ZA931133B - Process for preparing enantiomerically pure fluoronated epoxychromans - Google Patents
Process for preparing enantiomerically pure fluoronated epoxychromansInfo
- Publication number
- ZA931133B ZA931133B ZA931133A ZA931133A ZA931133B ZA 931133 B ZA931133 B ZA 931133B ZA 931133 A ZA931133 A ZA 931133A ZA 931133 A ZA931133 A ZA 931133A ZA 931133 B ZA931133 B ZA 931133B
- Authority
- ZA
- South Africa
- Prior art keywords
- hydrogen
- epoxychromans
- fluoronated
- enantiomerically pure
- preparing enantiomerically
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- -1 polymethylene moiety Polymers 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
- B01J31/2204—Organic complexes the ligands containing oxygen or sulfur as complexing atoms
- B01J31/2208—Oxygen, e.g. acetylacetonates
- B01J31/2226—Anionic ligands, i.e. the overall ligand carries at least one formal negative charge
- B01J31/2243—At least one oxygen and one nitrogen atom present as complexing atoms in an at least bidentate or bridging ligand
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/70—Oxidation reactions, e.g. epoxidation, (di)hydroxylation, dehydrogenation and analogues
- B01J2231/72—Epoxidation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/02—Compositional aspects of complexes used, e.g. polynuclearity
- B01J2531/0238—Complexes comprising multidentate ligands, i.e. more than 2 ionic or coordinative bonds from the central metal to the ligand, the latter having at least two donor atoms, e.g. N, O, S, P
- B01J2531/0241—Rigid ligands, e.g. extended sp2-carbon frameworks or geminal di- or trisubstitution
- B01J2531/0252—Salen ligands or analogues, e.g. derived from ethylenediamine and salicylaldehyde
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/70—Complexes comprising metals of Group VII (VIIB) as the central metal
- B01J2531/72—Manganese
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Saccharide Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Furan Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929203596A GB9203596D0 (en) | 1992-02-20 | 1992-02-20 | Novel process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA931133B true ZA931133B (en) | 1994-06-03 |
Family
ID=10710733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA931133A ZA931133B (en) | 1992-02-20 | 1993-02-18 | Process for preparing enantiomerically pure fluoronated epoxychromans |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0626967B1 (xx) |
| JP (1) | JPH07504183A (xx) |
| KR (1) | KR100245205B1 (xx) |
| AT (1) | ATE251626T1 (xx) |
| AU (1) | AU675420B2 (xx) |
| CA (1) | CA2130481A1 (xx) |
| DE (1) | DE69333240T2 (xx) |
| GB (1) | GB9203596D0 (xx) |
| MX (1) | MX9300895A (xx) |
| NZ (1) | NZ249200A (xx) |
| WO (1) | WO1993017026A1 (xx) |
| ZA (1) | ZA931133B (xx) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0415165A (pt) | 2003-10-01 | 2007-01-09 | Adolor Corp | composto heterocìclico espirocìclico, composição farmacêutica, método para ligar receptores opióides, métodos para prevenir ou tratar dor, disfunção gastrointestinal, um distúrbio do trato urogenital, um distúrbio imunomodulatório, um distúrbio inflamatório, um distúrbio de função respiratória, ansiedade, distúrbio do humor, um distúrbio relacionado a estresse, distúrbio do sistema nervoso simpático, tosse, e um distúrbio motor, método para tratar uma lesão traumática ao sistema nervoso central, métodos para prevenir ou tratar acidente vascular, arritmia cardìaca, glaucoma, e disfunção sexual, métodos para tratar uma condição selecionada do grupo consistindo de choque, edema cerebral, isquemia cerebral, déficit cerebral após cirurgia cardìaca (bypass) e enxerto, lupus eritematoso sistêmico, doença de hodgkin, doença de sjogren, epilepsia, e rejeição em transplantes de órgão e enxertos de pele, e para tratar dependência de substáncias, métodos para melhorar a sobrevivência de órgãos e células, e cardioproteção após infarto do miocárdio, métodos para reduzir a necessidade de anestesia, para produzir ou manter um estado anestésico, derivado radiomarcado de um composto, derivado isotopicamente marcado de um composto, composto e método de diagnóstico por imagem |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL86798A (en) * | 1987-06-23 | 1992-12-01 | Sanofi Sa | 2,2-dimethylchroman-3-ol derivatives, their preparation and pharmaceutical compositions containing them |
| DE68921972T2 (de) * | 1988-12-13 | 1995-11-16 | Beecham Group Plc | Benzopyran und verwandte Verbindungen. |
| JP3487847B2 (ja) * | 1990-03-21 | 2004-01-19 | リサーチ コーポレイション テクノロジーズ,インコーポレイテッド | キラル触媒及びそれにより触媒されたエポキシ化反応 |
-
1992
- 1992-02-20 GB GB929203596A patent/GB9203596D0/en active Pending
-
1993
- 1993-02-18 AU AU35095/93A patent/AU675420B2/en not_active Ceased
- 1993-02-18 CA CA002130481A patent/CA2130481A1/en not_active Abandoned
- 1993-02-18 KR KR1019940702882A patent/KR100245205B1/ko not_active Expired - Fee Related
- 1993-02-18 DE DE69333240T patent/DE69333240T2/de not_active Expired - Fee Related
- 1993-02-18 NZ NZ249200A patent/NZ249200A/en unknown
- 1993-02-18 AT AT93904228T patent/ATE251626T1/de not_active IP Right Cessation
- 1993-02-18 JP JP5514631A patent/JPH07504183A/ja active Pending
- 1993-02-18 EP EP93904228A patent/EP0626967B1/en not_active Expired - Lifetime
- 1993-02-18 WO PCT/GB1993/000344 patent/WO1993017026A1/en not_active Ceased
- 1993-02-18 ZA ZA931133A patent/ZA931133B/xx unknown
- 1993-02-19 MX MX9300895A patent/MX9300895A/es not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2130481A1 (en) | 1993-09-02 |
| EP0626967A1 (en) | 1994-12-07 |
| KR100245205B1 (ko) | 2000-03-02 |
| JPH07504183A (ja) | 1995-05-11 |
| DE69333240D1 (de) | 2003-11-13 |
| AU3509593A (en) | 1993-09-13 |
| NZ249200A (en) | 1996-06-25 |
| EP0626967B1 (en) | 2003-10-08 |
| KR950700306A (ko) | 1995-01-16 |
| AU675420B2 (en) | 1997-02-06 |
| MX9300895A (es) | 1994-08-31 |
| DE69333240T2 (de) | 2004-08-05 |
| ATE251626T1 (de) | 2003-10-15 |
| GB9203596D0 (en) | 1992-04-08 |
| WO1993017026A1 (en) | 1993-09-02 |
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