[go: up one dir, main page]

ZA200908281B - Skin permeation device for analyte sensing or transdermal drug delivery - Google Patents

Skin permeation device for analyte sensing or transdermal drug delivery

Info

Publication number
ZA200908281B
ZA200908281B ZA200908281A ZA200908281A ZA200908281B ZA 200908281 B ZA200908281 B ZA 200908281B ZA 200908281 A ZA200908281 A ZA 200908281A ZA 200908281 A ZA200908281 A ZA 200908281A ZA 200908281 B ZA200908281 B ZA 200908281B
Authority
ZA
South Africa
Prior art keywords
skin
feedback control
drug delivery
controlled
permeability
Prior art date
Application number
ZA200908281A
Other languages
English (en)
Inventor
Han Chuang
Juan P Eslava
James P Hurley
Debashis Ghosh
Keith Krystyniak
Scott C Kellogg
Original Assignee
Echo Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Echo Therapeutics Inc filed Critical Echo Therapeutics Inc
Publication of ZA200908281B publication Critical patent/ZA200908281B/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/54Chiropodists' instruments, e.g. pedicure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/08Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by means of electrically-heated probes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/053Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0531Measuring skin impedance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14542Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring blood gases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/44Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/442Evaluating skin mechanical properties, e.g. elasticity, hardness, texture, wrinkle assessment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0412Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416Anode and cathode
    • A61N1/042Material of the electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0412Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416Anode and cathode
    • A61N1/0424Shape of the electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432Anode and cathode
    • A61N1/0436Material of the electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432Anode and cathode
    • A61N1/044Shape of the electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/203Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B2017/00743Type of operation; Specification of treatment sites
    • A61B2017/00747Dermatology
    • A61B2017/00761Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B2017/00743Type of operation; Specification of treatment sites
    • A61B2017/00747Dermatology
    • A61B2017/00765Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/32Surgical cutting instruments
    • A61B2017/320004Surgical cutting instruments abrasive
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452Skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00642Sensing and controlling the application of energy with feedback, i.e. closed loop control
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235Details of waveform analysis
    • A61B5/7239Details of waveform analysis using differentiation including higher order derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/328Applying electric currents by contact electrodes alternating or intermittent currents for improving the appearance of the skin, e.g. facial toning or wrinkle treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Otolaryngology (AREA)
  • Optics & Photonics (AREA)
  • Dermatology (AREA)
  • Plasma & Fusion (AREA)
  • Electromagnetism (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Electrotherapy Devices (AREA)
  • Medicinal Preparation (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Surgical Instruments (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ZA200908281A 2007-04-27 2009-11-23 Skin permeation device for analyte sensing or transdermal drug delivery ZA200908281B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91455207P 2007-04-27 2007-04-27

Publications (1)

Publication Number Publication Date
ZA200908281B true ZA200908281B (en) 2010-08-25

Family

ID=39592101

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200908281A ZA200908281B (en) 2007-04-27 2009-11-23 Skin permeation device for analyte sensing or transdermal drug delivery

Country Status (23)

