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ZA96994B - Method of treatment for decreasing mortality resulting from congestive heart failure. - Google Patents

Method of treatment for decreasing mortality resulting from congestive heart failure.

Info

Publication number
ZA96994B
ZA96994B ZA9600994A ZA96994A ZA96994B ZA 96994 B ZA96994 B ZA 96994B ZA 9600994 A ZA9600994 A ZA 9600994A ZA 96994 A ZA96994 A ZA 96994A ZA 96994 B ZA96994 B ZA 96994B
Authority
ZA
South Africa
Prior art keywords
treatment
heart failure
congestive heart
mortality resulting
decreasing mortality
Prior art date
Application number
ZA9600994A
Other languages
English (en)
Inventor
Mary Ann Lukas-Laskey
Robert Ruffolo Jr
Neil Shusterman
Gisbert Sponer
Klaus Strein
Original Assignee
Boehringer Mannheim Pharm Corp
Smith Kline Beecham Corp Ltd P
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26012210&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA96994(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE1995103995 external-priority patent/DE19503995C2/de
Application filed by Boehringer Mannheim Pharm Corp, Smith Kline Beecham Corp Ltd P filed Critical Boehringer Mannheim Pharm Corp
Publication of ZA96994B publication Critical patent/ZA96994B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA9600994A 1995-02-08 1996-02-08 Method of treatment for decreasing mortality resulting from congestive heart failure. ZA96994B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1995103995 DE19503995C2 (de) 1995-02-08 1995-02-08 Verwendung von Carvedilol zur Verminderung der Mortalität bei Patienten mit eingeschränkter myocardialer Funktion
US08/483,635 US5760069A (en) 1995-02-08 1995-06-07 Method of treatment for decreasing mortality resulting from congestive heart failure

Publications (1)

Publication Number Publication Date
ZA96994B true ZA96994B (en) 1997-10-27

Family

ID=26012210

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9600994A ZA96994B (en) 1995-02-08 1996-02-08 Method of treatment for decreasing mortality resulting from congestive heart failure.

Country Status (26)

Country Link
US (6) US5760069A (fr)
EP (1) EP0808162B1 (fr)
JP (1) JP3546058B2 (fr)
KR (1) KR100295940B1 (fr)
CN (1) CN1093760C (fr)
AT (1) ATE179891T1 (fr)
AU (1) AU702106C (fr)
BR (1) BR9607111A (fr)
CA (1) CA2212548C (fr)
CZ (1) CZ292002B6 (fr)
DE (1) DE69602424T2 (fr)
DK (1) DK0808162T3 (fr)
ES (1) ES2134588T3 (fr)
FI (1) FI973255A0 (fr)
GR (1) GR3030966T3 (fr)
HU (1) HUP9900773A3 (fr)
NO (1) NO314830B1 (fr)
NZ (1) NZ301692A (fr)
PL (1) PL321737A1 (fr)
RO (1) RO121629B1 (fr)
RU (1) RU2197242C2 (fr)
SI (1) SI0808162T1 (fr)
SK (1) SK106897A3 (fr)
UA (1) UA55382C2 (fr)
WO (1) WO1996024348A2 (fr)
ZA (1) ZA96994B (fr)

