ZA951059B - 4-amino-1-piperidylbenzoylguanidine - Google Patents
4-amino-1-piperidylbenzoylguanidineInfo
- Publication number
- ZA951059B ZA951059B ZA951059A ZA951059A ZA951059B ZA 951059 B ZA951059 B ZA 951059B ZA 951059 A ZA951059 A ZA 951059A ZA 951059 A ZA951059 A ZA 951059A ZA 951059 B ZA951059 B ZA 951059B
- Authority
- ZA
- South Africa
- Prior art keywords
- alk
- hal
- opt
- alkylene
- amino
- Prior art date
Links
- BEDVALDDNUBBNZ-UHFFFAOYSA-N n-(4-aminopiperidin-1-yl)-n-carbamimidoylbenzamide Chemical compound C1CC(N)CCN1N(C(N)=N)C(=O)C1=CC=CC=C1 BEDVALDDNUBBNZ-UHFFFAOYSA-N 0.000 title abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- -1 tetrahydroquinolyl Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001070 dihydroindolyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4404183A DE4404183A1 (de) | 1994-02-10 | 1994-02-10 | 4-Amino-1-piperidylbenzoylguanidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA951059B true ZA951059B (en) | 1995-10-13 |
Family
ID=6509922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA951059A ZA951059B (en) | 1994-02-10 | 1995-02-09 | 4-amino-1-piperidylbenzoylguanidine |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5461066A (xx) |
| EP (1) | EP0667341B1 (xx) |
| JP (1) | JPH07267926A (xx) |
| KR (1) | KR950321212A (xx) |
| CN (1) | CN1082948C (xx) |
| AT (1) | ATE204864T1 (xx) |
| AU (1) | AU693496B2 (xx) |
| CA (1) | CA2142070A1 (xx) |
| CZ (1) | CZ286681B6 (xx) |
| DE (2) | DE4404183A1 (xx) |
| DK (1) | DK0667341T3 (xx) |
| ES (1) | ES2161789T3 (xx) |
| GR (1) | GR3036839T3 (xx) |
| HU (1) | HU215601B (xx) |
| NO (1) | NO303685B1 (xx) |
| PL (1) | PL179255B1 (xx) |
| PT (1) | PT667341E (xx) |
| RU (1) | RU2140412C1 (xx) |
| SK (1) | SK281721B6 (xx) |
| TW (1) | TW291476B (xx) |
| UA (1) | UA43834C2 (xx) |
| ZA (1) | ZA951059B (xx) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4328352A1 (de) | 1993-08-24 | 1995-03-02 | Hoechst Ag | Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE4421495A1 (de) * | 1994-06-20 | 1995-12-21 | Merck Patent Gmbh | Heterocyclyloxy-benzoylguanidine |
| DE4430212A1 (de) * | 1994-08-28 | 1996-02-29 | Merck Patent Gmbh | Ortho-substituierte Benzoesäure-Derivate |
| DE4430861A1 (de) * | 1994-08-31 | 1996-03-07 | Merck Patent Gmbh | Heterocyclyl-benzoylguanidine |
| DE19601303A1 (de) * | 1996-01-16 | 1997-07-17 | Boehringer Ingelheim Kg | Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln |
| DE19608161A1 (de) * | 1996-03-04 | 1997-09-11 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19608162A1 (de) * | 1996-03-04 | 1997-09-11 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19859727A1 (de) * | 1998-12-23 | 2000-06-29 | Aventis Pharma Gmbh | Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verhinderung von altersbedingten Organ-Dysfunktionen, altersbedingten Erkrankungen zur Lebensverlängerung |
| US7620611B1 (en) * | 1999-07-20 | 2009-11-17 | Trilithic, Inc. | Neural networks for ingress monitoring |
| CA2397981C (en) * | 2000-03-06 | 2010-12-21 | Acadia Pharmaceuticals, Inc. | Azacyclic compounds for use in the treatment of serotonin related diseases |
| CZ20032017A3 (cs) * | 2001-01-31 | 2004-05-12 | Pfizeráproductsáinc | Ethanoláty inhibitoru sodík@vodík měniče typu �Ź způsob jejich přípravyŹ jejich použití a farmaceutický prostředekŹ který je obsahuje |
| ATE466014T1 (de) * | 2001-12-28 | 2010-05-15 | Acadia Pharm Inc | Spiroazacyclische verbindungen als monoaminrezeptormodulatoren |
| US7253186B2 (en) * | 2002-06-24 | 2007-08-07 | Carl-Magnus Andersson | N-substituted piperidine derivatives as serotonin receptor agents |
| MXPA04012893A (es) * | 2002-06-24 | 2005-03-31 | Acadia Pharm Inc | Derivados de piperidina n-substituidos como agentes receptores de serotonina. |
