ZA981659B - Acarbose ACB cluster isolation of further acarbose biosynthesis and acarbose metabolism genes from actinoplanes SP.SE50/110 and their use - Google Patents

Acarbose ACB cluster isolation of further acarbose biosynthesis and acarbose metabolism genes from actinoplanes SP.SE50/110 and their use

Info

Publication number: ZA981659B
Authority: ZA; South Africa
Prior art keywords: acarbose; actinoplanes; acb; biosynthesis; metabolism genes
Prior art date: 1997-02-28

Application number

ZA981659A

Other languages

English (en)

Inventor

Anneliese Crueger

Heiner Apeler

Werner Schroder

Hermann Pape

Klaus Goeke

Wolfgang Piepersberg

Jurgen Distler

Uribe Paz Mart Diaz-Guardamino

Martin Jarling

Ansgar Stratmann

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-28

Filing date

1998-02-27

Publication date

1998-09-10

1998-02-27 Application filed by Bayer Ag filed Critical Bayer Ag

1998-09-10 Publication of ZA981659B publication Critical patent/ZA981659B/xx

Links

XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 title 3
229960002632 acarbose Drugs 0.000 title 3
XUFXOAAUWZOOIT-UHFFFAOYSA-N acarviostatin I01 Natural products OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O XUFXOAAUWZOOIT-UHFFFAOYSA-N 0.000 title 3
241000936716 Actinoplanes sp. SE50/110 Species 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000002955 isolation Methods 0.000 title 1
230000004060 metabolic process Effects 0.000 title 1
108090000623 proteins and genes Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/365—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinoplanes (G)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Saccharide Compounds (AREA)

ZA981659A 1997-02-28 1998-02-27 Acarbose ACB cluster isolation of further acarbose biosynthesis and acarbose metabolism genes from actinoplanes SP.SE50/110 and their use ZA981659B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19708127A DE19708127A1 (de)	1997-02-28	1997-02-28	Acarbose acb-Cluster: Isolierung von weiteren Genen der Acarbose Biosynthese und des Acarbose-Stoffwechsels aus Actinoplanes sp. SE 50/110 sowie deren Verwendung

Publications (1)

Publication Number	Publication Date
ZA981659B true ZA981659B (en)	1998-09-10

Family

ID=7821816

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA981659A ZA981659B (en)	1997-02-28	1998-02-27	Acarbose ACB cluster isolation of further acarbose biosynthesis and acarbose metabolism genes from actinoplanes SP.SE50/110 and their use

Country Status (15)

Country	Link
EP (1)	EP0968294A1 (xx)
KR (1)	KR20000075777A (xx)
CN (1)	CN1249001A (xx)
AU (1)	AU6296898A (xx)
BG (1)	BG103672A (xx)
BR (1)	BR9807640A (xx)
CA (1)	CA2282735A1 (xx)
CZ (1)	CZ9903054A3 (xx)
DE (1)	DE19708127A1 (xx)
HU (1)	HUP0000889A2 (xx)
IL (1)	IL131433A0 (xx)
NO (1)	NO994164L (xx)
PL (1)	PL335369A1 (xx)
WO (1)	WO1998038313A1 (xx)
ZA (1)	ZA981659B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0796915A3 (de) *	1996-03-22	1999-04-14	Bayer Ag	Verfahren zur Herstellung sowie zur Verwendung von Acarviosyl-Transferase bei der Umwandlung von Acarbose-Homologen in Acarbose, zur Herstellung von Acarbose-Homologen
TW201217533A (en)	2010-08-04	2012-05-01	Bayer Pharma AG	Genomics of actinoplanes utahensis
CN106167814B (zh) *	2016-08-31	2019-08-09	河北华荣制药有限公司	一种提高阿卡波糖发酵单位的方法
CN106566796B (zh) *	2016-10-28	2020-11-10	上海交通大学	阿卡波糖生产菌Actinoplanes spp.的遗传操作体系
JP7711052B2 (ja) *	2019-10-16	2025-07-22	バイエル・アクチエンゲゼルシヤフト	アカルボースの改善された形成方法
CN112592878B (zh) *	2020-12-25	2022-08-26	上海交通大学	增强正调控蛋白基因表达以提高阿卡波糖发酵水平的方法
CN113444670A (zh) *	2021-07-28	2021-09-28	山东鲁抗医药股份有限公司	一种高活性阿卡波糖产生菌的筛选方法和培养方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19507214A1 (de) *	1995-03-02	1996-10-31	Bayer Ag	Acarbose-Biosynthesegene aus Actinoplanes sp., Verfahren zu ihrer Isolierung sowie ihre Verwendung
DE19622783A1 (de) *	1996-06-07	1997-12-11	Hoechst Ag	Isolierung der Biosynthesegene für Pseudo-Oligosaccharide aus Streptomyces glaucescens GLA.O und ihre Verwendung