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US5760069A (en) * 1995-02-08 1998-06-02 Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 Method of treatment for decreasing mortality resulting from congestive heart failure
IL129326A0 (en) * 1996-10-09 2000-02-17 Boehringer Mannheim Pharm Corp Method for inhibiting stress-activated protein kinases
ZA989365B (en) * 1997-10-15 1999-04-15 Boehringer Mannheim Pharm Corp Preparation for treating alzheimer's disease
WO1999024017A1 (fr) * 1997-11-12 1999-05-20 Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Bechman Corporation Limited Partnership No.1 Nouvelle forme posologique par voie orale pour le carvedilol
US20020054911A1 (en) * 2000-05-11 2002-05-09 Boehringer Mannheim Pharmaceutical Corporation-Sm Ithkline Beckman Corporation, Limited Partnershi Novel oral dosage form for carvedilol
DE19833119A1 (de) * 1998-07-23 2000-01-27 Roche Diagnostics Gmbh Spritzfertige Injektionslösungen enthaltend Carvedilol
US6664284B2 (en) 1998-07-23 2003-12-16 Roche Diagnostics Gmbh Stabilized carvedilol injection solution
PE20001302A1 (es) * 1998-11-27 2000-11-30 Hoffmann La Roche Preparaciones de una combinacion farmaceutica que contiene carvedilol e hidroclorotiazida
US6465463B1 (en) * 1999-09-08 2002-10-15 Nitromed, Inc. Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
US7537785B2 (en) * 1999-10-29 2009-05-26 Nitromed, Inc. Composition for treating vascular diseases characterized by nitric oxide insufficiency
DE60042611D1 (de) * 1999-10-29 2009-09-03 Nitromed Inc Verfahren zur behandlung von gefässerkrankungen, dxid auszeichnen
US7235237B2 (en) * 1999-10-29 2007-06-26 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7708989B2 (en) * 1999-10-29 2010-05-04 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US20010036959A1 (en) * 2000-04-03 2001-11-01 Gabel Rolf Dieter Carvedilol-hydrophilic solutions
KR20030017569A (ko) 2000-06-28 2003-03-03 테바 파마슈티컬 인더스트리즈 리미티드 카르베딜올
WO2002078692A1 (fr) * 2001-04-02 2002-10-10 Smithkline Beecham Corporation Methode de traitement
WO2003028718A1 (fr) * 2001-10-01 2003-04-10 Smithkline Beecham Corporation Nouvelles formulations de carvedilol
US20040186158A1 (en) * 2001-10-02 2004-09-23 Oh Choon K. Novel composition of carvedilol
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
SE0103749D0 (sv) * 2001-11-08 2001-11-08 Sahltech Ab Treatment of congestive heart failure
MXPA04006909A (es) * 2002-01-15 2005-04-19 Teva Pharma Solidos cristalinos de carvedilol y procesos para su preparacion.
EP2316469A1 (fr) 2002-02-22 2011-05-04 Shire LLC Système de distribution et méthodes de protection et d'administration de dextroamphetamine
RU2203063C1 (ru) * 2002-03-12 2003-04-27 Нестерук Владимир Викторович Способ получения твердой лекарственной формы препарата, обладающего диуретическим действием
WO2003092622A2 (fr) * 2002-04-30 2003-11-13 Sb Pharmco Puerto Rico Inc. Monocitrate monohydrate de carvedilol
WO2004047724A2 (fr) * 2002-05-16 2004-06-10 Genelabs Technologies, Inc Composes aryle et heteroaryle a action anti-bacterienne et anti-fongique
AU2003251627A1 (en) * 2002-06-27 2004-01-19 Sb Pharmco Puerto Rico Inc. Carvedilol hydrobromide
CA2492060C (fr) * 2002-06-27 2011-11-01 Sb Pharmco Puerto Rico Inc. Sels de phospate de carvedilol et/ou solvates de celui-ci, compositions et/ou methodes de traitement associees
ES2211846T3 (es) * 2002-07-25 2004-07-16 BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG Uso de cilobradina o sus sales farmaceuticamente aceptables para el tratamiento o la prevencion de la insuficiencia cardiaca.
US6632832B1 (en) 2002-09-10 2003-10-14 Dabur Research Foundation Anti-cancer activity of carvedilol and its isomers
US20050032879A1 (en) * 2003-08-07 2005-02-10 Temple Okarter Formulations and use of a beta-blocker and an ACE-inhibitor for the treatment of cardiovascular diseases
JP2007512372A (ja) * 2003-11-25 2007-05-17 エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド カルベジロール塩、対応する組成物、送達および／または治療方法
US20050169994A1 (en) * 2003-11-25 2005-08-04 Burke Matthew D. Carvedilol free base, salts, anhydrous forms or solvates thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods
WO2005051322A2 (fr) * 2003-11-25 2005-06-09 Sb Pharmco Puerto Rico Inc. Base libre de carvedilol, ses sels, formes anhydres ou solvates, compositions pharmaceutiques correspondantes, formulations a liberation controlee, et procedes de traitement ou d'administration
JP2008506716A (ja) * 2004-07-16 2008-03-06 ニトロメッド インコーポレーティッド 心不全に関連する組成物および方法
US20070043099A1 (en) * 2005-06-09 2007-02-22 Igor Lifshitz Crystalline forms of carvedilol and processes for their preparation
CA2634473A1 (fr) * 2006-02-17 2007-08-30 Nitromed, Inc. Procedes utilisant des composes d'hydralazine et du dinitrate d'isosorbide ou du mononitrate d'isosorbide
US8367112B2 (en) * 2006-02-28 2013-02-05 Alkermes Pharma Ireland Limited Nanoparticulate carverdilol formulations
US8703804B2 (en) * 2006-03-26 2014-04-22 Uti Limited Partnership Ryanodine receptor inhibitors and methods relating thereto
CA2652135A1 (fr) * 2006-05-16 2007-11-29 Nitromed, Inc. Formulations en doses solides de composes d'hydralazine
WO2008002683A2 (fr) * 2006-06-28 2008-01-03 Teva Pharmaceutical Industries Ltd. Carvédilol phosphate
EP2114881A1 (fr) * 2007-02-26 2009-11-11 Teva Pharmaceutical Industries Ltd. Procédé de purification du carvédilol ou de ses sels
US20090076116A1 (en) * 2007-09-13 2009-03-19 Protia, Llc Deuterium-enriched carvediolo
CA2724540C (fr) 2008-05-16 2014-07-08 Corthera, Inc. Methode de traitement de la dyspnee associee a une insuffisance cardiaque aigue a l'aide de la relaxine
MX355697B (es) 2010-04-12 2018-04-27 Supernus Pharmaceuticals Inc Métodos para producir sales de viloxazina y polimorfos novedosos de las mismas.
AU2012296925A1 (en) 2011-08-12 2014-02-06 Boehringer Ingelheim Vetmedica Gmbh Taste masked pharmaceutical composition
CN110381929A (zh) * 2016-06-13 2019-10-25 阿森迪亚制药有限责任公司 卡维地洛分散系统的肠胃外缓释传递
US10772869B1 (en) 2019-07-24 2020-09-15 ECI Pharmaceuticals, LLC Pharmaceutical compositions including carvedilol and methods of using the same