| US7538222B2 (en) * | 2002-06-24 | 2009-05-26 | Acadia Pharmaceuticals, Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| MY139563A (en) * | 2002-09-04 | 2009-10-30 | Bristol Myers Squibb Co | Heterocyclic aromatic compounds useful as growth hormone secretagogues |
| SI1556045T1 (sl) * | 2002-10-04 | 2007-02-28 | Ucb Sa | Derivati 4-aminopiperidina, postopek izdelave in uporaba v medicini |
| US7601740B2 (en) * | 2003-01-16 | 2009-10-13 | Acadia Pharmaceuticals, Inc. | Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases |
| US7820695B2 (en) * | 2004-05-21 | 2010-10-26 | Acadia Pharmaceuticals, Inc. | Selective serotonin receptor inverse agonists as therapeutics for disease |
| US20050261278A1 (en) | 2004-05-21 | 2005-11-24 | Weiner David M | Selective serotonin receptor inverse agonists as therapeutics for disease |
| CN101014595A (zh) * | 2004-08-11 | 2007-08-08 | 杏林制药株式会社 | 新型环状氨基苯甲酸衍生物 |
| US7790899B2 (en) * | 2004-09-27 | 2010-09-07 | Acadia Pharmaceuticals, Inc. | Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms |
| DK1794126T3 (da) * | 2004-09-27 | 2013-06-24 | Acadia Pharm Inc | Krystallinsk form af N-(-4-fluorbenzyl)-N-(1-methylpiperidn-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamid-hemitartrat |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| BRPI0711558A2 (pt) | 2006-05-04 | 2011-11-08 | Boeringer Ingelheim Internat Gmbh | polimorfos |
| ES2423485T3 (es) | 2007-03-19 | 2013-09-20 | Acadia Pharmaceuticals Inc. | Asociaciones de agonistas y antagonistas inversos 5-HT2A con antipsicóticos |
| SI2200610T1 (en) * | 2007-09-21 | 2018-06-29 | Acadia Pharmaceuticals Inc. | Co-administration of pimavanserin with other agents |
| PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| AU2009331471B2 (en) | 2008-12-23 | 2015-09-03 | Boehringer Ingelheim International Gmbh | Salt forms of organic compound |
| PH12012501037A1 (en) | 2009-11-27 | 2013-01-14 | Boehringer Ingelheim Int | Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin |
| CA2797310C (en) | 2010-05-05 | 2020-03-31 | Boehringer Ingelheim International Gmbh | Glp-1 receptor agonist and dpp-4 inhibitor combination therapy |
| KR20230051307A (ko) | 2010-06-24 | 2023-04-17 | 베링거 인겔하임 인터내셔날 게엠베하 | 당뇨병 요법 |
| US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
| ES2713566T3 (es) | 2011-07-15 | 2019-05-22 | Boehringer Ingelheim Int | Derivado de quinazolina dimérico sustituido, su preparación y su uso en composiciones farmacéuticas para el tratamiento de la diabetes de tipo I y II |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| US20130303462A1 (en) | 2012-05-14 | 2013-11-14 | Boehringer Ingelheim International Gmbh | Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome |
| EP4151218A1 (en) | 2012-05-14 | 2023-03-22 | Boehringer Ingelheim International GmbH | Linagliptin, a xanthine derivative as dpp-4 inhibitor, for use in the treatment of sirs and/or sepsis |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| EP3110449B1 (en) | 2014-02-28 | 2023-06-28 | Boehringer Ingelheim International GmbH | Medical use of a dpp-4 inhibitor |
| ES2890492T3 (es) | 2015-07-20 | 2022-01-20 | Acadia Pharm Inc | Métodos para preparar N-(4-fluorobencil)-N-(1-metilpiperidin-4-il)-N'-(4-(2-metilpropiloxi)fenilmetil)carbamida y su sal de tartrato y forma polimórfica C |
| US10953000B2 (en) | 2016-03-25 | 2021-03-23 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome P450 modulators |
| WO2017165635A1 (en) | 2016-03-25 | 2017-09-28 | Acadia Pharmaceuticals Inc. | Combination of pimavanserin and cytochrome p450 modulators |
| WO2017211979A1 (en) | 2016-06-10 | 2017-12-14 | Boehringer Ingelheim International Gmbh | Combinations of linagliptin and metformin |