Country Link
US (2) US8386027B2 (fr)
EP (1) EP2152358B1 (fr)
JP (2) JP2010525881A (fr)
KR (1) KR101211252B1 (fr)
CN (1) CN101707872B (fr)
AT (1) ATE499967T1 (fr)
AU (1) AU2008245585B2 (fr)
BR (1) BRPI0810969A2 (fr)
CA (1) CA2685423C (fr)
CY (1) CY1112035T1 (fr)
DE (1) DE602008005299D1 (fr)
DK (1) DK2152358T3 (fr)
ES (1) ES2387419T3 (fr)
HR (1) HRP20110396T1 (fr)
IL (1) IL201699A (fr)
MX (1) MX2009011581A (fr)
NZ (1) NZ580997A (fr)
PL (1) PL2152358T3 (fr)
PT (1) PT2152358E (fr)
RU (1) RU2435616C2 (fr)
SI (1) SI2152358T1 (fr)
WO (1) WO2008134545A1 (fr)
ZA (1) ZA200908281B (fr)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005021338D1 (de) * 2004-04-30 2010-07-01 Gyung Su Cho Elektrische dermabrasionsvorrichtung
EP2037999B1 (fr) 2006-07-07 2016-12-28 Proteus Digital Health, Inc. Système d'administration parentérale intelligent
US8150505B2 (en) * 2007-05-03 2012-04-03 Path Scientific, Llc Method and apparatus for the formation of multiple microconduits
US11154698B2 (en) * 2007-08-24 2021-10-26 Deka Products Limited Partnership Microneedle systems and apparatus
JP5243548B2 (ja) 2007-10-25 2013-07-24 プロテウス デジタル ヘルス, インコーポレイテッド 情報システムのための流体伝達ポート
WO2009067463A1 (fr) 2007-11-19 2009-05-28 Proteus Biomedical, Inc. Dispositifs d'évaluation de structures de transport de fluides associées au corps
US10441764B2 (en) * 2008-06-09 2019-10-15 Robert E. Akridge Sonic applicator for skin formulations
RU2587795C2 (ru) 2010-02-01 2016-06-20 Проутьюс Диджитал Хэлс, Инк. Система сбора данных
MY169700A (en) 2010-02-01 2019-05-13 Proteus Digital Health Inc Data gathering system
EP3581105B1 (fr) 2010-05-08 2022-08-31 The Regents of the University of California Appareil de mesure par radiofréquence pour la détection précoce des escarres
EP3578205A1 (fr) 2010-08-06 2019-12-11 ModernaTX, Inc. Compositions pharmaceutiques a base d'acides nucléiques modifiés et leur utilisation medicale
CN103429606A (zh) 2010-10-01 2013-12-04 现代治疗公司 设计核酸及其使用方法
CA2819859A1 (fr) * 2010-12-06 2012-06-14 Follica, Inc. Procedes destines a traiter la calvitie et a favoriser la croissance des cheveux
CA2831613A1 (fr) 2011-03-31 2012-10-04 Moderna Therapeutics, Inc. Administration et formulation d'acides nucleiques genetiquement modifies
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US9143126B2 (en) 2011-09-22 2015-09-22 Ford Global Technologies, Llc Proximity switch having lockout control for controlling movable panel
KR20190099538A (ko) 2011-10-03 2019-08-27 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드, 및 핵산, 및 이들의 용도
US10112556B2 (en) 2011-11-03 2018-10-30 Ford Global Technologies, Llc Proximity switch having wrong touch adaptive learning and method
KR20140096267A (ko) * 2011-11-24 2014-08-05 시네론 메디컬 리미티드 안전한 개인용 피부 치료 장치 및 그것의 사용 방법
EP4144378A1 (fr) 2011-12-16 2023-03-08 ModernaTX, Inc. Nucléoside modifié, nucléotide, et compositions d'acides nucléiques
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
AU2013243954A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9568527B2 (en) 2012-04-11 2017-02-14 Ford Global Technologies, Llc Proximity switch assembly and activation method having virtual button mode
US9559688B2 (en) 2012-04-11 2017-01-31 Ford Global Technologies, Llc Proximity switch assembly having pliable surface and depression
US9944237B2 (en) 2012-04-11 2018-04-17 Ford Global Technologies, Llc Proximity switch assembly with signal drift rejection and method
US9520875B2 (en) 2012-04-11 2016-12-13 Ford Global Technologies, Llc Pliable proximity switch assembly and activation method
US9219472B2 (en) 2012-04-11 2015-12-22 Ford Global Technologies, Llc Proximity switch assembly and activation method using rate monitoring
US9197206B2 (en) 2012-04-11 2015-11-24 Ford Global Technologies, Llc Proximity switch having differential contact surface
US9184745B2 (en) 2012-04-11 2015-11-10 Ford Global Technologies, Llc Proximity switch assembly and method of sensing user input based on signal rate of change
US9287864B2 (en) 2012-04-11 2016-03-15 Ford Global Technologies, Llc Proximity switch assembly and calibration method therefor
US9660644B2 (en) 2012-04-11 2017-05-23 Ford Global Technologies, Llc Proximity switch assembly and activation method
US9065447B2 (en) * 2012-04-11 2015-06-23 Ford Global Technologies, Llc Proximity switch assembly and method having adaptive time delay
US9831870B2 (en) 2012-04-11 2017-11-28 Ford Global Technologies, Llc Proximity switch assembly and method of tuning same
US9531379B2 (en) 2012-04-11 2016-12-27 Ford Global Technologies, Llc Proximity switch assembly having groove between adjacent proximity sensors
US9136840B2 (en) 2012-05-17 2015-09-15 Ford Global Technologies, Llc Proximity switch assembly having dynamic tuned threshold
US9337832B2 (en) 2012-06-06 2016-05-10 Ford Global Technologies, Llc Proximity switch and method of adjusting sensitivity therefor
US9044582B2 (en) * 2012-06-26 2015-06-02 Franklin J. Chang Apparatus and method for transdermal fluid delivery
US9186490B2 (en) * 2012-06-26 2015-11-17 Franklin J. Chang Skin treatment device
US20130345661A1 (en) * 2012-06-26 2013-12-26 Franklin J. Chang Skin Treatment Device
US10842670B2 (en) * 2012-08-22 2020-11-24 Johnson & Johnson Vision Care, Inc. Apparatuses and methods for diagnosing and/or treating lipid transport deficiency in ocular tear films, and related components and devices
WO2014045300A2 (fr) * 2012-09-03 2014-03-27 Fdc Limited Système d'administration de médicament topique
US8922340B2 (en) 2012-09-11 2014-12-30 Ford Global Technologies, Llc Proximity switch based door latch release
DK2922554T3 (en) 2012-11-26 2022-05-23 Modernatx Inc Terminalt modificeret rna
JP2016504050A (ja) 2013-01-17 2016-02-12 モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. 細胞表現型の改変のためのシグナルセンサーポリヌクレオチド
WO2014136013A1 (fr) * 2013-03-04 2014-09-12 Koninklijke Philips N.V. Dispositif de microdermabrasion
US9311204B2 (en) 2013-03-13 2016-04-12 Ford Global Technologies, Llc Proximity interface development system having replicator and method
