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ZA904443B - N-heteroaryl-purin-6-amines,a process for their preparation and their use as medicaments - Google Patents

N-heteroaryl-purin-6-amines,a process for their preparation and their use as medicaments

Info

Publication number
ZA904443B
ZA904443B ZA904443A ZA904443A ZA904443B ZA 904443 B ZA904443 B ZA 904443B ZA 904443 A ZA904443 A ZA 904443A ZA 904443 A ZA904443 A ZA 904443A ZA 904443 B ZA904443 B ZA 904443B
Authority
ZA
South Africa
Prior art keywords
lower alkyl
purin
heteroaryl
aryl
hydrogen
Prior art date
Application number
ZA904443A
Other languages
English (en)
Inventor
Richard Charles Effland
Charles Effland Richard
Larry Davis
Davis Larry
Joseph Thomas Klein
Thomas Klein Joseph
Gordon Edward Olsen
Edward Olsen Gordon
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of ZA904443B publication Critical patent/ZA904443B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Television Signal Processing For Recording (AREA)
ZA904443A 1989-06-09 1990-06-08 N-heteroaryl-purin-6-amines,a process for their preparation and their use as medicaments ZA904443B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/363,837 US5017578A (en) 1989-06-09 1989-06-09 N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents

Publications (1)

Publication Number Publication Date
ZA904443B true ZA904443B (en) 1991-03-27

Family

ID=23431950

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA904443A ZA904443B (en) 1989-06-09 1990-06-08 N-heteroaryl-purin-6-amines,a process for their preparation and their use as medicaments

Country Status (21)

