ZA925726B - Novel N-alkylated 1,4-dihydropyridinedicarboxylic acid esters. - Google Patents
Novel N-alkylated 1,4-dihydropyridinedicarboxylic acid esters.Info
- Publication number
- ZA925726B ZA925726B ZA925726A ZA925726A ZA925726B ZA 925726 B ZA925726 B ZA 925726B ZA 925726 A ZA925726 A ZA 925726A ZA 925726 A ZA925726 A ZA 925726A ZA 925726 B ZA925726 B ZA 925726B
- Authority
- ZA
- South Africa
- Prior art keywords
- acid esters
- alkylated
- novel
- dihydropyridinedicarboxylic
- dihydropyridinedicarboxylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4125271A DE4125271A1 (de) | 1991-07-31 | 1991-07-31 | Neue n-alkylierte 1,4-dihydropyridindicarbonsaeureester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA925726B true ZA925726B (en) | 1993-03-10 |
Family
ID=6437351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA925726A ZA925726B (en) | 1991-07-31 | 1992-07-30 | Novel N-alkylated 1,4-dihydropyridinedicarboxylic acid esters. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5328931A (da) |
| EP (1) | EP0525568B1 (da) |
| JP (1) | JPH05194395A (da) |
| KR (1) | KR930002316A (da) |
| AT (1) | ATE122341T1 (da) |
| AU (1) | AU646349B2 (da) |
| CA (1) | CA2074777A1 (da) |
| CZ (1) | CZ233492A3 (da) |
| DE (2) | DE4125271A1 (da) |
| DK (1) | DK0525568T3 (da) |
| ES (1) | ES2072666T3 (da) |
| FI (1) | FI923423L (da) |
| HU (1) | HUT65434A (da) |
| IE (1) | IE922512A1 (da) |
| IL (1) | IL102670A0 (da) |
| MX (1) | MX9204238A (da) |
| NO (1) | NO177094B (da) |
| ZA (1) | ZA925726B (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4342196A1 (de) * | 1993-12-10 | 1995-06-14 | Bayer Ag | Neue 4-Phenyl-substituierte 1,4-Dihydropyridine |
| ES2096179T3 (es) * | 1992-10-30 | 1997-03-01 | Bayer Ag | Dihidropiridinas sustituidas en la posicion 4 con un heterociclilfenilo. |
| DE59410255D1 (de) | 1993-12-10 | 2003-04-17 | Bayer Ag | Phenyl-substituierte 1,4-Dihydropyridine mit cerebraler Aktivität |
| DE4342193A1 (de) * | 1993-12-10 | 1995-06-14 | Bayer Ag | Arylsubstituierte Alkoxycarbonyl-1,4-dihydropyridin-5-carbonsäureester |
| EE03192B1 (et) * | 1993-12-10 | 1999-06-15 | Bayer Aktiengesellschaft | Isopropüül-(2-metoksüetüül)-4-(2-kloro-3-tsüanofenüül)-1,4-dihüdro-2,6-dimetüülpüri diin-3,5-dikarboksülaat, selle enantiomeerid ja vaheühend, meetodid nimetatud ühendite valmistamiseks ja kasutamine |
| DE4342195A1 (de) * | 1993-12-10 | 1995-06-14 | Bayer Ag | Dihydropyridine mit heterocyclisch substituierten Estern |
| DE4430092A1 (de) * | 1994-08-25 | 1996-02-29 | Bayer Ag | 2,3-Cyclisch kondensierte 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| WO2003099790A1 (en) * | 2002-05-29 | 2003-12-04 | Council Of Scientific And Industrial Research | Process for the preparation of 1,4-dihydropyridines and novel 1,4-dihydropyridines useful as therapeutic agents |
| US11512052B2 (en) | 2017-11-21 | 2022-11-29 | Icahn School Of Medicine At Mount Sinai | Dihydropyridines for the treatment of cognitive impairment or traumatic brain injury |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1923990C3 (de) * | 1969-05-10 | 1978-11-23 | Bayer Ag | Verfahren zur Herstellung von N-substituierten M-Dihydropyridin-S.S-dicarbonsäureestern |
| DE1963188A1 (de) * | 1969-12-17 | 1971-06-24 | Bayer Ag | Neue Cyanphenyl-1,4-dihydropyridinderivate |