| WO2018118626A1 (en) | 2016-12-20 | 2018-06-28 | Acadia Pharmaceuticals Inc. | Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis |
| EP3615028A1 (en) | 2017-04-28 | 2020-03-04 | Acadia Pharmaceuticals Inc. | Pimavanserin for treating impulse control disorder |
| EP3675827A1 (en) | 2017-08-30 | 2020-07-08 | Acadia Pharmaceuticals Inc. | Formulations of pimavanserin |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
| DE4117904A1 (de) * | 1991-05-31 | 1992-12-03 | Basf Ag | Substituierte n-phenylpiperidine |
| CZ284456B6 (cs) * | 1992-02-15 | 1998-12-16 | Hoechst Aktiengesellschaft | Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje |
| EP0589336B1 (de) * | 1992-09-22 | 1997-01-08 | Hoechst Aktiengesellschaft | Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrhythmika |
| EP0600371B1 (de) * | 1992-12-02 | 1999-02-03 | Hoechst Aktiengesellschaft | Guanidinalkyl-1, 1-bisphosphonsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
-
1994
- 1994-02-10 DE DE4404183A patent/DE4404183A1/de not_active Withdrawn
-
1995
- 1995-02-06 AU AU11571/95A patent/AU693496B2/en not_active Ceased
- 1995-02-07 DE DE59509543T patent/DE59509543D1/de not_active Expired - Fee Related
- 1995-02-07 DK DK95101575T patent/DK0667341T3/da active
- 1995-02-07 PT PT95101575T patent/PT667341E/pt unknown
- 1995-02-07 CN CN95101910A patent/CN1082948C/zh not_active Expired - Fee Related
- 1995-02-07 EP EP95101575A patent/EP0667341B1/de not_active Expired - Lifetime
- 1995-02-07 TW TW084100981A patent/TW291476B/zh active
- 1995-02-07 ES ES95101575T patent/ES2161789T3/es not_active Expired - Lifetime
- 1995-02-07 SK SK157-95A patent/SK281721B6/sk unknown
- 1995-02-07 AT AT95101575T patent/ATE204864T1/de not_active IP Right Cessation
- 1995-02-08 CA CA002142070A patent/CA2142070A1/en not_active Abandoned
- 1995-02-08 UA UA95028120A patent/UA43834C2/uk unknown
- 1995-02-08 CZ CZ1995327A patent/CZ286681B6/cs not_active IP Right Cessation
- 1995-02-09 NO NO950485A patent/NO303685B1/no not_active IP Right Cessation
- 1995-02-09 PL PL95307190A patent/PL179255B1/pl unknown
- 1995-02-09 KR KR1019950002288A patent/KR950321212A/ko not_active Abandoned
- 1995-02-09 HU HU9500396A patent/HU215601B/hu not_active IP Right Cessation
- 1995-02-09 US US08/385,790 patent/US5461066A/en not_active Expired - Fee Related
- 1995-02-09 ZA ZA951059A patent/ZA951059B/xx unknown
- 1995-02-09 RU RU95101843A patent/RU2140412C1/ru active
- 1995-02-10 JP JP7022475A patent/JPH07267926A/ja active Pending
-
2001
- 2001-10-09 GR GR20010401701T patent/GR3036839T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT667341E (pt) | 2001-12-28 |
| RU95101843A (ru) | 1997-03-10 |
| JPH07267926A (ja) | 1995-10-17 |
| CA2142070A1 (en) | 1995-08-11 |
| TW291476B (xx) | 1996-11-21 |
| SK281721B6 (sk) | 2001-07-10 |
| NO303685B1 (no) | 1998-08-17 |
| RU2140412C1 (ru) | 1999-10-27 |
| HUT72306A (en) | 1996-04-29 |
| HU9500396D0 (en) | 1995-03-28 |
| GR3036839T3 (en) | 2002-01-31 |
| EP0667341B1 (de) | 2001-08-29 |
| NO950485D0 (no) | 1995-02-09 |
| AU693496B2 (en) | 1998-07-02 |
| ES2161789T3 (es) | 2001-12-16 |
| DE59509543D1 (de) | 2001-10-04 |
| DK0667341T3 (da) | 2001-10-22 |
| UA43834C2 (uk) | 2002-01-15 |
| PL179255B1 (pl) | 2000-08-31 |
| ATE204864T1 (de) | 2001-09-15 |
| PL307190A1 (en) | 1995-08-21 |
| DE4404183A1 (de) | 1995-08-17 |
| CN1112550A (zh) | 1995-11-29 |
| NO950485L (no) | 1995-08-11 |
| EP0667341A1 (de) | 1995-08-16 |
| HU215601B (hu) | 1999-01-28 |
| US5461066A (en) | 1995-10-24 |
| KR950321212A (ko) | 1995-12-20 |
| SK15795A3 (en) | 1995-09-13 |
| CN1082948C (zh) | 2002-04-17 |
| CZ286681B6 (en) | 2000-06-14 |
| CZ32795A3 (en) | 1995-10-18 |
| AU1157195A (en) | 1995-08-17 |
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