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ZA898498B - 1,2,3,4-tetrahydro-1,9-acridinediamines,a process for their preparation and their use as medicaments - Google Patents

1,2,3,4-tetrahydro-1,9-acridinediamines,a process for their preparation and their use as medicaments

Info

Publication number
ZA898498B
ZA898498B ZA898498A ZA898498A ZA898498B ZA 898498 B ZA898498 B ZA 898498B ZA 898498 A ZA898498 A ZA 898498A ZA 898498 A ZA898498 A ZA 898498A ZA 898498 B ZA898498 B ZA 898498B
Authority
ZA
South Africa
Prior art keywords
arylloweralkyl
loweralkyl
medicaments
preparation
chem
Prior art date
Application number
ZA898498A
Other languages
English (en)
Inventor
Gregory M Shutske
M Shutske Gregory
Kevin J Kapples
J Kapples Kevin
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of ZA898498B publication Critical patent/ZA898498B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D219/00Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D219/00Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08Nitrogen atoms
    • C07D219/10Nitrogen atoms attached in position 9
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • C07D221/06Ring systems of three rings
    • C07D221/16Ring systems of three rings containing carbocyclic rings other than six-membered

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
ZA898498A 1988-11-09 1989-11-08 1,2,3,4-tetrahydro-1,9-acridinediamines,a process for their preparation and their use as medicaments ZA898498B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/269,038 US4868177A (en) 1988-11-09 1988-11-09 1,2,3,4-tetrahydro-1,9-acridinediamines, pharmaceutical compositions and use

Publications (1)

Publication Number Publication Date
ZA898498B true ZA898498B (en) 1990-08-29

Family

ID=23025549

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA898498A ZA898498B (en) 1988-11-09 1989-11-08 1,2,3,4-tetrahydro-1,9-acridinediamines,a process for their preparation and their use as medicaments

Country Status (18)

Country Link
US (1) US4868177A (xx)
EP (1) EP0368188B1 (xx)
JP (1) JPH03153667A (xx)
KR (1) KR900007808A (xx)
AT (1) ATE111899T1 (xx)
AU (1) AU623701B2 (xx)
CA (1) CA2002531A1 (xx)
DE (1) DE68918402T2 (xx)
DK (1) DK166620B1 (xx)
ES (1) ES2059677T3 (xx)
FI (1) FI895288A7 (xx)
HU (1) HU208530B (xx)
IE (1) IE64499B1 (xx)
IL (1) IL92233A0 (xx)
NO (1) NO894445L (xx)
NZ (1) NZ231293A (xx)
PT (1) PT92234B (xx)
ZA (1) ZA898498B (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0282959A3 (en) * 1987-03-17 1989-05-31 Hoechst-Roussel Pharmaceuticals Incorporated Substituted 9-amino-tetrahydro-acridines and related compounds, a process for their preparation and their use as medicaments
US6075144A (en) * 1987-04-20 2000-06-13 Hoechst Marion Roussel, Inc. 9-hydroxyamino tetrahydroacridine and related compounds
US4970316A (en) * 1987-05-07 1990-11-13 American Home Products Corporation Pyrano-, thiopyrano- and cyclohexylquinolines as inhibitors of interleukin 1
US5053513A (en) * 1990-03-29 1991-10-01 Hoechst-Roussel Pharmaceuticals Incorporated Method of reducing a carbonyl containing acridine
US5783584A (en) * 1995-12-11 1998-07-21 Mayo Foundation For Medical Education And Research THA analogs useful as cholinesterase inhibitors
US5929093A (en) * 1996-06-13 1999-07-27 Mayo Foundation For Medical Education And Research Bifunctional acetylcholinesterase reactivators
NZ510685A (en) 1998-09-30 2003-10-31 Takeda Chemical Industries Ltd Drugs for improving vesical excretory strength
UY28538A1 (es) * 2003-09-26 2005-04-29 Vertex Pharma Derivados de fenil-piperazina como moduladores de receptores muscarínicos
WO2005072713A2 (en) 2004-01-27 2005-08-11 The Feinstein Institute For Medical Research Cholinesterase inhibitors for treating inflammation
DE102021119724A1 (de) * 2021-07-29 2023-02-02 Brückner Maschinenbau GmbH & Co. KG Folienaufwickelsystem, Verbund aus einer Folienreckanlage und einem solchen Folienaufwickelsystem und Verwendung eines solchen Verbunds zur Herstellung von Dünnstfilmen und Membranen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695573A (en) * 1984-10-25 1987-09-22 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
EP0268871A1 (en) * 1986-10-31 1988-06-01 Sumitomo Pharmaceuticals Company, Limited Quinoline derivatives
EP0282959A3 (en) * 1987-03-17 1989-05-31 Hoechst-Roussel Pharmaceuticals Incorporated Substituted 9-amino-tetrahydro-acridines and related compounds, a process for their preparation and their use as medicaments
US5013741A (en) * 1987-09-08 1991-05-07 Hoechst-Roussel Pharmaceuticals Incorporated N-[substituted alkylidene]-1,2,3,4-tetrahydro-9-acridinamines useful for enhancing the cholinergic function in a mammal
IL87861A0 (en) * 1987-10-05 1989-03-31 Pfizer 4-aminopyridine derivatives

Also Published As

Publication number Publication date
NZ231293A (en) 1991-09-25
DK557189D0 (da) 1989-11-08
FI895288A0 (fi) 1989-11-07
DK557189A (da) 1990-05-30
HU208530B (en) 1993-11-29
DK166620B1 (da) 1993-06-21
CA2002531A1 (en) 1990-05-09
KR900007808A (ko) 1990-06-02
ES2059677T3 (es) 1994-11-16
IE893592L (en) 1990-05-09
NO894445D0 (no) 1989-11-08
JPH03153667A (ja) 1991-07-01
PT92234B (pt) 1995-07-06
EP0368188B1 (en) 1994-09-21
DE68918402T2 (de) 1995-03-09
HU895830D0 (en) 1990-01-28
ATE111899T1 (de) 1994-10-15
AU4442389A (en) 1990-05-17
FI895288A7 (fi) 1990-05-10
IE64499B1 (en) 1995-08-09
DE68918402D1 (de) 1994-10-27
AU623701B2 (en) 1992-05-21
US4868177A (en) 1989-09-19
NO894445L (no) 1990-05-10
PT92234A (pt) 1990-05-31
IL92233A0 (en) 1990-07-26
EP0368188A1 (en) 1990-05-16

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