EP2968391A1 (fr) 2013-03-13 2016-01-20 Moderna Therapeutics, Inc. Molécules polynucléotidiques à longue durée de vie
US10820860B2 (en) 2013-03-14 2020-11-03 One Drop Biosensor Technologies, Llc On-body microsensor for biomonitoring
CN105228522B (zh) 2013-03-14 2018-06-26 萨诺智能公司 用于生物监测的人体上的微传感器
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
US10130275B2 (en) 2013-06-13 2018-11-20 Dyansys, Inc. Method and apparatus for autonomic nervous system sensitivity-point testing
BR112015031151B1 (pt) * 2013-06-13 2022-09-06 Dyansys, Inc Aparelho de teste elétrico e método para teste elétrico
US10052257B2 (en) 2013-06-13 2018-08-21 Dyansys, Inc. Method and apparatus for stimulative electrotherapy
DK3019619T3 (da) 2013-07-11 2021-10-11 Modernatx Inc Sammensætninger, der omfatter syntetiske polynukleotider, som koder for crispr-beslægtede proteiner, og syntetiske sgrna'er, og anvendelsesfremgangsmåder
US20160194368A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Circular polynucleotides
AU2014315287A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Chimeric polynucleotides
BR112016007255A2 (pt) 2013-10-03 2017-09-12 Moderna Therapeutics Inc polinucleotídeos que codificam receptor de lipoproteína de baixa densidade
CN103550795B (zh) * 2013-10-24 2015-04-22 苏州格林泰克科技有限公司 一种电极磨砂导电胶及其制备方法
US10595754B2 (en) 2014-03-13 2020-03-24 Sano Intelligence, Inc. System for monitoring body chemistry
US20150257685A1 (en) 2014-03-13 2015-09-17 Sano Intelligence, Inc. System for monitoring body chemistry
US20150265825A1 (en) * 2014-03-21 2015-09-24 L'oreal Combined sonic and iontophoretic skin care device
JP2017513683A (ja) * 2014-04-21 2017-06-01 チャン, フランクリン, ジェイ.CHANG, Franklin, J. 経皮送達の装置と方法
WO2016011226A1 (fr) 2014-07-16 2016-01-21 Moderna Therapeutics, Inc. Polynucléotides chimériques
GB201415611D0 (en) 2014-09-03 2014-10-15 Univ Strathclyde Apparatus for topical application of material
US10038443B2 (en) 2014-10-20 2018-07-31 Ford Global Technologies, Llc Directional proximity switch assembly
CA2973261A1 (fr) 2015-01-09 2016-07-14 Exhalix Llc Bande de prelevement d'echantillons transdermiques et procede d'analyse de gaz emis par voie transdermique
US10252044B2 (en) 2015-02-27 2019-04-09 Robert T. Bock Consultancy, Llc Ultrasonic method and device for cosmetic applications
US9654103B2 (en) 2015-03-18 2017-05-16 Ford Global Technologies, Llc Proximity switch assembly having haptic feedback and method
CA3059988C (fr) 2015-04-24 2023-03-07 Bruin Biometrics, Llc Appareil et procedes pour determiner un tissu endommage a l'aide de mesures d'humidite sous-epidermique
US9548733B2 (en) 2015-05-20 2017-01-17 Ford Global Technologies, Llc Proximity sensor assembly having interleaved electrode configuration
WO2017021585A1 (fr) 2015-08-04 2017-02-09 Helsingin Yliopisto Dispositif et procédé pour l'administration localisée et l'extraction de matériau
FR3043333B1 (fr) * 2015-11-06 2017-12-22 Seb Sa Dispositif d'application d'un produit a distribuer sur la peau d'un utilisateur par iontophorese comprenant des moyens de mesure d'absence de produit et procede correspondant
JP6876045B2 (ja) * 2015-12-15 2021-05-26 コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. 表面処理装置及び方法
FR3045289B1 (fr) * 2015-12-17 2021-09-03 Oreal Dispositif de traitement des matieres keratiniques humaines, notamment a l'aide d'un courant electrique
CA3009348A1 (fr) * 2015-12-30 2017-07-06 Inovio Pharmaceuticals, Inc. Dispositif d'electroporation avec ensemble d'aiguilles detachables avec systeme de verrouillage
CN106236087A (zh) * 2016-08-31 2016-12-21 苏州格林泰克科技有限公司 一种无胶生物电电极及电极辅助装置
WO2018117926A1 (fr) * 2016-12-23 2018-06-28 Atlasbalans Ab Machine portative adaptée pour l'administration de composés anti-inflammatoires dans un corps
RU184518U1 (ru) * 2017-01-27 2018-10-30 Виктор Филиппович Агафонников Электростимулятор желудочно-кишечного тракта с эндогенным ионофорезом ванадия
CA3042093A1 (fr) 2017-02-03 2018-08-09 Bruin Biometrics, Llc Mesure de viabilite tissulaire
ES3008659T3 (en) 2017-02-03 2025-03-24 Bbi Medical Innovations Llc Measurement of susceptibility to diabetic foot ulcers
MX2019004926A (es) 2017-02-03 2019-06-20 Bruin Biometrics Llc Medicion del edema.
CN107014877B (zh) * 2017-05-27 2023-06-20 北京怡唐生物科技有限公司 一种动态连续血糖监测系统
AU2018289297B9 (en) * 2017-06-19 2023-02-02 Bruin Biometrics, Llc Apparatus and methods for determining damaged tissue using sub-epidermal moisture measurements
EP3562392A4 (fr) 2017-11-16 2021-06-09 Bruin Biometrics, LLC Traitement stratégique d'une escarre de décubitus à l'aide de valeurs d'humidité sous-épidermique
ES2984425T3 (es) 2018-02-09 2024-10-29 Bruin Biometrics Llc Detección de daños tisulares
US20190247117A1 (en) * 2018-02-15 2019-08-15 Neuwave Medical, Inc. Energy delivery devices and related systems and methods thereof
CN109011130A (zh) * 2018-05-29 2018-12-18 上海大学 一种基于纳米针的经皮光电驱动离子药物输送装置
US10950960B2 (en) 2018-10-11 2021-03-16 Bruin Biometrics, Llc Device with disposable element
US11324414B2 (en) * 2018-11-28 2022-05-10 Vine Medical, LLC Devices, systems and methods for controlling a spring force exerted on a sensor for obtaining bio-conductance readings using a linear actuator
CN118476798A (zh) * 2018-12-21 2024-08-13 费森尤斯医疗保健控股公司 使用生物阻抗的皮肤钠测量
WO2022169850A1 (fr) 2021-02-03 2022-08-11 Bruin Biometrics, Llc Procédés de traitement d'une lésion tissulaire profonde et précoce induite par la pression
USD1086030S1 (en) 2021-04-21 2025-07-29 One Health Biosensing Inc. Charging station
USD988882S1 (en) 2021-04-21 2023-06-13 Informed Data Systems Inc. Sensor assembly
USD1076079S1 (en) 2021-04-21 2025-05-20 One Health Biosensing Inc. Applicator assembly
US20230293886A1 (en) * 2022-02-18 2023-09-21 Nse Products, Inc. Microcurrent-based skin treatment and pretreatment techniques
WO2025244305A1 (fr) * 2024-05-20 2025-11-27 주식회사 제이시스메디칼 Dispositif de sortie à haute fréquence
US12485280B1 (en) 2024-07-15 2025-12-02 Tav-Tech Ltd Unitary enhanced jet spray dermal treatment handpiece

