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Silvia Bonomo
Silvia Bonomo
Astex Pharmaceuticals
Verified email at astx.com
Title
Cited by
Cited by
Year
Promising tools in prostate cancer research: selective non-steroidal cytochrome P450 17A1 inhibitors
S Bonomo, CH Hansen, EM Petrunak, EE Scott, B Styrishave, ...
Scientific Reports 6 (1), 29468, 2016
642016
Dissecting the Cytochrome P450 1A2 and 3A4 Mediated Metabolism of Aflatoxin B1 in Ligand and Protein Contributions
S Bonomo, FS Jørgensen, L Olsen
Chemistry-A European Journal 23 (12), 2884 - 2893, 2017
472017
Mechanism of cytochrome P450 17A1-catalyzed hydroxylase and lyase reactions
S Bonomo, FS Jørgensen, L Olsen
Journal of Chemical Information and Modeling 57 (5), 1123-1133, 2017
332017
The role of fluorine in stabilizing the bioactive conformation of dihydroorotate dehydrogenase inhibitors
S Bonomo, P Tosco, M Giorgis, M Lolli, R Fruttero
Journal of molecular modeling 19 (3), 1099-1107, 2013
252013
Enantioselective endocrine disrupting effects of omeprazole studied in the H295R cell assay and by molecular modeling
AM Sørensen, CH Hansen, S Bonomo, L Olsen, FS Jørgensen, ...
Toxicology in Vitro 34, 71-80, 2016
162016
Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1
SCC Lucas, AG Milbradt, JH Blackwell, S Bonomo, A Brierley, DJ Cassar, ...
Journal of Medicinal Chemistry 67 (13), 11209-11225, 2024
102024
Identification and optimization of RNA-splicing modulators as Huntingtin protein-lowering agents for the treatment of Huntington’s disease
L Liu, K Malagu, AF Haughan, V Khetarpal, AJ Stott, W Esmieu, HD Vater, ...
Journal of Medicinal Chemistry 66 (18), 13205-13246, 2023
82023
The anti-epileptic drug lamotrigine inhibits the CYP17A1 lyase reaction in vitro
CH Munkboel, LR Christensen, J Islin, S Bonomo, L Olsen, FS Jørgensen, ...
Biology of Reproduction 99 (4), 888-897, 2018
62018
Focused Structure-Based Virtual Screening Identifies Novel Inhibitors of SOS1
S Bonomo, F Gibault, SK Bagal, JH Blackwell, J Breed, GW Collie, ...
ACS Medicinal Chemistry Letters 16 (10), 1905-1909, 2025
2025
Prediction of adverse male reproductive health effects by integrating in vitro data and physiologically-based kinetic modelling
C Taxvig, M Scholze, A Kortenkamp, J Boberg, T Svingen, S Ermler, ...
Toxicology Letters 295 (Suppl. 1), S61-S61, 2018
2018
From Drug Metabolism to Steroidogenesis: Computational Investigations of Human Cytochromes P450
S Bonomo
Graduate School of the Faculty of Health and Medical Science, Department of …, 2016
2016
New potent and selective P-gp inhibitors
S Guglielmo, S Bonomo, NA Colabufo, M Contino, MG Perrone, R Fruttero, ...
NPCF7, P1. 13-P1. 13, 2013
2013
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Articles 1–12