ZA932390B - Stability-enhanced variants of parathyroid hormone - Google Patents
Stability-enhanced variants of parathyroid hormoneInfo
- Publication number
- ZA932390B ZA932390B ZA932390A ZA932390A ZA932390B ZA 932390 B ZA932390 B ZA 932390B ZA 932390 A ZA932390 A ZA 932390A ZA 932390 A ZA932390 A ZA 932390A ZA 932390 B ZA932390 B ZA 932390B
- Authority
- ZA
- South Africa
- Prior art keywords
- stability
- parathyroid hormone
- enhanced variants
- variants
- enhanced
- Prior art date
Links
- 102000003982 Parathyroid hormone Human genes 0.000 title 1
- 108090000445 Parathyroid hormone Proteins 0.000 title 1
- 239000000199 parathyroid hormone Substances 0.000 title 1
- 229960001319 parathyroid hormone Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/863,014 US5382658A (en) | 1992-04-03 | 1992-04-03 | Stability-enhanced variants of parathyroid hormone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA932390B true ZA932390B (en) | 1994-01-14 |
Family
ID=25340025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA932390A ZA932390B (en) | 1992-04-03 | 1993-04-02 | Stability-enhanced variants of parathyroid hormone |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5382658A (xx) |
| EP (1) | EP0633935A1 (xx) |
| AU (1) | AU3883993A (xx) |
| CA (1) | CA2132949A1 (xx) |
| IL (1) | IL105283A0 (xx) |
| WO (1) | WO1993020203A2 (xx) |
| ZA (1) | ZA932390B (xx) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5317010A (en) * | 1991-10-10 | 1994-05-31 | Peter K. T. Pang | Parathyroid hormone analogues substituted at AA 25, 26, 27, and use in osteoporosis treatment |
| US5814603A (en) * | 1992-06-12 | 1998-09-29 | Affymax Technologies N.V. | Compounds with PTH activity |
| US5977070A (en) * | 1992-07-14 | 1999-11-02 | Piazza; Christin Teresa | Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis |
| US5821225A (en) * | 1992-07-14 | 1998-10-13 | Syntex (U.S.A.) Inc. | Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp |
| US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| AU672790B2 (en) * | 1992-07-15 | 1996-10-17 | Novartis Ag | Variants of parathyroid hormone and its fragments |
| IT1255723B (it) * | 1992-10-09 | 1995-11-13 | Uso di paratormone,suoi frammenti biologicamente attivi e peptidi correlati, per la preparazione di composizioni farmaceutiche utili nella prevenzione e terapia dell'aborto e del parto pretermine ed in generale per il trattamento della gestazione | |
| US6075124A (en) * | 1994-05-16 | 2000-06-13 | Human Genome Sciences, Inc. | Human chemotactin protein |
| US6100389A (en) | 1995-04-21 | 2000-08-08 | Human Genome Sciences, Inc. | Polynucleotides encoding a human chemotactic protein |
| US6028169A (en) * | 1997-03-31 | 2000-02-22 | Human Genome Sciences, Inc. | Chemokine β-6 antagonists |
| EP1123401A1 (en) * | 1998-10-22 | 2001-08-16 | The General Hospital Corporation | BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP) |
| US6689566B1 (en) * | 1999-01-14 | 2004-02-10 | Scantibodies Laboratory, Inc. | Methods, kits, and antibodies for detecting parathyroid hormone |
| US7820393B2 (en) * | 1999-01-14 | 2010-10-26 | Scantibodies Laboratory, Inc. | Methods, kits and antibodies for detecting parathyroid hormone |
| US20080108086A1 (en) * | 1999-06-02 | 2008-05-08 | Cantor Thomas L | Parathyroid hormone antagonists and uses thereof |
| US7893021B2 (en) * | 1999-06-02 | 2011-02-22 | Scantibodies Laboratory, Inc. | Parathyroid hormone antagonists and uses thereof |
| WO2001023521A2 (en) * | 1999-09-29 | 2001-04-05 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (pth) |
| WO2003009804A2 (en) * | 2001-07-23 | 2003-02-06 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (pth) analogs |
| JP2005525312A (ja) | 2002-01-10 | 2005-08-25 | オステオトロフィン エルエルシー | 骨同化物質を用いた骨疾患の治療方法 |
| US20030152588A1 (en) * | 2002-01-14 | 2003-08-14 | Hsu-Shan Huang | Chinese traditional medicines for psoriasis |
| WO2003099849A2 (en) * | 2002-05-23 | 2003-12-04 | Michael Holick | Use of a parathyroid hormone peptide analogs for the treatment of vaginal atrophy |
| US20040067526A1 (en) * | 2002-10-03 | 2004-04-08 | Cantor Thomas L. | Methods for diagnosing and guiding treatment of bone turnover disease |
| EP2201960A1 (en) * | 2003-03-19 | 2010-06-30 | The General Hospital Corporation | Conformationally constrained parathyroid hormones with alpha-helix stabilizers |
| KR100540659B1 (ko) * | 2003-07-02 | 2006-01-10 | 삼성전자주식회사 | 이미지 확대 인쇄 방법과 장치 및 컴퓨터 프로그램을저장하는 컴퓨터로 읽을 수 있는 기록 매체 |
| WO2005009358A2 (en) | 2003-07-17 | 2005-02-03 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (pth) analogs |
| US7465703B1 (en) | 2003-10-01 | 2008-12-16 | Scantibodies Laboratory, Inc. | Methods and kits useful for guiding osteoporosis related therapy |