Family Cites Families (237)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US498271A (en) 1893-05-30 Caster
US4005A (en) * 1845-04-22 Improvement in the manufacture of indurated rubber fabrics
US2887112A (en) * 1957-08-15 1959-05-19 Sanborn Company Pad for skin preparation for electrocardiography and the like
US3508540A (en) * 1967-02-14 1970-04-28 Us Navy Apparatus for direct measurement of skin conductance
US3551554A (en) 1968-08-16 1970-12-29 Crown Zellerbach Corp Enhancing tissue penetration of physiologically active agents with dmso
US3711606A (en) * 1970-09-02 1973-01-16 Crown Zellerbach Corp Enhancing tissue penetration of physiologically active steroidal agents with dmso
US3711602A (en) * 1970-10-30 1973-01-16 Crown Zellerbach Corp Compositions for topical application for enhancing tissue penetration of physiologically active agents with dmso
US3834374A (en) 1972-04-06 1974-09-10 M Ensanian Diagnostic electrical scanning
US4002221A (en) * 1972-09-19 1977-01-11 Gilbert Buchalter Method of transmitting ultrasonic impulses to surface using transducer coupling agent
US3828769A (en) 1973-02-28 1974-08-13 H Mettler Method and apparatus for ultrasonic treatment of lower tissues simultaneous with heating of subcutaneous, outer muscle and lower tissues
US3980077A (en) 1975-02-20 1976-09-14 Carletta M. Neeley Method for aiding diagnostic scanning of the body of a patient
US4020830A (en) * 1975-03-12 1977-05-03 The University Of Utah Selective chemical sensitive FET transducers
US4144317A (en) * 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
US4027664A (en) * 1975-11-17 1977-06-07 Baxter Travenol Laboratories, Inc. Diagnostic electrode assembly with a skin preparation surface
US4144646A (en) * 1975-12-05 1979-03-20 Lion Hamigaki Kabushiki Kaisha Torsional ultrasonic vibrators
US4127125A (en) 1975-12-22 1978-11-28 Lion Hamigaki Kabushiki Kaisha Devices for transmitting ultrasonic waves to teeth
CA1083040A (fr) 1976-02-09 1980-08-05 Mostafa Fahim Application locale de medicament par ultasons avec un agent de couplage
US4309989A (en) * 1976-02-09 1982-01-12 The Curators Of The University Of Missouri Topical application of medication by ultrasound with coupling agent
DE2756460A1 (de) 1977-12-17 1979-06-21 Fraunhofer Ges Forschung Verfahren zur lokal begrenzten applikation von therpeutika durch die oberflaeche von lebenden koerpern oder koerperorganen
US4176664A (en) 1978-03-13 1979-12-04 Stanley Kalish Impregnated bandage
US4280494A (en) * 1979-06-26 1981-07-28 Cosgrove Robert J Jun System for automatic feedback-controlled administration of drugs
US4249531A (en) * 1979-07-05 1981-02-10 Alza Corporation Bioerodible system for delivering drug manufactured from poly(carboxylic acid)
US4274419A (en) * 1979-10-19 1981-06-23 Quinton Instrument Co. Skin preparation device and method used in the application of medical electrodes
CA1165240A (fr) 1980-07-09 1984-04-10 The Procter & Gamble Company Composes pharmaceutiques a usage topique
US4372296A (en) * 1980-11-26 1983-02-08 Fahim Mostafa S Treatment of acne and skin disorders and compositions therefor
US4457748A (en) * 1982-01-11 1984-07-03 Medtronic, Inc. Non-invasive diagnosis method
US4622031A (en) 1983-08-18 1986-11-11 Drug Delivery Systems Inc. Indicator for electrophoretic transcutaneous drug delivery device
US4537776A (en) 1983-06-21 1985-08-27 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone
US4538612A (en) 1983-08-29 1985-09-03 Ndm Corporation Skin preparation method and product
US4563184A (en) * 1983-10-17 1986-01-07 Bernard Korol Synthetic resin wound dressing and method of treatment using same
US4557943A (en) 1983-10-31 1985-12-10 Advanced Semiconductor Materials America, Inc. Metal-silicide deposition using plasma-enhanced chemical vapor deposition
US4646725A (en) * 1983-11-16 1987-03-03 Manoutchehr Moasser Method for treating herpes lesions and other infectious skin conditions
US4605670A (en) 1984-02-01 1986-08-12 Nitto Electric Industrial Co., Ltd. Method for percutaneously administering metoclopramide
US4732153A (en) * 1984-07-18 1988-03-22 Michael Phillips Transdermal dosimeter
DK8601218A (fr) * 1984-07-18 1986-03-17
US4657543A (en) * 1984-07-23 1987-04-14 Massachusetts Institute Of Technology Ultrasonically modulated polymeric devices for delivering compositions
US4834978A (en) * 1984-10-01 1989-05-30 Biotek, Inc. Method of transdermal drug delivery
US4702732A (en) 1984-12-24 1987-10-27 Trustees Of Boston University Electrodes, electrode assemblies, methods, and systems for tissue stimulation and transdermal delivery of pharmacologically active ligands
JPS6218446A (ja) * 1985-07-08 1987-01-27 Bridgestone Corp 分散性改良カ−ボンブラツクを配合したゴム組成物
US4698058A (en) 1985-10-15 1987-10-06 Albert R. Greenfeld Ultrasonic self-cleaning catheter system for indwelling drains and medication supply
US4683242A (en) * 1985-10-28 1987-07-28 A. H. Robins Company, Incorporated Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters
JPS62270144A (ja) * 1986-03-03 1987-11-24 久光製薬株式会社 経皮投薬用皮膚損傷装置
US4775361A (en) 1986-04-10 1988-10-04 The General Hospital Corporation Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport
US4769022A (en) 1986-05-02 1988-09-06 Minnesota Mining And Manufacturing Company Cleansing pad
DE3670206D1 (de) 1986-05-20 1990-05-17 Massachusetts Inst Technology Bioerodierbare erzeugnisse zur verwendung als implantate oder prothese mit einem voraussehbaren resorbierungsgrad.
GB8612861D0 (en) 1986-05-27 1986-07-02 Cambridge Life Sciences Immobilised enzyme biosensors
US4981779A (en) * 1986-06-26 1991-01-01 Becton, Dickinson And Company Apparatus for monitoring glucose
US4767402A (en) 1986-07-08 1988-08-30 Massachusetts Institute Of Technology Ultrasound enhancement of transdermal drug delivery
US4948587A (en) 1986-07-08 1990-08-14 Massachusetts Institute Of Technology Ultrasound enhancement of transbuccal drug delivery
JPS6336172A (ja) 1986-07-29 1988-02-16 Toshiba Corp 超音波カプラ
US4778457A (en) 1986-11-06 1988-10-18 York Kenneth K Disposable applicator
US4863970A (en) 1986-11-14 1989-09-05 Theratech, Inc. Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
JPS63132889A (ja) 1986-11-21 1988-06-04 Tanabe Seiyaku Co Ltd キナゾリノン誘導体
US4786277A (en) 1986-11-21 1988-11-22 Trustees Of Boston University Electrodes, electrode assemblies, methods, and systems for tissue stimulation
JPS63135179A (ja) 1986-11-26 1988-06-07 立花 俊郎 薬物の経皮投与具
US5001051A (en) * 1986-12-12 1991-03-19 Regents Of The University Of California Dose critical in-vivo detection of anti-cancer drug levels in blood
US5006342A (en) * 1986-12-22 1991-04-09 Cygnus Corporation Resilient transdermal drug delivery device
EP0278599A3 (fr) 1987-02-02 1988-12-07 Seiko Epson Corporation Appareil pour la fabrication d'image photographique de type transfert
US4773806A (en) 1987-04-03 1988-09-27 Beaulieu Burl R Agricultural vehicle for transporting and feeding hay
