ZA904366B - Acylated derivatives of etoposide - Google Patents

Acylated derivatives of etoposide

Info

Publication number: ZA904366B
Authority: ZA; South Africa
Prior art keywords: etoposide; acylated derivatives; acylated; derivatives
Prior art date: 1989-06-07

Application number

ZA904366A

Other languages

English (en)

Inventor

Takeshi Ohnuma

Ohnuma Takeshi

Rika Obata

Obata Rika

Hideo Kamei

Kamei Hideo

Takayuki Naito

Naito Takayuki

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-07

Filing date

1990-06-06

Publication date

1991-05-29

1990-06-06 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1991-05-29 Publication of ZA904366B publication Critical patent/ZA904366B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

ZA904366A 1989-06-07 1990-06-06 Acylated derivatives of etoposide ZA904366B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/362,555 US5036055A (en)	1989-06-07	1989-06-07	Acylated derivatives of etoposide

Publications (1)

Publication Number	Publication Date
ZA904366B true ZA904366B (en)	1991-05-29

Family

ID=23426565

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA904366A ZA904366B (en)	1989-06-07	1990-06-06	Acylated derivatives of etoposide

Country Status (17)

Country	Link
US (1)	US5036055A (xx)
EP (1)	EP0401800A3 (xx)
JP (1)	JPH0324097A (xx)
KR (1)	KR910000778A (xx)
CN (1)	CN1024197C (xx)
AU (1)	AU637104B2 (xx)
CA (1)	CA2018067A1 (xx)
CZ (1)	CZ283890A3 (xx)
DD (1)	DD294947A5 (xx)
FI (1)	FI902767A7 (xx)
HU (1)	HU206221B (xx)
IL (1)	IL94606A0 (xx)
NO (1)	NO173239C (xx)
NZ (1)	NZ233900A (xx)
PT (1)	PT94281A (xx)
YU (1)	YU110690A (xx)
ZA (1)	ZA904366B (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5191071A (en) *	1987-08-21	1993-03-02	Novo Nordisk A/S	Monoesters of glycosides and a process for enzymatic preparation thereof
US6610299B1 (en)	1989-10-19	2003-08-26	Aventis Pharma Deutschland Gmbh	Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en)	1990-10-18	2002-11-05	Aventis Pharma Deutschland Gmbh	Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) *	1989-10-20	2007-07-10	Sanofi-Aventis Pharma Deutschland Gmbh	Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5034380A (en) *	1989-11-20	1991-07-23	Bristol-Myers Squibb Company	Alkoxymethylidene epipodophyllotoxin glucosides
CN1025918C (zh) *	1990-06-07	1994-09-14	国家医药管理局上海医药工业研究院	抗肿瘤药表鬼臼毒吡喃糖甙的合成新工艺
TW260671B (xx) *	1991-04-29	1995-10-21	Bristol Myers Squibb Co
IT1250692B (it) *	1991-07-23	1995-04-21		Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
JP3061476B2 (ja) *	1992-04-24	2000-07-10	日本化薬株式会社	エトポシド燐酸エステルの製造法
US5459248A (en) *	1993-11-04	1995-10-17	Bristol-Myers Squibb Company	Process of preparing etoposide phosphate and etoposide
EP0778282B1 (en) *	1995-12-04	2003-04-09	Nippon Kayaku Kabushiki Kaisha	Process for producing etoposide
AU728986B2 (en) *	1997-06-02	2001-01-25	Bristol-Myers Squibb Company	Process for preparing etoposide
EP1229934B1 (en)	1999-10-01	2014-03-05	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US8240508B2 (en)	2008-12-29	2012-08-14	Gojo Industries, Inc.	Low cost radio frequency identification (RFID) dispensing systems
EP2943497A4 (en) *	2013-01-14	2017-05-03	Advanomics Corp.	Gem-difluorinated c-glycoside compounds as anti-cancer agents