1997
- 1997-02-28 DE DE19708127A patent/DE19708127A1/de not_active Withdrawn
1998
- 1998-02-16 WO PCT/EP1998/000862 patent/WO1998038313A1/de not_active Ceased
- 1998-02-16 KR KR1019997007849A patent/KR20000075777A/ko not_active Withdrawn
- 1998-02-16 CN CN98802927A patent/CN1249001A/zh active Pending
- 1998-02-16 HU HU0000889A patent/HUP0000889A2/hu unknown
- 1998-02-16 PL PL98335369A patent/PL335369A1/xx unknown
- 1998-02-16 IL IL13143398A patent/IL131433A0/xx unknown
- 1998-02-16 BR BR9807640A patent/BR9807640A/pt not_active Application Discontinuation
- 1998-02-16 CZ CZ993054A patent/CZ9903054A3/cs unknown
- 1998-02-16 AU AU62968/98A patent/AU6296898A/en not_active Abandoned
- 1998-02-16 EP EP98906953A patent/EP0968294A1/de not_active Withdrawn
- 1998-02-16 CA CA002282735A patent/CA2282735A1/en not_active Abandoned
- 1998-02-27 ZA ZA981659A patent/ZA981659B/xx unknown
1999
- 1999-08-20 BG BG103672A patent/BG103672A/xx unknown
- 1999-08-27 NO NO994164A patent/NO994164L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU6296898A (en)	1998-09-18
PL335369A1 (en)	2000-04-25
HUP0000889A2 (en)	2000-07-28
IL131433A0 (en)	2001-01-28
BR9807640A (pt)	2000-03-21
CA2282735A1 (en)	1998-09-03
NO994164D0 (no)	1999-08-27
EP0968294A1 (de)	2000-01-05
CN1249001A (zh)	2000-03-29
BG103672A (en)	2000-05-31
WO1998038313A1 (de)	1998-09-03
NO994164L (no)	1999-08-27
DE19708127A1 (de)	1998-09-03
CZ9903054A3 (cs)	1999-11-17
KR20000075777A (ko)	2000-12-26

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GB2297572B (en)	1998-10-21	Well valve
IL116935A0 (en)	1996-05-14	Venlafaxine for the treatment of hypothalmic amenorrhea
GB9526522D0 (en)	1996-02-28	Valve arrangement
ZA981659B (en)	1998-09-10	Acarbose ACB cluster isolation of further acarbose biosynthesis and acarbose metabolism genes from actinoplanes SP.SE50/110 and their use
AU1813399A (en)	1999-07-05	In-line valve
IL119818A (en)	2000-02-29	Microbial 11alpha-hydroxylation of steroids
GB9506051D0 (en)	1995-05-10	Gene expression
PL326300A1 (en)	1998-09-14	Valve
HUP9600500A2 (en)	1996-11-28	Genes from actinoplanes sp. for biosynthesis of acarbose, process for their isolation and their use
GB2305489B (en)	2000-02-16	Valve
GB9514789D0 (en)	1995-09-20	Valves
ZA968873B (en)	1997-05-28	Isomerisation of equillin
GB9516228D0 (en)	1995-10-11	Anti-butterfly valve
GB2305713B (en)	1997-11-19	Valve
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TW301911U (en)	1997-04-01	Improved structure of open valve
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TW302062U (en)	1997-04-01	Improved structure of post-plug type valve
TW441733U (en)	2001-06-16	Structure improvement of ball-shaped valve
GB9615797D0 (en)	1996-09-04	Gene expression
GB9525962D0 (en)	1996-02-21	Gene expression
GB2300403B (en)	1998-09-09	Valve
GB9520433D0 (en)	1995-12-06	Gene therapy
GB9521711D0 (en)	1996-01-03	Gene therapy