US4787888A (en) 1987-06-01 1988-11-29 University Of Connecticut Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a)
US4821733A (en) * 1987-08-18 1989-04-18 Dermal Systems International Transdermal detection system
US4820720A (en) * 1987-08-24 1989-04-11 Alza Corporation Transdermal drug composition with dual permeation enhancers
AU614092B2 (en) * 1987-09-11 1991-08-22 Paul Max Grinwald Improved method and apparatus for enhanced drug permeation of skin
JPH01140054A (ja) 1987-11-26 1989-06-01 Nec Corp グルコースセンサ
DE68925030T2 (de) * 1988-01-21 1996-07-25 Massachusetts Inst Technology Molekültransport durch gewebe mit der verwendung von elektroporation.
US5362307A (en) 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
KR970011449B1 (ko) 1988-01-29 1997-07-11 더 리전트 오브 디 유니버시티 오브 캘리포니아 이온전기 영동형 비침입 검체 채취 또는 이송 장치 및 방법
US4866050A (en) 1988-04-27 1989-09-12 Ben Amoz Daniel Ultrasonic transdermal application of steroid compositions
US5078144A (en) 1988-08-19 1992-01-07 Olympus Optical Co. Ltd. System for applying ultrasonic waves and a treatment instrument to a body part
US5076273A (en) 1988-09-08 1991-12-31 Sudor Partners Method and apparatus for determination of chemical species in body fluid
EP0363504A1 (fr) * 1988-10-10 1990-04-18 Dräger Nederland B.V. Procédé pour réaliser une couche comprenant un hydrogel à base de polyvinyle et une substance à activité biochimique sur un substrat
US5008110A (en) * 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5250419A (en) 1988-12-16 1993-10-05 L'oreal Method for the direct measurement of at least one chemical parameter of skin using a biosensor
US5086229A (en) 1989-01-19 1992-02-04 Futrex, Inc. Non-invasive measurement of blood glucose
JP2703035B2 (ja) * 1989-02-28 1998-01-26 久光製薬株式会社 イオントフォレーゼ用デバイス
US4933062A (en) * 1989-03-07 1990-06-12 University Of Connecticut Modified composite electrodes with renewable surface for electrochemical applications and method of making same
US4953552A (en) 1989-04-21 1990-09-04 Demarzo Arthur P Blood glucose monitoring system
US5118404A (en) 1989-04-28 1992-06-02 Nec Corporation Enzyme electrode and a method of determining concentration of an analyte in a sample solution
US5139023A (en) 1989-06-02 1992-08-18 Theratech Inc. Apparatus and method for noninvasive blood glucose monitoring
KR920700014A (ko) 1989-06-02 1992-02-19 테오도르 에이취. 스탠리 비침입적인 혈중 글루코오스의 검사 장치 및 방법
US5069908A (en) 1989-06-19 1991-12-03 Henley International, Inc. Crosslinked hydrogel and method for making same
US5120544A (en) * 1989-06-19 1992-06-09 Henley International, Inc. Crosslinked hydrogel and method for making same
US4986271A (en) * 1989-07-19 1991-01-22 The University Of New Mexico Vivo refillable glucose sensor
US5050604A (en) 1989-10-16 1991-09-24 Israel Reshef Apparatus and method for monitoring the health condition of a subject
US5140985A (en) 1989-12-11 1992-08-25 Schroeder Jon M Noninvasive blood glucose measuring device
US5036861A (en) 1990-01-11 1991-08-06 Sembrowich Walter L Method and apparatus for non-invasively monitoring plasma glucose levels
US5179189A (en) 1990-01-19 1993-01-12 Nova Pharmaceutical Corporation Fatty acid terminated polyanhydrides
US5016615A (en) * 1990-02-20 1991-05-21 Riverside Research Institute Local application of medication with ultrasound
US5115805A (en) 1990-02-23 1992-05-26 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
CA2196746A1 (fr) 1990-02-23 1991-08-24 The Regents Of The University Of California Amelioration par ultrasons de la liberation des matieres dans et a travers la peau
US5231975A (en) 1990-02-23 1993-08-03 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
US5161532A (en) 1990-04-19 1992-11-10 Teknekron Sensor Development Corporation Integral interstitial fluid sensor
US5165407A (en) 1990-04-19 1992-11-24 The University Of Kansas Implantable glucose sensor
US5119819A (en) * 1990-05-02 1992-06-09 Miles Inc. Method and apparatus for non-invasive monitoring of blood glucose
EP0533816B1 (fr) 1990-06-15 1995-06-14 Cortrak Medical, Inc. Appareil d'acheminement de medicament
US5197946A (en) * 1990-06-27 1993-03-30 Shunro Tachibana Injection instrument with ultrasonic oscillating element
US5236410A (en) 1990-08-02 1993-08-17 Ferrotherm International, Inc. Tumor treatment method
WO1992006701A1 (fr) 1990-10-18 1992-04-30 Huffstutler, M., Conrad, Jr. Preparations d'extraits de symphytum fluide concentre, formes therapeutiques et procedes d'utilisation
JP2646848B2 (ja) * 1990-11-30 1997-08-27 日本電気株式会社 グルコースセンサの測定方法
ES2176189T3 (es) * 1991-02-01 2002-12-01 Massachusetts Inst Technology Mezlas de polimeros biodegradables para uso medicamentosos.
AU1442592A (en) * 1991-02-20 1992-09-15 Nova Pharmaceutical Corporation Controlled release microparticulate delivery system for proteins
US5135753A (en) 1991-03-12 1992-08-04 Pharmetrix Corporation Method and therapeutic system for smoking cessation
EP0504881B2 (fr) 1991-03-22 2000-11-08 Katsuro Tachibana Amplificateur pour la thérapie des maladies à ultrason et composition pharmaceutique liquide le contenant
JP2684871B2 (ja) 1991-05-16 1997-12-03 日本電気株式会社 体液成分測定方法および測定装置
JP3181071B2 (ja) 1991-06-28 2001-07-03 俊郎 立花 血液処理装置
US5171215A (en) 1991-08-22 1992-12-15 Flanagan Dennis F Endermic method and apparatus
US5178448A (en) * 1991-09-13 1993-01-12 Donnelly Corporation Rearview mirror with lighting assembly
US5215520A (en) * 1991-09-17 1993-06-01 Centre Internationale De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) Method for delivering an active substance topically or percutaneously
EP0612253A4 (fr) 1991-11-12 1995-08-09 Nepera Inc Hydrogels adhesifs presentant une vie utile prolongee et procede de preparation.
US5697882A (en) * 1992-01-07 1997-12-16 Arthrocare Corporation System and method for electrosurgical cutting and ablation
WO1993015722A1 (fr) 1992-02-07 1993-08-19 Syntex (Usa) Inc. Liberation controlee de produits pharmaceutiques a partir de microparticules poreuses preformees
US5165418B1 (en) 1992-03-02 1999-12-14 Nikola I Tankovich Blood sampling device and method using a laser
US5405614A (en) 1992-04-08 1995-04-11 International Medical Associates, Inc. Electronic transdermal drug delivery system
NL9200731A (nl) * 1992-04-22 1993-11-16 Jacob Korf Werkwijze en inrichting voor het niet-invasief bewaken van de concentratie van stoffen in bloed.
US5964723A (en) 1992-06-19 1999-10-12 Augustine Medical, Inc. Normothermic tissue heating wound covering
US5534496A (en) * 1992-07-07 1996-07-09 University Of Southern California Methods and compositions to enhance epithelial drug transport
US5230344A (en) 1992-07-31 1993-07-27 Intelligent Hearing Systems Corp. Evoked potential processing system with spectral averaging, adaptive averaging, two dimensional filters, electrode configuration and method therefor
JPH0670987A (ja) 1992-08-28 1994-03-15 Katsuro Tachibana 薬物投与・体液採取ユニット及び装置
US5421816A (en) * 1992-10-14 1995-06-06 Endodermic Medical Technologies Company Ultrasonic transdermal drug delivery system