Country Link
US (1) US5017578A (xx)
EP (1) EP0402752B1 (xx)
JP (1) JPH06102663B2 (xx)
KR (2) KR100199524B1 (xx)
CN (1) CN1029968C (xx)
AT (1) ATE127807T1 (xx)
AU (1) AU636351B2 (xx)
CA (1) CA2018563C (xx)
DE (1) DE69022294T2 (xx)
DK (1) DK0402752T3 (xx)
ES (1) ES2078267T3 (xx)
FI (1) FI902850A7 (xx)
GR (1) GR3017743T3 (xx)
HU (1) HU207320B (xx)
IE (1) IE68433B1 (xx)
IL (1) IL94665A (xx)
MX (1) MX21088A (xx)
NO (1) NO902555L (xx)
NZ (1) NZ233970A (xx)
PT (1) PT94297B (xx)
ZA (1) ZA904443B (xx)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432164A (en) * 1991-10-24 1995-07-11 Novo Nordisk A/S C2,N6 -disubstituted adenosine derivatives
US5319096A (en) * 1992-04-03 1994-06-07 Hoechst-Roussel Pharmaceuticals Inc. (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use
US5589467A (en) * 1993-09-17 1996-12-31 Novo Nordisk A/S 2,5',N6-trisubstituted adenosine derivatives
JP3355237B2 (ja) * 1993-10-15 2002-12-09 呉羽化学工業株式会社 Ｎ−（置換アミノ）ピロール誘導体、その製造方法及び除草剤
HUT75338A (en) * 1994-05-10 1997-05-28 Sandoz Ag Adenosine derivatives, their preparation and use, and pharmaceutical preparations containing them
US5789416B1 (en) * 1996-08-27 1999-10-05 Cv Therapeutics Inc N6 mono heterocyclic substituted adenosine derivatives
RU2172320C2 (ru) * 1996-08-27 2001-08-20 Си Ви Терапьютикс, Инк. Производные аденозина, фармацевтическая композиция и способ коррекции электрических нарушений в сердце млекопитающего
US6576619B2 (en) 1999-05-24 2003-06-10 Cv Therapeutics, Inc. Orally active A1 adenosine receptor agonists
JP4202250B2 (ja) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド 血液脳関門輸送を調節するための組成物および方法
CN100447143C (zh) * 2003-08-15 2008-12-31 Irm责任有限公司 作为rtk抑制剂的6-取代的苯胺基嘌呤
MXPA06001758A (es) * 2003-08-15 2006-08-11 Irm Llc Anilino purinas sustituidas en la posicion 6 utiles como inhibidores de rtk.
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
CN110075069A (zh) 2009-05-06 2019-08-02 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN104744470A (zh) * 2014-10-31 2015-07-01 合肥平光制药有限公司 一种茶碱的合成方法
WO2017160922A1 (en) 2016-03-16 2017-09-21 Kalyra Pharmaceuticals, Inc. Analgesic compounds
CN106632339B (zh) * 2016-12-16 2018-11-27 温州医科大学 一种6-取代-9h-嘌呤类衍生物及其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3016378A (en) * 1959-07-01 1962-01-09 Thomae Gmbh Dr K Amino-substituted purine derivatives
US3796700A (en) * 1970-06-30 1974-03-12 Takedo Chem Ind Ltd Adenosine derivatives and the production thereof
JPS4935635B1 (xx) * 1970-12-28 1974-09-25
US3936454A (en) * 1973-08-14 1976-02-03 Warner-Lambert Company 5-Amino-4-chloro-6-(substituted amino)-pyrimidines
US3862189A (en) * 1973-08-14 1975-01-21 Warner Lambert Co Aralkyl-substituted purines and pyrimidines as antianginal bronchodilator agents
JPS57171998A (en) * 1981-04-15 1982-10-22 Fujisawa Pharmaceut Co Ltd Adenosine derivative and its salt, preparation thereof and medicinal composition containing the same
US4514405A (en) * 1981-09-17 1985-04-30 Merck Patent Gesellschaft Mit Beschrankter Haftung Use of adenosine derivatives as anticonvulsants
DE3406533A1 (de) * 1984-02-23 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten
AU582359B2 (en) * 1984-04-18 1989-03-23 Nelson Research & Development Company N-6 substituted adenosine derivatives as cardiac vasodilators
US4657897A (en) * 1984-06-22 1987-04-14 Warner-Lambert Company N6 -substituted adenosines for treating pain
CA1254888A (en) * 1984-10-26 1989-05-30 Bharat Trivedi N.sup.6-bicycloadenosines
US4752610A (en) * 1985-12-04 1988-06-21 Hoechst-Roussel Pharmaceuticals Inc. N-(pyrrol-1-yl)pyridinamines having memory enhancing properties
US4780452A (en) * 1986-09-08 1988-10-25 Burroughs Wellcome Co. F-substituted-3-β-D-ribofuranosyl-3H-imidazo[4,5-b]pyridines and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
IE902077L (en) 1990-12-09
AU636351B2 (en) 1993-04-29
HU207320B (en) 1993-03-29
JPH0324080A (ja) 1991-02-01
NO902555D0 (no) 1990-06-08
DK0402752T3 (da) 1996-01-15
DE69022294T2 (de) 1996-03-14
DE69022294D1 (de) 1995-10-19
GR3017743T3 (en) 1996-01-31
CA2018563A1 (en) 1990-12-09
IL94665A (en) 1994-06-24
ES2078267T3 (es) 1995-12-16
EP0402752A1 (en) 1990-12-19
US5017578A (en) 1991-05-21
EP0402752B1 (en) 1995-09-13
CN1047866A (zh) 1990-12-19
CN1029968C (zh) 1995-10-11
KR910000730A (ko) 1991-01-30
HU903768D0 (en) 1990-11-28
IE68433B1 (en) 1996-06-12
CA2018563C (en) 2000-09-19
ATE127807T1 (de) 1995-09-15
KR100199524B1 (ko) 1999-06-15
NO902555L (no) 1990-12-10
NZ233970A (en) 1993-02-25
AU5691990A (en) 1990-12-13
PT94297B (pt) 1997-01-31
MX21088A (es) 1993-11-01
FI902850A7 (fi) 1990-12-10
PT94297A (pt) 1991-02-08
HUT54156A (en) 1991-01-28
IL94665A0 (en) 1991-04-15
FI902850A0 (fi) 1990-06-07
KR100210179B1 (ko) 1999-07-15
JPH06102663B2 (ja) 1994-12-14

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