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL6613143A (xx) *	1965-09-21	1967-03-22
CH507934A (de) *	1965-12-14	1971-05-31	Sandoz Ag	Verfahren zur Herstellung eines neuen Glucosids
FR1518706A (fr) *	1965-12-14	1968-03-29	Sandoz Sa	Glucosides dérivant de composés apparentés à la podophyllotoxine et leur préparation
CH514578A (de) *	1968-02-27	1971-10-31	Sandoz Ag	Verfahren zur Herstellung von Glucosiden
JPS58219196A (ja) *	1982-06-15	1983-12-20	Nippon Kayaku Co Ltd	４′−デメチル−エピポドフイロトキシン−β−Ｄ−エチリデングルコシドの製造法
JPS58225096A (ja) *	1982-06-25	1983-12-27	Nippon Kayaku Co Ltd	４′−デメチル−エピポドフイロトキシン−β−Ｄ−エチリデングルコシドの新規製造法
EP0111058B1 (en) *	1982-11-26	1987-11-04	Nippon Kayaku Kabushiki Kaisha	Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) *	1984-02-03	1986-01-28	Tony Durst	2-Substituted derivatives of podophyllotoxin and etoposide
JPS60246393A (ja) *	1984-05-22	1985-12-06	Nippon Kayaku Co Ltd	エトポシドの新規製造法
US4609644A (en) *	1984-06-15	1986-09-02	St. Jude Children's Research Hospital	Epipodophyllotoxinquinone glucoside derivatives, method of production and use
JPS61134396A (ja) *	1984-12-06	1986-06-21	Nippon Kayaku Co Ltd	エトポシドの新規製造法
JPS61227590A (ja) *	1985-04-02	1986-10-09	Microbial Chem Res Found	新規４′−デメチル−４−エピポドフイロトキシン誘導体
IL77334A (en) *	1985-12-16	1991-04-15	Univ Bar Ilan	Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
JPS63150293A (ja) *	1986-12-12	1988-06-22	Nippon Kayaku Co Ltd	エトポシド水溶性誘導体
US4916217A (en) *	1987-01-08	1990-04-10	Bristol-Myers Company	Phosphorus containing derivatives of epipodophyllotoxin
JPS63192793A (ja) *	1987-02-06	1988-08-10	Nippon Kayaku Co Ltd	４′−デメチル−エピポドフイロトキシン誘導体の新規エステル
US4853467A (en) *	1987-05-19	1989-08-01	Bristol-Myers Company	Nitrogen containing derivatives of epipodophyllotoxin glucosides
US4874851A (en) *	1987-07-01	1989-10-17	Bristol-Meyers Company	3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives
US4904768A (en) *	1987-08-04	1990-02-27	Bristol-Myers Company	Epipodophyllotoxin glucoside 4'-phosphate derivatives
US4868291A (en) *	1987-08-20	1989-09-19	Bristol-Myers Company	4'-deshydroxyepipodophyllotoxin glucosides: synthesis and use
US4888419A (en) *	1987-08-31	1989-12-19	Bristol-Myers Company	3'-demethoxyepipodophyllotoxin glucoside derivatives
ZA886810B (en) *	1987-12-18	1989-08-30	Bristol Myers Co	Epipodophyllotoxin glucoside 4'-acyl derivatives
US4912204A (en) *	1988-09-06	1990-03-27	Bristol-Myers Company	Fluoro-substituted epipodophyllotoxin glucosides
US5066645A (en) *	1989-09-01	1991-11-19	Bristol-Myers Company	Epipodophyllotoxin altroside derivatives

1989
- 1989-06-07 US US07/362,555 patent/US5036055A/en not_active Expired - Fee Related
1990
- 1990-06-01 NZ NZ233900A patent/NZ233900A/en unknown
- 1990-06-01 CA CA002018067A patent/CA2018067A1/en not_active Abandoned
- 1990-06-04 FI FI902767A patent/FI902767A7/fi not_active Application Discontinuation
- 1990-06-04 IL IL94606A patent/IL94606A0/xx unknown
- 1990-06-04 CN CN90104190A patent/CN1024197C/zh not_active Expired - Fee Related
- 1990-06-05 KR KR1019900008275A patent/KR910000778A/ko not_active Withdrawn
- 1990-06-06 EP EP19900110729 patent/EP0401800A3/en not_active Ceased
- 1990-06-06 YU YU01106/90A patent/YU110690A/xx unknown
- 1990-06-06 DD DD90341368A patent/DD294947A5/de not_active IP Right Cessation
- 1990-06-06 AU AU56828/90A patent/AU637104B2/en not_active Ceased
- 1990-06-06 ZA ZA904366A patent/ZA904366B/xx unknown
- 1990-06-06 PT PT94281A patent/PT94281A/pt not_active Application Discontinuation
- 1990-06-06 NO NO902495A patent/NO173239C/no unknown
- 1990-06-07 CZ CS902838A patent/CZ283890A3/cs unknown
- 1990-06-07 HU HU903517A patent/HU206221B/hu not_active IP Right Cessation
- 1990-06-07 JP JP2147535A patent/JPH0324097A/ja active Pending

Also Published As

Publication number	Publication date
FI902767A7 (fi)	1990-12-08
NO902495L (no)	1990-12-10
YU110690A (en)	1992-05-28
NO902495D0 (no)	1990-06-06
CN1047869A (zh)	1990-12-19
HU206221B (en)	1992-09-28
NO173239C (no)	1993-11-17
KR910000778A (ko)	1991-01-30
US5036055A (en)	1991-07-30
HUT54174A (en)	1991-01-28
NO173239B (no)	1993-08-09
NZ233900A (en)	1992-02-25
CN1024197C (zh)	1994-04-13
FI902767A0 (fi)	1990-06-04
DD294947A5 (de)	1991-10-17
HU903517D0 (en)	1990-10-28
AU5682890A (en)	1990-12-13
CA2018067A1 (en)	1990-12-07
EP0401800A2 (en)	1990-12-12
PT94281A (pt)	1991-02-08
IL94606A0 (en)	1991-04-15
AU637104B2 (en)	1993-05-20
CZ283890A3 (en)	1995-02-15
JPH0324097A (ja)	1991-02-01
EP0401800A3 (en)	1991-04-10

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