| EP1744683B1 (en) * | 2004-05-13 | 2016-03-16 | Alza Corporation | Apparatus and method for transdermal delivery of parathyroid hormone agents |
| US7541140B2 (en) * | 2004-06-03 | 2009-06-02 | Scantibodies Laboratory, Inc. | Assessing risk for kidney stones using parathyroid hormone agonist and antagonist |
| US8143374B2 (en) * | 2006-08-04 | 2012-03-27 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (PTH) |
| WO2009017809A2 (en) * | 2007-08-01 | 2009-02-05 | The General Hospital Corporation | Screening methods using g-protein coupled receptors and related compositions |
| BR112012028949B1 (pt) | 2010-05-13 | 2020-11-17 | Chugai Seiyaku Kabushiki Kaisha | polipeptídeo análogo do hormônio paratireoideo, seu uso e método de produção, bem como ácido nucleico, vetor de expressão, célula e composição farmacêutica |
| CN102775492A (zh) * | 2012-01-05 | 2012-11-14 | 江南大学 | 一种高活性的人甲状旁腺激素(1-34)突变蛋白及其活性检测方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4423037A (en) * | 1982-05-13 | 1983-12-27 | The General Hospital Corporation | Inhibitors of peptide hormone action |
| IL78342A (en) * | 1985-04-04 | 1991-06-10 | Gen Hospital Corp | Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof |
| WO1986006097A1 (en) * | 1985-04-15 | 1986-10-23 | Allelix, Inc. | Promoters of filamentous fungi and use thereof |
| US4761406A (en) * | 1985-06-06 | 1988-08-02 | The Procter & Gamble Company | Regimen for treating osteoporosis |
| US5116952A (en) * | 1986-07-18 | 1992-05-26 | The University Of Melbourne | Protein active in humoral hypercalcemia of malignancy-pthrp |
| DE3789316T2 (de) * | 1986-10-22 | 1994-08-25 | Peter Alestrom | Herstellung von human-parathyroidhormon. |
| US4771124A (en) * | 1987-05-26 | 1988-09-13 | Merck & Co., Inc. | Parathyroid hormone antagonists with simplified synthetic methodology |
| US4968669A (en) * | 1988-05-09 | 1990-11-06 | Merck & Co., Inc. | Parathyroid hormone antagonists |
| US5223407A (en) * | 1988-08-31 | 1993-06-29 | Allelix Inc. | Excretion of heterologous proteins from e. coli |
| WO1990010067A1 (de) * | 1989-02-23 | 1990-09-07 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Pth-varianten kodierende dna-sequenzen, pth-varianten, expressionsvektor, bakterieller wirt, verwendung und therapeutische zusammensetzung |
| JPH0532696A (ja) * | 1990-09-28 | 1993-02-09 | Takeda Chem Ind Ltd | 副甲状腺ホルモン誘導体 |
| US5317010A (en) * | 1991-10-10 | 1994-05-31 | Peter K. T. Pang | Parathyroid hormone analogues substituted at AA 25, 26, 27, and use in osteoporosis treatment |
| US5434246A (en) * | 1992-03-19 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Parathyroid hormone derivatives |
-
1992
- 1992-04-03 US US07/863,014 patent/US5382658A/en not_active Expired - Lifetime
-
1993
- 1993-03-31 EP EP93907711A patent/EP0633935A1/en not_active Withdrawn
- 1993-03-31 AU AU38839/93A patent/AU3883993A/en not_active Abandoned
- 1993-03-31 CA CA002132949A patent/CA2132949A1/en not_active Abandoned
- 1993-03-31 WO PCT/CA1993/000136 patent/WO1993020203A2/en not_active Ceased
- 1993-04-02 IL IL105283A patent/IL105283A0/xx unknown
- 1993-04-02 ZA ZA932390A patent/ZA932390B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2132949A1 (en) | 1993-10-14 |
| EP0633935A1 (en) | 1995-01-18 |
| IL105283A0 (en) | 1993-08-18 |
| AU3883993A (en) | 1993-11-08 |
| US5382658A (en) | 1995-01-17 |
| WO1993020203A3 (en) | 1993-11-25 |
| WO1993020203A2 (en) | 1993-10-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA932390B (en) | Stability-enhanced variants of parathyroid hormone | |
| HUP9901718A3 (en) | Analogs of parathyroid hormone | |
| IL130794A0 (en) | Analogs of parathyroid hormone | |
| GB9203790D0 (en) | Therapeutic agents | |
| GB9206266D0 (en) | Therapeutic agents | |
| EP0656784A4 (en) | PARATHYROID HORMONE FRAGMENTS AND ANALOGS. | |
| ZA936811B (en) | Somatotropin modifications | |
| AU9103791A (en) | Oxidation resistant variants of parathyroid hormone | |
| GB9200781D0 (en) | Therapeutic agents | |
| KR950000006Y1 (en) | Fastenings of sport-shoes | |
| ZA965886B (en) | Analogs of parathyroid hormone | |
| GB2275858B (en) | Application of agrichemicals | |
| CA70269S (en) | Shelter | |
| ZA936326B (en) | Dispensing of substance | |
| HU0600009D0 (en) | Analogs of parathyroid hormone | |
| AU117680S (en) | Formwork member | |
| AU117681S (en) | Formwork member | |
| GB9221318D0 (en) | Spray drift reducing apparatus | |
| ZA938460B (en) | Dispensing of medication | |
| GB9208106D0 (en) | Pharmaceutical agents | |
| GB9201119D0 (en) | Therapeutic agents | |
| GB9201881D0 (en) | Therapeutic agents | |
| GB9207278D0 (en) | Therapeutic agents | |
| GB9202990D0 (en) | Therapeutic agents | |
| GB9203085D0 (en) | Therapeutic agents |