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DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3319027A1 (de) 1983-05-26 1984-11-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten
SE460945B (sv) * 1987-01-15 1989-12-11 Lejus Medical Ab En multipel-unit-dos komposition av furosemid
RU2058144C1 (ru) * 1988-12-15 1996-04-20 Центр по химии лекарственных средств Средство для лечения сердечной недостаточности
US5312828A (en) * 1989-06-14 1994-05-17 Finkelstein Joseph A Substituted imidazoles having angiotensin II receptor blocking activity
US5225401A (en) * 1991-08-12 1993-07-06 E. R. Squibb & Sons, Inc. Treatment of congestive heart failure
RU2032685C1 (ru) * 1991-12-16 1995-04-10 Центр по химии лекарственных средств Производные пиридо (3,2-а)карбазола, обладающие кардиотонической активностью
US5308862A (en) * 1993-03-05 1994-05-03 Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Beecham Corp., Ltd. Partnership No. 1 Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation
US5760069A (en) 1995-02-08 1998-06-02 Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 Method of treatment for decreasing mortality resulting from congestive heart failure

Also Published As

Publication number Publication date
PL321737A1 (en) 1997-12-22
CA2212548C (fr) 1999-08-24
HUP9900773A2 (hu) 1999-07-28
FI973255A7 (fi) 1997-08-07
DK0808162T3 (da) 1999-11-15
BR9607111A (pt) 1997-11-04
AU702106C (en) 2005-02-17
CN1093760C (zh) 2002-11-06
KR19980702085A (ko) 1998-07-15
SK106897A3 (en) 1999-03-12
GR3030966T3 (en) 1999-11-30
WO1996024348A3 (fr) 1996-10-03
JPH10513463A (ja) 1998-12-22
NO314830B1 (no) 2003-06-02
AU4718196A (en) 1996-08-27
US5760069A (en) 1998-06-02
USRE40000E1 (en) 2008-01-08
CZ292002B6 (cs) 2003-07-16
CA2212548A1 (fr) 1996-08-15
CZ246397A3 (cs) 1998-11-11
NO973667D0 (no) 1997-08-08
RO121629B1 (ro) 2008-01-30
ATE179891T1 (de) 1999-05-15
CN1185106A (zh) 1998-06-17
US5902821A (en) 1999-05-11
RU2197242C2 (ru) 2003-01-27
EP0808162A2 (fr) 1997-11-26
USRE40707E1 (en) 2009-05-05
NO973667L (no) 1997-08-08
UA55382C2 (uk) 2003-04-15
DE69602424D1 (de) 1999-06-17
DE69602424T2 (de) 1999-10-07
WO1996024348A2 (fr) 1996-08-15
HUP9900773A3 (en) 2000-04-28
JP3546058B2 (ja) 2004-07-21
NZ301692A (en) 2000-09-29
FI973255A0 (fi) 1997-08-07
US20010044455A1 (en) 2001-11-22
KR100295940B1 (ko) 2001-08-07
SI0808162T1 (en) 1999-10-31
EP0808162B1 (fr) 1999-05-12
US20030105138A1 (en) 2003-06-05
AU702106B2 (en) 1999-02-11
HK1014861A1 (en) 1999-10-08
MX9706042A (es) 1998-06-30
ES2134588T3 (es) 1999-10-01

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