US5643252A (en) 1992-10-28 1997-07-01 Venisect, Inc. Laser perforator
US6315772B1 (en) * 1993-09-24 2001-11-13 Transmedica International, Inc. Laser assisted pharmaceutical delivery and fluid removal
US5633234A (en) 1993-01-22 1997-05-27 The Johns Hopkins University Lysosomal targeting of immunogens
US5364838A (en) 1993-01-29 1994-11-15 Miris Medical Corporation Method of administration of insulin
US5386837A (en) 1993-02-01 1995-02-07 Mmtc, Inc. Method for enhancing delivery of chemotherapy employing high-frequency force fields
US5267985A (en) 1993-02-11 1993-12-07 Trancell, Inc. Drug delivery by multiple frequency phonophoresis
CA2114968A1 (fr) 1993-02-25 1994-08-26 John Wille Traitement transdermique par des agents de degranulation des mastocytes pour l'hypersensibilite induite par voie medicamenteuse
US5667487A (en) 1993-04-07 1997-09-16 Henley; Julian L. Ionosonic drug delivery apparatus
WO1995002357A1 (fr) 1993-07-16 1995-01-26 Cygnus Therapeutic Systems Glucometre non invasif
US5413550A (en) * 1993-07-21 1995-05-09 Pti, Inc. Ultrasound therapy system with automatic dose control
US5415629A (en) * 1993-09-15 1995-05-16 Henley; Julian L. Programmable apparatus for the transdermal delivery of drugs and method
US5582184A (en) 1993-10-13 1996-12-10 Integ Incorporated Interstitial fluid collection and constituent measurement
EP0649628B1 (fr) 1993-10-22 1999-01-07 Siemens-Elema AB Procédé et appareil pour le contrÔle en continue du niveau d'un analyte
US5458140A (en) 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
US5814599A (en) * 1995-08-04 1998-09-29 Massachusetts Insitiute Of Technology Transdermal delivery of encapsulated drugs
US5885211A (en) * 1993-11-15 1999-03-23 Spectrix, Inc. Microporation of human skin for monitoring the concentration of an analyte
US5445611A (en) 1993-12-08 1995-08-29 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal delivery with ultrasound and chemical enhancers
US5443080A (en) 1993-12-22 1995-08-22 Americate Transtech, Inc. Integrated system for biological fluid constituent analysis
DE69519023T2 (de) 1994-06-24 2001-06-13 Cygnus, Inc. Einrichtung zur iontophoretischen probennahme
US5771890A (en) 1994-06-24 1998-06-30 Cygnus, Inc. Device and method for sampling of substances using alternating polarity
US5429735A (en) * 1994-06-27 1995-07-04 Miles Inc. Method of making and amperometric electrodes
JP3170172B2 (ja) 1995-03-30 2001-05-28 ティーディーケイ株式会社 チップ部品供給装置及び該装置に用いるチップ部品供給ケース
US5569198A (en) 1995-01-23 1996-10-29 Cortrak Medical Inc. Microporous catheter
US5626554A (en) 1995-02-21 1997-05-06 Exogen, Inc. Gel containment structure
US5573778A (en) 1995-03-17 1996-11-12 Adhesives Research, Inc. Drug flux enhancer-tolerant pressure sensitive adhesive composition
US5646221A (en) 1995-03-31 1997-07-08 Kowa Co., Ltd. Adhesive base material
US6041252A (en) * 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method
PT840597E (pt) 1995-07-12 2004-02-27 Cygnus Therapeutic Systems Penso de hidrogel
US6002961A (en) 1995-07-25 1999-12-14 Massachusetts Institute Of Technology Transdermal protein delivery using low-frequency sonophoresis
US5947921A (en) 1995-12-18 1999-09-07 Massachusetts Institute Of Technology Chemical and physical enhancers and ultrasound for transdermal drug delivery
EP0781150B1 (fr) 1995-07-25 2002-11-06 Massachusetts Institute Of Technology Transport transdermique ameliore grace aux ultrasons
PT1563788E (pt) 1995-08-29 2015-06-02 Nitto Denko Corp Microporação de pele humana para distribuição de fármaco e aplicações de monitorização
WO1997007853A1 (fr) 1995-08-31 1997-03-06 Hisamitsu Pharmaceutical Co., Inc. Dispositif d'iontophorese et procede approprie de regulation du courant
US5906830A (en) * 1995-09-08 1999-05-25 Cygnus, Inc. Supersaturated transdermal drug delivery systems, and methods for manufacturing the same
US5989409A (en) 1995-09-11 1999-11-23 Cygnus, Inc. Method for glucose sensing
US5735273A (en) 1995-09-12 1998-04-07 Cygnus, Inc. Chemical signal-impermeable mask
US5902603A (en) * 1995-09-14 1999-05-11 Cygnus, Inc. Polyurethane hydrogel drug reservoirs for use in transdermal drug delivery systems, and associated methods of manufacture and use
US5833647A (en) 1995-10-10 1998-11-10 The Penn State Research Foundation Hydrogels or lipogels with enhanced mass transfer for transdermal drug delivery
US5618275A (en) * 1995-10-27 1997-04-08 Sonex International Corporation Ultrasonic method and apparatus for cosmetic and dermatological applications
WO1997018851A1 (fr) 1995-11-24 1997-05-29 Ekos Corporation Matiere hemostatique et appareil d'hemostase
CA2212826C (fr) 1995-12-28 2002-02-19 Cygnus, Inc. Controle continu d'un analyte physiologique
US6032060A (en) * 1996-01-25 2000-02-29 3M Innovative Properties Company Method for conditioning skin and an electrode by passing electrical energy
AU721034B2 (en) 1996-02-15 2000-06-22 Biosense, Inc. Catheter based surgery
US6009343A (en) 1996-02-23 1999-12-28 Abbott Laboratories Enhanced transdermal transport of fluid using vacuum
US5895362A (en) 1996-02-23 1999-04-20 Abbott Laboratories Transdermal transport using ultrasonic standing waves
US5655539A (en) 1996-02-26 1997-08-12 Abbott Laboratories Method for conducting an ultrasound procedure using an ultrasound transmissive pad
US5656016A (en) 1996-03-18 1997-08-12 Abbott Laboratories Sonophoretic drug delivery system
JP2002515786A (ja) * 1996-06-28 2002-05-28 ソントラ メディカル,エル.ピー. 経皮輸送の超音波増強
US6024717A (en) 1996-10-24 2000-02-15 Vibrx, Inc. Apparatus and method for sonically enhanced drug delivery
DE69730612T2 (de) 1996-11-07 2005-01-27 Cambridge Sensors Ltd., Godmanchester Elektroden und ihre verwendung in assays
US6063039A (en) 1996-12-06 2000-05-16 Abbott Laboratories Method and apparatus for obtaining blood for diagnostic tests
KR100453132B1 (ko) 1996-12-20 2004-10-15 앨자 코포레이션 경피 약제 플럭스를 향상시키기 위한 장치 및 방법
US5913833A (en) * 1997-02-07 1999-06-22 Abbott Laboratories Method and apparatus for obtaining biological fluids
US6139718A (en) 1997-03-25 2000-10-31 Cygnus, Inc. Electrode with improved signal to noise ratio
US5961451A (en) 1997-04-07 1999-10-05 Motorola, Inc. Noninvasive apparatus having a retaining member to retain a removable biosensor
US6546378B1 (en) * 1997-04-24 2003-04-08 Bright Ideas, L.L.C. Signal interpretation engine
US5851438A (en) 1997-08-29 1998-12-22 E. I. Du Pont De Nemours And Company Thick film compositions for making medical electrodes
US6126619A (en) 1997-09-02 2000-10-03 Transon Llc Multiple transducer assembly and method for coupling ultrasound energy to a body
US6503198B1 (en) * 1997-09-11 2003-01-07 Jack L. Aronowtiz Noninvasive transdermal systems for detecting an analyte obtained from or underneath skin and methods
CA2317777C (fr) * 1998-01-08 2005-05-03 Sontra Medical, Inc. Transport transdermique par sonophorese ameliore
US7066884B2 (en) * 1998-01-08 2006-06-27 Sontra Medical, Inc. System, method, and device for non-invasive body fluid sampling and analysis