| DE2210672C3 (de) * | 1972-03-06 | 1980-03-20 | Bayer Ag, 5090 Leverkusen | N-substituierte unsymmetrische 1 ^-Dihydropyridin-S^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| DE2210667A1 (de) * | 1972-03-06 | 1973-09-20 | Bayer Ag | Kondensiert aromatisch substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE2508181A1 (de) * | 1975-02-26 | 1976-09-09 | Bayer Ag | 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4284634A (en) * | 1975-07-02 | 1981-08-18 | Fujisawa Pharmaceutical Co., Ltd. | 1,4-Dihydropyridine derivatives, and pharmaceutical method of the same |
| DK142287A (da) * | 1986-03-27 | 1987-09-28 | Byk Gulden Lomberg Chem Fab | Optisk aktive 1,4-dihydropyridinderivater |
| FR2596760B1 (fr) * | 1986-04-02 | 1988-12-09 | Sori Soc Rech Ind | Derives dissymetriques de l'acide 1,4-dihydropyridine-3,5-dicarboxylique, procedes de preparation et utilisation en therapeutique |
| EP0322747B1 (en) * | 1987-12-29 | 1994-03-02 | Fujisawa Pharmaceutical Co., Ltd. | A brain neuron protecting agent containing a dihydropyridine compound |
| AU650567B2 (en) * | 1988-09-06 | 1994-06-23 | Davis, Warren L. | Dental syringe tip and adaptor |
| DE4011695A1 (de) * | 1990-04-11 | 1991-10-17 | Bayer Ag | Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung |
-
1991
- 1991-07-31 DE DE4125271A patent/DE4125271A1/de not_active Withdrawn
-
1992
- 1992-07-17 NO NO922852A patent/NO177094B/no unknown
- 1992-07-20 DE DE59202132T patent/DE59202132D1/de not_active Expired - Fee Related
- 1992-07-20 DK DK92112355.0T patent/DK0525568T3/da active
- 1992-07-20 ES ES92112355T patent/ES2072666T3/es not_active Expired - Lifetime
- 1992-07-20 MX MX9204238A patent/MX9204238A/es not_active IP Right Cessation
- 1992-07-20 EP EP92112355A patent/EP0525568B1/de not_active Expired - Lifetime
- 1992-07-20 AT AT92112355T patent/ATE122341T1/de not_active IP Right Cessation
- 1992-07-21 US US07/917,565 patent/US5328931A/en not_active Expired - Fee Related
- 1992-07-22 AU AU20483/92A patent/AU646349B2/en not_active Ceased
- 1992-07-24 CZ CS922334A patent/CZ233492A3/cs unknown
- 1992-07-28 CA CA002074777A patent/CA2074777A1/en not_active Abandoned
- 1992-07-29 FI FI923423A patent/FI923423L/fi unknown
- 1992-07-29 JP JP4220979A patent/JPH05194395A/ja active Pending
- 1992-07-29 IL IL102670A patent/IL102670A0/xx unknown
- 1992-07-30 IE IE251292A patent/IE922512A1/en not_active Application Discontinuation
- 1992-07-30 HU HU9202489A patent/HUT65434A/hu unknown
- 1992-07-30 ZA ZA925726A patent/ZA925726B/xx unknown
- 1992-07-30 KR KR1019920013669A patent/KR930002316A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DK0525568T3 (da) | 1995-10-09 |
| IE922512A1 (en) | 1993-02-10 |
| AU646349B2 (en) | 1994-02-17 |
| NO177094B (no) | 1995-04-10 |
| CZ233492A3 (en) | 1993-05-12 |
| ATE122341T1 (de) | 1995-05-15 |
| KR930002316A (ko) | 1993-02-22 |
| FI923423A7 (fi) | 1993-02-01 |
| MX9204238A (es) | 1993-01-01 |
| NO922852D0 (no) | 1992-07-17 |
| HUT65434A (en) | 1994-06-28 |
| FI923423A0 (fi) | 1992-07-29 |
| FI923423L (fi) | 1993-02-01 |
| DE4125271A1 (de) | 1993-02-11 |
| EP0525568A1 (de) | 1993-02-03 |
| EP0525568B1 (de) | 1995-05-10 |
| US5328931A (en) | 1994-07-12 |
| HU9202489D0 (en) | 1992-10-28 |
| IL102670A0 (en) | 1993-01-14 |
| DE59202132D1 (de) | 1995-06-14 |
| JPH05194395A (ja) | 1993-08-03 |
| NO922852L (no) | 1993-02-01 |
| AU2048392A (en) | 1993-02-04 |
| ES2072666T3 (es) | 1995-07-16 |
| CA2074777A1 (en) | 1993-02-01 |
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