6531), 850-854, 2021 | 851 | 2021 |
| Permissive secondary mutations enable the evolution of influenza oseltamivir resistance JD Bloom, LI Gong, D Baltimore Science 328 (5983), 1272-1275, 2010 | 811 | 2010 |
| Spread of a SARS-CoV-2 variant through Europe in the summer of 2020 EB Hodcroft, M Zuber, S Nadeau, TG Vaughan, KHD Crawford, ... Nature 595 (7869), 707-712, 2021 | 678 | 2021 |
| Neutralizing antibodies correlate with protection from SARS-CoV-2 in humans during a fishery vessel outbreak with a high attack rate A Addetia, KHD Crawford, A Dingens, H Zhu, P Roychoudhury, ML Huang, ... Journal of clinical microbiology 58 (11), 10.1128/jcm. 02107-20, 2020 | 665 | 2020 |
| In the light of directed evolution: pathways of adaptive protein evolution JD Bloom, FH Arnold Proceedings of the National Academy of Sciences 106 (supplement_1), 9995-10000, 2009 | 624 | 2009 |
| SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape TN Starr, N Czudnochowski, Z Liu, F Zatta, YJ Park, A Addetia, D Pinto, ... Nature 597 (7874), 97-102, 2021 | 561 | 2021 |
| Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016 TN Starr, AJ Greaney, AS Dingens, JD Bloom Cell Reports Medicine 2 (4), 2021 | 551 | 2021 |
| Evolving strategies for enzyme engineering JD Bloom, MM Meyer, P Meinhold, CR Otey, D MacMillan, FH Arnold Current opinion in structural biology 15 (4), 447-452, 2005 | 501 | 2005 |
| Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies AJ Greaney, TN Starr, CO Barnes, Y Weisblum, F Schmidt, M Caskey, ... Nature communications 12 (1), 4196, 2021 | 480* | 2021 |
| Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail J Dong, SJ Zost, AJ Greaney, TN Starr, AS Dingens, EC Chen, RE Chen, ... Nature microbiology 6 (10), 1233-1244, 2021 | 449* | 2021 |
| Thermodynamic prediction of protein neutrality JD Bloom, JJ Silberg, CO Wilke, DA Drummond, C Adami, FH Arnold Proceedings of the National Academy of Sciences 102 (3), 606-611, 2005 | 424 | 2005 |
| Stability-mediated epistasis constrains the evolution of an influenza protein LI Gong, MA Suchard, JD Bloom Elife 2, e00631, 2013 | 416 | 2013 |
| Dynamics of neutralizing antibody titers in the months after severe acute respiratory syndrome coronavirus 2 infection KHD Crawford, AS Dingens, R Eguia, CR Wolf, N Wilcox, JK Logue, ... The Journal of infectious diseases 223 (2), 197-205, 2021 | 339 | 2021 |
| Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution TN Starr, AJ Greaney, WW Hannon, AN Loes, K Hauser, JR Dillen, E Ferri, ... Science 377 (6604), 420-424, 2022 | 307 | 2022 |
Allison J GreaneyUniversity of Washington, Fred Hutchinson Cancer Research CenterVerified email at uw.edu