WO2000035357A1 (fr) 1998-12-18 2000-06-22 Sontra Medical, Inc. Methode et dispositif favorisant le transport transdermique
WO2001070330A2 (fr) 2000-03-17 2001-09-27 Sontra Medical, Inc. Systeme, procede et dispositif pour le prelevement non-invasif et l'analyse de fluides organiques
US8287483B2 (en) 1998-01-08 2012-10-16 Echo Therapeutics, Inc. Method and apparatus for enhancement of transdermal transport
WO1999034858A1 (fr) 1998-01-12 1999-07-15 Georgia Tech Research Corporation Estimation et regulation des effet de l'energie acoustique sur des tissus
US20020055702A1 (en) 1998-02-10 2002-05-09 Anthony Atala Ultrasound-mediated drug delivery
JP3594794B2 (ja) 1998-03-24 2004-12-02 独立行政法人 科学技術振興機構 ナノ秒時間ゲート分光診断装置
US6398753B2 (en) * 1998-04-03 2002-06-04 Mcdaniel David H. Ultrasound enhancement of percutaneous drug absorption
EP1098589B1 (fr) 1998-07-21 2006-02-22 SPECTRX, Inc. Dispositif de prelevement et de detection en continu de fluide
US6535753B1 (en) * 1998-08-20 2003-03-18 Microsense International, Llc Micro-invasive method for painless detection of analytes in extra-cellular space
AU765763B2 (en) 1998-09-04 2003-09-25 Powderject Research Limited Monitoring methods using particle delivery methods
US6468229B1 (en) 1998-10-20 2002-10-22 Abbott Laboratories Apparatus and method for the collection of interstitial fluids
JP2000126182A (ja) 1998-10-27 2000-05-09 Mitani Sangyo Co Ltd 腫瘍診断方法
US6148232A (en) 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
CA2355187A1 (fr) 1998-12-18 2000-06-22 Sontra Medical, Inc. Methode et appareil permettant de produire une cavitation homogene en vue d'un transport transdermique
US20040171980A1 (en) 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
US6477410B1 (en) * 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
JP4210386B2 (ja) 1999-03-30 2009-01-14 テルモ株式会社 体腔内超音波診断装置
US6920455B1 (en) * 1999-05-19 2005-07-19 Sun Microsystems, Inc. Mechanism and method for managing service-specified data in a profile service
WO2001003638A1 (fr) * 1999-07-12 2001-01-18 Dermispa Group, Inc. Dispositif de massage et de stimulation et son procede d'utilisation
US6645184B1 (en) * 1999-08-09 2003-11-11 Brian D. Zelickson Tape stripping system and method
US7133717B2 (en) * 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US6251083B1 (en) * 1999-09-07 2001-06-26 Amira Medical Interstitial fluid methods and devices for determination of an analyte in the body
JP2001286569A (ja) * 2000-04-05 2001-10-16 Polytronics Ltd 経皮投薬装置
US6540675B2 (en) * 2000-06-27 2003-04-01 Rosedale Medical, Inc. Analyte monitor
US7664484B2 (en) * 2000-09-07 2010-02-16 Tangoe, Inc. Pooling groups of wireless communication users
US6487447B1 (en) 2000-10-17 2002-11-26 Ultra-Sonic Technologies, L.L.C. Method and apparatus for in-vivo transdermal and/or intradermal delivery of drugs by sonoporation
ES2322023T3 (es) * 2000-10-26 2009-06-16 Alza Corporation Dispositivos de administracion transdermica de farmacos que presentan unas microprotuberancias recubiertas.
US7180855B1 (en) * 2001-04-19 2007-02-20 At&T Corp. Service interface for QoS-driven HPNA networks
US7027408B2 (en) * 2001-03-05 2006-04-11 Qwest Communications International, Inc Method and system for dynamic service profile integration by a service controller
US7083580B2 (en) * 2001-04-06 2006-08-01 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery
US7496401B2 (en) * 2001-04-06 2009-02-24 Mattioli Engineering Ltd Method and apparatus for skin absorption enhancement and transdermal drug delivery
US7158792B1 (en) * 2001-09-20 2007-01-02 Sprint Communications Company L.P. Selecting a wireless link in a public wireless communication network
US7882029B2 (en) * 2001-10-16 2011-02-01 Hewlett-Packard Development Company, L.P. Centralized billing credit system utilizing a predetermined unit of usage
US6795727B2 (en) * 2001-10-17 2004-09-21 Pedro Giammarusti Devices and methods for promoting transcutaneous movement of substances
EP1450876B1 (fr) * 2001-11-07 2016-08-17 Syneron Medical Ltd. Systeme integre d'administration transdermique de medicament
US6887239B2 (en) * 2002-04-17 2005-05-03 Sontra Medical Inc. Preparation for transmission and reception of electrical signals
US7483736B2 (en) 2002-04-24 2009-01-27 Rocky Mountain Biosystems, Inc. Feedback control device for transcutaneous drug delivery and uses therefor
JP2005537057A (ja) * 2002-08-29 2005-12-08 ベクトン・ディキンソン・アンド・カンパニー 微小突起物アレイ及びそれを用いて物質を組織内に送達する方法
WO2004028379A1 (fr) * 2002-09-25 2004-04-08 Flock, Stephen, T. Systeme microchirurgical permettant de traiter un tissu
US7324447B1 (en) * 2002-09-30 2008-01-29 Packeteer, Inc. Methods, apparatuses and systems facilitating concurrent classification and control of tunneled and non-tunneled network traffic
US7221929B2 (en) * 2002-10-12 2007-05-22 Lg Electronics Inc. Handling charging information in interworking structure of mobile communication and wireless local area networks
US6998985B2 (en) * 2003-03-05 2006-02-14 Dmatek, Ltd. Monitoring and tracking network
US7668903B2 (en) * 2003-07-07 2010-02-23 Xerox Corporation Method and apparatus for dynamically delivering service profiles to clients
US7873705B2 (en) * 2004-03-12 2011-01-18 Flash Networks Ltd. System and method for identifying content service within content server
US7292159B2 (en) * 2004-07-14 2007-11-06 Spectrum Tracking Systems, Inc. Method and system for providing tracking services to locate an asset
US20060100567A1 (en) * 2004-07-30 2006-05-11 Rocky Mountain Biosystems, Inc Microsurgical tissue treatment system
US20060094944A1 (en) * 2004-10-28 2006-05-04 Sontra Medical Corporation System and method for analyte sampling and analysis with error correction
WO2006045149A1 (fr) * 2004-10-28 2006-05-04 Ronald Allan Greenberg Procede et appareil pour abrasion de la peau a l'aide d'un appareil de dermabrasion vibrant
US8156128B2 (en) * 2005-09-14 2012-04-10 Jumptap, Inc. Contextual mobile content placement on a mobile communication facility
US7868778B2 (en) * 2005-09-20 2011-01-11 David Norris Kenwright Apparatus and method for proximity-responsive display materials
US20070093243A1 (en) * 2005-10-25 2007-04-26 Vivek Kapadekar Device management system
US9636035B2 (en) * 2005-12-14 2017-05-02 Scibase Ab Medical apparatus for determination of biological conditions using impedance measurements
US7720505B2 (en) * 2006-03-07 2010-05-18 Marvell World Trade Ltd. Personal lifestyle device
US8064391B2 (en) * 2006-08-22 2011-11-22 Embarq Holdings Company, Llc System and method for monitoring and optimizing network performance to a wireless device
US7941184B2 (en) * 2006-11-10 2011-05-10 Dell Products L.P. Methods and systems for managing and/or tracking use of subscriber identity module components
US8612320B2 (en) * 2006-12-14 2013-12-17 Corelogic Solutions, Llc Method and apparatus for detecting fraudulent loans
JP5995060B2 (ja) 2012-05-18 2016-09-21 日本精機株式会社 車両用表示装置

Also Published As

Publication number Publication date
ATE499967T1 (de) 2011-03-15
EP2152358B1 (fr) 2011-03-02
IL201699A0 (en) 2010-05-31
WO2008134545A1 (fr) 2008-11-06
CA2685423C (fr) 2014-02-18
HK1140709A1 (en) 2010-10-22
KR101211252B1 (ko) 2012-12-12
RU2009143880A (ru) 2011-06-10
MX2009011581A (es) 2010-02-17
IL201699A (en) 2013-06-27
US20130137951A1 (en) 2013-05-30
CN101707872B (zh) 2014-10-22
BRPI0810969A2 (pt) 2015-01-27
JP5827632B2 (ja) 2015-12-02
SI2152358T1 (sl) 2011-08-31
RU2435616C2 (ru) 2011-12-10
EP2152358A1 (fr) 2010-02-17
US8386027B2 (en) 2013-02-26
US9572527B2 (en) 2017-02-21
CA2685423A1 (fr) 2008-11-06
AU2008245585B2 (en) 2011-10-06
DK2152358T3 (da) 2011-06-27
ES2387419T3 (es) 2012-09-21
US20080275468A1 (en) 2008-11-06
PL2152358T3 (pl) 2011-09-30
CN101707872A (zh) 2010-05-12
PT2152358E (pt) 2011-06-07
NZ580997A (en) 2011-08-26
DE602008005299D1 (de) 2011-04-14
JP2010525881A (ja) 2010-07-29
JP2013063328A (ja) 2013-04-11
AU2008245585A1 (en) 2008-11-06
KR20100028539A (ko) 2010-03-12
CY1112035T1 (el) 2015-11-04
HRP20110396T1 (hr) 2011-08-31

Similar Documents

Publication Publication Date Title
IL201699A0 (en) Skin permeation device for analyte sensing or transdermal drug delivery
DE502007003787D1 (de) Einrichtung
JP2010525881A5 (fr)
WO2005060621A3 (fr) Procede et dispositif permettant de perforer une surface afin d'extraire, d'analyser et/ou d'administrer une substance, au moyen de micro-aiguilles
ATE413860T1 (de) Bausatz, vorrichtung und verfahren zur gesteuerten abgabe eines oxidationsmittels in die haut
WO2004063718A3 (fr) Ensemble d'elements capteur a usage unique
WO2006099413A3 (fr) Dispositifs, procedes et kits de traitement par rayonnements par l'intermediaire d'une surface corporelle cible
WO2008033829A3 (fr) Cartographie automatisée de caractéristiques anatomiques de cavités cardiaques
WO2009089094A3 (fr) Dispositifs d'administration de médicament implantables, appareil et procédés de remplissage des dispositifs
WO2009036105A3 (fr) Système de capteur pour thérapie par perfusion
WO2010141719A3 (fr) Matériaux et procédés de mesure des taux d'oxyde nitrique dans des fluides biologiques
WO2011022732A3 (fr) Appareil et procédé pour mesurer des paramètres biochimiques
WO2009060823A1 (fr) Système pour mesurer avec précision une concentration de composant sanguin et procédé de commande du système
DE502006001900D1 (de) Vorrichtung zum kontrollierten Einstechen in ein Objekt und Verfahren zum Betreiben der Vorrichtung
ATE349295T1 (de) Vorrichtung und verfahren zur bestimmung der beanspruchung eines werkzeugs mit dünnschichtsensoren
WO2006063063A3 (fr) Appareil et procede d'echantillonnage biomoleculaire, d'analyse et d'administration transdermique de traces en temps reel et en continu
EP3803362C0 (fr) Capteur électrochimique, électrode, procédé de production de l'électrode, procédé de détection d'un analyte et utilisation du capteur électrochimique
DK2180289T3 (da) Apparat til kontrol af gevind
WO2012073239A3 (fr) Techniques destinées à être utilisées avec un dispositif de perçage d'ongle
ATE439801T1 (de) Vorrichtung zum messen von aus leckstrom stammendem druck
DE602007001656D1 (de) Verfahren zum Ermitteln der Wirksamkeit eines Anthracyclin-Antikrebsmittels
EP1902749A3 (fr) Appareil iontophorèse
EP2051068A3 (fr) Appareil de contrôle de l'humidité pour capteurs électrochimiques
DE50311039D1 (de) Verfahren zur Blutdruckmessung und Blutdruckmessgerät mit Benutzerführung
CN202313344U (zh) 一种ppd试验定位测量薄膜